Published in J Biol Chem on February 10, 1968
The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci U S A (1968) 6.96
Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. Proc Natl Acad Sci U S A (1993) 2.77
Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood (2012) 2.10
The bacteriostatic effect of serum on Pasteurella septica and its abolition by iron compounds. Immunology (1971) 2.06
Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood (2013) 2.05
Catabolism of heme in vivo: comparison of the simultaneous production of bilirubin and carbon monoxide. J Clin Invest (1970) 1.96
Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice. J Clin Invest (2006) 1.91
The interaction of 2,3-diphosphoglycerate with various human hemoglobins. J Clin Invest (1970) 1.81
Characterization of globin domains: heme binding to the central exon product. Proc Natl Acad Sci U S A (1980) 1.63
Extracellular hemin crisis triggers acute chest syndrome in sickle mice. J Clin Invest (2013) 1.58
Use of heme-protein complexes by the Yersinia enterocolitica HemR receptor: histidine residues are essential for receptor function. J Bacteriol (1999) 1.54
Iron compounds and resistance to infection. Further experiments with Clostridium welchii type A in vivo and in vitro. Immunology (1970) 1.53
Accelerated autoxidation and heme loss due to instability of sickle hemoglobin. Proc Natl Acad Sci U S A (1988) 1.51
Heme degradation and vascular injury. Antioxid Redox Signal (2010) 1.48
Red cells, hemoglobin, heme, iron, and atherogenesis. Arterioscler Thromb Vasc Biol (2010) 1.44
The renal handling of hemoglobin. I. Glomerular filtration. J Exp Med (1969) 1.38
Haem transport to the liver by haemopexin. Receptor-mediated uptake with recycling of the protein. Biochem J (1979) 1.31
Erythropoietin effects on fetal mouse erythroid cells. I. Cell population and hemoglobin synthesis. J Cell Biol (1971) 1.27
Mechanism of hemolysis induced by ferriprotoporphyrin IX. J Clin Invest (1981) 1.27
Altered sulfhydryl reactivity of hemoglobins and red blood cell membranes in congenital Heinz body hemolytic anemia. J Clin Invest (1968) 1.26
The surface protein Shr of Streptococcus pyogenes binds heme and transfers it to the streptococcal heme-binding protein Shp. BMC Microbiol (2008) 1.22
The role of hemoglobin heme loss in Heinz body formation: studies with a partially heme-deficient hemoglobin and with genetically unstable hemoglobins. J Clin Invest (1970) 1.22
Haem disorder in reconstituted human haemoglobin. Biochem J (1982) 1.11
Effect of excess alpha-hemoglobin chains on cellular and membrane oxidation in model beta-thalassemic erythrocytes. J Clin Invest (1993) 1.11
Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development. Front Physiol (2014) 1.10
Coupling heme and iron metabolism via ferritin H chain. Antioxid Redox Signal (2013) 1.08
Oxidation and haem loss kinetics of poly(ethylene glycol)-conjugated haemoglobin (MP4): dissociation between in vitro and in vivo oxidation rates. Biochem J (2006) 1.07
Subunit dissociations in natural and recombinant hemoglobins. Protein Sci (1996) 1.07
Increased striatal injury and behavioral deficits after intracerebral hemorrhage in hemopexin knockout mice. J Neurosurg (2010) 1.06
Mitochondria-targeted heme oxygenase-1 induces oxidative stress and mitochondrial dysfunction in macrophages, kidney fibroblasts and in chronic alcohol hepatotoxicity. Redox Biol (2013) 1.01
Heme-protein fission under nondenaturing conditions. Proc Natl Acad Sci U S A (1991) 0.98
Free alpha-globin pool in human bone marrow. J Clin Invest (1973) 0.97
Tetramer-dimer equilibrium of oxyhemoglobin mutants determined from auto-oxidation rates. Protein Sci (1998) 0.96
Effect of heme oxygenase-1 on the vulnerability of astrocytes and neurons to hemoglobin. Biochem Biophys Res Commun (2006) 0.95
MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice. Blood (2013) 0.95
Heme cytotoxicity and the pathogenesis of immune-mediated inflammatory diseases. Front Pharmacol (2012) 0.94
HmuY haemophore and gingipain proteases constitute a unique syntrophic system of haem acquisition by Porphyromonas gingivalis. PLoS One (2011) 0.94
Insights on how the Mycobacterium tuberculosis heme uptake pathway can be used as a drug target. Future Med Chem (2013) 0.93
Blood-brain barrier disruption and oxidative stress in guinea pig after systemic exposure to modified cell-free hemoglobin. Am J Pathol (2011) 0.92
Subunit dissociation of certain abnormal human hemoglobins. J Clin Invest (1969) 0.92
Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease. Blood Cells Mol Dis (2014) 0.91
Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin. Free Radic Biol Med (2014) 0.90
Mechanism of methaemoglobin breakdown by the lysine-specific gingipain of the periodontal pathogen Porphyromonas gingivalis. Biol Chem (2008) 0.90
Accelerated hemolysis and neurotoxicity in neuron-glia-blood clot co-cultures. J Neurochem (2010) 0.90
A study of the properties of hybrids of oxyhaemoglobin and deoxyhaemoglobin with two porphyringlobin species. Biochem J (1974) 0.90
Reaction of hemoglobin with HOCl: mechanism of heme destruction and free iron release. Free Radic Biol Med (2011) 0.89
Vasculotoxic and Proinflammatory Effects of Plasma Heme: Cell Signaling and Cytoprotective Responses. ISRN Oxidative Med (2013) 0.87
Systemic hemin therapy attenuates blood-brain barrier disruption after intracerebral hemorrhage. Neurobiol Dis (2014) 0.87
The pathophysiology of extracellular hemoglobin associated with enhanced oxidative reactions. Front Physiol (2015) 0.86
Haem disorder in modified myoglobins. Effect of reconstitution procedures. Biochem J (1983) 0.86
The Iron age of host-microbe interactions. EMBO Rep (2015) 0.85
Red blood cell, hemoglobin and heme in the progression of atherosclerosis. Front Physiol (2014) 0.85
Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction. Br J Haematol (2011) 0.85
Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders. Front Physiol (2015) 0.85
Oxidative stress in β-thalassaemia and sickle cell disease. Redox Biol (2015) 0.84
Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease. Br J Haematol (2013) 0.84
Targeting heme oxygenase after intracerebral hemorrhage. Ther Targets Neurol Dis (2015) 0.84
Haptoglobin genotype-dependent differences in macrophage lysosomal oxidative injury. J Biol Chem (2014) 0.83
Hemoglobin stability: observations on the denaturation of normal and abnormal hemoglobins by oxidant dyes, heat, and alkali. J Clin Invest (1970) 0.83
Disposal of plasma heme in normal man and patients with intravascular hemolysis. J Clin Invest (1970) 0.83
Haem degradation in human haemoglobin in vitro. Separation of the contribution of the alpha- and beta-subunits. Biochem J (1984) 0.82
Covalent heme attachment in Synechocystis hemoglobin is required to prevent ferrous heme dissociation. Protein Sci (2007) 0.82
Heme Oxygenases in Cardiovascular Health and Disease. Physiol Rev (2016) 0.82
Comparison of immunoadsorbents prepared by coupling sperm-whale myoglobin to a variety of insoluble polymers. Biochem J (1970) 0.81
Non-heme protein in the giant extracellular hemoglobin of the earthworm Lumbricus terrestris. Proc Natl Acad Sci U S A (1988) 0.81
Carbon monoxide promotes respiratory hemoproteins iron reduction using peroxides as electron donors. PLoS One (2012) 0.81
Free heme and the polymerization of sickle cell hemoglobin. Biophys J (2010) 0.80
Astrocyte-specific heme oxygenase-1 hyperexpression attenuates heme-mediated oxidative injury. Neurobiol Dis (2007) 0.80
Pathway and mechanism of pH dependent human hemoglobin tetramer-dimer-monomer dissociations. PLoS One (2013) 0.79
Crystallographic trapping of heme loss intermediates during the nitrite-induced degradation of human hemoglobin. Biochemistry (2011) 0.79
Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes. J Am Chem Soc (2016) 0.78
Increasing expression of H- or L-ferritin protects cortical astrocytes from hemin toxicity. Free Radic Res (2009) 0.78
Hemoglobin binding to A beta and HBG2 SNP association suggest a role in Alzheimer's disease. Neurobiol Aging (2006) 0.78
Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage. J Neuroinflammation (2016) 0.77
Colorimetric protein sensing using catalytically amplified sensor arrays. Small (2012) 0.77
High Presence of Extracellular Hemoglobin in the Periventricular White Matter Following Preterm Intraventricular Hemorrhage. Front Physiol (2016) 0.77
Immunoregulation in human malaria: the challenge of understanding asymptomatic infection. Mem Inst Oswaldo Cruz (2015) 0.77
Differential heme release from various hemoglobin redox states and the upregulation of cellular heme oxygenase-1. FEBS Open Bio (2016) 0.76
Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease. Mol Med (2016) 0.76
Purification and some properties of the three common genetic types of haptoglovins and the hemoglobin-haptoglobin complexes. Am J Hum Genet (1969) 0.76
The free heme concentration in healthy human erythrocytes. Blood Cells Mol Dis (2015) 0.75
Can gas replace protein function? CO abrogates the oxidative toxicity of myoglobin. PLoS One (2014) 0.75
Heme as a Target for Therapeutic Interventions. Front Pharmacol (2017) 0.75
In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines. Transfusion (2013) 0.75
Acute kidney function and morphology following topload administration of recombinant hemoglobin solution. Artif Cells Nanomed Biotechnol (2016) 0.75
Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction. Proc Natl Acad Sci U S A (1990) 10.01
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (1998) 9.56
Red cells coated with immunoglobulin G: binding and sphering by mononuclear cells in man. Science (1967) 6.42
Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science (1988) 5.71
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem (1996) 5.15
An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci U S A (1996) 4.57
The glycosylation of hemoglobin: relevance to diabetes mellitus. Science (1978) 3.87
The biosynthesis of human hemoglobin A1c. Slow glycosylation of hemoglobin in vivo. J Clin Invest (1976) 3.00
Studies in vivo and in vitro on an abnormality in the metabolism of C3 in a patient with increased susceptibility to infection. J Clin Invest (1970) 2.92
Deficiency of C3 inactivator in man. J Immunol (1971) 2.86
Glycosylated hemoglobins and long-term blood glucose control in diabetes mellitus. J Clin Endocrinol Metab (1977) 2.84
The regulated expression of erythropoietin by two human hepatoma cell lines. Proc Natl Acad Sci U S A (1987) 2.51
Further identification of the nature and linkage of the carbohydrate in hemoglobin A1c. Biochem Biophys Res Commun (1975) 2.46
Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events. Blood (1991) 2.41
Continuous subcutaenous administration of deferoxamine in patients with iron overload. N Engl J Med (1977) 2.31
Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q- syndrome. Cell (1985) 2.28
Preservation of vascular integrity in organs perfused in vitro with a platelet-rich medium. Nature (1969) 2.16
Regulation of the erythropoietin gene. Blood (1999) 2.10
Increased susceptibility to infection associated with abnormalities of complement-mediated functions and of the third component of complement (C3). N Engl J Med (1970) 2.08
The interaction between human monocytes and red cells. Specificity for IgG subclasses and IgG fragments. J Exp Med (1970) 2.05
Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction. Proc Natl Acad Sci U S A (1991) 1.95
Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements. Mol Cell Biol (1992) 1.94
Exchange of heme among hemoglobin molecules. Proc Natl Acad Sci U S A (1966) 1.81
The interaction of 2,3-diphosphoglycerate with various human hemoglobins. J Clin Invest (1970) 1.81
Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein. Mol Cell Biol (1998) 1.80
Nonenzymatic glycosylation of human serum albumin alters its conformation and function. J Biol Chem (1984) 1.80
The interaction between human monocytes and red cells. Binding characteristics. J Exp Med (1970) 1.77
Regulation of erythrocyte cation and water content in sickle cell anemia. Science (1986) 1.65
Evaluation of glycosylated hemoglobin diabetic patients. Diabetes (1981) 1.65
Effects of sulfhydryl inhibition on red blood cells. 3. Glutathione in the regulation of the hexose monophosphate pathway. J Biol Chem (1966) 1.62
Sites of nonenzymatic glycosylation of human hemoglobin A. J Biol Chem (1980) 1.56
A study of induced hyponatremia in the prevention and treatment of sickle-cell crisis. N Engl J Med (1980) 1.54
Fatal anaphylaxis after intramuscular iron-dextran. Ann Intern Med (1966) 1.51
The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1. Mol Cell Biol (1995) 1.50
Kinetic analysis of the nonenzymatic glycosylation of hemoglobin. J Biol Chem (1981) 1.50
Treatment of sickle cell anemia with hydroxyurea and erythropoietin. N Engl J Med (1990) 1.47
Nonenzymatic glycosylation of erythrocyte membrane proteins. Relevance to diabetes. J Clin Invest (1980) 1.47
Cotranslational amino-terminal processing of cytosolic proteins. Cell-free expression of site-directed mutants of human hemoglobin. J Biol Chem (1988) 1.46
Educating the biomedical scientist. FASEB J (1995) 1.43
The separation of human and animal hemoglobins by isoelectric focusing in polyacrylamide gel. Biochim Biophys Acta (1971) 1.42
In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction. Blood (1993) 1.41
Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. Proc Natl Acad Sci U S A (1999) 1.39
The renal handling of hemoglobin. I. Glomerular filtration. J Exp Med (1969) 1.38
Glycosylation of hemoglobin in vitro: affinity labeling of hemoglobin by glucose-6-phosphate. Proc Natl Acad Sci U S A (1976) 1.38
Amino-terminal processing of proteins: hemoglobin South Florida, a variant with retention of initiator methionine and N alpha-acetylation. Proc Natl Acad Sci U S A (1985) 1.37
The nature of the alpha-methyldopa red-cell antibody. N Engl J Med (1967) 1.37
Differences in the interaction of 2,3-diphosphoglycerate with certain mammalian hemoglobins. Science (1971) 1.36
Nonenzymatic glycosylation of protein: relevance to diabetes. Am J Med (1981) 1.34
Clinical consequences of acquired transfusional iron overload in adults. N Engl J Med (1981) 1.33
Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling. J Biol Chem (1999) 1.33
Molecular and cellular pathogenesis of hemoglobin SC disease. Proc Natl Acad Sci U S A (1982) 1.32
Electrostatic attraction governs the dimer assembly of human hemoglobin. J Biol Chem (1986) 1.31
Structural heterogeneity of human hemoglobin A due to nonenzymatic glycosylation. J Biol Chem (1979) 1.30
Characterization of glycosylated hemoglobins. Relevance to monitoring of diabetic control and analysis of other proteins. J Clin Invest (1983) 1.29
Signal transduction. How do cells sense oxygen? Science (2001) 1.27
The interaction between erythrocyte organic phosphates, magnesium ion, and hemoglobin. J Biol Chem (1971) 1.26
Subunit assembly of hemoglobin: an important determinant of hematologic phenotype. Blood (1987) 1.25
Hemoglobin function in stored blood. J Clin Invest (1969) 1.25
Bile salts and cholesterol in the pathogenesis of target cells in obstructive jaundice. J Clin Invest (1968) 1.22
Regulation of cation content and cell volume in hemoglobin erythrocytes from patients with homozygous hemoglobin C disease. J Clin Invest (1985) 1.22
Erythropoietin structure-function relationships. Mutant proteins that test a model of tertiary structure. J Biol Chem (1993) 1.21
Glycosylated minor components of human adult hemoglobin. Purification, identification, and partial structural analysis. J Biol Chem (1978) 1.20
A rapid method for the determination of glycosylated hemoglobins using high pressure liquid chromatography. Metabolism (1978) 1.20
The value of the peripheral blood smear in anemic inpatients. The laboratory's reading v a physician's reading. Arch Intern Med (1983) 1.18
Functional properties of hemoglobin Kempsey. J Biol Chem (1974) 1.18
Increased splenic pooling and the pathogenesis of hypersplenism. Am J Med Sci (1967) 1.18
Participation of hemoglobins A and F in polymerization of sickle hemoglobin. J Biol Chem (1977) 1.15
Glycosylated hemoglobin in human and animal red cells. Role of glucose permeability. Diabetes (1982) 1.14
Erythropoietin structure-function relationships. Identification of functionally important domains. J Biol Chem (1994) 1.14
A simple visual screening test for glucose-6-phosphate dehydrogenase deficiency employing ascorbate and cyanide. N Engl J Med (1966) 1.11
Effects of transition metals on the expression of the erythropoietin gene: further evidence that the oxygen sensor is a heme protein. Biochem Biophys Res Commun (1996) 1.11
Hemoglobin Cranston, an unstable variant having an elongated beta chain due to nonhomologous crossover between two normal beta chain genes. Proc Natl Acad Sci U S A (1975) 1.10
The separation of partially oxidized hemoglobins. Biochim Biophys Acta (1971) 1.09
The sites of hemoglobin catabolism. Blood (1965) 1.08
Hypoxia up-regulates the activity of a novel erythropoietin mRNA binding protein. J Biol Chem (1991) 1.08
Oxygen sensing and signaling: impact on the regulation of physiologically important genes. Respir Physiol (1999) 1.07
Erythropoietin structure-function relationships: high degree of sequence homology among mammals. Blood (1993) 1.05
The role of membrane lipids in the survival of red cells in hereditary spherocytosis. J Clin Invest (1969) 1.05
Regulatory elements of the erythropoietin gene. Blood (1991) 1.05
Control of hemoglobin function within the red cell. N Engl J Med (1970) 1.04
Nonenzymatic glycosylation of bovine lens crystallins. Effect of aging. J Biol Chem (1981) 1.01
The renal handling of hemoglobin. II. Catabolism. J Exp Med (1969) 1.01
Effects of cyanate and 2,3-diphosphoglycerate on sickling. Relationship to oxygenation. J Clin Invest (1973) 1.00
Acute methemoglobinemia and hemolytic anemia with phenazopyridine: possible relation to acute renal failure. Arch Intern Med (1977) 0.98
National Diabetes Data Group: report of the expert committee on glucosylated hemoglobin. Diabetes Care (1985) 0.97
The effect of erythrocyte membrane preparations on the polymerization of sickle hemoglobin. J Biol Chem (1981) 0.97
"Replacement" of COOH-terminal truncation of v-fms with c-fms sequences markedly reduces transformation potential. Proc Natl Acad Sci U S A (1986) 0.96
Nonenzymatic glycation of human lens crystallin. Effect of aging and diabetes mellitus. J Clin Invest (1984) 0.95
Evolution of mammalian hemoglobin function. Blood (1981) 0.94
Electrostatic interactions in the assembly of haemoglobin. Nature (1984) 0.94
Hemoglobin function in the horse: the role of 2,3-diphosphoglycerate in modifying the oxygen affinity of maternal and fetal blood. Blood (1973) 0.94
What determines severity in sickle-cell disease? N Engl J Med (1982) 0.93
Homodimerization restores biological activity to an inactive erythropoietin mutant. J Biol Chem (1998) 0.93
Erythocyte destruction and hemoglobin catabolism. Semin Hematol (1972) 0.92
The reaction of cyanate with the alpha and beta subunits in hemoglobin. Effects of oxygenation, phosphates, and carbon dioxide. J Biol Chem (1973) 0.92
Cellular distribution of hemoglobin F in a clonal hemopoietic stem-cell disorder. N Engl J Med (1978) 0.92
The phylogenetic distribution of red cell 2,3 diphosphoglycerate and its interaction with mammalian hemoglobins. J Exp Zool (1977) 0.92