Published in Science on February 17, 2006
Dopamine signaling in the dorsal striatum is essential for motivated behaviors: lessons from dopamine-deficient mice. Ann N Y Acad Sci (2008) 2.15
Common cellular and molecular mechanisms in obesity and drug addiction. Nat Rev Neurosci (2011) 1.93
Modulation of Drosophila male behavioral choice. Proc Natl Acad Sci U S A (2007) 1.63
Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence. Brain Struct Funct (2008) 1.54
Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease. Proc Natl Acad Sci U S A (2006) 1.51
Hindbrain noradrenergic A2 neurons: diverse roles in autonomic, endocrine, cognitive, and behavioral functions. Am J Physiol Regul Integr Comp Physiol (2010) 1.36
Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy. J Neurosci (2011) 1.28
Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability. Neuropharmacology (2013) 1.18
Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo. J Neurosci (2008) 1.12
Inputs to the ventrolateral bed nucleus of the stria terminalis. J Comp Neurol (2008) 1.11
Galanin protects against behavioral and neurochemical correlates of opiate reward. Neuropsychopharmacology (2007) 1.11
Modulation of glutamatergic synaptic transmission in the bed nucleus of the stria terminalis. Prog Neuropsychopharmacol Biol Psychiatry (2009) 1.10
Alpha1-adrenergic receptor-induced heterosynaptic long-term depression in the bed nucleus of the stria terminalis is disrupted in mouse models of affective disorders. Neuropsychopharmacology (2007) 1.09
Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine reward. Proc Natl Acad Sci U S A (2007) 1.09
The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration. Pharmacol Biochem Behav (2008) 1.09
Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Abeta levels. Mol Neurodegener (2007) 1.06
α-1 Adrenergic receptors are localized on presynaptic elements in the nucleus accumbens and regulate mesolimbic dopamine transmission. Neuropsychopharmacology (2012) 1.06
Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress. Proc Natl Acad Sci U S A (2010) 1.04
The midbrain raphe nuclei mediate primary reinforcement via GABA(A) receptors. Eur J Neurosci (2007) 1.03
Inhibition of β-adrenergic receptors induces a persistent deficit in retrieval of a cocaine-associated memory providing protection against reinstatement. Neuropsychopharmacology (2011) 1.03
Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward. Nat Neurosci (2014) 1.02
Effects of galanin on monoaminergic systems and HPA axis: Potential mechanisms underlying the effects of galanin on addiction- and stress-related behaviors. Brain Res (2009) 1.01
alpha2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis. Neuroscience (2009) 0.96
The role of norepinephrine in differential response to stress in an animal model of posttraumatic stress disorder. Biol Psychiatry (2011) 0.96
Cannabinoid modulation of limbic forebrain noradrenergic circuitry. Eur J Neurosci (2010) 0.92
Endogenous opiates and behavior: 2006. Peptides (2007) 0.92
Inhibition of hippocampal β-adrenergic receptors impairs retrieval but not reconsolidation of cocaine-associated memory and prevents subsequent reinstatement. Neuropsychopharmacology (2013) 0.90
Activation of the GLP-1 receptors in the nucleus of the solitary tract reduces food reward behavior and targets the mesolimbic system. PLoS One (2015) 0.88
Light and electron microscopic localization of alpha-1 adrenergic receptor immunoreactivity in the rat striatum and ventral midbrain. Neuroscience (2008) 0.87
Serotonin activates catecholamine neurons in the solitary tract nucleus by increasing spontaneous glutamate inputs. J Neurosci (2012) 0.86
Regulation of the postnatal development of dopamine neurons of the substantia nigra in vivo by Akt/protein kinase B. J Neurochem (2009) 0.86
Role of oxytocin signaling in the regulation of body weight. Rev Endocr Metab Disord (2013) 0.85
Noradrenergic control of the bed nucleus of the stria terminalis in stress and reward. Neuropharmacology (2013) 0.84
Defining functional gene-circuit interfaces in the mouse nervous system. Genes Brain Behav (2013) 0.84
Involvement of alpha1-adrenoceptors in conditioned place preference supported by nicotine in rats. Psychopharmacology (Berl) (2009) 0.83
Neonatal quinpirole treatment enhances locomotor activation and dopamine release in the nucleus accumbens core in response to amphetamine treatment in adulthood. Synapse (2010) 0.82
Candidate gene polymorphisms predicting individual sensitivity to opioids. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.82
Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons. Mol Psychiatry (2013) 0.82
Glial cell line-derived neurotrophic factor receptor-α1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra. J Neurochem (2011) 0.81
Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling. Neurobiol Dis (2011) 0.80
An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of substance P. Am J Pathol (2006) 0.80
Opioids inhibit visceral afferent activation of catecholamine neurons in the solitary tract nucleus. Neuroscience (2012) 0.80
Cumulative mtDNA damage and mutations contribute to the progressive loss of RGCs in a rat model of glaucoma. Neurobiol Dis (2014) 0.80
Enhanced tyrosine hydroxylase phosphorylation in the nucleus accumbens and nucleus tractus solitarius-A2 cell group after morphine-conditioned place preference. Naunyn Schmiedebergs Arch Pharmacol (2010) 0.78
Dissociation of β1- and β2-adrenergic receptor subtypes in the retrieval of cocaine-associated memory. Behav Brain Res (2015) 0.77
Norepinephrine at the nexus of arousal, motivation and relapse. Brain Res (2016) 0.76
Allostatic Mechanisms of Opioid Tolerance Beyond Desensitization and Downregulation. Trends Pharmacol Sci (2016) 0.76
Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice. PLoS One (2016) 0.76
Reciprocal Catecholamine Changes during Opiate Exposure and Withdrawal. Neuropsychopharmacology (2016) 0.76
Medullary Norepinephrine Projections Release Norepinephrine into the Contralateral Bed Nucleus of the Stria Terminalis. ACS Chem Neurosci (2016) 0.75
Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin. Brain Res (2015) 0.75
Nortriptyline Enhances Morphine-Conditioned Place Preference in Neuropathic Rats: Role of the Central Noradrenergic System. Anesth Analg (2017) 0.75
High glucose increases action potential firing of catecholamine neurons in the nucleus of the solitary tract by increasing spontaneous glutamate inputs. Am J Physiol Regul Integr Comp Physiol (2017) 0.75
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci (2009) 21.94
Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial. Lancet (2007) 7.01
NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science (2005) 6.55
AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial. Lancet Neurol (2011) 4.23
Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach. Neuron (2009) 4.18
Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation. Cell (2009) 3.94
Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition. Cell (2010) 3.71
VEGF links hippocampal activity with neurogenesis, learning and memory. Nat Genet (2004) 3.60
Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med (2003) 3.57
mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome. Science (2013) 3.41
Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior. Proc Natl Acad Sci U S A (2009) 3.15
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J Cell Biol (2007) 3.13
Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron (2010) 2.75
Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy. Cell Metab (2008) 2.72
White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis. Cell Metab (2011) 2.68
Role of NMDA receptors in dopamine neurons for plasticity and addictive behaviors. Neuron (2008) 2.41
Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacity. J Neurosci (2009) 2.29
Parkin-deficient mice are not a robust model of parkinsonism. Proc Natl Acad Sci U S A (2005) 2.27
Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age. J Biol Chem (2003) 2.26
GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex. Neuron (2007) 2.23
Deciphering a neuronal circuit that mediates appetite. Nature (2012) 2.21
Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nat Med (2007) 2.20
Genetic identification of a neural circuit that suppresses appetite. Nature (2013) 2.18
Distinguishing whether dopamine regulates liking, wanting, and/or learning about rewards. Behav Neurosci (2005) 2.02
Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease. Proc Natl Acad Sci U S A (2007) 1.98
AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats. Mol Cell Neurosci (2005) 1.92
Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Proc Natl Acad Sci U S A (2009) 1.88
Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia. Proc Natl Acad Sci U S A (2006) 1.85
Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction. Neuron (2011) 1.83
Homer proteins regulate sensitivity to cocaine. Neuron (2004) 1.83
Reward without dopamine. J Neurosci (2003) 1.80
Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo. Neuron (2011) 1.78
Psychosis pathways converge via D2high dopamine receptors. Synapse (2006) 1.78
Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice. Proc Natl Acad Sci U S A (2002) 1.68
Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis. Proc Natl Acad Sci U S A (2005) 1.67
Morphine reward in dopamine-deficient mice. Nature (2005) 1.66
Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus. J Neurosci (2004) 1.66
Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primates. Mol Ther (2009) 1.66
Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome. Proc Natl Acad Sci U S A (2010) 1.62
NPY/AgRP neurons are not essential for feeding responses to glucoprivation. Peptides (2006) 1.61
Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat. Proc Natl Acad Sci U S A (2008) 1.61
Multiple pathways involved in the biosynthesis of anandamide. Neuropharmacology (2007) 1.59
The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage. Proc Natl Acad Sci U S A (2007) 1.57
Cocaine-conditioned place preference by dopamine-deficient mice is mediated by serotonin. J Neurosci (2007) 1.57
Dopamine modulates release from corticostriatal terminals. J Neurosci (2004) 1.54
NMDA receptors inhibit synapse unsilencing during brain development. Proc Natl Acad Sci U S A (2008) 1.52
Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease. Proc Natl Acad Sci U S A (2006) 1.51
Redundancy in Kiss1 expression safeguards reproduction in the mouse. Endocrinology (2013) 1.49
Striking differences in glucose and lactate levels between brain extracellular fluid and plasma in conscious human subjects: effects of hyperglycemia and hypoglycemia. J Cereb Blood Flow Metab (2002) 1.48
Firing properties of dopamine neurons in freely moving dopamine-deficient mice: effects of dopamine receptor activation and anesthesia. Proc Natl Acad Sci U S A (2004) 1.48
Neuropeptide Y is an essential in vivo developmental regulator of cardiac ICa,L. Circ Res (2003) 1.47
Activation of dopamine neurons is critical for aversive conditioning and prevention of generalized anxiety. Nat Neurosci (2011) 1.46
Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes. Diabetes (2002) 1.43
Retinal dopamine mediates multiple dimensions of light-adapted vision. J Neurosci (2012) 1.42
Deletion of GAD67 in dopamine receptor-1 expressing cells causes specific motor deficits. Genesis (2008) 1.42
Promoters and regulatory elements that improve adeno-associated virus transgene expression in the brain. Methods (2002) 1.42
Gene therapy for spinal cord injury and disease. J Spinal Cord Med (2002) 1.41
Subthalamic GAD gene therapy in a Parkinson's disease rat model. Science (2002) 1.40
Dopamine is necessary for cue-dependent fear conditioning. J Neurosci (2009) 1.38
Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy. Brain (2008) 1.36
Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain. Nat Med (2006) 1.35
Dopamine beta-hydroxylase knockout mice have alterations in dopamine signaling and are hypersensitive to cocaine. Neuropsychopharmacology (2005) 1.35
QseC mediates Salmonella enterica serovar typhimurium virulence in vitro and in vivo. Infect Immun (2009) 1.33
Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development. Eur J Neurosci (2003) 1.32
Starvation after AgRP neuron ablation is independent of melanocortin signaling. Proc Natl Acad Sci U S A (2008) 1.32
AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease. Mol Ther (2008) 1.31
RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory. Proc Natl Acad Sci U S A (2010) 1.31
Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brain. J Virol (2002) 1.30
Molecular therapy of obesity and diabetes by a physiological autoregulatory approach. Nat Med (2009) 1.28
Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model. J Cell Biol (2011) 1.28
Disulfiram attenuates drug-primed reinstatement of cocaine seeking via inhibition of dopamine β-hydroxylase. Neuropsychopharmacology (2010) 1.27
Requirement of dopamine signaling in the amygdala and striatum for learning and maintenance of a conditioned avoidance response. Learn Mem (2011) 1.27
Mice with chronic norepinephrine deficiency resemble amphetamine-sensitized animals. Proc Natl Acad Sci U S A (2002) 1.27
Absence of NMDA receptors in dopamine neurons attenuates dopamine release but not conditioned approach during Pavlovian conditioning. Proc Natl Acad Sci U S A (2010) 1.26
Subthalamic glutamic acid decarboxylase gene therapy: changes in motor function and cortical metabolism. J Cereb Blood Flow Metab (2006) 1.26
Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo. Proc Natl Acad Sci U S A (2005) 1.26
Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors. Nat Neurosci (2012) 1.25
Expression of mutant NMDA receptors in dopamine D1 receptor-containing cells prevents cocaine sensitization and decreases cocaine preference. J Neurosci (2005) 1.25
Brain uptake of the glucagon-like peptide-1 antagonist exendin(9-39) after intranasal administration. J Pharmacol Exp Ther (2004) 1.23
mechanisms of disulfiram-induced cocaine abstinence: antabuse and cocaine relapse. Mol Interv (2009) 1.23
Long-term follow-up after gene therapy for canavan disease. Sci Transl Med (2012) 1.22
Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury. Exp Neurol (2003) 1.22
Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonists. Neuropsychopharmacology (2005) 1.21
Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse. Endocrinology (2011) 1.21
Effects of dopamine beta-hydroxylase genotype and disulfiram inhibition on catecholamine homeostasis in mice. Psychopharmacology (Berl) (2005) 1.20
Zinc transporter ZnT-3 regulates presynaptic Erk1/2 signaling and hippocampus-dependent memory. Proc Natl Acad Sci U S A (2011) 1.16
Dysregulation of dopamine signaling in the dorsal striatum inhibits feeding. Brain Res (2005) 1.16
AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease. Mol Ther (2004) 1.16
Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease. J Neurosci (2004) 1.15
The origins of oncomice: a history of the first transgenic mice genetically engineered to develop cancer. Genes Dev (2007) 1.15
Dbh(-/-) mice are hypotensive, have altered circadian rhythms, and have abnormal responses to dieting and stress. Am J Physiol Regul Integr Comp Physiol (2003) 1.14
GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism. Eur J Pharmacol (2011) 1.14