Published in Org Lett on March 02, 2006
Foldamers as versatile frameworks for the design and evolution of function. Nat Chem Biol (2007) 2.79
Biophysical and structural characterization of a robust octameric beta-peptide bundle. J Am Chem Soc (2007) 1.11
Computational design of a self-assembling β-peptide oligomer. Org Lett (2010) 0.98
Development of a rotamer library for use in beta-peptide foldamer computational design. J Am Chem Soc (2010) 0.93
Tetrameric beta(3)-peptide bundles. Chembiochem (2008) 0.92
Comparison of design strategies for promotion of beta-peptide 14-helix stability in water. Chembiochem (2008) 0.85
Positive allostery in metal ion binding by a cooperatively folded β-peptide bundle. J Am Chem Soc (2014) 0.78
Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science (2003) 3.22
Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel. Proc Natl Acad Sci U S A (2009) 2.32
Computational design of peptides that target transmembrane helices. Science (2007) 2.28
Helical beta-peptide inhibitors of the p53-hDM2 interaction. J Am Chem Soc (2004) 2.15
A comprehensive model for the allosteric regulation of mammalian ribonucleotide reductase. Functional consequences of ATP- and dATP-induced oligomerization of the large subunit. Biochemistry (2002) 1.88
A push-pull mechanism for regulating integrin function. Proc Natl Acad Sci U S A (2005) 1.82
Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers. Proc Natl Acad Sci U S A (2003) 1.82
Surveying polypeptide and protein domain conformation and association with FlAsH and ReAsH. Nat Chem Biol (2007) 1.80
High-resolution structure of a beta-peptide bundle. J Am Chem Soc (2007) 1.74
Computational de novo design, and characterization of an A(2)B(2) diiron protein. J Mol Biol (2002) 1.71
Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes. J Biol Chem (2004) 1.65
Structural and functional basis of CXCL12 (stromal cell-derived factor-1 alpha) binding to heparin. J Biol Chem (2007) 1.58
Pediatric fatality following ingestion of dinitrophenol: postmortem identification of a "dietary supplement". Clin Toxicol (Phila) (2005) 1.55
Inhibiting HIV fusion with a beta-peptide foldamer. J Am Chem Soc (2005) 1.55
Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain. Proc Natl Acad Sci U S A (2005) 1.46
Selective recognition of protein tetraserine motifs with a cell-permeable, pro-fluorescent bis-boronic acid. J Am Chem Soc (2009) 1.44
Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein. Proc Natl Acad Sci U S A (2002) 1.39
The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus. Structure (2008) 1.38
How do helix-helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo-oligomeric helical bundles. Protein Sci (2003) 1.38
Toward beta-amino acid proteins: a cooperatively folded beta-peptide quaternary structure. J Am Chem Soc (2006) 1.36
Relationship between side chain structure and 14-helix stability of beta3-peptides in water. J Am Chem Soc (2005) 1.36
Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function. J Mol Biol (2005) 1.35
Computational design of water-soluble analogues of the potassium channel KcsA. Proc Natl Acad Sci U S A (2004) 1.31
Intrinsically cell-permeable miniature proteins based on a minimal cationic PPII motif. J Am Chem Soc (2007) 1.27
Helix macrodipole control of beta 3 peptide 14-helix stability in water. J Am Chem Soc (2003) 1.27
beta-Peptides as inhibitors of protein-protein interactions. Bioorg Med Chem (2005) 1.24
A rapid library screen for tailoring beta-peptide structure and function. J Am Chem Soc (2005) 1.24
Minimally cationic cell-permeable miniature proteins via alpha-helical arginine display. J Am Chem Soc (2008) 1.23
Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc Natl Acad Sci U S A (2010) 1.21
A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism. EMBO J (2009) 1.20
Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy. Biochemistry (2002) 1.18
A view to a kill: ligands for Bcl-2 family proteins. Curr Opin Chem Biol (2002) 1.18
Arginine topology controls escape of minimally cationic proteins from early endosomes to the cytoplasm. Chem Biol (2012) 1.18
Solution structure of a beta-peptide ligand for hDM2. J Am Chem Soc (2005) 1.18
Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation. ACS Chem Biol (2012) 1.18
Biochemical and structural characterization of the Pak1-LC8 interaction. J Biol Chem (2008) 1.17
Effect of divalent cations on the structure of the antibiotic daptomycin. Eur Biophys J (2007) 1.17
Bridged beta(3)-peptide inhibitors of p53-hDM2 complexation: correlation between affinity and cell permeability. J Am Chem Soc (2010) 1.14
Toward beta-amino acid proteins: design, synthesis, and characterization of a fifteen kilodalton beta-peptide tetramer. J Am Chem Soc (2008) 1.13
Sophistication of foldamer form and function in vitro and in vivo. Curr Opin Chem Biol (2007) 1.11
De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex. J Am Chem Soc (2010) 1.11
Biophysical and structural characterization of a robust octameric beta-peptide bundle. J Am Chem Soc (2007) 1.11
Miniature protein inhibitors of the p53-hDM2 interaction. Chembiochem (2006) 1.11
Paralog-selective ligands for bcl-2 proteins. J Am Chem Soc (2005) 1.10
Biophysical characterization of a beta-peptide bundle: comparison to natural proteins. J Am Chem Soc (2007) 1.10
A hierarchic approach to the design of hexameric helical barrels. J Mol Biol (2002) 1.10
Oligomerization of fusogenic peptides promotes membrane fusion by enhancing membrane destabilization. Biophys J (2004) 1.09
Determination of membrane protein stability via thermodynamic coupling of folding to thiol-disulfide interchange. Protein Sci (2003) 1.08
Two independent histidines, one in human prolactin and one in its receptor, are critical for pH-dependent receptor recognition and activation. J Biol Chem (2010) 1.07
Beta-peptides with improved affinity for hDM2 and hDMX. Bioorg Med Chem (2009) 1.06
Bipartite tetracysteine display requires site flexibility for ReAsH coordination. Chembiochem (2009) 1.05
Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa. J Biol Chem (2008) 1.05
Design of amphiphilic protein maquettes: controlling assembly, membrane insertion, and cofactor interactions. Biochemistry (2005) 1.05
Surveying protein structure and function using bis-arsenical small molecules. Acc Chem Res (2011) 1.04
The tertiary structure and backbone dynamics of human prolactin. J Mol Biol (2003) 1.04
Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity. Proc Natl Acad Sci U S A (2010) 1.03
Using alpha-helical coiled-coils to design nanostructured metalloporphyrin arrays. J Am Chem Soc (2008) 1.02
Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb. J Biol Chem (2006) 1.02
A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein. Biochemistry (2010) 1.01
Molecular recognition of protein surfaces: high affinity ligands for the CBP KIX domain. J Am Chem Soc (2003) 1.01
Ayurvedic herbal medicine and lead poisoning. J Hematol Oncol (2011) 1.00
Super-resolution imaging of the Golgi in live cells with a bioorthogonal ceramide probe. Angew Chem Int Ed Engl (2014) 0.98
Computational design of a self-assembling β-peptide oligomer. Org Lett (2010) 0.98
The kinetics of binding human prolactin, but not growth hormone, to the prolactin receptor vary over a physiologic pH range. Biochemistry (2007) 0.97
Miniature homeodomains: high specificity without an N-terminal arm. J Am Chem Soc (2003) 0.97
Polar networks control oligomeric assembly in membranes. J Am Chem Soc (2006) 0.96
Increasing the kinase specificity of k252a by protein surface recognition. Org Lett (2005) 0.96
Experimental and computational evaluation of forces directing the association of transmembrane helices. J Am Chem Soc (2009) 0.96
In Silico Improvement of beta3-peptide inhibitors of p53 x hDM2 and p53 x hDMX. J Am Chem Soc (2009) 0.96
Visualizing protein partnerships in living cells and organisms. Curr Opin Chem Biol (2011) 0.95
Cell-permeable beta-peptide inhibitors of p53/hDM2 complexation. Chembiochem (2009) 0.95
An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors. Proc Natl Acad Sci U S A (2011) 0.95
Dynein and dynactin leverage their bivalent character to form a high-affinity interaction. PLoS One (2013) 0.94
Is there structural specificity in the reversible protein aggregates that are stored in secretory granules? J Mol Neurosci (2004) 0.93
A β-peptide agonist of the GLP-1 receptor, a class B GPCR. Org Lett (2013) 0.93
Tetrameric beta(3)-peptide bundles. Chembiochem (2008) 0.92
Direct analysis of protein sedimentation equilibrium in detergent solutions without density matching. Anal Biochem (2003) 0.92
Structural basis for ligand-mediated mouse GITR activation. Proc Natl Acad Sci U S A (2008) 0.92
Computational design of a water-soluble analog of phospholamban. Protein Sci (2003) 0.91
Binding mode and transcriptional activation potential of high affinity ligands for the CBP KIX domain. J Am Chem Soc (2005) 0.91
Improved assays for determining the cytosolic access of peptides, proteins, and their mimetics. Biochemistry (2013) 0.90
Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide. FEBS Lett (2004) 0.90
Calcium-induced conformational changes in C-terminal tail of polycystin-2 are necessary for channel gating. J Biol Chem (2012) 0.90
Design and high-resolution structure of a β³-peptide bundle catalyst. J Am Chem Soc (2014) 0.90
Location of the epitope for an anti-CD8alpha antibody 53.6.7 which enhances CD8alpha-MHC class I interaction indicates antibody stabilization of a higher affinity CD8 conformation. Immunol Lett (2004) 0.89
Design of a functional membrane protein by engineering a heme-binding site in glycophorin A. J Am Chem Soc (2007) 0.89
Tertiary structure of thiopurine methyltransferase from Pseudomonas syringae, a bacterial orthologue of a polymorphic, drug-metabolizing enzyme. J Mol Biol (2003) 0.89
A model of GAG/MIP-2/CXCR2 interfaces and its functional effects. Biochemistry (2012) 0.89
High affinity, paralog-specific recognition of the Mena EVH1 domain by a miniature protein. J Am Chem Soc (2004) 0.89
Beta-peptide bundles with fluorous cores. J Am Chem Soc (2010) 0.89
Identification of a beta3-peptide HIV fusion inhibitor with improved potency in live cells. Bioorg Med Chem Lett (2009) 0.87
Cooperativity and specificity of association of a designed transmembrane peptide. Biophys J (2002) 0.87
Characterization of a membrane protein folding motif, the Ser zipper, using designed peptides. J Mol Biol (2006) 0.86
Analysis of site-specific histidine protonation in human prolactin. Biochemistry (2008) 0.86