Published in J Biol Chem on February 14, 2006
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Regulation and pharmacology of the mitochondrial permeability transition pore. Cardiovasc Res (2009) 1.66
Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition. Proc Natl Acad Sci U S A (2009) 1.48
BH3 mimetics to improve cancer therapy; mechanisms and examples. Drug Resist Updat (2007) 1.33
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Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II. Oncogene (2008) 1.21
Mitochondria and cardioprotection. Heart Fail Rev (2007) 1.14
Prosurvival Bcl-2 proteins stabilize pancreatic mitochondria and protect against necrosis in experimental pancreatitis. Exp Cell Res (2009) 1.06
Pseudomonas aeruginosa biofilm-associated homoserine lactone C12 rapidly activates apoptosis in airway epithelia. Cell Microbiol (2012) 1.04
Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysis. J Virol (2008) 1.02
Targeting DDX3 with a small molecule inhibitor for lung cancer therapy. EMBO Mol Med (2015) 1.00
Nonesterified cholesterol content of lysosomes modulates susceptibility to oxidant-induced permeabilization. Free Radic Biol Med (2010) 0.98
Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism. J Biol Chem (2008) 0.94
Bcl-2 is a novel interacting partner for the 2-oxoglutarate carrier and a key regulator of mitochondrial glutathione. Free Radic Biol Med (2011) 0.92
KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions. J Cardiovasc Pharmacol (2008) 0.91
Targeting BCL2-Proteins for the Treatment of Solid Tumours. Adv Med (2014) 0.89
Blockade of electron transport during ischemia preserves bcl-2 and inhibits opening of the mitochondrial permeability transition pore. FEBS Lett (2011) 0.88
The mitochondrial permeability transition pore and its adaptive responses in tumor cells. Cell Calcium (2014) 0.88
Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells. Oncotarget (2014) 0.86
Rapid detection of an ABT-737-sensitive primed for death state in cells using microplate-based respirometry. PLoS One (2012) 0.83
Pre-clinical characterization of PKC412, a multi-kinase inhibitor, against colorectal cancer cells. Oncotarget (2016) 0.78
Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III. Sci Rep (2017) 0.75
HSP70 mediates survival in apoptotic cells-Boolean network prediction and experimental validation. Front Cell Neurosci (2015) 0.75
BRAF mutations in hairy-cell leukemia. N Engl J Med (2011) 7.05
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell (2005) 4.36
Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol (2003) 4.31
Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D. J Biol Chem (2005) 4.29
The mitochondrial permeability transition from in vitro artifact to disease target. FEBS J (2006) 3.26
Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency. Nat Genet (2003) 3.15
Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration. Nat Med (2010) 3.01
Dimers of mitochondrial ATP synthase form the permeability transition pore. Proc Natl Acad Sci U S A (2013) 2.96
Sarcoidosis is a Th1/Th17 multisystem disorder. Thorax (2010) 2.60
The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis. Apoptosis (2007) 2.59
A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. Oncogene (2002) 2.55
Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosis. Cell Calcium (2011) 2.06
The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses. J Clin Invest (2006) 1.93
Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis. J Clin Invest (2005) 1.93
Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. PLoS One (2008) 1.87
Mitochondria and ischemia-reperfusion injury of the heart: fixing a hole. Cardiovasc Res (2006) 1.85
Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Proc Natl Acad Sci U S A (2007) 1.76
Mitochondrial dysfunction in the pathogenesis of Ullrich congenital muscular dystrophy and prospective therapy with cyclosporins. Proc Natl Acad Sci U S A (2007) 1.74
Properties of the permeability transition in VDAC1(-/-) mitochondria. Biochim Biophys Acta (2006) 1.74
Cyclosporin A corrects mitochondrial dysfunction and muscle apoptosis in patients with collagen VI myopathies. Proc Natl Acad Sci U S A (2008) 1.59
Immune tolerance to tumor antigens occurs in a specialized environment of the spleen. Cell Rep (2012) 1.59
Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complex. J Biol Chem (2009) 1.58
Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition. Proc Natl Acad Sci U S A (2009) 1.48
Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation. J Biol Chem (2008) 1.43
Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetes. Circ Res (2011) 1.41
p66Shc-generated oxidative signal promotes fat accumulation. J Biol Chem (2008) 1.39
Multiple myeloma cell survival relies on high activity of protein kinase CK2. Blood (2006) 1.37
Expression and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes. Blood (2003) 1.37
Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis. J Leukoc Biol (2007) 1.37
The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase. Cell Metab (2013) 1.36
Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury. J Neurosci (2009) 1.35
Mitochondrial deoxynucleotide pool sizes in mouse liver and evidence for a transport mechanism for thymidine monophosphate. Proc Natl Acad Sci U S A (2006) 1.34
Signal transduction to the permeability transition pore. FEBS Lett (2010) 1.30
Overexpression of the stress protein Grp94 reduces cardiomyocyte necrosis due to calcium overload and simulated ischemia. FASEB J (2003) 1.29
Cyclophilin D in mitochondrial pathophysiology. Biochim Biophys Acta (2009) 1.27
Arachidonic acid released by phospholipase A(2) activation triggers Ca(2+)-dependent apoptosis through the mitochondrial pathway. J Biol Chem (2004) 1.27
Abnormal re-epithelialization and lung remodeling in idiopathic pulmonary fibrosis: the role of deltaN-p63. Lab Invest (2002) 1.27
Glycine reuptake inhibitor RG1678: a pharmacologic characterization of an investigational agent for the treatment of schizophrenia. Neuropharmacology (2011) 1.23
Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D. Biochim Biophys Acta (2012) 1.21
Role for CXCR6 and its ligand CXCL16 in the pathogenesis of T-cell alveolitis in sarcoidosis. Am J Respir Crit Care Med (2005) 1.19
Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice. Hum Mol Genet (2009) 1.17
Mitochondrial alterations induced by the p13II protein of human T-cell leukemia virus type 1. Critical role of arginine residues. J Biol Chem (2002) 1.17
UCPs--unlikely calcium porters. Nat Cell Biol (2008) 1.17
The mitochondrial permeability transition from yeast to mammals. FEBS Lett (2010) 1.17
Homeostatic chemokines drive migration of malignant B cells in patients with non-Hodgkin lymphomas. Blood (2004) 1.16
Immunosuppressive therapy for idiopathic retroperitoneal fibrosis: a retrospective analysis of 26 cases. Am J Med (2004) 1.15
The voltage-dependent anion channel is the target for a new class of inhibitors of the mitochondrial permeability transition pore. J Biol Chem (2003) 1.15
Mitochondria and cardioprotection. Heart Fail Rev (2007) 1.14
ALMS1-deficient fibroblasts over-express extra-cellular matrix components, display cell cycle delay and are resistant to apoptosis. PLoS One (2011) 1.13
T cells in the myenteric plexus of achalasia patients show a skewed TCR repertoire and react to HSV-1 antigens. Am J Gastroenterol (2008) 1.12
Bupivacaine myotoxicity is mediated by mitochondria. J Biol Chem (2002) 1.10
Mitochondria and reperfusion injury. The role of permeability transition. Basic Res Cardiol (2003) 1.10
The effects of idebenone on mitochondrial bioenergetics. Biochim Biophys Acta (2011) 1.10
Combination of rituximab, bendamustine, and cytarabine for patients with mantle-cell non-Hodgkin lymphoma ineligible for intensive regimens or autologous transplantation. J Clin Oncol (2013) 1.10
Genetic dissection of the permeability transition pore. J Bioenerg Biomembr (2005) 1.09
Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia. Blood (2013) 1.08
BMAP-28, an antibiotic peptide of innate immunity, induces cell death through opening of the mitochondrial permeability transition pore. Mol Cell Biol (2002) 1.08
The mitochondrial permeability transition pore and cyclophilin D in cardioprotection. Biochim Biophys Acta (2011) 1.07
Respiratory complex I dysfunction due to mitochondrial DNA mutations shifts the voltage threshold for opening of the permeability transition pore toward resting levels. J Biol Chem (2008) 1.07
The neutrophil-activating protein of Helicobacter pylori crosses endothelia to promote neutrophil adhesion in vivo. J Immunol (2007) 1.06
Regulation of the inner membrane mitochondrial permeability transition by the outer membrane translocator protein (peripheral benzodiazepine receptor). J Biol Chem (2010) 1.06
Shedding light on the mitochondrial permeability transition. Biochim Biophys Acta (2011) 1.05
In vivo phenotyping of the ob/ob mouse by magnetic resonance imaging and 1H-magnetic resonance spectroscopy. Obesity (Silver Spring) (2006) 1.05
Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists. Mol Pharmacol (2009) 1.05
A CaPful of mechanisms regulating the mitochondrial permeability transition. J Mol Cell Cardiol (2009) 1.04
Activation of the mitochondrial permeability transition pore modulates Ca2+ responses to physiological stimuli in adult neurons. Eur J Neurosci (2011) 1.02
The neutrophil-activating protein of Helicobacter pylori (HP-NAP) activates the MAPK pathway in human neutrophils. Eur J Immunol (2003) 1.02
Mitochondrial function and myocardial aging. A critical analysis of the role of permeability transition. Cardiovasc Res (2005) 1.01
Laryngeal chemosensory clusters. Chem Senses (2004) 1.01
Desensitization of the permeability transition pore by cyclosporin a prevents activation of the mitochondrial apoptotic pathway and liver damage by tumor necrosis factor-alpha. J Biol Chem (2004) 1.00
Pancreatic tumors and immature immunosuppressive myeloid cells in blood and spleen: role of inhibitory co-stimulatory molecules PDL1 and CTLA4. An in vivo and in vitro study. PLoS One (2013) 1.00
Identification and characterization of a specific sensory epithelium in the rat larynx. J Comp Neurol (2004) 1.00
Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response. Clin Cancer Res (2012) 0.99
T-lymphocytes and cytokines in sarcoidosis. Curr Opin Pulm Med (2002) 0.99