Published in Mol Cell on February 17, 2006
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet (2010) 2.95
Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation. Structure (2012) 1.73
Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases. Proc Natl Acad Sci U S A (2011) 1.57
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration. J Cell Biol (2006) 1.38
Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. Hum Mutat (2010) 1.24
Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II. EMBO J (2008) 1.21
Role of phospholipase Cε in physiological phosphoinositide signaling networks. Cell Signal (2012) 1.10
Phospholipase signalling networks in cancer. Nat Rev Cancer (2012) 1.10
Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes. J Biol Chem (2011) 1.05
Dual activation of phospholipase C-epsilon by Rho and Ras GTPases. J Biol Chem (2008) 0.99
The phospholipase C isozymes and their regulation. Subcell Biochem (2012) 0.97
rac regulates its effector phospholipase Cgamma2 through interaction with a split pleckstrin homology domain. J Biol Chem (2008) 0.94
Differential expression of phospholipase C epsilon 1 is associated with chronic atrophic gastritis and gastric cancer. PLoS One (2012) 0.92
Phospholipase C isozymes as effectors of Ras superfamily GTPases. J Lipid Res (2008) 0.92
The structure of the ternary complex of Krev interaction trapped 1 (KRIT1) bound to both the Rap1 GTPase and the heart of glass (HEG1) cytoplasmic tail. J Biol Chem (2013) 0.90
Tumor suppressor role of phospholipase C epsilon in Ras-triggered cancers. Proc Natl Acad Sci U S A (2014) 0.89
Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels. PLoS One (2013) 0.86
Specific Conformational States of Ras GTPase upon Effector Binding. J Chem Theory Comput (2012) 0.85
Comparative analysis of interactions of RASSF1-10. Adv Biol Regul (2013) 0.83
Activity of PLCε contributes to chemotaxis of fibroblasts towards PDGF. J Cell Sci (2012) 0.83
Phospholipase C epsilon (PLCε) induced TRPC6 activation: a common but redundant mechanism in primary podocytes. J Cell Physiol (2015) 0.82
Crystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signaling. Protein Cell (2013) 0.82
Association between PLCE1 rs2274223 A > G polymorphism and cancer risk: proof from a meta-analysis. Sci Rep (2015) 0.81
Association rate constants of ras-effector interactions are evolutionarily conserved. PLoS Comput Biol (2008) 0.81
Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view. Chem Soc Rev (2016) 0.80
Esophageal squamous cell carcinoma and gastric cardia adenocarcinoma shared susceptibility locus in PLCE1: a meta-analysis. PLoS One (2013) 0.78
Phospholipase C-β in immune cells. Adv Biol Regul (2013) 0.78
Structural basis for the interaction of the adaptor protein grb14 with activated ras. PLoS One (2013) 0.78
A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis. Mol Carcinog (2013) 0.78
Predicting protein backbone chemical shifts from Cα coordinates: extracting high resolution experimental observables from low resolution models. J Chem Theory Comput (2015) 0.77
HPV seropositivity joints with susceptibility loci identified in GWASs at apoptosis associated genes to increase the risk of Esophageal Squamous Cell Carcinoma (ESCC). BMC Cancer (2014) 0.76
The Function of Embryonic Stem Cell-expressed RAS (E-RAS), a Unique RAS Family Member, Correlates with Its Additional Motifs and Its Structural Properties. J Biol Chem (2015) 0.76
Regulation of PLCβ2 by the electrostatic and mechanical properties of lipid bilayers. Sci Rep (2015) 0.75
The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions. PLoS One (2016) 0.75
Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier. PLoS One (2016) 0.75
PLCε1 regulates SDF-1α-induced lymphocyte adhesion and migration to sites of inflammation. Proc Natl Acad Sci U S A (2017) 0.75
The controversial role of phospholipase C epsilon (PLCε) in cancer development and progression. J Cancer (2017) 0.75
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
Recent improvements to the SMART domain-based sequence annotation resource. Nucleic Acids Res (2002) 25.06
The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res (2003) 24.72
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature (2005) 23.04
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell (2004) 19.51
SMART 4.0: towards genomic data integration. Nucleic Acids Res (2004) 19.37
Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
InterPro, progress and status in 2005. Nucleic Acids Res (2005) 17.53
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Mouse genomic variation and its effect on phenotypes and gene regulation. Nature (2011) 10.66
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature (2007) 7.91
Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs. Genome Res (2007) 7.34
Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex. Nature (2005) 6.23
The genome of a songbird. Nature (2010) 5.90
Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74
Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol (2009) 5.45
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature (2006) 5.42
Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat Genet (2006) 5.29
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection. Nat Genet (2006) 5.26
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24
The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains. Trends Biochem Sci (2003) 5.19
A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Res (2010) 4.77
Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system. Cell Rep (2013) 4.72
GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol (2003) 4.60
Bias of selection on human copy-number variants. PLoS Genet (2006) 4.44
EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell (2003) 4.33
Insights into hominid evolution from the gorilla genome sequence. Nature (2012) 4.12
Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Mol Cell (2005) 4.05
Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. Mol Cell (2002) 3.89
Comparative and demographic analysis of orang-utan genomes. Nature (2011) 3.83
Comparison of mouse and human genomes followed by experimental verification yields an estimated 1,019 additional genes. Proc Natl Acad Sci U S A (2003) 3.73
Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa. PLoS Genet (2009) 3.60
Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J (2004) 3.57
Systematic identification of novel protein domain families associated with nuclear functions. Genome Res (2002) 3.50
The reality of pervasive transcription. PLoS Biol (2011) 3.41
Genomic and transcriptional co-localization of protein-coding and long non-coding RNA pairs in the developing brain. PLoS Genet (2009) 3.38
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol Cell (2009) 3.38
The genome of the green anole lizard and a comparative analysis with birds and mammals. Nature (2011) 3.32
The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Cell (2010) 3.26
Genome-wide identification of human functional DNA using a neutral indel model. PLoS Comput Biol (2006) 3.16
RalGDS is required for tumor formation in a model of skin carcinogenesis. Cancer Cell (2005) 3.09
Phylogenetic reconstruction of orthology, paralogy, and conserved synteny for dog and human. PLoS Comput Biol (2006) 3.07
Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. Nat Cell Biol (2005) 3.02
Natural genetic variation caused by small insertions and deletions in the human genome. Genome Res (2011) 3.00
Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep (2008) 2.90
Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions. Mol Cell (2003) 2.83
The African coelacanth genome provides insights into tetrapod evolution. Nature (2013) 2.78
Catalogues of mammalian long noncoding RNAs: modest conservation and incompleteness. Genome Biol (2009) 2.70
InterPro: an integrated documentation resource for protein families, domains and functional sites. Brief Bioinform (2002) 2.66
Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila. Cell (2011) 2.64
Structure of an Hsp90-Cdc37-Cdk4 complex. Mol Cell (2006) 2.62
Elevated rates of protein secretion, evolution, and disease among tissue-specific genes. Genome Res (2004) 2.58
The bonobo genome compared with the chimpanzee and human genomes. Nature (2012) 2.49
EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa. Nat Genet (2008) 2.46
Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair. Mol Cell (2006) 2.43
The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37). Cell (2004) 2.36
Phosphoinositide signalling in cancer: beyond PI3K and PTEN. Nat Rev Cancer (2010) 2.35
Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. EMBO J (2003) 2.33
Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks. Mol Cell (2009) 2.32
Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37. J Biol Chem (2002) 2.32
Structural basis for uracil recognition by archaeal family B DNA polymerases. Nat Struct Biol (2002) 2.27
Enhancement of the seed-target recognition step in RNA silencing by a PIWI/MID domain protein. Mol Cell (2009) 2.27
Biologically inactive leptin and early-onset extreme obesity. N Engl J Med (2015) 2.26
Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the beta-clamp. EMBO J (2003) 2.25
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function. Mol Cell (2010) 2.24
Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Nat Genet (2003) 2.21
Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes. Genome Biol (2010) 2.20
Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat Genet (2003) 2.16
SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells. Circ Res (2005) 2.15
Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO J (2008) 2.12
A transcriptomic atlas of mouse neocortical layers. Neuron (2011) 2.08
Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. N Engl J Med (2012) 2.08
A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. J Pharmacol Exp Ther (2006) 2.06
Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomes. Genome Biol (2004) 2.05
Rapid turnover of long noncoding RNAs and the evolution of gene expression. PLoS Genet (2012) 2.05
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands. Elife (2012) 1.99
Predicting protein cellular localization using a domain projection method. Genome Res (2002) 1.98
The phosphatidylinositol 3-phosphate-binding FYVE finger. FEBS Lett (2002) 1.96
Common ancestry of the CENP-A chaperones Scm3 and HJURP. Cell (2009) 1.96
Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity. Mol Cell (2011) 1.94
Homology explains the functional similarities of Treslin/Ticrr and Sld3. Curr Biol (2010) 1.94
Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor. Mol Cell (2006) 1.91
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system. Nat Chem Biol (2013) 1.90
Massive turnover of functional sequence in human and other mammalian genomes. Genome Res (2010) 1.89
The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biol (2013) 1.87
Molecular basis for TPR domain-mediated regulation of protein phosphatase 5. EMBO J (2004) 1.86
Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways. Am J Hum Genet (2008) 1.86
Comparison of the genomes of human and mouse lays the foundation of genome zoology. Hum Mol Genet (2003) 1.83
Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity. Cell (2010) 1.82
Stem cell collection and gene transfer in Fanconi anemia. Mol Ther (2007) 1.81
A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency. Am J Hum Genet (2012) 1.81
Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange. EMBO J (2006) 1.77