Published in Chem Res Toxicol on March 01, 2006
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Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control. Oncogene (2000) 1.18
Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): potential role of cyclin D1. Proc Natl Acad Sci U S A (2001) 1.17
The interaction of p53 with replication protein A mediates suppression of homologous recombination. Oncogene (2004) 1.16
Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res (2004) 1.06
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Absence of 2'-deoxyoxanosine and presence of abasic sites in DNA exposed to nitric oxide at controlled physiological concentrations. Chem Res Toxicol (2003) 1.06
p53 protects from replication-associated DNA double-strand breaks in mammalian cells. Oncogene (2004) 1.04
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Nitric oxide-induced homologous recombination in Escherichia coli is promoted by DNA glycosylases. J Bacteriol (2002) 1.03
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Activities of wildtype and mutant p53 in suppression of homologous recombination as measured by a retroviral vector system. Mutat Res (2003) 0.96
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Delineation of the chemical pathways underlying nitric oxide-induced homologous recombination in mammalian cells. Chem Biol (2005) 0.87
Wild-type p53 inhibits replication-associated homologous recombination. Oncogene (2002) 0.86
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Down-regulation of nuclear factor kappaB is required for p53-dependent apoptosis in X-ray-irradiated mouse lymphoma cells and thymocytes. Cancer Res (1999) 0.84
Wild-type p53 stimulates homologous recombination upon sequence-specific binding to the ribosomal gene cluster repeat. Oncogene (2005) 0.79
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DNA double-strand break repair: from mechanistic understanding to cancer treatment. DNA Repair (Amst) (2007) 3.69
DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J Clin Invest (2008) 3.17
Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation. Nat Chem Biol (2006) 3.08
A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. PLoS Genet (2010) 2.73
Phosphorothioation of DNA in bacteria by dnd genes. Nat Chem Biol (2007) 2.57
The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo. Clin Cancer Res (2009) 2.25
Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology. Toxicol Sci (2010) 2.03
The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia. Blood (2007) 1.99
Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. J Biol Chem (2003) 1.95
Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins. Nat Commun (2012) 1.93
Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma. Blood (2012) 1.81
PI3K/p110{delta} is a novel therapeutic target in multiple myeloma. Blood (2010) 1.75
Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates. Int J Cancer (2011) 1.70
DNA phosphorothioation is widespread and quantized in bacterial genomes. Proc Natl Acad Sci U S A (2011) 1.69
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Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer. Proc Natl Acad Sci U S A (2012) 1.67
The rational design of nitric oxide selectivity in single-walled carbon nanotube near-infrared fluorescence sensors for biological detection. Nat Chem (2009) 1.64
Engineered nanoparticles for drug delivery in cancer therapy. Angew Chem Int Ed Engl (2014) 1.62
Quantification of DNA damage products resulting from deamination, oxidation and reaction with products of lipid peroxidation by liquid chromatography isotope dilution tandem mass spectrometry. Nat Protoc (2008) 1.62
Lipid peroxidation dominates the chemistry of DNA adduct formation in a mouse model of inflammation. Carcinogenesis (2007) 1.55
Single cell trapping and DNA damage analysis using microwell arrays. Proc Natl Acad Sci U S A (2010) 1.53
Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. Mol Cell Biol (2010) 1.53
Monoclonal versus polyclonal antibodies: distinguishing characteristics, applications, and information resources. ILAR J (2005) 1.48
Nitric oxide as a modulator of apoptosis. Cancer Lett (2004) 1.48
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc Natl Acad Sci U S A (2008) 1.41
Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications. Blood (2009) 1.41
Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells. Br J Haematol (2007) 1.41
2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase. PLoS Pathog (2012) 1.32
N-formylation of lysine in histone proteins as a secondary modification arising from oxidative DNA damage. Proc Natl Acad Sci U S A (2006) 1.32
Chemical and biological evidence for base propenals as the major source of the endogenous M1dG adduct in cellular DNA. J Biol Chem (2005) 1.31
AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer Res (2008) 1.30
Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proc Natl Acad Sci U S A (2013) 1.29
Nitric oxide in cancer and chemoprevention. Free Radic Biol Med (2003) 1.29
One family cluster of avian influenza A(H7N9) virus infection in Shandong, China. BMC Infect Dis (2014) 1.26
MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts. Blood (2007) 1.21
5'-(2-phosphoryl-1,4-dioxobutane) as a product of 5'-oxidation of deoxyribose in DNA: elimination as trans-1,4-dioxo-2-butene and approaches to analysis. Chem Res Toxicol (2004) 1.18
Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene. Proc Natl Acad Sci U S A (2004) 1.16
Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response. Cell Cycle (2012) 1.16
Computerized diagnosis from tongue appearance using quantitative feature classification. Am J Chin Med (2005) 1.15
Integrated molecular analysis indicates undetectable change in DNA damage in mice after continuous irradiation at ~ 400-fold natural background radiation. Environ Health Perspect (2012) 1.15
Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications. RNA Biol (2012) 1.13
Spontaneous mitotic homologous recombination at an enhanced yellow fluorescent protein (EYFP) cDNA direct repeat in transgenic mice. Proc Natl Acad Sci U S A (2003) 1.12
Three-dimensional tissue cytometer based on high-speed multiphoton microscopy. Cytometry A (2007) 1.11
Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics. Mol Ther (2013) 1.11
Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells. Proc Natl Acad Sci U S A (2009) 1.08
Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA. Proc Natl Acad Sci U S A (2012) 1.07
Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res (2004) 1.06
In vivo biosensing via tissue-localizable near-infrared-fluorescent single-walled carbon nanotubes. Nat Nanotechnol (2013) 1.06
Nitric oxide-induced genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells expressing wild-type and mutant p53. Proc Natl Acad Sci U S A (2002) 1.06
Absence of 2'-deoxyoxanosine and presence of abasic sites in DNA exposed to nitric oxide at controlled physiological concentrations. Chem Res Toxicol (2003) 1.06
Radioactive 198Au-doped nanostructures with different shapes for in vivo analyses of their biodistribution, tumor uptake, and intratumoral distribution. ACS Nano (2014) 1.04
Homologous recombination prevents methylation-induced toxicity in Escherichia coli. Nucleic Acids Res (2006) 1.04
Thresholds of nitric oxide-mediated toxicity in human lymphoblastoid cells. Chem Res Toxicol (2003) 1.03
High-throughput screening platform for engineered nanoparticle-mediated genotoxicity using CometChip technology. ACS Nano (2014) 1.03
DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis. PLoS Pathog (2013) 1.03
Nitric oxide-induced homologous recombination in Escherichia coli is promoted by DNA glycosylases. J Bacteriol (2002) 1.03
Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes. DNA Repair (Amst) (2002) 1.02
Genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells exposed to peroxynitrite generated from SIN-1. Chem Res Toxicol (2002) 1.00
Design of a heterobivalent ligand to inhibit IgE clustering on mast cells. Chem Biol (2011) 1.00
Variation in dietary salt intake induces coordinated dynamics of monocyte subsets and monocyte-platelet aggregates in humans: implications in end organ inflammation. PLoS One (2013) 1.00
Kinetic analysis of intracellular concentrations of reactive nitrogen species. Chem Res Toxicol (2008) 0.99
Detection and quantification of 4-ABP adducts in DNA from bladder cancer patients. Carcinogenesis (2006) 0.98
Comprehensive evaluation of canonical versus Dicer-substrate siRNA in vitro and in vivo. RNA (2012) 0.98
Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids. Free Radic Res (2012) 0.97
Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors. Cell Cycle (2013) 0.97
Age-dependent accumulation of recombinant cells in the mouse pancreas revealed by in situ fluorescence imaging. Proc Natl Acad Sci U S A (2006) 0.97
Formation of 1,4-dioxo-2-butene-derived adducts of 2'-deoxyadenosine and 2'-deoxycytidine in oxidized DNA. Chem Res Toxicol (2006) 0.97
XRCC1 and base excision repair balance in response to nitric oxide. DNA Repair (Amst) (2011) 0.97
Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease. Proc Natl Acad Sci U S A (2013) 0.97
RGD-conjugated gold nanorods induce radiosensitization in melanoma cancer cells by downregulating α(v)β₃ expression. Int J Nanomedicine (2012) 0.97
A systematic analysis of peptide linker length and liposomal polyethylene glycol coating on cellular uptake of peptide-targeted liposomes. ACS Nano (2013) 0.96
Aflatoxin B1-DNA adduct formation and mutagenicity in livers of neonatal male and female B6C3F1 mice. Toxicol Sci (2011) 0.96
p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications. Br J Haematol (2008) 0.96
Mutagenic potency of Helicobacter pylori in the gastric mucosa of mice is determined by sex and duration of infection. Proc Natl Acad Sci U S A (2010) 0.96