Published in Oncogene on September 15, 2008
Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3. J Cell Biol (2010) 2.01
Phospho-control of TGF-beta superfamily signaling. Cell Res (2009) 1.91
A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev (2011) 1.60
TGF-β control of stem cell differentiation genes. FEBS Lett (2012) 1.25
Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin. Mol Biol Cell (2008) 0.92
Akt suppression of TGFβ signaling contributes to the maintenance of vascular identity in embryonic stem cell-derived endothelial cells. Stem Cells (2014) 0.88
Phosphorylation of the anaphase-promoting complex/Cdc27 is involved in TGF-beta signaling. J Biol Chem (2011) 0.83
Casein kinase iγ2 impairs fibroblasts actin stress fibers formation and delays cell cycle progression in g1. Int J Cell Biol (2012) 0.76
Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell (2003) 25.94
TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature (1997) 15.75
Smad transcription factors. Genes Dev (2005) 13.43
TGFbeta signaling in growth control, cancer, and heritable disorders. Cell (2000) 12.38
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell (2002) 10.34
How cells read TGF-beta signals. Nat Rev Mol Cell Biol (2000) 8.93
Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer (2006) 8.59
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature (2005) 5.50
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell (2006) 5.28
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature (2005) 4.88
Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling. Cell (1998) 3.86
The casein kinase 1 family: participation in multiple cellular processes in eukaryotes. Cell Signal (2005) 3.50
Casein kinase I transduces Wnt signals. Nature (1999) 3.38
Ubiquitin-dependent degradation of TGF-beta-activated smad2. Nat Cell Biol (1999) 3.25
Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling. J Biol Chem (2000) 3.12
Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity. Mol Cell (2002) 3.10
Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts. J Biol Chem (2001) 2.85
Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Cell (2002) 2.73
Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis. Cytokine Growth Factor Rev (2005) 2.69
Casein kinase I: spatial organization and positioning of a multifunctional protein kinase family. Cell Signal (1998) 2.50
CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling. Genes Dev (2006) 2.39
Transforming growth factor-beta and Smad signalling in kidney diseases. Nephrology (Carlton) (2005) 2.23
Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3. J Biol Chem (1999) 2.12
Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Mol Cell (2002) 2.05
Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling. Genes Dev (2008) 1.93
Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor beta-dependent nuclear accumulation of Smads. Mol Cell Biol (2005) 1.84
Functions of mammalian Smad genes as revealed by targeted gene disruption in mice. Cytokine Growth Factor Rev (2000) 1.81
Smads bind directly to the Jun family of AP-1 transcription factors. Proc Natl Acad Sci U S A (1999) 1.81
Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins. Mol Biol Cell (2001) 1.69
Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4. Oncogene (2003) 1.46
A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3. Oncogene (1999) 1.43
Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). Oncogene (2004) 1.42
Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile. Genes Dev (2005) 1.36
Distinct oligomeric states of SMAD proteins in the transforming growth factor-beta pathway. J Biol Chem (2000) 1.35
Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3). Proc Natl Acad Sci U S A (2003) 1.29
Casein kinase I: from obscurity to center stage. IUBMB Life (2001) 1.21
Ubiquitin-dependent regulation of TGFbeta signaling in cancer. Neoplasia (2006) 1.14
Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes. J Biol Chem (1995) 1.11
Casein kinase Iepsilon plays a functional role in the transforming growth factor-beta signaling pathway. J Biol Chem (2004) 1.05
In or out? The dynamics of Smad nucleocytoplasmic shuttling. Trends Cell Biol (2003) 1.00
Cell phenotype-specific down-regulation of Smad3 involves decreased gene activation as well as protein degradation. J Biol Chem (2007) 1.00
An essential role for Mad homology domain 1 in the association of Smad3 with histone deacetylase activity*. J Biol Chem (2001) 0.95
A phosphatase controls the fate of receptor-regulated Smads. Cell (2006) 0.85
SMAD destruction turns off signalling. Nat Cell Biol (1999) 0.83
Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2). Genomics (1997) 0.79
Roles for lysine residues of the MH2 domain of Smad3 in transforming growth factor-beta signaling. FEBS Lett (2005) 0.78
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science (1997) 16.09
Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association. Nat Genet (2001) 13.05
The Biomolecular Interaction Network Database and related tools 2005 update. Nucleic Acids Res (2005) 12.94
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell (1997) 12.83
Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models. Acc Chem Res (2000) 10.78
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest (1999) 8.38
Cereal genome evolution. Grasses, line up and form a circle. Curr Biol (1995) 8.33
Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell (2001) 8.09
A new class of membrane-bound chemokine with a CX3C motif. Nature (1997) 7.87
NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell (1998) 7.58
Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. Science (1999) 7.51
Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature (1998) 7.26
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem (1999) 6.88
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science (2001) 6.84
The Y-family of DNA polymerases. Mol Cell (2001) 6.49
Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5. Science (1994) 5.47
Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature (2011) 5.41
Genetic diversity and disease control in rice. Nature (2000) 5.34
Rapid evolution of male reproductive genes in the descent of man. Nature (2000) 5.33
Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development (1995) 5.18
Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell (1998) 4.95
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A (1999) 4.90
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell (1995) 4.73
Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor. Cell (1991) 4.66
An internal control for routine diagnostic PCR: design, properties, and effect on clinical performance. J Clin Microbiol (1998) 4.58
Genetic evidence for selective transport of opsin and arrestin by kinesin-II in mammalian photoreceptors. Cell (2000) 4.51
Activation of memory circuits during cue-elicited cocaine craving. Proc Natl Acad Sci U S A (1996) 4.31
SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol (2000) 4.30
Bone development. Annu Rev Cell Dev Biol (2000) 4.24
Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J Clin Invest (2000) 4.16
Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease. Neurology (2007) 3.97
Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus. J Immunol (2001) 3.87
Cardiac hypertrophy is not a required compensatory response to short-term pressure overload. Circulation (2000) 3.82
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nat Genet (2002) 3.67
Organ-tissue mass measurement allows modeling of REE and metabolically active tissue mass. Am J Physiol (1998) 3.65
A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet (2000) 3.63
Statistical power and optimal design for multisite randomized trials. Psychol Methods (2000) 3.58
Olfactory deficits in patients with mild cognitive impairment predict Alzheimer's disease at follow-up. Am J Psychiatry (2000) 3.54
Disrupted circadian rhythms in VIP- and PHI-deficient mice. Am J Physiol Regul Integr Comp Physiol (2003) 3.37
Safety and immunogenicity trial in adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine. J Natl Cancer Inst (2001) 3.28
The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes. Proc Natl Acad Sci U S A (2000) 3.16
Regulation of imprinted X-chromosome inactivation in mice by Tsix. Development (2001) 3.12
Size and shape effects in the biodistribution of intravascularly injected particles. J Control Release (2009) 3.08
CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling. Oncogene (2011) 3.08
Integrated human genome-wide maps constructed using the CEPH reference panel. Nat Genet (1994) 3.06
Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science (2001) 2.97
Clinical and molecular cytogenetic characterisation of a newly recognised microdeletion syndrome involving 2p15-16.1. J Med Genet (2006) 2.97
BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Cell (2000) 2.94
Lead exposure and intelligence in 7-year-old children: the Yugoslavia Prospective Study. Environ Health Perspect (1997) 2.88
Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nat Med (2001) 2.87
Phenobarbital compared with phenytoin for the treatment of neonatal seizures. N Engl J Med (1999) 2.84
HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells. Leukemia (2010) 2.83
Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet (2000) 2.82
Rho GTPase function in tumorigenesis. Biochim Biophys Acta (2009) 2.81
Functional deficits in patients with mild cognitive impairment: prediction of AD. Neurology (2002) 2.79
The biological lifetime of nitric oxide: implications for the perivascular dynamics of NO and O2. Proc Natl Acad Sci U S A (2001) 2.75
Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Nat Genet (2001) 2.75
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature (2005) 2.74
Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild-type viruses. Hum Gene Ther (1999) 2.73
Total-body skeletal muscle mass: development and cross-validation of anthropometric prediction models. Am J Clin Nutr (2000) 2.71
Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science (1999) 2.71
Paternal population history of East Asia: sources, patterns, and microevolutionary processes. Am J Hum Genet (2001) 2.71
A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex. Mol Cell Biol (2000) 2.70
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene (2007) 2.68
A transmission/disequilibrium test that allows for genotyping errors in the analysis of single-nucleotide polymorphism data. Am J Hum Genet (2001) 2.68
Localization of a domain on the paramyxovirus attachment protein required for the promotion of cellular fusion by its homologous fusion protein spike. Virology (1995) 2.67
The intermediate endpoint effect in logistic and probit regression. Clin Trials (2007) 2.67
Study of 962 patients indicates progressive muscular atrophy is a form of ALS. Neurology (2009) 2.60
Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation. Mol Cell Biol (1994) 2.59
Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group. Blood (1999) 2.59
Different forms of TFIIH for transcription and DNA repair: holo-TFIIH and a nucleotide excision repairosome. Cell (1995) 2.58
The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway. Genes Dev (1996) 2.58
Atrial G protein-activated K+ channel: expression cloning and molecular properties. Proc Natl Acad Sci U S A (1993) 2.57
Sino-MONICA project: a collaborative study on trends and determinants in cardiovascular diseases in China, Part i: morbidity and mortality monitoring. Circulation (2001) 2.56
Unique TATA-binding protein-containing complexes and cofactors involved in transcription by RNA polymerases II and III. EMBO J (1993) 2.56
Use of MM-PBSA in reproducing the binding free energies to HIV-1 RT of TIBO derivatives and predicting the binding mode to HIV-1 RT of efavirenz by docking and MM-PBSA. J Am Chem Soc (2001) 2.55
Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53. Genes Dev (1994) 2.54
Hormonal changes in the grains of rice subjected to water stress during grain filling. Plant Physiol (2001) 2.52
The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling. Genes Dev (1999) 2.52
Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis (2013) 2.52
Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther (2001) 2.51
Diabetes is related to cerebral infarction but not to AD pathology in older persons. Neurology (2006) 2.48
p53 modulation of TFIIH-associated nucleotide excision repair activity. Nat Genet (1995) 2.47
Genetic influence on the structural variations of the abnormal prion protein. Proc Natl Acad Sci U S A (2000) 2.46
Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains. J Biol Chem (2000) 2.43
Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature (1995) 2.43
All-cause mortality and cardiovascular disease mortality in three American Indian populations, aged 45-74 years, 1984-1988. The Strong Heart Study. Am J Epidemiol (1998) 2.43
Biomarker risk assessment and bladder cancer detection in a cohort exposed to benzidine. J Natl Cancer Inst (2001) 2.41
Transfusion and alloimmunization in sickle cell disease. The Cooperative Study of Sickle Cell Disease. Blood (1990) 2.38
Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circ Res (1997) 2.38
Pattern of marine mass extinction near the Permian-Triassic boundary in South China. Science (2000) 2.38
De novo amyloid proteins from designed combinatorial libraries. Proc Natl Acad Sci U S A (1999) 2.38
Fire and flood management of coastal swamp enabled first rice paddy cultivation in east China. Nature (2007) 2.36
Predicting caries in permanent teeth from caries in primary teeth: an eight-year cohort study. J Dent Res (2002) 2.35
Estrogen-related receptor alpha 1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements. Mol Endocrinol (1997) 2.34