Published in Biochem J on April 15, 2012
Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice. Immunity (2015) 2.60
cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation. Cell Death Differ (2012) 1.29
Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling. EMBO Mol Med (2013) 1.14
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling. Nat Rev Immunol (2012) 0.97
Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2. Int Immunol (2013) 0.92
Revisiting caspases in sepsis. Cell Death Dis (2014) 0.91
A discrete ubiquitin-mediated network regulates the strength of NOD2 signaling. Mol Cell Biol (2012) 0.85
Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins. Immunol Cell Biol (2016) 0.82
Several classical mouse inbred strains, including DBA/2, NOD/Lt, FVB/N, and SJL/J, carry a putative loss-of-function allele of Gpr84. J Hered (2013) 0.82
cIAP2 supports viability of mice lacking cIAP1 and XIAP. EMBO J (2015) 0.80
A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways. Mucosal Immunol (2015) 0.78
Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice. Hum Mol Genet (2012) 0.78
Response to Heard et al. EMBO J (2015) 0.76
Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains. J Thromb Haemost (2016) 0.75
Mousing around with caspases and IAPs. Biochem J (2012) 0.75
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature (2000) 13.45
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science (1995) 11.38
Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell (1995) 9.11
Non-canonical inflammasome activation targets caspase-11. Nature (2011) 8.85
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell (2008) 5.89
Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice. Nat Genet (1997) 5.13
IAPs: what's in a name? Mol Cell (2008) 3.66
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell (1998) 3.62
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity (2009) 2.91
Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo. Mol Cell Biol (2005) 2.57
Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature (2006) 2.17
Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J Biol Chem (1996) 2.05
Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival. Mol Cell Biol (2006) 2.04
Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions. J Cell Biol (2000) 2.04
Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway. EMBO J (2005) 1.79
Genetic variation in C57BL/6 ES cell lines and genetic instability in the Bruce4 C57BL/6 ES cell line. Mamm Genome (2007) 1.68
An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila. EMBO Rep (2005) 1.67
The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection. Mol Cell Biol (2006) 1.35
Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response. Cell Death Differ (2002) 1.30
Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response. Blood (2011) 1.22
Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2. Cell Death Differ (2011) 1.18
Cytoprotective effects of IAPs revealed by a small molecule antagonist. Biochem J (2009) 1.15
To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death. Curr Opin Cell Biol (2010) 0.99
Apoptotic sensitivity of murine IAP-deficient cells. Biochem J (2008) 0.97
Iap2 is required for a sustained response in the Drosophila Imd pathway. Dev Comp Immunol (2007) 0.95
A locus on chromosome 9 is associated with differential response of 129S1/SvImJ and FVB/NJ strains of mice to systemic LPS. Mamm Genome (2011) 0.81
IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol (2002) 7.23
Endothelial and perivascular cells maintain haematopoietic stem cells. Nature (2012) 6.60
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell (2008) 5.89
Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol (2005) 4.79
Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell (2007) 4.18
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature (2010) 3.93
De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia. Proc Natl Acad Sci U S A (2010) 3.13
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity (2009) 2.91
The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes. Nature (2003) 2.63
Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute. Development (2004) 2.54
Neurotrophin signaling through the p75 neurotrophin receptor. Prog Neurobiol (2002) 2.39
Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration. Hum Mol Genet (2003) 2.36
Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. J Neurosci (2009) 2.25
COMMD proteins, a novel family of structural and functional homologs of MURR1. J Biol Chem (2005) 2.24
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature (2003) 2.22
Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression. J Virol (2005) 2.21
Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs. J Cell Biol (2009) 1.99
The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3. J Biol Chem (2005) 1.96
Constitutive nuclear factor-kappa B activity is required for central neuron survival. J Neurosci (2002) 1.95
Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci (2004) 1.92
A novel role for XIAP in copper homeostasis through regulation of MURR1. EMBO J (2003) 1.90
Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling. J Neurosci (2009) 1.89
To knockout in 129 or in C57BL/6: that is the question. Trends Genet (2004) 1.76
Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron (2006) 1.74
Genetic variation in C57BL/6 ES cell lines and genetic instability in the Bruce4 C57BL/6 ES cell line. Mamm Genome (2007) 1.68
Mutations in the calcium-related gene IL1RAPL1 are associated with autism. Hum Mol Genet (2008) 1.66
AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem Biol (2006) 1.64
RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis. Dev Cell (2010) 1.57
Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function. J Clin Invest (2005) 1.55
Distant regulatory elements in a Sox10-beta GEO BAC transgene are required for expression of Sox10 in the enteric nervous system and other neural crest-derived tissues. Dev Dyn (2006) 1.54
Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proc Natl Acad Sci U S A (2002) 1.52
Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele. Mol Cell Biol (2006) 1.51
XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders. Mol Cell (2006) 1.50
NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway. J Biol Chem (2002) 1.48
Regulation of the cytoplasmic quality control protein degradation pathway by BAG2. J Biol Chem (2005) 1.46
The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing. J Biol Chem (2009) 1.44
Generating transgenic mice from bacterial artificial chromosomes: transgenesis efficiency, integration and expression outcomes. Transgenic Res (2009) 1.43
Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis. J Biol Chem (2003) 1.41
Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis. J Biol Chem (2003) 1.37
Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion. J Biol Chem (2009) 1.37
XIAP regulates cytosol-specific innate immunity to Listeria infection. PLoS Pathog (2008) 1.36
Advances in transgenic rat production. Transgenic Res (2006) 1.36
Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad. J Neurosci (2003) 1.36
An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis. J Biol Chem (2003) 1.34
Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol Cell Biol (2008) 1.29
The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface. Hum Mol Genet (2006) 1.29
Upstream regulatory role for XIAP in receptor-mediated apoptosis. Mol Cell Biol (2004) 1.28
Neutralization of Smac/Diablo by inhibitors of apoptosis (IAPs). A caspase-independent mechanism for apoptotic inhibition. J Biol Chem (2004) 1.27
Pituitary-specific Gata2 knockout: effects on gonadotrope and thyrotrope function. Mol Endocrinol (2006) 1.27
Characterization of COMMD protein-protein interactions in NF-kappaB signalling. Biochem J (2006) 1.27
The p75 neurotrophin receptor: multiple interactors and numerous functions. Prog Brain Res (2004) 1.26
Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism. J Neurosci (2009) 1.26
Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice. Hum Mol Genet (2004) 1.26
Identification of essential residues in the type II Hsp40 Sis1 that function in polypeptide binding. J Biol Chem (2002) 1.25
Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis. J Neurosci (2004) 1.24
Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation. Dev Cell (2008) 1.21
Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery. Curr Opin Cell Biol (2003) 1.18
Aurora A is essential for early embryonic development and tumor suppression. J Biol Chem (2008) 1.17
Activator of G protein signaling 3 null mice: I. Unexpected alterations in metabolic and cardiovascular function. Endocrinology (2008) 1.17
RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27. Proc Natl Acad Sci U S A (2009) 1.16
Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells. Cancer Res (2005) 1.16
Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins. J Biol Chem (2004) 1.15
Cytoprotective effects of IAPs revealed by a small molecule antagonist. Biochem J (2009) 1.15
The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription. Science (2009) 1.14
LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based growth inhibition. J Neurosci (2010) 1.14
SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation. Dev Cell (2011) 1.13
Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein. Biochem J (2003) 1.12
K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK. J Biol Chem (2002) 1.12
CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. J Biol Chem (2007) 1.11
ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway. Proc Natl Acad Sci U S A (2010) 1.10
Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension. J Neurosci (2004) 1.10
XIAP: cell death regulation meets copper homeostasis. Arch Biochem Biophys (2007) 1.10
IAP proteins: regulators of cell migration and development. Curr Opin Cell Biol (2012) 1.09
Tumor necrosis factor-alpha triggers mucus production in airway epithelium through an IkappaB kinase beta-dependent mechanism. J Biol Chem (2005) 1.09
Mouse model of enlarged vestibular aqueducts defines temporal requirement of Slc26a4 expression for hearing acquisition. J Clin Invest (2011) 1.07
p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation. EMBO Rep (2005) 1.07
TRPC channels underlie cholinergic plateau potentials and persistent activity in entorhinal cortex. Hippocampus (2011) 1.06
A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO. J Biol Chem (2003) 1.06
Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation. J Biol Chem (2008) 1.05
Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2. J Biol Chem (2009) 1.05
Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development. Hum Mol Genet (2008) 1.05
Targeted disruption of the meprin beta gene in mice leads to underrepresentation of knockout mice and changes in renal gene expression profiles. Mol Cell Biol (2003) 1.03
Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination. Mol Cell Biol (2010) 1.03
Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP. Mol Cell Biol (2007) 1.03
Generation of mice with a conditional allele of the p120 Ras GTPase-activating protein. Genesis (2007) 1.03
A pro-apoptotic fragment of the p75 neurotrophin receptor is expressed in p75NTRExonIV null mice. J Neurosci (2004) 1.02
Targeted disruption of Adamts16 gene in a rat genetic model of hypertension. Proc Natl Acad Sci U S A (2012) 1.00
A simple qPCR-based method to detect correct insertion of homologous targeting vectors in murine ES cells. Transgenic Res (2007) 1.00
Soluble adenylyl cyclase is not required for axon guidance to netrin-1. J Neurosci (2008) 0.99
XIAP regulates caspase activity in degenerating axons. Cell Rep (2013) 0.99
Rederivation of transgenic and gene-targeted mice by embryo transfer. Transgenic Res (2004) 0.98
Hypo-osmolar stress induces p75NTR expression by activating Sp1-dependent transcription. J Neurosci (2007) 0.98
Apoptotic sensitivity of murine IAP-deficient cells. Biochem J (2008) 0.97
The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling. J Cell Sci (2010) 0.96
Stabilization of p73 by nuclear IkappaB kinase-alpha mediates cisplatin-induced apoptosis. J Biol Chem (2007) 0.95
Production of the butyrylcholinesterase knockout mouse. J Mol Neurosci (2006) 0.93
Two distinct signalling cascades target the NF-kappaB regulatory factor c-IAP1 for degradation. Biochem J (2009) 0.93