Published in J Immunol on March 01, 2006
VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown. Proc Natl Acad Sci U S A (2009) 2.25
Ion channels in innate and adaptive immunity. Annu Rev Immunol (2015) 1.99
The role of the purinergic P2X7 receptor in inflammation. J Inflamm (Lond) (2007) 1.50
Molecular and functional properties of P2X receptors--recent progress and persisting challenges. Purinergic Signal (2012) 1.31
The role of the P2X₇ receptor in infectious diseases. PLoS Pathog (2011) 1.15
P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis. J Neuroinflammation (2008) 1.12
Glutamate and ATP signalling in white matter pathology. J Anat (2011) 1.11
Neurotransmitter signaling in the pathophysiology of microglia. Front Cell Neurosci (2013) 0.98
Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation. Recent Pat CNS Drug Discov (2010) 0.97
Purinergic P2X7 receptor regulates lung surfactant secretion in a paracrine manner. J Cell Sci (2011) 0.97
Physiological and pathological functions of P2X7 receptor in the spinal cord. Purinergic Signal (2009) 0.95
Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis. J Neuroinflammation (2011) 0.95
IL-11 regulates autoimmune demyelination. J Immunol (2009) 0.95
Purinergic signalling and immune cells. Purinergic Signal (2014) 0.94
P2 receptors and immunity. Microbes Infect (2012) 0.93
Contribution of pannexin1 to experimental autoimmune encephalomyelitis. PLoS One (2013) 0.91
Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice. J Immunol (2011) 0.88
P2X and P2Y receptors—role in the pathophysiology of the nervous system. Int J Mol Sci (2014) 0.84
Ca(2+) influx in T cells: how many ca(2+) channels? Front Immunol (2013) 0.84
Central nervous system myeloid cells as drug targets: current status and translational challenges. Nat Rev Drug Discov (2015) 0.83
Roles of white matter in central nervous system pathophysiologies. ASN Neuro (2012) 0.83
Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease. Mol Neurodegener (2011) 0.82
Pannexin1 channels act downstream of P2X 7 receptors in ATP-induced murine T-cell death. Channels (Austin) (2014) 0.79
P2X7 on Mouse T Cells: One Channel, Many Functions. Front Immunol (2015) 0.78
P2Y2R deficiency attenuates experimental autoimmune uveitis development. PLoS One (2015) 0.77
Lipopolysaccharide inhibits the channel activity of the P2X7 receptor. Mediators Inflamm (2011) 0.77
Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4+ T lymphocytes. J Immunol (2013) 0.76
Emerging role of extracellular nucleotides and adenosine in multiple sclerosis. Purinergic Signal (2011) 0.75
Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7. Mucosal Immunol (2016) 0.75
Purinergic receptors as potential therapeutic targets in Alzheimer's disease. Neuropharmacology (2015) 0.75
Diadenosine homodinucleotide products of ADP-ribosyl cyclases behave as modulators of the purinergic receptor P2X7. J Biol Chem (2010) 0.75
P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling. J Neurosci (2006) 3.14
Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation. Nat Med (2002) 3.04
Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis. Ann Neurol (2002) 1.86
IL-1beta regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program. J Immunol (2006) 1.57
IL-1-regulated responses in astrocytes: relevance to injury and recovery. Glia (2005) 1.56
Cytokines: powerful regulators of glial cell activation. Neuroscientist (2003) 1.54
Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination. Proc Natl Acad Sci U S A (2009) 1.46
TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5. J Immunol (2006) 1.45
The cytokine IL-1beta transiently enhances P2X7 receptor expression and function in human astrocytes. Glia (2005) 1.42
Interleukin-1beta induces a reactive astroglial phenotype via deactivation of the Rho GTPase-Rock axis. J Neurosci (2004) 1.40
Deletion of astrocyte connexins 43 and 30 leads to a dysmyelinating phenotype and hippocampal CA1 vacuolation. J Neurosci (2009) 1.39
Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation. J Neurosci (2006) 1.35
Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis. J Neurosci (2006) 1.34
New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43. FASEB J (2005) 1.28
Regulation of immune response by P2X7 receptor. Crit Rev Immunol (2006) 1.22
Astrocyte indoleamine 2,3-dioxygenase is induced by the TLR3 ligand poly(I:C): mechanism of induction and role in antiviral response. J Virol (2007) 1.20
Modified amino acid copolymers suppress myelin basic protein 85-99-induced encephalomyelitis in humanized mice through different effects on T cells. Proc Natl Acad Sci U S A (2004) 1.08
Toll-like receptors in CNS viral infections. Curr Top Microbiol Immunol (2009) 1.07
The cytokine IL-1beta activates IFN response factor 3 in human fetal astrocytes in culture. J Immunol (2005) 1.05
Role of mitogen-activated protein kinases in inducible nitric oxide synthase and TNFalpha expression in human fetal astrocytes. J Neuroimmunol (2002) 1.02
The TLR3 ligand polyI: C downregulates connexin 43 expression and function in astrocytes by a mechanism involving the NF-kappaB and PI3 kinase pathways. Glia (2006) 1.01
TLR3 and TLR4 are innate antiviral immune receptors in human microglia: role of IRF3 in modulating antiviral and inflammatory response in the CNS. Virology (2009) 1.00
Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms. Proc Natl Acad Sci U S A (2004) 0.98
Inducible heat shock protein 70 promotes myelin autoantigen presentation by the HLA class II. J Immunol (2004) 0.96
Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis. J Neuroinflammation (2011) 0.95
Regulation of RANTES/CCL5 expression in human astrocytes by interleukin-1 and interferon-beta. J Neurochem (2004) 0.94
Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity. Brain Res (2008) 0.92
Interferon-beta activates multiple signaling cascades in primary human microglia. J Neurochem (2002) 0.91
Canonical transient receptor potential channel 4 (TRPC4) co-localizes with the scaffolding protein ZO-1 in human fetal astrocytes in culture. Glia (2005) 0.89
Heat shock protein 70 associations with myelin basic protein and proteolipid protein in multiple sclerosis brains. Int Immunol (2003) 0.88
Brain-derived heat shock protein 70-peptide complexes induce NK cell-dependent tolerance to experimental autoimmune encephalomyelitis. J Immunol (2006) 0.86
Mice devoid of Tau have increased susceptibility to neuronal damage in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. J Neuropathol Exp Neurol (2012) 0.86
15-deoxy-delta (12,14)-PGJ2 inhibits astrocyte IL-1 signaling: inhibition of NF-kappaB and MAP kinase pathways and suppression of cytokine and chemokine expression. J Neuroimmunol (2004) 0.85
Modulation of astrocyte inducible nitric oxide synthase and cytokine expression by interferon beta is associated with induction and inhibition of interferon gamma-activated sequence binding activity. J Neurochem (2002) 0.84
Transcriptional profiling of gamma delta T cells identifies a role for vitamin D in the immunoregulation of the V gamma 9V delta 2 response to phosphate-containing ligands. J Immunol (2005) 0.83
EAE tolerance induction with Hsp70-peptide complexes depends on H60 and NKG2D activity. J Immunol (2007) 0.83
Upregulation of group 1 CD1 antigen presenting molecules in guinea pigs with experimental autoimmune encephalomyelitis: an immunohistochemical study. Brain Pathol (2003) 0.82
15-deoxy-Delta12,14-prostaglandin J2 inhibits IFN-inducible protein 10/CXC chemokine ligand 10 expression in human microglia: mechanisms and implications. J Immunol (2004) 0.81
Copolymer effects on microglia and T cells in the central nervous system of humanized mice. Eur J Immunol (2005) 0.80
Loss of astrocyte connexins 43 and 30 does not significantly alter susceptibility or severity of acute experimental autoimmune encephalomyelitis in mice. J Neuroimmunol (2012) 0.80
Involvement of classical and novel protein kinase C isoforms in the response of human V gamma 9V delta 2 T cells to phosphate antigens. J Immunol (2002) 0.80
Transcriptional profiling of microdissected areas of active multiple sclerosis lesions reveals activation of heat shock protein genes. J Neurosci Res (2012) 0.75