Published in Nature on March 09, 2006
The proteome of the mouse photoreceptor sensory cilium complex. Mol Cell Proteomics (2007) 3.53
Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome. Am J Hum Genet (2008) 2.65
The transcriptome of the human pathogen Trypanosoma brucei at single-nucleotide resolution. PLoS Pathog (2010) 2.15
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J (2011) 2.14
Mutations in radial spoke head protein genes RSPH9 and RSPH4A cause primary ciliary dyskinesia with central-microtubular-pair abnormalities. Am J Hum Genet (2009) 2.07
Mutations in Hydin impair ciliary motility in mice. J Cell Biol (2008) 2.06
Widespread variation in transcript abundance within and across developmental stages of Trypanosoma brucei. BMC Genomics (2009) 2.00
New Tetrahymena basal body protein components identify basal body domain structure. J Cell Biol (2007) 1.97
Functional genomics in Trypanosoma brucei: a collection of vectors for the expression of tagged proteins from endogenous and ectopic gene loci. Mol Biochem Parasitol (2007) 1.96
A comprehensive analysis of Trypanosoma brucei mitochondrial proteome. Proteomics (2009) 1.94
Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia. Am J Hum Genet (2013) 1.90
Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles. Mol Biol Cell (2007) 1.82
Three-dimensional cellular architecture of the flagellar pocket and associated cytoskeleton in trypanosomes revealed by electron microscope tomography. J Cell Sci (2009) 1.82
Intraflagellar transport and functional analysis of genes required for flagellum formation in trypanosomes. Mol Biol Cell (2007) 1.69
The role of primary cilia in neuronal function. Neurobiol Dis (2010) 1.69
Evolution: Tracing the origins of centrioles, cilia, and flagella. J Cell Biol (2011) 1.69
Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons. BMC Genomics (2009) 1.68
The Trypanosoma brucei flagellum: moving parasites in new directions. Annu Rev Microbiol (2009) 1.66
Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia. Cell (2016) 1.65
Organellar proteomics: turning inventories into insights. EMBO Rep (2006) 1.63
Phytomonas: trypanosomatids adapted to plant environments. PLoS Pathog (2015) 1.61
Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control. Mol Biol Cell (2008) 1.58
Centrin3 in trypanosomes maintains the stability of a flagellar inner-arm dynein for cell motility. Nat Commun (2014) 1.54
Cilia in vertebrate development and disease. Development (2012) 1.50
Cell cycle regulation in Trypanosoma brucei. Mol Biochem Parasitol (2007) 1.49
Biogenesis of the trypanosome endo-exocytotic organelle is cytoskeleton mediated. PLoS Biol (2008) 1.48
Chlamydomonas reinhardtii hydin is a central pair protein required for flagellar motility. J Cell Biol (2007) 1.47
Functional modules, mutational load and human genetic disease. Trends Genet (2010) 1.45
Proteomic analysis of mammalian primary cilia. Curr Biol (2012) 1.45
Independent analysis of the flagellum surface and matrix proteomes provides insight into flagellum signaling in mammalian-infectious Trypanosoma brucei. Mol Cell Proteomics (2011) 1.44
Trypanin, a component of the flagellar Dynein regulatory complex, is essential in bloodstream form African trypanosomes. PLoS Pathog (2006) 1.41
Novel bilobe components in Trypanosoma brucei identified using proximity-dependent biotinylation. Eukaryot Cell (2012) 1.39
Basal body stability and ciliogenesis requires the conserved component Poc1. J Cell Biol (2009) 1.38
Cildb: a knowledgebase for centrosomes and cilia. Database (Oxford) (2009) 1.35
Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes. Mol Microbiol (2008) 1.33
Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease. PLoS One (2012) 1.32
The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium. Cilia (2013) 1.31
Proteome remodelling during development from blood to insect-form Trypanosoma brucei quantified by SILAC and mass spectrometry. BMC Genomics (2012) 1.31
Leishmania sand fly interaction: progress and challenges. Curr Opin Microbiol (2008) 1.30
Identification of novel regulatory factor X (RFX) target genes by comparative genomics in Drosophila species. Genome Biol (2007) 1.28
Propulsion of African trypanosomes is driven by bihelical waves with alternating chirality separated by kinks. Proc Natl Acad Sci U S A (2009) 1.26
The paraflagellar rod of kinetoplastid parasites: from structure to components and function. Int J Parasitol (2009) 1.25
The evolution of the cytoskeleton. J Cell Biol (2011) 1.22
The cell cycle of Leishmania: morphogenetic events and their implications for parasite biology. Mol Microbiol (2010) 1.21
Combining RNA interference mutants and comparative proteomics to identify protein components and dependences in a eukaryotic flagellum. J Biol Chem (2008) 1.19
Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of Trypanosoma brucei. J Proteome Res (2013) 1.18
ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry. Am J Hum Genet (2013) 1.17
Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia. Am J Hum Genet (2013) 1.17
A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway. Genes Dev (2010) 1.16
The flagellum of Trypanosoma brucei: new tricks from an old dog. Int J Parasitol (2008) 1.15
Induction of Ran GTP drives ciliogenesis. Mol Biol Cell (2011) 1.13
Functional characterization of putative cilia genes by high-content analysis. Mol Biol Cell (2011) 1.12
Motility and more: the flagellum of Trypanosoma brucei. Nat Rev Microbiol (2014) 1.11
The hydrocephalus inducing gene product, Hydin, positions axonemal central pair microtubules. BMC Biol (2007) 1.11
The chromosomal passenger complex and a mitotic kinesin interact with the Tousled-like kinase in trypanosomes to regulate mitosis and cytokinesis. PLoS One (2008) 1.10
A modular and optimized single marker system for generating Trypanosoma brucei cell lines expressing T7 RNA polymerase and the tetracycline repressor. Open Biol (2012) 1.10
Impact of microscopic motility on the swimming behavior of parasites: straighter trypanosomes are more directional. PLoS Comput Biol (2011) 1.09
Building blocks of the nexin-dynein regulatory complex in Chlamydomonas flagella. J Biol Chem (2011) 1.08
An informatic pipeline for the data capture and submission of quantitative proteomic data using iTRAQ. Proteome Sci (2007) 1.08
A comparative proteomic analysis reveals a new bi-lobe protein required for bi-lobe duplication and cell division in Trypanosoma brucei. PLoS One (2010) 1.07
Trypanosome motion represents an adaptation to the crowded environment of the vertebrate bloodstream. PLoS Pathog (2012) 1.06
Identification and specific localization of tyrosine-phosphorylated proteins in Trypanosoma brucei. Eukaryot Cell (2009) 1.06
Parasites in motion: flagellum-driven cell motility in African trypanosomes. Curr Opin Microbiol (2010) 1.05
Calflagin inhibition prolongs host survival and suppresses parasitemia in Trypanosoma brucei infection. Eukaryot Cell (2010) 1.05
Cytokinesis in Trypanosoma brucei differs between bloodstream and tsetse trypomastigote forms: implications for microtubule-based morphogenesis and mutant analysis. Mol Microbiol (2013) 1.04
A toolkit enabling efficient, scalable and reproducible gene tagging in trypanosomatids. Open Biol (2015) 1.03
Proteomic analysis of intact flagella of procyclic Trypanosoma brucei cells identifies novel flagellar proteins with unique sub-localization and dynamics. Mol Cell Proteomics (2014) 1.03
High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis. PLoS Pathog (2011) 1.01
KMP-11, a basal body and flagellar protein, is required for cell division in Trypanosoma brucei. Eukaryot Cell (2008) 1.00
Trypanosoma brucei metacaspase 4 is a pseudopeptidase and a virulence factor. J Biol Chem (2011) 0.99
Structure of Trypanosoma brucei flagellum accounts for its bihelical motion. Proc Natl Acad Sci U S A (2011) 0.97
Regulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme. Arch Biochem Biophys (2011) 0.97
Subcellular proteomics of Trypanosoma cruzi reservosomes. Proteomics (2009) 0.97
Cryo-electron tomography and 3-D analysis of the intact flagellum in Trypanosoma brucei. J Struct Biol (2012) 0.96
Assembly and maintenance of the flagellum attachment zone filament in Trypanosoma brucei. J Cell Sci (2015) 0.95
A protein-protein interaction map of the Trypanosoma brucei paraflagellar rod. PLoS One (2009) 0.94
TbPRMT6 is a type I protein arginine methyltransferase that contributes to cytokinesis in Trypanosoma brucei. Eukaryot Cell (2010) 0.94
Immunobiology of African trypanosomes: need of alternative interventions. J Biomed Biotechnol (2010) 0.94
Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation. PLoS One (2009) 0.94
RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection. Eukaryot Cell (2007) 0.94
Insect stage-specific receptor adenylate cyclases are localized to distinct subdomains of the Trypanosoma brucei Flagellar membrane. Eukaryot Cell (2014) 0.93
Large-scale molecular analysis of a 34 Mb interval on chromosome 6q: major refinement of the RP25 interval. Ann Hum Genet (2007) 0.93
The Armadillo repeat protein PF16 is essential for flagellar structure and function in Plasmodium male gametes. PLoS One (2010) 0.92
The small GTPase ARL2 is required for cytokinesis in Trypanosoma brucei. Mol Biochem Parasitol (2010) 0.92
CMF70 is a subunit of the dynein regulatory complex. J Cell Sci (2010) 0.92
CEP proteins: the knights of centrosome dynasty. Protoplasma (2013) 0.92
Novel 44-kilodalton subunit of axonemal Dynein conserved from chlamydomonas to mammals. Eukaryot Cell (2007) 0.92
Conservation of ciliary proteins in plants with no cilia. BMC Plant Biol (2011) 0.91
Biochemical analysis of PIFTC3, the Trypanosoma brucei orthologue of nematode DYF-13, reveals interactions with established and putative intraflagellar transport components. Mol Microbiol (2010) 0.91
Getting to the heart of intraflagellar transport using Trypanosoma and Chlamydomonas models: the strength is in their differences. Cilia (2013) 0.91
A kinetoplastid-specific kinesin is required for cytokinesis and for maintenance of cell morphology in Trypanosoma brucei. Mol Microbiol (2012) 0.90
Kinesin 9 family members perform separate functions in the trypanosome flagellum. J Cell Biol (2009) 0.90
Biochemical characterization of the bi-lobe reveals a continuous structural network linking the bi-lobe to other single-copied organelles in Trypanosoma brucei. J Biol Chem (2012) 0.90
Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA. Antimicrob Agents Chemother (2013) 0.90
Functional characterisation and drug target validation of a mitotic kinesin-13 in Trypanosoma brucei. PLoS Pathog (2010) 0.90
Structure-function analysis of dynein light chain 1 identifies viable motility mutants in bloodstream-form Trypanosoma brucei. Eukaryot Cell (2011) 0.90
An orphan kinesin in trypanosomes cooperates with a kinetoplastid-specific kinesin to maintain cell morphology by regulating subpellicular microtubules. J Cell Sci (2012) 0.90
Protein composition of Trypanosoma brucei mitochondrial membranes. Proteomics (2009) 0.89
Architecture of a Host-Parasite Interface: Complex Targeting Mechanisms Revealed Through Proteomics. Mol Cell Proteomics (2015) 0.89
Bug22p, a conserved centrosomal/ciliary protein also present in higher plants, is required for an effective ciliary stroke in Paramecium. Eukaryot Cell (2010) 0.89
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
The genome of the African trypanosome Trypanosoma brucei. Science (2005) 11.48
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science (2005) 7.61
A systematic approach to modeling, capturing, and disseminating proteomics experimental data. Nat Biotechnol (2003) 3.57
The Meckel-Gruber Syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation. Hum Mol Genet (2006) 3.06
The genome of Naegleria gruberi illuminates early eukaryotic versatility. Cell (2010) 2.93
Multiplexed absolute quantification in proteomics using artificial QCAT proteins of concatenated signature peptides. Nat Methods (2005) 2.81
Targeting of a tetracycline-inducible expression system to the transcriptionally silent minichromosomes of Trypanosoma brucei. Mol Biochem Parasitol (2002) 2.74
Dynamics of protein turnover, a missing dimension in proteomics. Mol Cell Proteomics (2002) 2.70
Centriole/basal body morphogenesis and migration during ciliogenesis in animal cells. J Cell Sci (2007) 2.46
Multiplexed absolute quantification for proteomics using concatenated signature peptides encoded by QconCAT genes. Nat Protoc (2006) 2.37
Coalignment of plasma membrane channels and protrusions (fibripositors) specifies the parallelism of tendon. J Cell Biol (2004) 2.19
Turnover of the human proteome: determination of protein intracellular stability by dynamic SILAC. J Proteome Res (2009) 2.18
A high-order trans-membrane structural linkage is responsible for mitochondrial genome positioning and segregation by flagellar basal bodies in trypanosomes. Mol Biol Cell (2003) 2.09
Myristoyl-CoA:protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites. J Biol Chem (2002) 2.08
Functional genomics in Trypanosoma brucei: a collection of vectors for the expression of tagged proteins from endogenous and ectopic gene loci. Mol Biochem Parasitol (2007) 1.96
Reconstructing the evolutionary history of the centriole from protein components. J Cell Sci (2010) 1.87
Three-dimensional cellular architecture of the flagellar pocket and associated cytoskeleton in trypanosomes revealed by electron microscope tomography. J Cell Sci (2009) 1.82
Dyneins across eukaryotes: a comparative genomic analysis. Traffic (2007) 1.81
Proteome dynamics in complex organisms: using stable isotopes to monitor individual protein turnover rates. Proteomics (2005) 1.69
Within-host evolution of Staphylococcus aureus during asymptomatic carriage. PLoS One (2013) 1.67
Molecular evolution of FtsZ protein sequences encoded within the genomes of archaea, bacteria, and eukaryota. J Mol Evol (2004) 1.65
Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling. Genome Biol (2013) 1.62
A "holistic" kinesin phylogeny reveals new kinesin families and predicts protein functions. Mol Biol Cell (2006) 1.59
Variant surface glycoprotein RNA interference triggers a precytokinesis cell cycle arrest in African trypanosomes. Proc Natl Acad Sci U S A (2005) 1.58
Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton. J Cell Sci (2009) 1.58
An optimized protocol for metabolome analysis in yeast using direct infusion electrospray mass spectrometry. Phytochemistry (2003) 1.57
The heart of darkness: growth and form of Trypanosoma brucei in the tsetse fly. Trends Parasitol (2009) 1.54
A protocol for patients with cardiovascular implantable devices undergoing magnetic resonance imaging (MRI): should defibrillation threshold testing be performed post-(MRI). J Interv Card Electrophysiol (2010) 1.53
Chromosome-wide analysis of gene function by RNA interference in the african trypanosome. Eukaryot Cell (2006) 1.47
Absolute multiplexed quantitative analysis of protein expression during muscle development using QconCAT. Mol Cell Proteomics (2007) 1.45
A repetitive protein essential for the flagellum attachment zone filament structure and function in Trypanosoma brucei. Protist (2007) 1.44
Asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes. Protist (2007) 1.43
The flagella connector of Trypanosoma brucei: an unusual mobile transmembrane junction. J Cell Sci (2004) 1.43
Molecular paleontology and complexity in the last eukaryotic common ancestor. Crit Rev Biochem Mol Biol (2013) 1.39
Swimming with protists: perception, motility and flagellum assembly. Nat Rev Microbiol (2008) 1.37
More than one way to build a flagellum: comparative genomics of parasitic protozoa. Curr Biol (2004) 1.36
PEDRo: a database for storing, searching and disseminating experimental proteomics data. BMC Genomics (2004) 1.34
The DNA sequence of chromosome I of an African trypanosome: gene content, chromosome organisation, recombination and polymorphism. Nucleic Acids Res (2003) 1.33
Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes. PLoS One (2012) 1.30
Autophagy in protists. Autophagy (2011) 1.29
Trypanosome IFT mutants provide insight into the motor location for mobility of the flagella connector and flagellar membrane formation. J Cell Sci (2006) 1.29
Cell biology of the trypanosome genome. Microbiol Mol Biol Rev (2010) 1.27
An essential quality control mechanism at the eukaryotic basal body prior to intraflagellar transport. Traffic (2007) 1.27
The paraflagellar rod of kinetoplastid parasites: from structure to components and function. Int J Parasitol (2009) 1.25
Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species. Proc Natl Acad Sci U S A (2012) 1.22
The evolution of the cytoskeleton. J Cell Biol (2011) 1.22
The Parkin co-regulated gene product, PACRG, is an evolutionarily conserved axonemal protein that functions in outer-doublet microtubule morphogenesis. J Cell Sci (2005) 1.21
The cell cycle of Leishmania: morphogenetic events and their implications for parasite biology. Mol Microbiol (2010) 1.21
The small chromosomes of Trypanosoma brucei involved in antigenic variation are constructed around repetitive palindromes. Genome Res (2004) 1.20
Actin filament turnover removes bundles from Drosophila bristle cells. J Cell Sci (2002) 1.19
Combining RNA interference mutants and comparative proteomics to identify protein components and dependences in a eukaryotic flagellum. J Biol Chem (2008) 1.19
Autophagy in parasitic protists: unique features and drug targets. Mol Biochem Parasitol (2011) 1.19
Patterns of kinesin evolution reveal a complex ancestral eukaryote with a multifunctional cytoskeleton. BMC Evol Biol (2010) 1.17
Gamma-tubulin functions in the nucleation of a discrete subset of microtubules in the eukaryotic flagellum. Curr Biol (2003) 1.17
Global absolute quantification of a proteome: Challenges in the deployment of a QconCAT strategy. Proteomics (2011) 1.16
Flagellum assembly and function during the Leishmania life cycle. Curr Opin Microbiol (2010) 1.15
Basal body movements orchestrate membrane organelle division and cell morphogenesis in Trypanosoma brucei. J Cell Sci (2010) 1.14
The kinetoplast duplication cycle in Trypanosoma brucei is orchestrated by cytoskeleton-mediated cell morphogenesis. Mol Cell Biol (2010) 1.14
Systematic integration of experimental data and models in systems biology. BMC Bioinformatics (2010) 1.13
A meckelin-filamin A interaction mediates ciliogenesis. Hum Mol Genet (2011) 1.12
CONSeQuence: prediction of reference peptides for absolute quantitative proteomics using consensus machine learning approaches. Mol Cell Proteomics (2011) 1.12
Basal body and flagellum mutants reveal a rotational constraint of the central pair microtubules in the axonemes of trypanosomes. J Cell Sci (2006) 1.11
Diversification of function by different isoforms of conventionally shared RNA polymerase subunits. Mol Biol Cell (2007) 1.11
Absolute quantification of the glycolytic pathway in yeast: deployment of a complete QconCAT approach. Mol Cell Proteomics (2011) 1.11
The hydrocephalus inducing gene product, Hydin, positions axonemal central pair microtubules. BMC Biol (2007) 1.11
Order within a mosaic distribution of mitochondrial c-type cytochrome biogenesis systems? FEBS J (2008) 1.11
Evolutionary relationships and protein domain architecture in an expanded calpain superfamily in kinetoplastid parasites. J Mol Evol (2005) 1.10
Ku is important for telomere maintenance, but not for differential expression of telomeric VSG genes, in African trypanosomes. J Biol Chem (2002) 1.10
Phosphorylated BRCA1 is predominantly located in the nucleus and mitochondria. Mol Biol Cell (2004) 1.09
Mining the Plasmodium genome database to define organellar function: what does the apicoplast do? Philos Trans R Soc Lond B Biol Sci (2002) 1.09
Repetitive elements in genomes of parasitic protozoa. Microbiol Mol Biol Rev (2003) 1.09
Membrane domains and flagellar pocket boundaries are influenced by the cytoskeleton in African trypanosomes. Proc Natl Acad Sci U S A (2009) 1.08
Integration of pZJM library plasmids into unexpected locations in the Trypanosoma brucei genome. Mol Biochem Parasitol (2004) 1.08
Cytokinesis in Trypanosoma brucei differs between bloodstream and tsetse trypomastigote forms: implications for microtubule-based morphogenesis and mutant analysis. Mol Microbiol (2013) 1.04
Flagellar and ciliary beating in trypanosome motility. Cell Motil Cytoskeleton (2007) 1.04
Beyond 9+0: noncanonical axoneme structures characterize sensory cilia from protists to humans. FASEB J (2010) 1.04
The Naegleria genome: a free-living microbial eukaryote lends unique insights into core eukaryotic cell biology. Res Microbiol (2011) 1.03
Protein targeting of an unusual, evolutionarily conserved adenylate kinase to a eukaryotic flagellum. Mol Biol Cell (2004) 1.03