Published in Cell Death Differ on February 17, 2006
Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer (2014) 3.37
p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome. Hum Mol Genet (2012) 1.04
PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J Cell Sci (2011) 0.89
New insights into germ cell migration and survival/apoptosis in spermatogenesis: Lessons from CD147. Spermatogenesis (2012) 0.85
Differential PERP regulation by TP63 mutants provides insight into AEC pathogenesis. Am J Med Genet A (2009) 0.84
Inhibition of Notch Signaling During Mouse Incisor Renewal Leads to Enamel Defects. J Bone Miner Res (2015) 0.77
Transmembrane protein PERP is a component of tessellate junctions and of other junctional and non-junctional plasma membrane regions in diverse epithelial and epithelium-derived cells. Cell Tissue Res (2013) 0.77
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell (1997) 18.91
Tumor spectrum analysis in p53-mutant mice. Curr Biol (1994) 16.60
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev (2001) 15.97
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature (1999) 14.38
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell (1991) 14.23
Effects of an Rb mutation in the mouse. Nature (1992) 11.06
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature (2001) 10.56
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature (1995) 10.36
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci U S A (1998) 7.69
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature (1990) 6.82
Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell (1998) 6.73
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev (1996) 6.32
Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell (1995) 6.08
Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev (2000) 5.80
A mouse model for Down syndrome exhibits learning and behaviour deficits. Nat Genet (1995) 4.95
Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science (1994) 4.81
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell (1998) 4.78
Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev (1994) 4.58
Skeletal and CNS defects in Presenilin-1-deficient mice. Cell (1997) 4.50
Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice. Genes Dev (1995) 4.38
K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev (1997) 4.24
Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators. Cell (1994) 4.06
Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature (1996) 4.05
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat Genet (2000) 3.98
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat Genet (1994) 3.97
Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev (1996) 3.61
Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature (1997) 3.57
Mouse models of tumor development in neurofibromatosis type 1. Science (1999) 3.40
A subset of p53-deficient embryos exhibit exencephaly. Nat Genet (1995) 3.24
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev (2000) 3.24
Essential roles for the Abl and Arg tyrosine kinases in neurulation. Neuron (1998) 3.20
Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome. Nat Genet (1997) 2.81
K-ras activation generates an inflammatory response in lung tumors. Oncogene (2006) 2.78
Cooperative tumorigenic effects of germline mutations in Rb and p53. Nat Genet (1994) 2.73
Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev (1996) 2.71
Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev (1998) 2.66
Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J (1994) 2.57
Rescue of cyclin D1 deficiency by knockin cyclin E. Cell (1999) 2.54
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha. Nat Genet (2000) 2.39
Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia. J Biol Chem (1997) 2.35
Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res (1993) 2.29
Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta. Proc Natl Acad Sci U S A (1996) 2.23
E2F4 is essential for normal erythrocyte maturation and neonatal viability. Mol Cell (2000) 2.21
A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Genes Dev (1998) 2.19
Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke. J Natl Cancer Inst (1999) 2.11
Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Nat Genet (2000) 2.07
Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells. Immunity (1997) 1.97
The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries. Nat Genet (1998) 1.96
Molecular basis of viral neurotropism: experimental reovirus infection. Neurology (1985) 1.94
Mutations in the p53 and SCID genes cooperate in tumorigenesis. Genes Dev (1996) 1.89
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci (2001) 1.87
Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system. Mol Cell Biol (2003) 1.86
Hemagglutinin variants of reovirus type 3 have altered central nervous system tropism. Science (1983) 1.82
Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice. Cell (1997) 1.75
The impact of reduced frequency of cage changes on the health of mice housed in ventilated cages. Lab Anim (2001) 1.74
The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. Development (2000) 1.74
Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide. J Biol Chem (1998) 1.73
Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. J Clin Invest (2000) 1.65
Reduced fertility in female mice lacking copper-zinc superoxide dismutase. J Biol Chem (1998) 1.63
A defect in nurturing in mice lacking the immediate early gene fosB. Cell (1996) 1.63
p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells. J Cell Biol (1998) 1.59
Pathologic characterization of brown Norway, brown Norway x Fischer 344, and Fischer 344 x brown Norway rats with relation to age. J Gerontol A Biol Sci Med Sci (1996) 1.57
Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1. Mol Cell Biol (2000) 1.55
Genetic and structural analysis of a virulence determinant in polyomavirus VP1. J Virol (1995) 1.52
Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice. Proc Natl Acad Sci U S A (2001) 1.48
A very large protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice. Proc Natl Acad Sci U S A (1998) 1.46
The development of a model for the homing of multiple myeloma cells to human bone marrow. Blood (1997) 1.42
Functional analysis of NTF-1, a developmentally regulated Drosophila transcription factor that binds neuronal cis elements. Genes Dev (1989) 1.41
Serrate2 is disrupted in the mouse limb-development mutant syndactylism. Nature (1997) 1.40
Altered histopathology in protein-deprived mice during Sendai virus pneumonia: evidence for delayed inflammatory response and recovery. J Infect Dis (1992) 1.39
Characterization of the peripheral neuropathy in neonatal and adult mice that are homozygous for the fatty liver dystrophy (fld) mutation. J Biol Chem (1991) 1.39
Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures. Epilepsy Res (1990) 1.37
The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron (1997) 1.32
Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice. J Cell Biol (1991) 1.32
Murine infection by vesicular stomatitis virus: initial characterization of the H-2d system. J Virol (1991) 1.30
Enhancement of experimental ulcerative colitis by immunization with Bacteroides vulgatus. Infect Immun (1983) 1.28
Lung carcinogenesis induced by chronic tuberculosis infection: the experimental model and genetic control. Oncogene (2009) 1.26
Studies of aging in ames dwarf mice: Effects of caloric restriction. J Am Aging Assoc (2000) 1.23
Dystrophic muscle in mice chimeric for expression of alpha5 integrin. J Cell Biol (1998) 1.18
MRI detection of the thermal effects of focused ultrasound on the brain. Ultrasound Med Biol (2000) 1.18
Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration. Mamm Genome (1996) 1.17
A new spontaneous mouse mutation of Hoxd13 with a polyalanine expansion and phenotype similar to human synpolydactyly. Hum Mol Genet (1998) 1.17
Complete deletion of Apc results in severe polyposis in mice. Oncogene (2009) 1.16
Separation of immortalization from tumor induction with polyoma large T mutants that fail to bind the retinoblastoma gene product. Oncogene (1992) 1.15
Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice. Am J Pathol (2001) 1.15
Variation in age at death of dogs of different sexes and breeds. Am J Vet Res (1982) 1.15
The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor. Oncogene (2011) 1.13
Colonic adenocarcinoma associated with chronic colitis in cotton top marmosets, Saguinus oedipus. Gastroenterology (1981) 1.09
Fatal fasting syndrome of obese macaques. Lab Anim Sci (1982) 1.09
A test of the role of alpha5 integrin/fibronectin interactions in tumorigenesis. Cancer Res (1998) 1.09
E2f3a and E2f3b make overlapping but different contributions to total E2f3 activity. Oncogene (2008) 1.08
Siva is an apoptosis-selective p53 target gene important for neuronal cell death. Cell Death Differ (2007) 1.07
Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme. Oncogene (2011) 1.07
Effects of physiological versus pharmacological beta-carotene supplementation on cell proliferation and histopathological changes in the lungs of cigarette smoke-exposed ferrets. Carcinogenesis (2000) 1.07
A contribution to the electron microscopic morphometric analysis of peripheral nerve. J Comp Neurol (1978) 1.06
Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas. Proc Natl Acad Sci U S A (1997) 1.05
GFP-tagged expression and immunohistochemical studies to determine the subcellular localization of the tubby gene family members. Brain Res Mol Brain Res (2000) 1.02
Radiation-resistant and radiation-sensitive forms of host resistance to polyomavirus. J Virol (1999) 1.02
Adoptive transfer of immune enhancement of experimental ulcerative colitis. Infect Immun (1984) 1.00