Published in Nat Rev Drug Discov on February 01, 2006
Lipid-based nanotherapeutics for siRNA delivery. J Intern Med (2010) 2.15
A highly efficient synthetic vector: nonhydrodynamic delivery of DNA to hepatocyte nuclei in vivo. ACS Nano (2013) 1.22
Differential expression of syndecan-1 mediates cationic nanoparticle toxicity in undifferentiated versus differentiated normal human bronchial epithelial cells. ACS Nano (2011) 1.21
Controlling and switching the morphology of micellar nanoparticles with enzymes. J Am Chem Soc (2011) 1.11
Nanoscale cell adhesion ligand presentation regulates nonviral gene delivery and expression. Nano Lett (2007) 1.09
Dynein light chain association sequences can facilitate nuclear protein import. Mol Biol Cell (2007) 1.08
Nonviral approaches for neuronal delivery of nucleic acids. Pharm Res (2007) 1.07
Engineering building blocks for self-assembling protein nanoparticles. Microb Cell Fact (2010) 0.95
Polymeric micelles from poly(ethylene glycol)-poly(amino acid) block copolymer for drug and gene delivery. J R Soc Interface (2009) 0.93
A sight on the current nanoparticle-based gene delivery vectors. Nanoscale Res Lett (2014) 0.93
Peptide-modified vectors for nucleic acid delivery to neurons. J Control Release (2008) 0.90
Design and self-assembly of simple coat proteins for artificial viruses. Nat Nanotechnol (2014) 0.90
Enzyme-directed assembly and manipulation of organic nanomaterials. Chem Commun (Camb) (2011) 0.88
Mechanical disassembly of single virus particles reveals kinetic intermediates predicted by theory. Biophys J (2012) 0.88
A cell-targeted, size-photocontrollable, nuclear-uptake nanodrug delivery system for drug-resistant cancer therapy. Nano Lett (2014) 0.87
Glycosphingolipid-functionalized nanoparticles recapitulate CD169-dependent HIV-1 uptake and trafficking in dendritic cells. Nat Commun (2014) 0.87
Self-assembled supramolecular nano vesicles for safe and highly efficient gene delivery to solid tumors. Int J Nanomedicine (2012) 0.87
Controlling subcellular delivery to optimize therapeutic effect. Ther Deliv (2010) 0.84
Evaluation of an LC8-binding peptide for the attachment of artificial cargo to dynein. Mol Pharm (2007) 0.84
The convergence of quantum-dot-mediated fluorescence resonance energy transfer and microfluidics for monitoring DNA polyplex self-assembly in real time. Nanotechnology (2009) 0.84
Polystyrene nanoparticle exposure induces ion-selective pores in lipid bilayers. Biochim Biophys Acta (2013) 0.83
Optimization of brush-like cationic copolymers for nonviral gene delivery. Biomacromolecules (2012) 0.83
Polymers for gene delivery: Charged for success. Nat Mater (2011) 0.83
Quantitative analysis of condensation/decondensation status of pDNA in the nuclear sub-domains by QD-FRET. Nucleic Acids Res (2011) 0.82
Current status of gene delivery and gene therapy in lacrimal gland using viral vectors. Adv Drug Deliv Rev (2006) 0.82
The multiple faces of self-assembled lipidic systems. PMC Biophys (2009) 0.81
pH-sensitive multi-PEGylated block copolymer as a bioresponsive pDNA delivery vector. Pharm Res (2010) 0.80
Fluid phase endocytosis contributes to transfection of DNA by PEI-25. Mol Ther (2009) 0.80
Phospholipid-based artificial viruses assembled by multivalent cations. Biophys J (2007) 0.79
Unlocking a caged lysosomal protein from a polymeric nanogel with a pH trigger. Biomacromolecules (2014) 0.78
Particle tracking analysis for the intracellular trafficking of nanoparticles modified with African swine fever virus protein p54-derived peptide. Mol Ther (2012) 0.78
Delivery of nucleic acids. Pharm Res (2007) 0.78
Decationized polyplexes as stable and safe carrier systems for improved biodistribution in systemic gene therapy. J Control Release (2014) 0.78
Human erythropoietin gene delivery using an arginine-grafted bioreducible polymer system. Mol Ther (2012) 0.78
Comparative analysis of lentiviral vectors and modular protein nanovectors for traumatic brain injury gene therapy. Mol Ther Methods Clin Dev (2014) 0.78
Dressing up Nanoparticles: A Membrane Wrap to Induce Formation of the Virological Synapse. ACS Nano (2015) 0.77
Design and characterization of novel recombinant listeriolysin O-protamine fusion proteins for enhanced gene delivery. Mol Pharm (2015) 0.76
Lipid nanoparticles for gene delivery. Adv Genet (2014) 0.76
DNA vaccines: MHC II-targeted vaccine protein produced by transfected muscle fibres induces a local inflammatory cell infiltrate in mice. PLoS One (2014) 0.76
Nanotechnology in urology. Urol Clin North Am (2009) 0.76
Post-Transcriptional Regulation of the GASC1 Oncogene with Active Tumor-Targeted siRNA-Nanoparticles. Mol Pharm (2016) 0.75
Nano-biomimetic carriers are implicated in mechanistic evaluation of intracellular gene delivery. Sci Rep (2017) 0.75
Identification of formaldehyde-induced modifications in proteins: reactions with model peptides. J Biol Chem (2003) 2.60
Structure-immunogenicity relationships of therapeutic proteins. Pharm Res (2004) 2.39
Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress. J Control Release (2011) 2.37
Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality. J Pharm Sci (2009) 2.36
Sheddable coatings for long-circulating nanoparticles. Pharm Res (2007) 2.15
Theranostic nanomedicine. Acc Chem Res (2011) 1.84
Polymeric micelles in anticancer therapy: targeting, imaging and triggered release. Pharm Res (2010) 1.83
Reduction-sensitive polymers and bioconjugates for biomedical applications. Biomaterials (2009) 1.70
Biodegradable polymers as non-viral carriers for plasmid DNA delivery. J Control Release (2007) 1.64
Nanotheranostics and image-guided drug delivery: current concepts and future directions. Mol Pharm (2010) 1.60
Novel bioreducible poly(amido amine)s for highly efficient gene delivery. Bioconjug Chem (2007) 1.56
25th anniversary article: Engineering hydrogels for biofabrication. Adv Mater (2013) 1.54
Hydrogels for protein delivery. Chem Rev (2012) 1.44
Intratumoral administration of holmium-166 acetylacetonate microspheres: antitumor efficacy and feasibility of multimodality imaging in renal cancer. PLoS One (2013) 1.42
Hydrogels as extracellular matrices for skeletal tissue engineering: state-of-the-art and novel application in organ printing. Tissue Eng (2007) 1.42
In situ gelling hydrogels for pharmaceutical and biomedical applications. Int J Pharm (2008) 1.41
The effect of photopolymerization on stem cells embedded in hydrogels. Biomaterials (2008) 1.39
Passive versus active tumor targeting using RGD- and NGR-modified polymeric nanomedicines. Nano Lett (2014) 1.37
Identification of formaldehyde-induced modifications in proteins: reactions with insulin. Bioconjug Chem (2006) 1.37
Micelle-associated protein in epoetin formulations: aA risk factor for immunogenicity? Pharm Res (2003) 1.34
Cyclodextrin-based polymeric materials: synthesis, properties, and pharmaceutical/biomedical applications. Biomacromolecules (2009) 1.33
Antibody response to aggregated human interferon alpha2b in wild-type and transgenic immune tolerant mice depends on type and level of aggregation. J Pharm Sci (2006) 1.32
Structural characterization and immunogenicity in wild-type and immune tolerant mice of degraded recombinant human interferon alpha2b. Pharm Res (2005) 1.32
Hydrolysable core-crosslinked thermosensitive polymeric micelles: synthesis, characterisation and in vivo studies. Biomaterials (2007) 1.30
Linear poly(amido amine)s with secondary and tertiary amino groups and variable amounts of disulfide linkages: synthesis and in vitro gene transfer properties. J Control Release (2006) 1.26
Chitosan-based delivery systems for protein therapeutics and antigens. Adv Drug Deliv Rev (2009) 1.26
Organ printing: the future of bone regeneration? Trends Biotechnol (2011) 1.26
Effect of cationic carriers on the pharmacokinetics and tumor localization of nucleic acids after intravenous administration. Int J Pharm (2006) 1.25
Synthesis and characterization of hyperbranched polyglycerol hydrogels. Biomaterials (2006) 1.24
Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers. Biomaterials (2009) 1.24
The immunogenicity of polyethylene glycol: facts and fiction. Pharm Res (2013) 1.24
Bioreducible poly(amido amine)s with oligoamine side chains: synthesis, characterization, and structural effects on gene delivery. J Control Release (2007) 1.21
The therapeutic equivalence of complex drugs. Regul Toxicol Pharmacol (2010) 1.20
Nonnatural amino acids for site-specific protein conjugation. Bioconjug Chem (2009) 1.18
Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin. Biomaterials (2010) 1.17
How to screen non-viral gene delivery systems in vitro? J Control Release (2011) 1.17
Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products. J Pharm Sci (2010) 1.16
A versatile family of degradable non-viral gene carriers based on hyperbranched poly(ester amine)s. J Control Release (2005) 1.16
Pulsed in vitro release and in vivo behavior of exploding microcapsules. J Control Release (2009) 1.15
Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system. J Control Release (2005) 1.13
Endosomal escape of polymeric gene delivery complexes is not always enhanced by polymers buffering at low pH. Biomacromolecules (2004) 1.09
Quantification of plasmid DNA copies in the nucleus after lipoplex and polyplex transfection. J Control Release (2009) 1.07
The nuclear pore complex: the gateway to successful nonviral gene delivery. Pharm Res (2006) 1.07
Degradable-brushed pHEMA-pDMAEMA synthesized via ATRP and click chemistry for gene delivery. Bioconjug Chem (2007) 1.06
Hydrogels for protein delivery in tissue engineering. J Control Release (2012) 1.04
Self-assembly of recombinant amphiphilic oligopeptides into vesicles. Biomacromolecules (2007) 1.02
Challenges for the effective molecular imprinting of proteins. Biomaterials (2011) 1.02
Sensitive spectroscopic detection of large and denatured protein aggregates in solution by use of the fluorescent dye Nile red. J Fluoresc (2007) 1.02
Shifting paradigms: biopharmaceuticals versus low molecular weight drugs. Int J Pharm (2003) 1.02
Superparamagnetic iron oxide nanoparticles encapsulated in biodegradable thermosensitive polymeric micelles: toward a targeted nanomedicine suitable for image-guided drug delivery. Langmuir (2009) 1.02
Local perivascular delivery of anti-restenotic agents from a drug-eluting poly(epsilon-caprolactone) stent cuff. Biomaterials (2005) 1.01
Functional aliphatic polyesters for biomedical and pharmaceutical applications. J Control Release (2011) 1.01
Synthesis and applications of biomedical and pharmaceutical polymers via click chemistry methodologies. Bioconjug Chem (2009) 1.01
Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery. J Control Release (2005) 0.98
Polymer side-chain degradation as a tool to control the destabilization of polyplexes. Pharm Res (2004) 0.98
Microcapsules ejecting nanosized species into the environment. J Am Chem Soc (2008) 0.98
Methacrylamide polymers with hydrolysis-sensitive cationic side groups as degradable gene carriers. Bioconjug Chem (2006) 0.97
Poly(3-guanidinopropyl methacrylate): a novel cationic polymer for gene delivery. Bioconjug Chem (2004) 0.97
Biocompatibility and degradation characteristics of PLGA-based electrospun nanofibrous scaffolds with nanoapatite incorporation. Biomaterials (2012) 0.96
Mobility of model proteins in hydrogels composed of oppositely charged dextran microspheres studied by protein release and fluorescence recovery after photobleaching. J Control Release (2005) 0.95
Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain. J Control Release (2010) 0.95
Photopolymerized thermosensitive hydrogels: synthesis, degradation, and cytocompatibility. Biomacromolecules (2008) 0.95
In vivo biocompatibility and biodegradation of 3D-printed porous scaffolds based on a hydroxyl-functionalized poly(ε-caprolactone). Biomaterials (2012) 0.95
N-trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: biological properties and immunogenicity in a mouse model. Vaccine (2006) 0.94
Holmium-loaded poly(L-lactic acid) microspheres: in vitro degradation study. Biomacromolecules (2006) 0.94
A novel family of L-amino acid-based biodegradable polymer-lipid conjugates for the development of long-circulating liposomes with effective drug-targeting capacity. Bioconjug Chem (2003) 0.94
Controlled release of octreotide and assessment of peptide acylation from poly(D,L-lactide-co-hydroxymethyl glycolide) compared to PLGA microspheres. Pharm Res (2011) 0.94
Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release. J Pharm Sci (2011) 0.94
Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy. Biomaterials (2012) 0.93
Self-gelling hydrogels based on oppositely charged dextran microspheres. Biomaterials (2005) 0.93
Molar-mass characterization of cationic polymers for gene delivery by aqueous size-exclusion chromatography. Pharm Res (2006) 0.92
Liposomes and ISCOMs. Vaccine (2003) 0.92
Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. Angew Chem Int Ed Engl (2012) 0.91
Long-term toxicity of holmium-loaded poly(L-lactic acid) microspheres in rats. Biomaterials (2007) 0.91
Assuring quality and performance of sustained and controlled release parenterals: EUFEPS workshop report. AAPS PharmSci (2004) 0.91
Optimization of intradermal vaccination by DNA tattooing in human skin. Hum Gene Ther (2009) 0.91
In vitro hydrolytic degradation of hydroxyl-functionalized poly(alpha-hydroxy acid)s. Biomacromolecules (2007) 0.91
Macroscopic hydrogels by self-assembly of oligolactate-grafted dextran microspheres. Biomacromolecules (2007) 0.90
Stabilization of peptide vesicles by introducing inter-peptide disulfide bonds. Pharm Res (2009) 0.90
Preparation and characterization of cephalexin loaded PLGA microspheres. Curr Drug Deliv (2009) 0.90
Recombinant gelatin hydrogels for the sustained release of proteins. J Control Release (2007) 0.90
Physicochemical and immunochemical techniques predict the quality of diphtheria toxoid vaccines. Vaccine (2003) 0.90
A comparison between the use of dynamic mechanical analysis and oscillatory shear rheometry for the characterisation of hydrogels. Int J Pharm (2002) 0.90
Identification of peptide ligands for targeting to the blood-brain barrier. Pharm Res (2010) 0.90
Low molecular weight linear polyethylenimine-b-poly(ethylene glycol)-b-polyethylenimine triblock copolymers: synthesis, characterization, and in vitro gene transfer properties. Biomacromolecules (2005) 0.90
Development of a murine model to evaluate the effect of vernix caseosa on skin barrier recovery. Exp Dermatol (2008) 0.89
Biodegradable dextran hydrogels for protein delivery applications. Expert Rev Med Devices (2007) 0.89
Pharmacokinetics of poly(hydroxyethyl-l-asparagine)-coated liposomes is superior over that of PEG-coated liposomes at low lipid dose and upon repeated administration. Biochim Biophys Acta (2006) 0.89