Published in Genes Dev on February 15, 2006
Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. Nat Chem Biol (2010) 2.71
Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival. Nature (2008) 1.91
Processing and phosphorylation of the Fat receptor. Proc Natl Acad Sci U S A (2009) 1.66
Functional genomics identifies therapeutic targets for MYC-driven cancer. Proc Natl Acad Sci U S A (2012) 1.65
Substrate and docking interactions in serine/threonine protein kinases. Chem Rev (2007) 1.55
Gli1 acts through Snail and E-cadherin to promote nuclear signaling by beta-catenin. Oncogene (2007) 1.53
kin-19/casein kinase Iα has dual functions in regulating asymmetric division and terminal differentiation in C. elegans epidermal stem cells. Cell Cycle (2010) 1.49
Regulation of Wnt/beta-catenin signaling by protein kinases. Dev Dyn (2010) 1.45
Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling. Cold Spring Harb Perspect Biol (2012) 1.43
Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor. Biochem J (2011) 1.41
High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. PLoS Biol (2010) 1.38
beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt. Mol Cell Biol (2009) 1.37
The way Wnt works: components and mechanism. Growth Factors (2012) 1.37
The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis. Front Oncol (2014) 1.33
Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation. Genes Dev (2007) 1.24
CK1epsilon is required for breast cancers dependent on beta-catenin activity. PLoS One (2010) 1.22
A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein. Dev Cell (2007) 1.22
Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6. FEBS Lett (2007) 1.20
Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair. PLoS One (2011) 1.20
IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation. Oncogene (2011) 1.15
Casein kinase I delta controls centrosome positioning during T cell activation. J Cell Biol (2011) 1.15
Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway. EMBO J (2012) 1.13
Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2. J Biol Chem (2011) 1.11
A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine. Psychopharmacology (Berl) (2008) 1.10
Interfering with Wnt signalling alters the periodicity of the segmentation clock. Dev Biol (2009) 1.05
Regulation of wingless signaling by the CKI family in Drosophila limb development. Dev Biol (2006) 1.04
The role of kinases in the Hedgehog signalling pathway. EMBO Rep (2008) 1.03
The Per2 negative feedback loop sets the period in the mammalian circadian clock mechanism. PLoS Comput Biol (2007) 1.02
Arabidopsis casein kinase 1-like 6 contains a microtubule-binding domain and affects the organization of cortical microtubules,. Plant Physiol (2008) 1.00
Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage. Exp Cell Res (2009) 0.99
Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells. EMBO Mol Med (2012) 0.99
Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis. Mol Cancer (2014) 0.98
GLIPR1 suppresses prostate cancer development through targeted oncoprotein destruction. Cancer Res (2011) 0.98
Dpr Acts as a molecular switch, inhibiting Wnt signaling when unphosphorylated, but promoting Wnt signaling when phosphorylated by casein kinase Idelta/epsilon. PLoS One (2009) 0.97
Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling. Oncogenesis (2013) 0.96
The Drosophila casein kinase Iepsilon/delta Discs overgrown promotes cell survival via activation of DIAP1 expression. Dev Biol (2006) 0.96
An evolving role for DEPTOR in tumor development and progression. Neoplasia (2012) 0.96
Interactions between Casein kinase Iepsilon (CKIepsilon) and two substrates from disparate signaling pathways reveal mechanisms for substrate-kinase specificity. PLoS One (2009) 0.95
Coordinated action of CK1 isoforms in canonical Wnt signaling. Mol Cell Biol (2011) 0.95
The Wnt/β-catenin pathway in human fibrotic-like diseases and its eligibility as a therapeutic target. Mol Cell Ther (2015) 0.94
Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett (2013) 0.93
Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin. J Bone Miner Res (2008) 0.93
Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin. Mol Biol Cell (2008) 0.92
Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis. Cell Rep (2015) 0.92
Hrr25/CK1δ-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth. J Cell Biol (2015) 0.91
Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling. Oncogene (2008) 0.90
Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo. PLoS One (2012) 0.88
Casein kinase 1 suppresses activation of REST in insulted hippocampal neurons and halts ischemia-induced neuronal death. J Neurosci (2014) 0.88
Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers. J Clin Invest (2015) 0.87
Analysis of cell type-specific expression of CK1 epsilon in various tissues of young adult BALB/c Mice and in mammary tumors of SV40 T-Ag-transgenic mice. J Histochem Cytochem (2009) 0.87
Structure-Based Design of Potent and Selective CK1γ Inhibitors. ACS Med Chem Lett (2012) 0.85
Activating mutations in β-catenin in colon cancer cells alter their interaction with macrophages; the role of snail. PLoS One (2012) 0.85
Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation. Biochem J (2012) 0.83
Modeling and validating chronic pharmacological manipulation of circadian rhythms. CPT Pharmacometrics Syst Pharmacol (2013) 0.83
Upregulation of casein kinase 1epsilon in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain. Mol Pain (2009) 0.82
Wnt signaling in estrogen-induced lactotroph proliferation. J Cell Sci (2011) 0.81
Casein kinase 1 epsilon expression predicts poorer prognosis in low T-stage oral cancer patients. Int J Mol Sci (2014) 0.81
The role of Wnt signaling in the development of Alzheimer's disease: a potential therapeutic target? Biomed Res Int (2014) 0.80
Regulation of protein kinase CK1alphaLS by dephosphorylation in response to hydrogen peroxide. Arch Biochem Biophys (2007) 0.80
Neurite outgrowth of mature retinal ganglion cells and PC12 cells requires activity of CK1δ and CK1ε. PLoS One (2011) 0.80
The casein kinase I protein Cck1 regulates multiple signaling pathways and is essential for cell integrity and fungal virulence in Cryptococcus neoformans. Eukaryot Cell (2011) 0.79
Potential of casein kinase I in digestive cancer screening. World J Gastrointest Oncol (2009) 0.79
2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1δ/ε. Amino Acids (2012) 0.79
Assembly of Dishevelled 3-based supermolecular complexes via phosphorylation and Axin. J Mol Signal (2012) 0.79
Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis. J Biol Chem (2013) 0.79
Electroacupuncture stimulation at CV4 prevents ovariectomy‑induced osteoporosis in rats via Wnt‑β‑catenin signaling. Mol Med Rep (2016) 0.78
Near-membrane ensemble elongation in the proline-rich LRP6 intracellular domain may explain the mysterious initiation of the Wnt signaling pathway. BMC Bioinformatics (2011) 0.78
Role of Novel Serine 316 Phosphorylation of the p65 Subunit of NF-κB in Differential Gene Regulation. J Biol Chem (2015) 0.78
Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics. Curr Med Chem (2015) 0.77
Partitioning of casein kinase 1-like 6 to late endosome-like vesicles. Protoplasma (2009) 0.77
The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation. Elife (2016) 0.77
Protein kinase CK1alphaLS promotes vascular cell proliferation and intimal hyperplasia. Am J Pathol (2010) 0.77
Wnt/β-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration. FASEB J (2016) 0.77
A monoclinic crystal form of casein kinase 1 δ. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.76
Inter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression. Cancer Cell Int (2008) 0.76
Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test. Genes Brain Behav (2016) 0.76
Smoothened regulation in response to Hedgehog stimulation. Front Biol (Beijing) (2015) 0.76
LEAFY COTYLEDON1-CASEIN KINASE I-TCP15-PHYTOCHROME INTERACTING FACTOR4 Network Regulates Somatic Embryogenesis by Regulating Auxin Homeostasis. Plant Physiol (2015) 0.76
Structure of the kinase domain of Gilgamesh from Drosophila melanogaster. Acta Crystallogr F Struct Biol Commun (2014) 0.75
Correlated Evolution Between CK1δ and the Serine Rich Motif Contributes to Regulating the Mammalian Circadian Clock. J Biol Chem (2016) 0.75
Casein kinase 1 is recruited to nuclear speckles by FAM83H and SON. Sci Rep (2016) 0.75
Novel group-based QSAR and combinatorial design of CK-1δ inhibitors as neuroprotective agents. BMC Bioinformatics (2016) 0.75
CK1δ in lymphoma: gene expression and mutation analyses and validation of CK1δ kinase activity for therapeutic application. Front Cell Dev Biol (2015) 0.75
A computation using mutually exclusive processing is sufficient to identify specific Hedgehog signaling components. Front Genet (2013) 0.75
Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs. Cell Rep (2016) 0.75
High casein kinase 1 epsilon levels are correlated with better prognosis in subsets of patients with breast cancer. Oncotarget (2015) 0.75
Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator. EMBO J (2016) 0.75
Regulation of Wnt/β-catenin signaling by herpesviruses. World J Virol (2016) 0.75
Casein kinase 1-epsilon or 1-delta required for Wnt-mediated intestinal stem cell maintenance. EMBO J (2017) 0.75
Serum carcinoembryonic antigen-related cell adhesion molecule 1 level in postmenopausal women: correlation with β-catenin and bone mineral density. Osteoporos Int (2015) 0.75
Molecular Mechanisms Regulating Temperature Compensation of the Circadian Clock. Front Neurol (2017) 0.75