| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.
|
Nat Genet
|
2006
|
5.29
|
|
2
|
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
|
BMB Rep
|
2008
|
2.90
|
|
3
|
Phosphoinositide signalling in cancer: beyond PI3K and PTEN.
|
Nat Rev Cancer
|
2010
|
2.35
|
|
4
|
Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.
|
N Engl J Med
|
2012
|
2.08
|
|
5
|
A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency.
|
Am J Hum Genet
|
2012
|
1.81
|
|
6
|
Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation.
|
Structure
|
2012
|
1.73
|
|
7
|
Phospholipase C epsilon: linking second messengers and small GTPases.
|
Trends Cell Biol
|
2006
|
1.49
|
|
8
|
Structural and mechanistic insights into ras association domains of phospholipase C epsilon.
|
Mol Cell
|
2006
|
1.48
|
|
9
|
PLC regulation: emerging pictures for molecular mechanisms.
|
Trends Biochem Sci
|
2010
|
1.48
|
|
10
|
Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry.
|
Immunity
|
2005
|
1.33
|
|
11
|
PLCgamma1 is essential for early events in integrin signalling required for cell motility.
|
J Cell Sci
|
2005
|
1.32
|
|
12
|
Regulatory links between PLC enzymes and Ras superfamily GTPases: signalling via PLCepsilon.
|
Adv Enzyme Regul
|
2009
|
1.31
|
|
13
|
Multiplexed FRET to image multiple signaling events in live cells.
|
Biophys J
|
2008
|
1.23
|
|
14
|
Rapid global fitting of large fluorescence lifetime imaging microscopy datasets.
|
PLoS One
|
2013
|
1.16
|
|
15
|
Characterization of phospholipase C gamma enzymes with gain-of-function mutations.
|
J Biol Chem
|
2009
|
1.09
|
|
16
|
FLIM FRET technology for drug discovery: automated multiwell-plate high-content analysis, multiplexed readouts and application in situ.
|
Chemphyschem
|
2011
|
1.08
|
|
17
|
Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1.
|
Mol Cell Biol
|
2007
|
1.07
|
|
18
|
Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2.
|
Mol Cell
|
2009
|
1.05
|
|
19
|
A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model.
|
Arthritis Rheum
|
2011
|
1.04
|
|
20
|
Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants.
|
Oncogene
|
2005
|
1.00
|
|
21
|
Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration.
|
J Biol Chem
|
2007
|
0.95
|
|
22
|
rac regulates its effector phospholipase Cgamma2 through interaction with a split pleckstrin homology domain.
|
J Biol Chem
|
2008
|
0.94
|
|
23
|
The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) spontaneously forms conjugates with common components of cell culture medium.
|
Drug Metab Dispos
|
2007
|
0.93
|
|
24
|
Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions.
|
Structure
|
2014
|
0.92
|
|
25
|
Tumor suppressor role of phospholipase C epsilon in Ras-triggered cancers.
|
Proc Natl Acad Sci U S A
|
2014
|
0.89
|
|
26
|
Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling.
|
Biochem J
|
2003
|
0.88
|
|
27
|
Membrane environment exerts an important influence on rac-mediated activation of phospholipase Cγ2.
|
Mol Cell Biol
|
2011
|
0.87
|
|
28
|
Nuclear envelope assembly is promoted by phosphoinositide-specific phospholipase C with selective recruitment of phosphatidylinositol-enriched membranes.
|
Biochem J
|
2005
|
0.87
|
|
29
|
Comparative analysis of interactions of RASSF1-10.
|
Adv Biol Regul
|
2013
|
0.83
|
|
30
|
Activity of PLCε contributes to chemotaxis of fibroblasts towards PDGF.
|
J Cell Sci
|
2012
|
0.83
|
|
31
|
PLCɛ and the RASSF family in tumour suppression and other functions.
|
Adv Biol Regul
|
2013
|
0.83
|
|
32
|
The identification of novel PLC-gamma inhibitors using virtual high throughput screening.
|
Bioorg Med Chem
|
2009
|
0.80
|
|
33
|
Irreversible inactivation of magnesium-dependent neutral sphingomyelinase 1 (NSM1) by peroxynitrite, a nitric oxide-derived oxidant.
|
FEBS Lett
|
2002
|
0.80
|
|
34
|
Biochemical identification of a neutral sphingomyelinase 1 (NSM1)-like enzyme as the major NSM activity in the DT40 B-cell line: absence of a role in the apoptotic response to endoplasmic reticulum stress.
|
Biochem J
|
2002
|
0.78
|
|
35
|
In vitro reconstitution of activation of PLCepsilon by Ras and Rho GTPases.
|
Methods Mol Biol
|
2009
|
0.78
|
|
36
|
PLCγ1 participates in protein transport and diacylglycerol production triggered by cargo arrival at the Golgi.
|
Traffic
|
2015
|
0.76
|
|
37
|
Backbone 1H, 13C, and 15N resonance assignments for the two 13 kD Ras associating domains (RA1 and RA2) from phospholipase C epsilon.
|
J Biomol NMR
|
2005
|
0.75
|
|
38
|
Corrigendum: Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM).
|
Sci Rep
|
2016
|
0.75
|