Published in Nat Med on September 23, 2002
Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO J (2004) 4.77
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency. Nat Neurosci (2008) 3.24
MicroRNA-mediated control of oligodendrocyte differentiation. Neuron (2010) 3.24
Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev (2009) 2.96
Signals to promote myelin formation and repair. Nat Rev Neurol (2010) 1.95
Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nat Neurosci (2009) 1.93
Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants. Ann Neurol (2012) 1.71
Not(ch) just development: Notch signalling in the adult brain. Nat Rev Neurosci (2011) 1.69
The glial regenerative response to central nervous system injury is enabled by pros-notch and pros-NFκB feedback. PLoS Biol (2011) 1.63
The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat Neurosci (2009) 1.60
Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling. Brain (2009) 1.49
A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players. EMBO J (2006) 1.49
Notch and disease: a growing field. Semin Cell Dev Biol (2012) 1.48
The epigenetics of autoimmunity. Cell Mol Immunol (2011) 1.47
Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination. Proc Natl Acad Sci U S A (2009) 1.46
An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination. Nat Commun (2016) 1.40
c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling. J Cell Biol (2012) 1.38
Oligodendrocytes and progenitors become progressively depleted within chronically demyelinated lesions. Am J Pathol (2004) 1.35
Highly conserved O-fucose sites have distinct effects on Notch1 function. J Biol Chem (2005) 1.35
Endogenous cell repair of chronic demyelination. J Neuropathol Exp Neurol (2006) 1.27
Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cells. Stem Cells (2007) 1.27
Astrocytes from the contused spinal cord inhibit oligodendrocyte differentiation of adult oligodendrocyte precursor cells by increasing the expression of bone morphogenetic proteins. J Neurosci (2011) 1.21
Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis. J Clin Invest (2008) 1.19
Glial development: the crossroads of regeneration and repair in the CNS. Neuron (2014) 1.12
Brain and bone damage in KARAP/DAP12 loss-of-function mice correlate with alterations in microglia and osteoclast lineages. Am J Pathol (2005) 1.11
Platelet-derived growth factor promotes repair of chronically demyelinated white matter. J Neuropathol Exp Neurol (2007) 1.08
Paradoxical dysregulation of the neural stem cell pathway sonic hedgehog-Gli1 in autoimmune encephalomyelitis and multiple sclerosis. Ann Neurol (2008) 1.08
Remyelination therapy for multiple sclerosis. Neurotherapeutics (2013) 1.08
The neuroprotective functions of transforming growth factor beta proteins. Int J Mol Sci (2012) 1.06
A network analysis of the human T-cell activation gene network identifies JAGGED1 as a therapeutic target for autoimmune diseases. PLoS One (2007) 1.03
The TLR3 ligand polyI: C downregulates connexin 43 expression and function in astrocytes by a mechanism involving the NF-kappaB and PI3 kinase pathways. Glia (2006) 1.01
Pathophysiology of glia in perinatal white matter injury. Glia (2014) 1.00
Association between protective and deleterious HLA alleles with multiple sclerosis in Central East Sardinia. PLoS One (2009) 1.00
Proteomics comparison of cerebrospinal fluid of relapsing remitting and primary progressive multiple sclerosis. PLoS One (2010) 0.98
Astrocyte-derived endothelin-1 inhibits remyelination through notch activation. Neuron (2014) 0.98
Retroviral lineage analysis of fibroblast growth factor receptor signaling in FGF2 inhibition of oligodendrocyte progenitor differentiation. Glia (2006) 0.96
Post-translational modifications of nucleosomal histones in oligodendrocyte lineage cells in development and disease. J Mol Neurosci (2008) 0.96
Genetics meets epigenetics: HDACs and Wnt signaling in myelin development and regeneration. Nat Neurosci (2009) 0.95
IL-11 regulates autoimmune demyelination. J Immunol (2009) 0.95
Changed histone acetylation patterns in normal-appearing white matter and early multiple sclerosis lesions. J Neurosci (2011) 0.95
Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases. Front Cell Neurosci (2013) 0.94
Reduced axonopathy and enhanced remyelination after chronic demyelination in fibroblast growth factor 2 (Fgf2)-null mice: differential detection with diffusion tensor imaging. J Neuropathol Exp Neurol (2011) 0.94
Myelin regeneration in multiple sclerosis: targeting endogenous stem cells. Neurotherapeutics (2011) 0.93
Mediators of oligodendrocyte differentiation during remyelination. FEBS Lett (2011) 0.93
Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved. Proc Natl Acad Sci U S A (2007) 0.93
Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: a contribution to the current debate on disease pathogenesis. Prog Neurobiol (2008) 0.91
Promoting remyelination in multiple sclerosis-recent advances. Drugs (2013) 0.91
Astrogliosis during acute and chronic cuprizone demyelination and implications for remyelination. ASN Neuro (2012) 0.90
Optic neuritis in neuromyelitis optica. Prog Retin Eye Res (2013) 0.90
Cell therapy for multiple sclerosis. Neurotherapeutics (2011) 0.89
Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline. Age (Dordr) (2011) 0.89
Myelin repair strategies: a cellular view. Curr Opin Neurol (2008) 0.89
Interaction of fibroblast growth factor 2 (FGF2) and notch signaling components in inhibition of oligodendrocyte progenitor (OP) differentiation. Neurosci Lett (2007) 0.86
Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination. Sci Rep (2011) 0.86
Evidence that nuclear factor IA inhibits repair after white matter injury. Ann Neurol (2012) 0.85
Neuroprotection and neuroregeneration in multiple sclerosis. J Neurol (2008) 0.84
Enolase and arrestin are novel nonmyelin autoantigens in multiple sclerosis. J Clin Immunol (2007) 0.84
Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach. PLoS One (2012) 0.83
Oligodendrocyte regeneration: Its significance in myelin replacement and neuroprotection in multiple sclerosis. Neuropharmacology (2015) 0.83
Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures. J Neuroinflammation (2009) 0.83
α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy. Neurobiol Aging (2014) 0.82
Signalling pathways that inhibit the capacity of precursor cells for myelin repair. Int J Mol Sci (2013) 0.81
Myelin recovery in multiple sclerosis: the challenge of remyelination. Brain Sci (2013) 0.81
RhoA-inhibiting NSAIDs promote axonal myelination after spinal cord injury. Exp Neurol (2011) 0.81
Re-expression of a developmentally restricted potassium channel in autoimmune demyelination: Kv1.4 is implicated in oligodendroglial proliferation. Am J Pathol (2007) 0.81
Oligodendrocyte progenitor cells proliferate and survive in an immature state following treatment with an axolemma-enriched fraction. ASN Neuro (2011) 0.81
Revisiting Notch in remyelination of multiple sclerosis lesions. J Clin Invest (2009) 0.81
Structural and mechanistic insights into lunatic fringe from a kinetic analysis of enzyme mutants. J Biol Chem (2008) 0.80
Two distinct mechanisms segregate Prospero in the longitudinal glia underlying the timing of interactions with axons. Neuron Glia Biol (2007) 0.80
Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination. Acta Neuropathol Commun (2014) 0.79
An organotypic slice culture model of chronic white matter injury with maturation arrest of oligodendrocyte progenitors. Mol Neurodegener (2011) 0.79
Inflammation and remyelination in the central nervous system: a tale of two systems. Am J Pathol (2004) 0.78
Pharmacological approaches to intervention in hypomyelinating and demyelinating white matter pathology. Neuropharmacology (2015) 0.78
Immunopathogenesis of multiple sclerosis. Ann Indian Acad Neurol (2009) 0.78
Targeting oligodendrocyte protection and remyelination in multiple sclerosis. Mt Sinai J Med (2011) 0.78
Fbxw7 Limits Myelination by Inhibiting mTOR Signaling. J Neurosci (2015) 0.77
Activation of endogenous neural stem cells for multiple sclerosis therapy. Front Neurosci (2015) 0.77
Delayed onset of experimental autoimmune encephalomyelitis in Olig1 deficient mice. PLoS One (2010) 0.77
Intracellular Protein Shuttling: A Mechanism Relevant for Myelin Repair in Multiple Sclerosis? Int J Mol Sci (2015) 0.77
Neuroprotective effects of the complement terminal pathway during demyelination: implications for oligodendrocyte survival. J Neuroimmunol (2009) 0.77
Promoting myelin repair and return of function in multiple sclerosis. FEBS Lett (2011) 0.77
Strategies for protecting oligodendrocytes and enhancing remyelination in multiple sclerosis. Discov Med (2013) 0.77
Reprogramming cells for brain repair. Brain Sci (2013) 0.76
Effect of type-2 astrocytes on the viability of dorsal root ganglion neurons and length of neuronal processes. Neural Regen Res (2014) 0.76
Combinatorial actions of Tgfβ and Activin ligands promote oligodendrocyte development and CNS myelination. Development (2014) 0.76
Promoting return of function in multiple sclerosis: An integrated approach. Mult Scler Relat Disord (2013) 0.76
Systems approach to the study of brain damage in the very preterm newborn. Front Syst Neurosci (2015) 0.76
Nutritional factors and aging in demyelinating diseases. Genes Nutr (2013) 0.76
Extracellular cues influencing oligodendrocyte differentiation and (re)myelination. Exp Neurol (2016) 0.76
Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination. Acta Neuropathol (2015) 0.75
Myelin failure in multiple sclerosis: breaking the spell of Notch. Nat Med (2002) 0.75
Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors. ACS Med Chem Lett (2014) 0.75
Investigation of astrocyte - oligodendrocyte interactions in human cultures. Methods Mol Biol (2012) 0.75
Stem cell therapy for central nervous system demyelinating disease. Curr Neurol Neurosci Rep (2005) 0.75
A mouse model for testing remyelinating therapies. Exp Neurol (2016) 0.75
ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway. Oncotarget (2016) 0.75
On the occurrence of hypomyelination in a transgenic mouse model: a consequence of the myelin basic protein promoter? J Neuropathol Exp Neurol (2011) 0.75
Leukemia/lymphoma-related factor (LRF) exhibits stage- and context-dependent transcriptional controls in the oligodendrocyte lineage and modulates remyelination. J Neurosci Res (2017) 0.75
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med (2002) 8.33
Multiple sclerosis--the plaque and its pathogenesis. N Engl J Med (2006) 6.60
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature (2008) 3.48
bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science (2004) 3.20
P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling. J Neurosci (2006) 3.14
The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. Neuron (2006) 2.55
Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity. Proc Natl Acad Sci U S A (2009) 2.07
MicroRNA-23b cluster microRNAs regulate transforming growth factor-beta/bone morphogenetic protein signaling and liver stem cell differentiation by targeting Smads. Hepatology (2009) 2.04
Human brain parenchymal microglia express CD14 and CD45 and are productively infected by HIV-1 in HIV-1 encephalitis. Brain Pathol (2002) 2.03
Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis. Ann Neurol (2002) 1.86
Inhibition of Notch signaling enhances tissue repair in an animal model of multiple sclerosis. J Neuroimmunol (2005) 1.76
IL-1beta regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program. J Immunol (2006) 1.57
IL-1-regulated responses in astrocytes: relevance to injury and recovery. Glia (2005) 1.56
Cytokines: powerful regulators of glial cell activation. Neuroscientist (2003) 1.54
Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination. Proc Natl Acad Sci U S A (2009) 1.46
TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5. J Immunol (2006) 1.45
The cytokine IL-1beta transiently enhances P2X7 receptor expression and function in human astrocytes. Glia (2005) 1.42
Interleukin-1beta induces a reactive astroglial phenotype via deactivation of the Rho GTPase-Rock axis. J Neurosci (2004) 1.40
Deletion of astrocyte connexins 43 and 30 leads to a dysmyelinating phenotype and hippocampal CA1 vacuolation. J Neurosci (2009) 1.39
Failure of neuronal maturation in Alzheimer disease dentate gyrus. J Neuropathol Exp Neurol (2008) 1.39
The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphatidylinositol 3-kinase-dependent pathway. J Neurosci (2003) 1.36
Experimental autoimmune encephalomyelitis (EAE) in CCR2(-/-) mice: susceptibility in multiple strains. Am J Pathol (2003) 1.36
A role for CXCL12 (SDF-1alpha) in the pathogenesis of multiple sclerosis: regulation of CXCL12 expression in astrocytes by soluble myelin basic protein. J Neuroimmunol (2006) 1.35
Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation. J Neurosci (2006) 1.35
Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis. J Neurosci (2006) 1.34
Glutamate uptake by oligodendrocytes: Implications for excitotoxicity in multiple sclerosis. Neurology (2003) 1.34
Semaphorin 7A is a negative regulator of T cell responses. Immunity (2006) 1.33
Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalomyelitis. Ann Neurol (2009) 1.32
CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis. Brain (2005) 1.30
Co-expression of PDGF alpha receptor and NG2 by oligodendrocyte precursors in human CNS and multiple sclerosis lesions. J Neuroimmunol (2006) 1.29
New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43. FASEB J (2005) 1.28
Activation of microglial poly(ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination and neuronal damage. J Exp Med (2003) 1.25
Regulation of immune response by P2X7 receptor. Crit Rev Immunol (2006) 1.22
Tumour necrosis factor-induced death of adult human oligodendrocytes is mediated by apoptosis inducing factor. Brain (2005) 1.21
Astrocyte indoleamine 2,3-dioxygenase is induced by the TLR3 ligand poly(I:C): mechanism of induction and role in antiviral response. J Virol (2007) 1.20
Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase C theta and attenuates experimental autoimmune encephalomyelitis. J Immunol (2008) 1.19
Role for CXCR2 and CXCL1 on glia in multiple sclerosis. Glia (2006) 1.17
cDNA microarray analysis in multiple sclerosis lesions: detection of genes associated with disease activity. Brain (2003) 1.13
The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system. J Neuroimmune Pharmacol (2012) 1.13
Multiple sclerosis: cytokine receptors on oligodendrocytes predict innate regulation. Ann Neurol (2004) 1.10
Inhibition of granulocyte-macrophage colony-stimulating factor signaling and microglial proliferation by anti-CD45RO: role of Hck tyrosine kinase and phosphatidylinositol 3-kinase/Akt. J Immunol (2005) 1.10
Exacerbation of experimental autoimmune encephalomyelitis in P2X7R-/- mice: evidence for loss of apoptotic activity in lymphocytes. J Immunol (2006) 1.09
Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1. Am J Pathol (2008) 1.08
Big results from small samples: evaluation of amplification protocols for gene expression profiling. J Biomol Tech (2007) 1.08
Modified amino acid copolymers suppress myelin basic protein 85-99-induced encephalomyelitis in humanized mice through different effects on T cells. Proc Natl Acad Sci U S A (2004) 1.08
Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and astrocytes. J Neuroimmune Pharmacol (2010) 1.08
Toll-like receptors in CNS viral infections. Curr Top Microbiol Immunol (2009) 1.07
Endothelin in a murine model of cerebral malaria. Exp Biol Med (Maywood) (2006) 1.06
A novel model of demyelinating encephalomyelitis induced by monocytes and dendritic cells. J Immunol (2006) 1.06
Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155*. Glia (2011) 1.06
The cytokine IL-1beta activates IFN response factor 3 in human fetal astrocytes in culture. J Immunol (2005) 1.05
Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators. J Neuroinflammation (2013) 1.04
Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice. J Exp Med (2012) 1.04
Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions. Am J Pathol (2009) 1.03
Gammadelta T cells enhance the expression of experimental autoimmune encephalomyelitis by promoting antigen presentation and IL-12 production. J Immunol (2004) 1.03
GAS6 enhances repair following cuprizone-induced demyelination. PLoS One (2010) 1.03
Role of mitogen-activated protein kinases in inducible nitric oxide synthase and TNFalpha expression in human fetal astrocytes. J Neuroimmunol (2002) 1.02
The astrocyte in multiple sclerosis revisited. Glia (2013) 1.02
Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems. Am J Pathol (2002) 1.02
The TLR3 ligand polyI: C downregulates connexin 43 expression and function in astrocytes by a mechanism involving the NF-kappaB and PI3 kinase pathways. Glia (2006) 1.01
Fcgamma receptor signaling in primary human microglia: differential roles of PI-3K and Ras/ERK MAPK pathways in phagocytosis and chemokine induction. J Leukoc Biol (2004) 1.00
TLR3 and TLR4 are innate antiviral immune receptors in human microglia: role of IRF3 in modulating antiviral and inflammatory response in the CNS. Virology (2009) 1.00
Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12). PLoS One (2012) 0.99
Stem cells ameliorate EAE via an indoleamine 2,3-dioxygenase (IDO) mechanism. J Neuroimmunol (2008) 0.99
Complement C5 in experimental autoimmune encephalomyelitis (EAE) facilitates remyelination and prevents gliosis. Am J Pathol (2003) 0.99
Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms. Proc Natl Acad Sci U S A (2004) 0.98
Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition. J Immunol (2008) 0.98
Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway. J Neuroinflammation (2011) 0.98
Reduced cerebral blood flow and N-acetyl aspartate in a murine model of cerebral malaria. Parasitol Res (2005) 0.97
Phagocytic activity and monocyte chemotactic protein expression by pulmonary macrophages in persistent pulmonary cryptococcosis. Infect Immun (2003) 0.97
Insulin-like growth factor 2 receptor is an IFNgamma-inducible microglial protein that facilitates intracellular HIV replication: implications for HIV-induced neurocognitive disorders. Am J Pathol (2010) 0.97
Human oligodendrocyte precursor cells in vitro: phenotypic analysis and differential response to growth factors. Glia (2003) 0.96
Inducible heat shock protein 70 promotes myelin autoantigen presentation by the HLA class II. J Immunol (2004) 0.96
CD45 isoform expression in microglia and inflammatory cells in HIV-1 encephalitis. Brain Pathol (2006) 0.95
Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis. J Neuroinflammation (2011) 0.95
Soluble Nogo-A, an inhibitor of axonal regeneration, as a biomarker for multiple sclerosis. Neurology (2007) 0.95
Caveolin-1 expression determines the route of neutrophil extravasation through skin microvasculature. Am J Pathol (2009) 0.94
Regulation of RANTES/CCL5 expression in human astrocytes by interleukin-1 and interferon-beta. J Neurochem (2004) 0.94