Published in Dev Biol on July 28, 2006
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PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development (2008) 1.23
Gilgamesh is required for rutabaga-independent olfactory learning in Drosophila. Neuron (2010) 1.08
Decoding the phosphorylation code in Hedgehog signal transduction. Cell Res (2013) 1.06
Dpr Acts as a molecular switch, inhibiting Wnt signaling when unphosphorylated, but promoting Wnt signaling when phosphorylated by casein kinase Idelta/epsilon. PLoS One (2009) 0.97
The Drosophila casein kinase Iepsilon/delta Discs overgrown promotes cell survival via activation of DIAP1 expression. Dev Biol (2006) 0.96
Interactions between Casein kinase Iepsilon (CKIepsilon) and two substrates from disparate signaling pathways reveal mechanisms for substrate-kinase specificity. PLoS One (2009) 0.95
Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases. Mol Cell Biol (2009) 0.94
Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling. Dev Biol (2008) 0.86
Drosophila as a model for intractable epilepsy: gilgamesh suppresses seizures in para(bss1) heterozygote flies. G3 (Bethesda) (2013) 0.85
A screen for X-linked mutations affecting Drosophila photoreceptor differentiation identifies Casein kinase 1α as an essential negative regulator of wingless signaling. Genetics (2011) 0.84
Translational regulation of the DOUBLETIME/CKIδ/ε kinase by LARK contributes to circadian period modulation. PLoS Genet (2014) 0.83
The Dishevelled Protein Family: Still Rather a Mystery After Over 20 Years of Molecular Studies. Curr Top Dev Biol (2016) 0.79
Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase. PLoS Biol (2016) 0.78
Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator. Proc Natl Acad Sci U S A (2014) 0.76
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LDL-receptor-related proteins in Wnt signal transduction. Nature (2000) 6.94
An LDL-receptor-related protein mediates Wnt signalling in mice. Nature (2000) 6.34
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A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature (2005) 5.50
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double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell (1998) 5.10
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature (2005) 4.88
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Direct and long-range action of a wingless morphogen gradient. Cell (1996) 3.73
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science (2003) 3.63
The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. Cell (1997) 3.61
Casein kinase I transduces Wnt signals. Nature (1999) 3.38
Novel genomic cDNA hybrids produce effective RNA interference in adult Drosophila. Neuron (2002) 2.65
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CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling. Genes Dev (2006) 2.39
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature (2004) 2.39
naked cuticle encodes an inducible antagonist of Wnt signalling. Nature (2000) 2.35
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature (2002) 2.26
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Protein kinase A and hedgehog signaling in Drosophila limb development. Cell (1995) 2.22
Naked cuticle targets dishevelled to antagonize Wnt signal transduction. Genes Dev (2001) 2.16
Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. Proc Natl Acad Sci U S A (2002) 2.04
Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila. EMBO J (2002) 1.91
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Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon. J Cell Biol (2001) 1.80
Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes Dev (1999) 1.79
The casein kinase I family in Wnt signaling. Dev Biol (2001) 1.63
Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell (2005) 1.62
Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila. Cell (2003) 1.49
Casein kinase Iepsilon modulates the signaling specificities of dishevelled. Mol Cell Biol (2004) 1.41
Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon. J Biol Chem (2001) 1.39
Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon. J Biol Chem (2001) 1.31
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Complementary and mutually exclusive activities of decapentaplegic and wingless organize axial patterning during Drosophila leg development. Cell (1996) 1.18
Interactions between Wingless and DFz2 during Drosophila wing development. Development (1998) 1.14
Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference. Mol Cell Biol (2004) 1.06
wingless signaling in the Drosophila eye and embryonic epidermis. Development (1996) 1.06
Drosophila Lyra mutations are gain-of-function mutations of senseless. Genetics (2001) 1.01
The Amber biomolecular simulation programs. J Comput Chem (2005) 28.84
Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart. Nat Biotechnol (2005) 5.27
The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell (2008) 4.90
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A (2010) 4.17
Toxicity of cationic lipids and cationic polymers in gene delivery. J Control Release (2006) 3.85
The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev (2003) 3.53
Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell (2009) 3.43
Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime. Nature (2002) 2.99
Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev Cell (2005) 2.50
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc Natl Acad Sci U S A (2009) 2.41
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature (2004) 2.39
Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum. PLoS Genet (2011) 2.35
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature (2002) 2.26
Hedgehog regulates smoothened activity by inducing a conformational switch. Nature (2007) 2.23
Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc Natl Acad Sci U S A (2010) 2.16
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Dev Cell (2006) 2.13
A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Mol Cancer Ther (2008) 2.07
Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector. Mol Ther (2011) 2.04
Controlling the Kondo effect of an adsorbed magnetic ion through its chemical bonding. Science (2005) 1.98
Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma. J Allergy Clin Immunol (2010) 1.86
Cationic lipids and polymers mediated vectors for delivery of siRNA. J Control Release (2007) 1.79
Bradykinin-induced microglial migration mediated by B1-bradykinin receptors depends on Ca2+ influx via reverse-mode activity of the Na+/Ca2+ exchanger. J Neurosci (2007) 1.74
Myostatin propeptide gene delivery by adeno-associated virus serotype 8 vectors enhances muscle growth and ameliorates dystrophic phenotypes in mdx mice. Hum Gene Ther (2008) 1.65
Injection of AAV2-BMP2 and AAV2-TIMP1 into the nucleus pulposus slows the course of intervertebral disc degeneration in an in vivo rabbit model. Spine J (2011) 1.63
Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell (2005) 1.62
Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models. Nat Med (2010) 1.62
Nuclear localization sequence of FUS and induction of stress granules by ALS mutants. Neurobiol Aging (2010) 1.62
Microporous and photoluminescent chalcogenide zeolite analogs. Science (2002) 1.61
Adeno-associated virus vector-mediated minidystrophin gene therapy improves dystrophic muscle contractile function in mdx mice. Hum Gene Ther (2002) 1.56
Widespread muscle expression of an AAV9 human mini-dystrophin vector after intravenous injection in neonatal dystrophin-deficient dogs. Mol Ther (2010) 1.56
Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms. Dev Biol (2009) 1.54
Monoamine oxidase A gene polymorphism predicts adolescent outcome of attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet (2007) 1.51
Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo. Development (2005) 1.51
Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase. Proc Natl Acad Sci U S A (2009) 1.47
BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency. Clin Cancer Res (2013) 1.47
Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J x SM/J murine model of obesity. Diabetes (2005) 1.47
Regulation of TopBP1 oligomerization by Akt/PKB for cell survival. EMBO J (2006) 1.45
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev (2003) 1.44
Planar cell polarity and vertebrate organogenesis. Semin Cell Dev Biol (2006) 1.43
Oxidation of sulfoxides and arsenic(III) in corrosion of nanoscale zero valent iron by oxygen: evidence against ferryl ions (Fe(IV)) as active intermediates in Fenton reaction. Environ Sci Technol (2010) 1.42
Retracted Investigation of the hub genes and related mechanism in ovarian cancer via bioinformatics analysis. J Ovarian Res (2013) 1.42
Atomic structure, energetics, and dynamics of topological solitons in indium chains on Si(111) surfaces. Phys Rev Lett (2011) 1.42
Structural Survey of Zinc Containing Proteins and the Development of the Zinc AMBER Force Field (ZAFF). J Chem Theory Comput (2010) 1.37
Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened. PLoS Biol (2011) 1.36
Formal Estimation of Errors in Computed Absolute Interaction Energies of Protein-ligand Complexes. J Chem Theory Comput (2011) 1.32
Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circ Res (2005) 1.32
Genomic imprinting effects on adult body composition in mice. Proc Natl Acad Sci U S A (2008) 1.31
SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. PLoS One (2012) 1.29
Poly(amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery. Biomaterials (2009) 1.29
A method of calculating the second dimension retention index in comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry. J Chromatogr A (2011) 1.28
Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer. Mol Cell Biol (2009) 1.28
Prediction of protein-protein interactions from amino acid sequences with ensemble extreme learning machines and principal component analysis. BMC Bioinformatics (2013) 1.26
Identification of quantitative trait loci affecting murine long bone length in a two-generation intercross of LG/J and SM/J Mice. J Bone Miner Res (2008) 1.26
Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation (2004) 1.25
The immediate environment during postnatal development has long-term impact on gut community structure in pigs. ISME J (2008) 1.25
Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation. Genes Dev (2007) 1.24
PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development (2008) 1.23
Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization. Sci Signal (2012) 1.23
An optimal peak alignment for comprehensive two-dimensional gas chromatography mass spectrometry using mixture similarity measure. Bioinformatics (2011) 1.22
Hippo signaling pathway and organ size control. Fly (Austin) (2009) 1.21
Elevated expression of Wnt antagonists is a common event in hepatoblastomas. Clin Cancer Res (2005) 1.20
PR55 alpha, a regulatory subunit of PP2A, specifically regulates PP2A-mediated beta-catenin dephosphorylation. J Biol Chem (2009) 1.20
Genetic architecture of adiposity and organ weight using combined generation QTL analysis. Obesity (Silver Spring) (2008) 1.20
MetSign: a computational platform for high-resolution mass spectrometry-based metabolomics. Anal Chem (2011) 1.19
Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor. Clin Cancer Res (2008) 1.19
Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats. Toxicology (2008) 1.19
Dietary anthocyanin-rich tart cherry extract inhibits intestinal tumorigenesis in APC(Min) mice fed suboptimal levels of sulindac. J Agric Food Chem (2006) 1.18
Pleiotropic patterns of quantitative trait loci for 70 murine skeletal traits. Genetics (2008) 1.18
Monitoring nitrogen deposition in typical forest ecosystems along a large transect in China. Environ Monit Assess (2012) 1.18
Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis. Ann Rheum Dis (2012) 1.17
G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes Dev (2010) 1.17
Salmonella enterica serovar Senftenberg human clinical isolates lacking SPI-1. J Clin Microbiol (2008) 1.17
The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway. Dev Cell (2012) 1.16
Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B. J Biol Chem (2003) 1.16
Correlates of methadone client retention: a prospective cohort study in Guizhou province, China. Int J Drug Policy (2008) 1.16
Interface-confined ferrous centers for catalytic oxidation. Science (2010) 1.15
Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells. J Cell Biol (2011) 1.13
Dendrimer-drug conjugates for tailored intracellular drug release based on glutathione levels. Bioconjug Chem (2008) 1.13
A novel mutation in the major intrinsic protein (MIP) associated with autosomal dominant congenital cataracts in a Chinese family. Mol Vis (2010) 1.13
USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization. PLoS Biol (2012) 1.13
Cytotoxicity evaluation of endosequence root repair material. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2010) 1.12
Hepatoprotective and antioxidant effects of licorice extract against CCl₄-induced oxidative damage in rats. Int J Mol Sci (2011) 1.12
Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2. Cell Res (2012) 1.11
iMatch: a retention index tool for analysis of gas chromatography-mass spectrometry data. J Chromatogr A (2011) 1.11