Published in Cell on May 01, 1998
ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature (2009) 18.38
Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell (2011) 6.80
Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature (2011) 5.20
CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature (2009) 4.83
ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet (2010) 4.32
Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation. Genes Dev (1998) 3.79
Esa1p is an essential histone acetyltransferase required for cell cycle progression. Mol Cell Biol (1999) 3.57
Transcriptional cross talk between NF-kappaB and p53. Mol Cell Biol (1999) 3.40
p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J (2001) 3.37
The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res (2004) 3.30
Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J (2010) 3.25
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev (2000) 3.24
Biochemical analysis of distinct activation functions in p300 that enhance transcription initiation with chromatin templates. Mol Cell Biol (1999) 2.80
KLF8 recruits the p300 and PCAF co-activators to its amino terminal activation domain to activate transcription. Cell Cycle (2010) 2.69
Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nat Cell Biol (2008) 2.56
Bromodomains as therapeutic targets. Expert Rev Mol Med (2011) 2.52
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev (1999) 2.51
A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc Natl Acad Sci U S A (2005) 2.50
Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression. Mol Cell Biol (2006) 2.48
TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev (1998) 2.40
Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease. Am J Hum Genet (2005) 2.40
Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes. Nucleic Acids Res (2010) 2.37
Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol (2005) 2.30
Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1. Mol Cell Biol (2000) 2.24
Regulation of somatic growth by the p160 coactivator p/CIP. Proc Natl Acad Sci U S A (2000) 2.17
Beyond transcription factors: the role of chromatin modifying enzymes in regulating transcription required for memory. Learn Mem (2008) 2.15
Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene. Mol Cell Biol (2000) 2.12
Genetics and development of neural tube defects. J Pathol (2010) 2.10
Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol (2006) 2.00
Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis. Proc Natl Acad Sci U S A (2000) 1.99
Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal. Proc Natl Acad Sci U S A (2002) 1.99
Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation. Genes Dev (2000) 1.96
Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases. Epigenetics (2010) 1.92
The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J Clin Invest (2008) 1.89
VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection. J Virol (2004) 1.89
Re-employment of developmental transcription factors in adult heart disease. Semin Cell Dev Biol (2006) 1.82
Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases. Mol Cell Biol (2000) 1.82
Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration. EMBO J (2003) 1.80
Dual functions of thyroid hormone receptors in vertebrate development: the roles of histone-modifying cofactor complexes. Thyroid (2009) 1.71
Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. J Clin Invest (2010) 1.70
Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science (2011) 1.70
Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity. Mol Cell Biol (2003) 1.69
Neural tube defects. Annu Rev Neurosci (2014) 1.69
Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms. EMBO J (2007) 1.67
Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation. Proc Natl Acad Sci U S A (2005) 1.67
p300 requires its histone acetyltransferase activity and SRC-1 interaction domain to facilitate thyroid hormone receptor activation in chromatin. Mol Cell Biol (2000) 1.66
The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation. Proc Natl Acad Sci U S A (2002) 1.64
Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells. Genes Dev (2006) 1.61
PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner. Mol Cell Biol (1999) 1.59
Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos. Mol Cell Biol (2007) 1.58
A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging. Genes Dev (2004) 1.57
Interaction between acetylated MyoD and the bromodomain of CBP and/or p300. Mol Cell Biol (2001) 1.56
Physical and functional HAT/HDAC interplay regulates protein acetylation balance. J Biomed Biotechnol (2010) 1.55
CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation. EMBO J (2010) 1.55
Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. EMBO J (2003) 1.53
Mechanism of action of a distal NF-kappaB-dependent enhancer. Mol Cell Biol (2006) 1.53
Retracted Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors. Proc Natl Acad Sci U S A (1999) 1.52
Chromatin regulatory mechanisms in pluripotency. Annu Rev Cell Dev Biol (2010) 1.51
A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation. Mol Cell Biol (2000) 1.51
Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation. EMBO J (2003) 1.48
Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits. Learn Mem (2007) 1.48
MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300. EMBO J (2003) 1.47
CBP and p300 are essential for renin cell identity and morphological integrity of the kidney. Am J Physiol Heart Circ Physiol (2009) 1.47
Cardiac p300 is involved in myocyte growth with decompensated heart failure. Mol Cell Biol (2003) 1.45
Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF. Mol Cell Biol (2003) 1.41
Regulation of beta -catenin transformation by the p300 transcriptional coactivator. Proc Natl Acad Sci U S A (2000) 1.41
Functional analysis of the p300 acetyltransferase domain: the PHD finger of p300 but not of CBP is dispensable for enzymatic activity. Nucleic Acids Res (2001) 1.40
Linking prenatal maternal adversity to developmental outcomes in infants: the role of epigenetic pathways. Dev Psychopathol (2012) 1.39
Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3. Mol Cell Biol (2002) 1.38
Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Dev Cell (2010) 1.38
Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J (2006) 1.37
The PHD type zinc finger is an integral part of the CBP acetyltransferase domain. Mol Cell Biol (2002) 1.36
Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo. Mol Cell Biol (2005) 1.36
Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Sci Transl Med (2010) 1.35
Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle. Mol Cell Biol (2000) 1.35
Chromatin remodeling in cardiovascular development and physiology. Circ Res (2011) 1.34
Estrogen action and cytoplasmic signaling cascades. Part I: membrane-associated signaling complexes. Trends Endocrinol Metab (2002) 1.34
Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers. Mol Cell Biol (2000) 1.32
Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice. Genes Dev (1999) 1.31
Proteasome-mediated degradation of the coactivator p300 impairs cardiac transcription. Mol Cell Biol (2000) 1.31
Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. Mol Cell Biol (2002) 1.31
CBP/p300 and muscle differentiation: no HAT, no muscle. EMBO J (2001) 1.30
Quantitative analysis of CBP- and P300-induced histone acetylations in vivo using native chromatin. Mol Cell Biol (2003) 1.29
The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP. J Biol Chem (2008) 1.27
Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells. Mol Cell Biol (2005) 1.27
Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu. Mol Cell Biol (2003) 1.27
Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development. Mol Cell Biol (2009) 1.27
Diagnostic analysis of the Rubinstein-Taybi syndrome: five cosmids should be used for microdeletion detection and low number of protein truncating mutations. J Med Genet (2000) 1.26
Genome-wide assessment of differential roles for p300 and CBP in transcription regulation. Nucleic Acids Res (2010) 1.25
Gene expression profile of HIV-1 Tat expressing cells: a close interplay between proliferative and differentiation signals. BMC Biochem (2002) 1.24
Genetic heterogeneity in Rubinstein-Taybi syndrome: delineation of the phenotype of the first patients carrying mutations in EP300. J Med Genet (2007) 1.23
Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function. Curr Opin Immunol (2010) 1.23
Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood (2006) 1.21
Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia. Oncogene (2013) 1.20
MOZ increases p53 acetylation and premature senescence through its complex formation with PML. Proc Natl Acad Sci U S A (2013) 1.19
Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function. Proc Natl Acad Sci U S A (2001) 1.19
p300 (histone acetyltransferase) biomarker predicts prostate cancer biochemical recurrence and correlates with changes in epithelia nuclear size and shape. Prostate (2008) 1.19
Differences in specificity and selectivity between CBP and p300 acetylation of histone H3 and H3/H4. Biochemistry (2013) 1.17
Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland. Proc Natl Acad Sci U S A (2006) 1.17
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell (1999) 25.75
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell (1997) 18.91
Tumor spectrum analysis in p53-mutant mice. Curr Biol (1994) 16.60
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev (2001) 15.97
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature (1999) 14.38
The genome sequence of Schizosaccharomyces pombe. Nature (2002) 14.26
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell (1991) 14.23
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature (2000) 13.45
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell (1988) 12.69
Effects of an Rb mutation in the mouse. Nature (1992) 11.06
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature (2001) 10.56
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature (1995) 10.36
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev (1994) 8.92
Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell (1997) 8.28
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development (1996) 7.98
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci U S A (1998) 7.69
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet (1998) 7.52
Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell (1993) 7.19
Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product. Cell (1991) 6.55
The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell (1989) 6.43
Immunoaffinity chromatography of proteins. Methods Enzymol (1974) 6.40
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev (1996) 6.32
Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell (1995) 6.08
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell (1997) 5.92
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science (2001) 5.58
E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell (1996) 5.26
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem (1996) 5.15
Binding and modulation of p53 by p300/CBP coactivators. Nature (1997) 5.12
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci U S A (1994) 5.11
The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell (1992) 5.05
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell (2001) 5.05
Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Nature (1999) 5.03
A mouse model for Down syndrome exhibits learning and behaviour deficits. Nat Genet (1995) 4.95
T antigen repression of SV40 early transcription from two promoters. Cell (1981) 4.83
Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science (1994) 4.81
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell (1998) 4.78
Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev (1994) 4.58
An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci U S A (1996) 4.57
Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev (1992) 4.56
Skeletal and CNS defects in Presenilin-1-deficient mice. Cell (1997) 4.50
Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature (1989) 4.46
A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature (1995) 4.40
Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice. Genes Dev (1995) 4.38
In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature (2000) 4.38
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell (1991) 4.24
K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev (1997) 4.24
Suppression of intestinal neoplasia by DNA hypomethylation. Cell (1995) 4.16
Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A (2000) 4.08
Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature (1996) 4.05
Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell (1994) 4.01
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat Genet (2000) 3.98
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat Genet (1994) 3.97
Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell (1992) 3.91
Spinocerebellar ataxia type 5 in a family descended from the grandparents of President Lincoln maps to chromosome 11. Nat Genet (1994) 3.89
Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature (1996) 3.88
SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family. Cell (1989) 3.88
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell (1998) 3.86
Genetic analysis of BRCA1 function in a defined tumor cell line. Mol Cell (1999) 3.83
Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat Med (2000) 3.72
Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2. Nature (1997) 3.70
Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature (1998) 3.65
Mapping of SV40 DNA replication origin region binding sites for the SV40 T antigen by protection against exonuclease III digestion. Cell (1980) 3.62
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell (1998) 3.62
Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev (1996) 3.61
Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation. Cell (1990) 3.61
Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature (1997) 3.57
Potential energy barriers to ion transport within lipid bilayers. Studies with tetraphenylborate. Biophys J (1975) 3.56
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature (2000) 3.48
Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell (1991) 3.47
The synthesis of complex-type oligosaccharides. II. Characterization of the processing intermediates in the synthesis of the complex oligosaccharide units of the vesicular stomatitis virus G protein. J Biol Chem (1978) 3.43
The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc Natl Acad Sci U S A (1996) 3.43
Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity. Mol Cell (2001) 3.43
Mouse models of tumor development in neurofibromatosis type 1. Science (1999) 3.40
Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature (1995) 3.39
lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells. Cell (1987) 3.33
Infectious C-type virus isolated from a baboon placenta. Nature (1974) 3.32
Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes. Genes Dev (1996) 3.29
Stringent regulation of stably integrated chloramphenicol acetyl transferase genes by E. coli lac repressor in monkey cells. Cell (1988) 3.29
p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol Cell (1998) 3.27
A subset of p53-deficient embryos exhibit exencephaly. Nat Genet (1995) 3.24
Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev (1998) 3.24
Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev (1996) 3.24
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev (2000) 3.24
E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell (1994) 3.24
Radioimmunoassay of mammalian type C viral proteins. I. Species specific reactions of murine and feline viruses. J Immunol (1972) 3.23
CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc Natl Acad Sci U S A (1998) 3.22
Essential roles for the Abl and Arg tyrosine kinases in neurulation. Neuron (1998) 3.20
The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell (1990) 3.19
Regulation of imprinted X-chromosome inactivation in mice by Tsix. Development (2001) 3.12
Disruption of alpha3 connexin gene leads to proteolysis and cataractogenesis in mice. Cell (1997) 3.10
DNA methylation specifies chromosomal localization of MeCP2. Mol Cell Biol (1996) 3.10