Tumor spectrum analysis in p53-mutant mice.

PubWeight™: 16.60‹?› | Rank: Top 0.1% | All-Time Top 10000

🔗 View Article (PMID 7922305)

Published in Curr Biol on January 01, 1994

Authors

T Jacks1, L Remington, B O Williams, E M Schmitt, S Halachmi, R T Bronson, R A Weinberg

Author Affiliations

1: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.

Articles citing this

(truncated to the top 100)

p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer (2009) 9.21

Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55

The antioxidant function of the p53 tumor suppressor. Nat Med (2005) 7.57

ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev (2000) 7.28

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev (1999) 6.87

Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci U S A (1998) 6.82

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity (2011) 6.00

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76

Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev (2000) 5.71

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev (2001) 5.67

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev (1998) 5.60

Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell (2005) 5.51

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell (2007) 5.20

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96

E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev (1998) 4.60

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev (2003) 4.40

Telomeres and telomerase in cancer. Carcinogenesis (2009) 4.28

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J (2002) 4.17

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A (2005) 4.15

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes Dev (1999) 4.13

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature (2000) 4.10

Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes Dev (2006) 4.06

Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat Genet (2008) 4.02

Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res (2008) 3.99

Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol (1998) 3.88

p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol (2011) 3.85

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc Natl Acad Sci U S A (2007) 3.58

Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev (1999) 3.51

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell (2002) 3.50

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature (2010) 3.37

Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer (2014) 3.37

Short telomeres limit tumor progression in vivo by inducing senescence. Cancer Cell (2007) 3.23

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss. Genes Dev (2008) 3.17

Constitutive expression of AID leads to tumorigenesis. J Exp Med (2003) 3.16

Genetic determinants of susceptibility to excitotoxic cell death: implications for gene targeting approaches. Proc Natl Acad Sci U S A (1997) 3.15

TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell (2009) 3.15

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J (1998) 3.12

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol (2002) 3.10

p53 and E2f: partners in life and death. Nat Rev Cancer (2009) 3.06

Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia. Proc Natl Acad Sci U S A (2006) 3.04

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma. J Exp Med (2000) 3.04

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Invest (2012) 2.95

Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev (2004) 2.91

Mouse tumor model for neurofibromatosis type 1. Science (1999) 2.89

Different telomere damage signaling pathways in human and mouse cells. EMBO J (2002) 2.87

AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell (2009) 2.75

Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74

p53-independent functions of the p19(ARF) tumor suppressor. Genes Dev (2000) 2.74

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet (2009) 2.68

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev (1998) 2.66

A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection. Cell (2013) 2.60

bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc Natl Acad Sci U S A (1997) 2.59

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell (2011) 2.58

Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell (2009) 2.58

BRCA1 regulates p53-dependent gene expression. Proc Natl Acad Sci U S A (1998) 2.50

The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet (2011) 2.47

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors. Nat Struct Mol Biol (2011) 2.42

Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation. Mol Cell Biol (1997) 2.41

Tumors associated with p53 germline mutations: a synopsis of 91 families. Am J Pathol (1997) 2.40

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J (2000) 2.38

Early events in DNA replication require cyclin E and are blocked by p21CIP1. J Cell Biol (1995) 2.34

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex. Mol Cell Biol (2000) 2.34

mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation. Mol Cell Biol (2003) 2.32

The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc Natl Acad Sci U S A (2003) 2.29

Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis. Genes Dev (2003) 2.27

Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function. Proc Natl Acad Sci U S A (2002) 2.24

A novel allele of Saccharomyces cerevisiae RFA1 that is deficient in recombination and repair and suppressible by RAD52. Mol Cell Biol (1995) 2.21

Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment. Nature (2015) 2.21

Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. Proc Natl Acad Sci U S A (2006) 2.20

Cell type-specific effects of Rb deletion in the murine retina. Genes Dev (2004) 2.18

Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell (2012) 2.15

Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res (2008) 2.15

The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev (2005) 2.14

Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell (2009) 2.14

The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends Genet (2012) 2.13

A minimally invasive assay for individual assessment of the ATM/CHEK2/p53 pathway activity. Cell Cycle (2011) 2.13

Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J (2006) 2.12

Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive. Genes Dev (2010) 2.12

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J (1996) 2.12

Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol (2005) 2.10

The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood (2006) 2.10

Early thymocyte development is regulated by modulation of E2A protein activity. J Exp Med (2001) 2.05

A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease. Genes Dev (2001) 2.05

p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. Cancer Cell (2012) 2.04

Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis. Genes Dev (2004) 2.04

Estrogen Receptor-β Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma. Endocrinology (2015) 2.03

Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique. BMC Dev Biol (2004) 2.01

Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells. Proc Natl Acad Sci U S A (2011) 2.01

20 years studying p53 functions in genetically engineered mice. Nat Rev Cancer (2009) 2.00

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function. Mol Cell Biol (1996) 1.99

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia. Cancer Cell (2014) 1.98

MDM4 is a key therapeutic target in cutaneous melanoma. Nat Med (2012) 1.93

DUX4, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53-dependent myopathy in vivo. Ann Neurol (2010) 1.89

Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis. Genes Dev (2002) 1.89

Evolutionarily conserved role of nucleostemin: controlling proliferation of stem/progenitor cells during early vertebrate development. Mol Cell Biol (2006) 1.89

Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development. J Exp Med (2002) 1.88

Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev (2002) 1.87

Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Mol Cell Biol (2006) 1.86

Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation. Development (2005) 1.85

Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell (2013) 1.85

Articles by these authors

The hallmarks of cancer. Cell (2000) 113.05

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature (1983) 19.76

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell (1997) 18.91

Creation of human tumour cells with defined genetic elements. Nature (1999) 16.47

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev (2001) 15.97

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature (1999) 14.38

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell (1991) 14.23

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature (1986) 13.96

p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (1993) 13.46

Mechanism of activation of a human oncogene. Nature (1982) 12.09

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev (2001) 11.25

Effects of an Rb mutation in the mouse. Nature (1992) 11.06

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature (1988) 10.98

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature (2001) 10.56

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature (1995) 10.36

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell (1997) 8.74

Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci U S A (1998) 7.69

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell (1992) 7.61

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature (1993) 7.20

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation. Nature (1985) 7.07

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Cell (1986) 7.06

Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression. Mol Cell Biol (1986) 7.06

Isolation of a transforming sequence from a human bladder carcinoma cell line. Cell (1982) 6.93

Do stroke units save lives? Lancet (1993) 6.79

Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell (1998) 6.73

p53 status and the efficacy of cancer therapy in vivo. Science (1994) 6.72

Cellular oncogenes and multistep carcinogenesis. Science (1983) 6.52

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev (1996) 6.32

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature (1985) 6.23

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature (1982) 6.09

Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell (1995) 6.08

The integrated genome of murine leukemia virus. Cell (1978) 5.84

The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature (1986) 5.77

Sunburn and p53 in the onset of skin cancer. Nature (1995) 5.35

Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. Proc Natl Acad Sci U S A (1979) 5.32

Physical interaction of the retinoblastoma protein with human D cyclins. Cell (1993) 5.31

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol (2000) 5.28

Acrylamide gel electrophoresis of HeLa cell nucleolar RNA. Proc Natl Acad Sci U S A (1967) 5.06

Small molecular weight monodisperse nuclear RNA. J Mol Biol (1968) 4.96

Inhibition of telomerase limits the growth of human cancer cells. Nat Med (1999) 4.96

A mouse model for Down syndrome exhibits learning and behaviour deficits. Nat Genet (1995) 4.95

Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science (1994) 4.81

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell (1998) 4.78

Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res (1997) 4.73

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts. Nature (1981) 4.72

Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. Cell (1992) 4.68

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev (1994) 4.58

Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol (1998) 4.54

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature (1994) 4.52

Skeletal and CNS defects in Presenilin-1-deficient mice. Cell (1997) 4.50

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice. Genes Dev (1995) 4.38

K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev (1997) 4.24

DNA sequences homologous to vertebrate oncogenes are conserved in Drosophila melanogaster. Proc Natl Acad Sci U S A (1981) 4.17

Suppression of intestinal neoplasia by DNA hypomethylation. Cell (1995) 4.16

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci U S A (1998) 4.11

Isolation and characterization of simian virus 40 ribonucleic acid. J Virol (1972) 4.09

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. Proc Natl Acad Sci U S A (1990) 4.06

Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature (1996) 4.05

Restriction endonuclease cleavage of linear and closed circular murine leukemia viral DNAs: discovery of a smaller circular form. Cell (1979) 4.04

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat Genet (2000) 3.98

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat Genet (1994) 3.97

Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature (1995) 3.90

A defined subgenomic fragment of in vitro synthesized Moloney sarcoma virus DNA can induce cell transformation upon transfection. Cell (1979) 3.74

Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein. Proc Natl Acad Sci U S A (1987) 3.72

p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell (1994) 3.69

Identification of DNA fragments carrying ecotropic proviruses of AKR mice. Proc Natl Acad Sci U S A (1979) 3.64

The action of oncogenes in the cytoplasm and nucleus. Science (1985) 3.62

Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev (1996) 3.61

Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature (1997) 3.57

Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp Cell Res (2001) 3.48

Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev (1993) 3.41

Mouse models of tumor development in neurofibromatosis type 1. Science (1999) 3.40

Point mutational inactivation of the retinoblastoma antioncogene. Science (1989) 3.37

Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev (2000) 3.30

Characterization of a human colon/lung carcinoma oncogene. Nature (1983) 3.26

A subset of p53-deficient embryos exhibit exencephaly. Nat Genet (1995) 3.24

Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev (2000) 3.24

A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc Natl Acad Sci U S A (1998) 3.23

Essential roles for the Abl and Arg tyrosine kinases in neurulation. Neuron (1998) 3.20

Proposal for naming host cell-derived inserts in retrovirus genomes. J Virol (1981) 3.18

Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol Cell Biol (1996) 3.15

Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin. Mol Cell (1999) 3.15

Infectious viral DNA of murine leukemia virus. Proc Natl Acad Sci U S A (1975) 3.09

Growth suppression by p16ink4 requires functional retinoblastoma protein. Proc Natl Acad Sci U S A (1995) 3.08

Murine leukemia virus: detection of unintegrated double-stranded DNA forms of the provirus. Proc Natl Acad Sci U S A (1975) 3.07

The pathway to signal achievement. Nature (1993) 3.03

The HL-60 transforming sequence: a ras oncogene coexisting with altered myc genes in hematopoietic tumors. Cell (1983) 3.00

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc Natl Acad Sci U S A (1995) 2.99