Published in Chem Biol on February 01, 2006
Heat shock proteins: essential proteins for apoptosis regulation. J Cell Mol Med (2008) 1.93
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases. Nat Rev Drug Discov (2011) 1.71
To fold or not to fold: modulation and consequences of Hsp90 inhibition. Future Med Chem (2009) 1.29
Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in diabetic mice. ASN Neuro (2010) 1.21
Protein homeostasis as a therapeutic target for diseases of protein conformation. Curr Top Med Chem (2012) 1.10
Targeting HSP90 to halt neurodegeneration. Chem Biol (2006) 0.89
Inducible hsp70 in the regulation of cancer cell survival: analysis of chaperone induction, expression and activity. Cancers (Basel) (2011) 0.83
Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun. ASN Neuro (2012) 0.81
Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors. Assay Drug Dev Technol (2013) 0.78
Mapping of NRAGE domains reveals clues to cell viability in BMP signaling. Apoptosis (2010) 0.76
Targeting the Diabetic Chaperome to Improve Peripheral Neuropathy. Curr Diab Rep (2016) 0.75
Eiger-induced cell death relies on Rac1-dependent endocytosis. Cell Death Dis (2016) 0.75
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell (2008) 5.89
De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia. Proc Natl Acad Sci U S A (2010) 3.13
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity (2009) 2.91
Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci (2003) 2.67
Neurotrophin signaling through the p75 neurotrophin receptor. Prog Neurobiol (2002) 2.39
Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. J Neurosci (2009) 2.25
Constitutive nuclear factor-kappa B activity is required for central neuron survival. J Neurosci (2002) 1.95
Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling. J Neurosci (2009) 1.89
Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron (2006) 1.74
An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. Biochem J (2012) 1.71
Mutations in the calcium-related gene IL1RAPL1 are associated with autism. Hum Mol Genet (2008) 1.66
NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway. J Biol Chem (2002) 1.48
Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics. Oncogene (2004) 1.47
Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion. J Neurosci (2005) 1.36
Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad. J Neurosci (2003) 1.36
The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface. Hum Mol Genet (2006) 1.29
The p75 neurotrophin receptor: multiple interactors and numerous functions. Prog Brain Res (2004) 1.26
Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism. J Neurosci (2009) 1.26
Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis. J Neurosci (2004) 1.24
Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia. J Clin Oncol (2009) 1.23
Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting X-linked inhibitor of apoptosis. Clin Cancer Res (2006) 1.22
Phase I trial of AEG35156 administered as a 7-day and 3-day continuous intravenous infusion in patients with advanced refractory cancer. J Clin Oncol (2009) 1.19
Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases. Biosci Rep (2012) 1.17
Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells. Cancer Res (2005) 1.16
Cytoprotective effects of IAPs revealed by a small molecule antagonist. Biochem J (2009) 1.15
LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based growth inhibition. J Neurosci (2010) 1.14
K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK. J Biol Chem (2002) 1.12
ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway. Proc Natl Acad Sci U S A (2010) 1.10
Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension. J Neurosci (2004) 1.10
Tumor necrosis factor-alpha triggers mucus production in airway epithelium through an IkappaB kinase beta-dependent mechanism. J Biol Chem (2005) 1.09
Longitudinal evaluation of memory performance and peripheral neuropathy in the Ins2C96Y Akita mice. Behav Brain Res (2005) 1.07
p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation. EMBO Rep (2005) 1.07
TRPC channels underlie cholinergic plateau potentials and persistent activity in entorhinal cortex. Hippocampus (2011) 1.06
Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation. J Biol Chem (2008) 1.05
Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development. Hum Mol Genet (2008) 1.05
A pro-apoptotic fragment of the p75 neurotrophin receptor is expressed in p75NTRExonIV null mice. J Neurosci (2004) 1.02
Application of XIAP antisense to cancer and other proliferative disorders: development of AEG35156/ GEM640. Ann N Y Acad Sci (2005) 1.00
Soluble adenylyl cyclase is not required for axon guidance to netrin-1. J Neurosci (2008) 0.99
XIAP regulates caspase activity in degenerating axons. Cell Rep (2013) 0.99
Hypo-osmolar stress induces p75NTR expression by activating Sp1-dependent transcription. J Neurosci (2007) 0.98
Apoptotic sensitivity of murine IAP-deficient cells. Biochem J (2008) 0.97
The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling. J Cell Sci (2010) 0.96
Stabilization of p73 by nuclear IkappaB kinase-alpha mediates cisplatin-induced apoptosis. J Biol Chem (2007) 0.95
XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38- cells in a phase 1/2 study of patients with relapsed/refractory AML. Apoptosis (2011) 0.94
Something old, something new: BDNF-induced neuron survival requires TRPC channel function. Nat Neurosci (2007) 0.91
p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells. J Biol Chem (2014) 0.91
Disruption of a receptor-mediated mechanism for intracellular sorting of proinsulin in familial hyperproinsulinemia. Mol Endocrinol (2003) 0.89
ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo. J Neurosci (2013) 0.89
Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling. FASEB J (2011) 0.88
TRAF6-dependent NF-kB transcriptional activity during mouse development. Dev Dyn (2004) 0.88
Expression analysis of a novel p75(NTR) signaling protein, which regulates cell cycle progression and apoptosis. Mech Dev (2002) 0.86
Developing a methodology for carbon isotope analysis of lacustrine diatoms. Rapid Commun Mass Spectrom (2011) 0.85
Neurotrophin-4, alone or heterodimerized with brain-derived neurotrophic factor, is sorted to the constitutive secretory pathway. J Biol Chem (2003) 0.85
X-linked inhibitor of apoptosis regulates T cell effector function. J Immunol (2007) 0.83
Extremely low frequency electromagnetic field exposure promotes differentiation of pituitary corticotrope-derived AtT20 D16V cells. Bioelectromagnetics (2006) 0.83
Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis. Mol Cell Biol (2013) 0.81
Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain. Mol Cell Neurosci (2007) 0.80
Wengen, the sole tumour necrosis factor receptor in Drosophila, collaborates with moesin to control photoreceptor axon targeting during development. PLoS One (2013) 0.80
Stress-induced expression of the p75 neurotrophin receptor is regulated by O-GlcNAcylation of the Sp1 transcription factor. J Neurochem (2010) 0.80
Neurotrophins in the regulation of cellular survival and death. Handb Exp Pharmacol (2014) 0.79
p75NTR-dependent Rac1 activation requires receptor cleavage and activation of an NRAGE and NEDD9 signaling cascade. J Cell Sci (2015) 0.77
Observations on the function of nuclear factor kappa B (NF-kappaB) in the survival of adult primary sensory neurons after nerve injury. Mol Cell Neurosci (2008) 0.77
Getting RIP'd Stunts Your Growth. Neuron (2005) 0.75