Published in Science on March 30, 2007
Design of protein-interaction specificity gives selective bZIP-binding peptides. Nature (2009) 2.88
Structure and mechanics of integrin-based cell adhesion. Curr Opin Cell Biol (2007) 2.48
Integrins as therapeutic targets: lessons and opportunities. Nat Rev Drug Discov (2010) 2.27
Toward high-resolution prediction and design of transmembrane helical protein structures. Proc Natl Acad Sci U S A (2007) 2.12
Protein-protein interactions in the membrane: sequence, structural, and biological motifs. Structure (2008) 1.75
High-resolution design of a protein loop. Proc Natl Acad Sci U S A (2007) 1.68
Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation. Blood (2009) 1.41
PepX: a structural database of non-redundant protein-peptide complexes. Nucleic Acids Res (2009) 1.35
Consensus motif for integrin transmembrane helix association. Proc Natl Acad Sci U S A (2009) 1.33
Interaction and conformational dynamics of membrane-spanning protein helices. Protein Sci (2009) 1.19
Transmembrane orientation and possible role of the fusogenic peptide from parainfluenza virus 5 (PIV5) in promoting fusion. Proc Natl Acad Sci U S A (2011) 1.14
Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism. Proc Natl Acad Sci U S A (2009) 1.13
Transmembrane domains of the syndecan family of growth factor coreceptors display a hierarchy of homotypic and heterotypic interactions. Proc Natl Acad Sci U S A (2007) 1.12
Predicting helix-helix interactions from residue contacts in membrane proteins. Bioinformatics (2009) 1.11
Sophistication of foldamer form and function in vitro and in vivo. Curr Opin Chem Biol (2007) 1.11
Knowledge-based potential for positioning membrane-associated structures and assessing residue-specific energetic contributions. Structure (2012) 1.10
Using two fluorescent probes to dissect the binding, insertion, and dimerization kinetics of a model membrane peptide. J Am Chem Soc (2009) 1.09
Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery? Life Sci (2009) 1.09
Talin activates integrins by altering the topology of the β transmembrane domain. J Cell Biol (2012) 1.09
Computationally designed peptide inhibitors of protein-protein interactions in membranes. Biochemistry (2008) 1.05
Reconstruction of integrin activation. Blood (2011) 1.04
Challenges in the computational design of proteins. J R Soc Interface (2009) 1.03
Transmembrane domain interactions control biological functions of neuropilin-1. Mol Biol Cell (2007) 1.03
Specific heteromeric association of four transmembrane peptides derived from platelet glycoprotein Ib-IX complex. J Mol Biol (2008) 1.02
Single-spanning transmembrane domains in cell growth and cell-cell interactions: More than meets the eye? Cell Adh Migr (2010) 1.01
Exploring the molecular design of protein interaction sites with molecular dynamics simulations and free energy calculations. Biochemistry (2009) 0.99
TMKink: a method to predict transmembrane helix kinks. Protein Sci (2011) 0.98
Predicting the Impact of Missense Mutations on Protein-Protein Binding Affinity. J Chem Theory Comput (2014) 0.98
Peptides modulating conformational changes in secreted chaperones: from in silico design to preclinical proof of concept. Proc Natl Acad Sci U S A (2009) 0.98
Computational design of a self-assembling β-peptide oligomer. Org Lett (2010) 0.98
Computational design of membrane proteins. Structure (2012) 0.95
A divide-and-conquer approach to determine the Pareto frontier for optimization of protein engineering experiments. Proteins (2011) 0.94
Designed beta-boomerang antiendotoxic and antimicrobial peptides: structures and activities in lipopolysaccharide. J Biol Chem (2009) 0.94
Adding diverse noncanonical backbones to rosetta: enabling peptidomimetic design. PLoS One (2013) 0.94
Development of a rotamer library for use in beta-peptide foldamer computational design. J Am Chem Soc (2010) 0.93
Naturally evolved G protein-coupled receptors adopt metastable conformations. Proc Natl Acad Sci U S A (2012) 0.92
Isolated Toll-like receptor transmembrane domains are capable of oligomerization. PLoS One (2012) 0.91
Computational design of a β-peptide that targets transmembrane helices. J Am Chem Soc (2011) 0.89
Transmembrane helix-helix interactions involved in ErbB receptor signaling. Cell Adh Migr (2010) 0.89
Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles. Proc Natl Acad Sci U S A (2011) 0.89
Thermodynamic additivity of sequence variations: an algorithm for creating high affinity peptides without large libraries or structural information. PLoS One (2010) 0.88
Computational studies of membrane proteins: models and predictions for biological understanding. Biochim Biophys Acta (2011) 0.88
Noncovalent keystone interactions controlling biomembrane structure. Chemistry (2008) 0.88
A knowledge-based potential highlights unique features of membrane α-helical and β-barrel protein insertion and folding. Protein Sci (2011) 0.88
Molecular mechanisms, thermodynamics, and dissociation kinetics of knob-hole interactions in fibrin. J Biol Chem (2013) 0.87
TMPad: an integrated structural database for helix-packing folds in transmembrane proteins. Nucleic Acids Res (2011) 0.87
Computational protein design: engineering molecular diversity, nonnatural enzymes, nonbiological cofactor complexes, and membrane proteins. Curr Opin Chem Biol (2011) 0.85
Intermonomer hydrogen bonds enhance GxxxG-driven dimerization of the BNIP3 transmembrane domain: roles for sequence context in helix-helix association in membranes. J Mol Biol (2009) 0.85
Transmembrane recognition of the semaphorin co-receptors neuropilin 1 and plexin A1: coarse-grained simulations. PLoS One (2014) 0.85
GxxxG motifs, phenylalanine, and cholesterol guide the self-association of transmembrane domains of ErbB2 receptors. Biophys J (2011) 0.85
Vpu matchmakers as a therapeutic strategy for HIV infection. PLoS Pathog (2009) 0.84
Transmembrane helix association affinity can be modulated by flanking and noninterfacial residues. Biophys J (2009) 0.84
Evolutionary-guided de novo structure prediction of self-associated transmembrane helical proteins with near-atomic accuracy. Nat Commun (2015) 0.83
Computational modeling of membrane proteins. Proteins (2014) 0.83
Dimerization of the EphA1 receptor tyrosine kinase transmembrane domain: Insights into the mechanism of receptor activation. Biochemistry (2014) 0.83
Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain. J Virol (2013) 0.83
Computational design of selective peptides to discriminate between similar PDZ domains in an oncogenic pathway. J Mol Biol (2014) 0.82
Novel mechanistic insights into viral modulation of immune receptor signaling. PLoS Pathog (2009) 0.82
High-resolution structure prediction of a circular permutation loop. Protein Sci (2011) 0.82
Structure and binding interface of the cytosolic tails of αXβ2 integrin. PLoS One (2012) 0.80
Mapping the specific cytoprotective interaction of humanin with the pro-apoptotic protein bid. Chem Biol Drug Des (2007) 0.80
Design of self-assembling transmembrane helical bundles to elucidate principles required for membrane protein folding and ion transport. Philos Trans R Soc Lond B Biol Sci (2017) 0.80
Talin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations. Proteins (2014) 0.79
T-cell antigen receptor (TCR) transmembrane peptides: A new paradigm for the treatment of autoimmune diseases. Cell Adh Migr (2010) 0.79
Membrane-spanning α-helical barrels as tractable protein-design targets. Philos Trans R Soc Lond B Biol Sci (2017) 0.79
Conformational Changes in the Epidermal Growth Factor Receptor: Role of the Transmembrane Domain Investigated by Coarse-Grained MetaDynamics Free Energy Calculations. J Am Chem Soc (2016) 0.79
Mechanistic and quantitative insight into cell surface targeted molecular imaging agent design. Sci Rep (2016) 0.78
Directly Activating the Integrin αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering. J Biol Chem (2016) 0.78
Drugging Membrane Protein Interactions. Annu Rev Biomed Eng (2016) 0.78
New therapeutic strategies targeting transmembrane signal transduction in the immune system. Cell Adh Migr (2010) 0.78
De novo selection of oncogenes. Proc Natl Acad Sci U S A (2013) 0.78
The HIV-1 envelope transmembrane domain binds TLR2 through a distinct dimerization motif and inhibits TLR2-mediated responses. PLoS Pathog (2014) 0.78
Modulation of function in a minimalist heme-binding membrane protein. J Biol Inorg Chem (2012) 0.77
Computational design and experimental characterization of peptides intended for pH-dependent membrane insertion and pore formation. ACS Chem Biol (2015) 0.77
Targeting the lateral interactions of transmembrane domain 5 of Epstein-Barr virus latent membrane protein 1. Biochim Biophys Acta (2012) 0.77
Fluorophores, environments, and quantification techniques in the analysis of transmembrane helix interaction using FRET. Biopolymers (2015) 0.77
The SCHOOL of nature: III. From mechanistic understanding to novel therapies. Self Nonself (2010) 0.77
Biologically active LIL proteins built with minimal chemical diversity. Proc Natl Acad Sci U S A (2015) 0.76
Toward high-resolution computational design of the structure and function of helical membrane proteins. Nat Struct Mol Biol (2016) 0.76
Neutralization of pro-inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis. EMBO J (2016) 0.76
Protein design: Past, present, and future. Biopolymers (2015) 0.76
Functional characterization of a melittin analog containing a non-natural tryptophan analog. Biopolymers (2015) 0.76
Coarse-grained molecular dynamics of tetrameric transmembrane peptide bundles within a lipid bilayer. Chem Phys Lipids (2010) 0.75
Role of the Lipid Environment in the Dimerization of Transmembrane Domains of Glycophorin A. Acta Naturae (2016) 0.75
Photoactive Spatial Proximity Probes for Binding Pairs with Epigenetic Marks. J Photochem Photobiol A Chem (2014) 0.75
PepComposer: computational design of peptides binding to a given protein surface. Nucleic Acids Res (2016) 0.75
A rational route to probing membrane proteins. Genome Biol (2007) 0.75
Structural basis for the function and inhibition of an influenza virus proton channel. Nature (2008) 5.69
Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol (2004) 3.42
Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association. Circulation (2007) 3.27
Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science (2003) 3.22
Foldamers as versatile frameworks for the design and evolution of function. Nat Chem Biol (2007) 2.79
Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus. Proc Natl Acad Sci U S A (2010) 2.43
Helix formation via conformation diffusion search. Proc Natl Acad Sci U S A (2002) 2.34
Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel. Proc Natl Acad Sci U S A (2009) 2.32
Multiscale mechanics of fibrin polymer: gel stretching with protein unfolding and loss of water. Science (2009) 2.30
Using nitrile-derivatized amino acids as infrared probes of local environment. J Am Chem Soc (2003) 2.30
Control of membrane protein topology by a single C-terminal residue. Science (2010) 2.28
Helical beta-peptide inhibitors of the p53-hDM2 interaction. J Am Chem Soc (2004) 2.15
Forced unfolding of coiled-coils in fibrinogen by single-molecule AFM. Biophys J (2006) 1.96
De novo design of biomimetic antimicrobial polymers. Proc Natl Acad Sci U S A (2002) 1.95
Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus. Proc Natl Acad Sci U S A (2009) 1.93
A comprehensive model for the allosteric regulation of mammalian ribonucleotide reductase. Functional consequences of ATP- and dATP-induced oligomerization of the large subunit. Biochemistry (2002) 1.88
Amphiphilic polymethacrylate derivatives as antimicrobial agents. J Am Chem Soc (2005) 1.84
A push-pull mechanism for regulating integrin function. Proc Natl Acad Sci U S A (2005) 1.82
Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers. Proc Natl Acad Sci U S A (2003) 1.82
Protein-protein interactions in the membrane: sequence, structural, and biological motifs. Structure (2008) 1.75
Mechanism of fibrin(ogen) forced unfolding. Structure (2011) 1.72
Computational de novo design, and characterization of an A(2)B(2) diiron protein. J Mol Biol (2002) 1.71
Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes. J Biol Chem (2004) 1.65
Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells. Exp Hematol (2002) 1.64
Determining the orientation of uniaxially rotating membrane proteins using unoriented samples: a 2H, 13C, AND 15N solid-state NMR investigation of the dynamics and orientation of a transmembrane helical bundle. J Am Chem Soc (2007) 1.63
Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin. Blood (2013) 1.63
The hydration of amides in helices; a comprehensive picture from molecular dynamics, IR, and NMR. Protein Sci (2003) 1.62
Computational design and characterization of a monomeric helical dinuclear metalloprotein. J Mol Biol (2003) 1.60
Dynamic antibody-binding properties in the pathogenesis of HIT. Blood (2012) 1.59
De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers. Proc Natl Acad Sci U S A (2009) 1.58
Ultrafast folding of alpha3D: a de novo designed three-helix bundle protein. Proc Natl Acad Sci U S A (2003) 1.57
Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus. Curr Opin Struct Biol (2011) 1.56
Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor. J Am Chem Soc (2005) 1.52
A new method for determining the local environment and orientation of individual side chains of membrane-binding peptides. J Am Chem Soc (2004) 1.51
pH-induced conformational change of the influenza M2 protein C-terminal domain. Biochemistry (2008) 1.48
Computational design of virus-like protein assemblies on carbon nanotube surfaces. Science (2011) 1.45
Binding strength and activation state of single fibrinogen-integrin pairs on living cells. Proc Natl Acad Sci U S A (2002) 1.44
Mechanisms of fibrin polymerization and clinical implications. Blood (2013) 1.42
Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay. Antimicrob Agents Chemother (2010) 1.42
Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein. Proc Natl Acad Sci U S A (2002) 1.39
Salt bridges: geometrically specific, designable interactions. Proteins (2011) 1.39
The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus. Structure (2008) 1.38
How do helix-helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo-oligomeric helical bundles. Protein Sci (2003) 1.38
An artificial di-iron oxo-protein with phenol oxidase activity. Nat Chem Biol (2009) 1.37
Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2. J Am Chem Soc (2011) 1.37
Multi-step fibrinogen binding to the integrin (alpha)IIb(beta)3 detected using force spectroscopy. Biophys J (2005) 1.37
Structural basis for proton conduction and inhibition by the influenza M2 protein. Protein Sci (2012) 1.36
Relationship between side chain structure and 14-helix stability of beta3-peptides in water. J Am Chem Soc (2005) 1.36
Pro-thrombotic state induced by post-translational modification of fibrinogen by reactive nitrogen species. J Biol Chem (2003) 1.36
Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function. J Mol Biol (2005) 1.35
Design of a switchable eliminase. Proc Natl Acad Sci U S A (2011) 1.34
Long-range interactions stabilize the fold of a non-natural oligomer. J Am Chem Soc (2002) 1.33
Consensus motif for integrin transmembrane helix association. Proc Natl Acad Sci U S A (2009) 1.33
Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J Clin Invest (2008) 1.33
Protein-protein unbinding induced by force: single-molecule studies. Curr Opin Struct Biol (2003) 1.33
Computational design of water-soluble analogues of the potassium channel KcsA. Proc Natl Acad Sci U S A (2004) 1.31
Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy. J Am Chem Soc (2011) 1.30
De novo designed synthetic mimics of antimicrobial peptides. Curr Opin Biotechnol (2008) 1.30
Functional and structural correlations of individual alphaIIbbeta3 molecules. Blood (2004) 1.30
De novo design of a single-chain diphenylporphyrin metalloprotein. J Am Chem Soc (2007) 1.28
Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus. J Am Chem Soc (2009) 1.28
Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy. Proc Natl Acad Sci U S A (2011) 1.27
Nontoxic membrane-active antimicrobial arylamide oligomers. Angew Chem Int Ed Engl (2004) 1.26
Proton and cation transport activity of the M2 proton channel from influenza A virus. Proc Natl Acad Sci U S A (2010) 1.24
Computational design of a protein crystal. Proc Natl Acad Sci U S A (2012) 1.23
Iron acquisition from transferrin by Candida albicans depends on the reductive pathway. Infect Immun (2005) 1.22
Site-specific hydration status of an amphipathic peptide in AOT reverse micelles. Langmuir (2007) 1.21
Structural organization and interactions of transmembrane domains in tetraspanin proteins. BMC Struct Biol (2005) 1.19
Empirical lipid propensities of amino acid residues in multispan alpha helical membrane proteins. Proteins (2005) 1.19
Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy. Biochemistry (2002) 1.18
Development of α-helical calpain probes by mimicking a natural protein-protein interaction. J Am Chem Soc (2012) 1.18
Residue-specific vibrational echoes yield 3D structures of a transmembrane helix dimer. Science (2011) 1.17
Amide vibrations are delocalized across the hydrophobic interface of a transmembrane helix dimer. Proc Natl Acad Sci U S A (2006) 1.17
Biochemical and structural characterization of the Pak1-LC8 interaction. J Biol Chem (2008) 1.17
Effect of divalent cations on the structure of the antibiotic daptomycin. Eur Biophys J (2007) 1.17
Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. Cell Host Microbe (2012) 1.16
Functional analysis of the transmembrane domain in paramyxovirus F protein-mediated membrane fusion. J Mol Biol (2008) 1.16
NMR analysis of the alphaIIb beta3 cytoplasmic interaction suggests a mechanism for integrin regulation. Proc Natl Acad Sci U S A (2010) 1.16
Transmembrane orientation and possible role of the fusogenic peptide from parainfluenza virus 5 (PIV5) in promoting fusion. Proc Natl Acad Sci U S A (2011) 1.14