Published in DNA Repair (Amst) on October 12, 2011
Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase. Proc Natl Acad Sci U S A (2013) 1.27
Inflammation-induced cell proliferation potentiates DNA damage-induced mutations in vivo. PLoS Genet (2015) 0.88
Rosa26-GFP direct repeat (RaDR-GFP) mice reveal tissue- and age-dependence of homologous recombination in mammals in vivo. PLoS Genet (2014) 0.84
Evidence that BRCA1- or BRCA2-associated cancers are not inevitable. Mol Med (2012) 0.78
Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation. Nat Commun (2016) 0.78
A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining. Open Biol (2016) 0.75
Creation of Mice Bearing a Partial Duplication of HPRT Gene Marked with a GFP Gene and Detection of Revertant Cells In Situ as GFP-Positive Somatic Cells. PLoS One (2015) 0.75
p53 mutations in human cancers. Science (1991) 31.96
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science (1990) 16.68
Tumor spectrum analysis in p53-mutant mice. Curr Biol (1994) 16.60
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell (1993) 12.02
Brca1 controls homology-directed DNA repair. Mol Cell (1999) 7.82
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome. Nature (1991) 7.49
BRCA2 is required for homology-directed repair of chromosomal breaks. Mol Cell (2001) 6.75
A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes. Proc Natl Acad Sci U S A (1974) 6.51
The Fanconi anaemia/BRCA pathway. Nat Rev Cancer (2003) 5.89
Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells. Mol Cell Biol (1999) 4.20
Determining mutation rates in bacterial populations. Methods (2000) 4.15
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat Genet (1994) 3.97
DNA double-strand break repair: from mechanistic understanding to cancer treatment. DNA Repair (Amst) (2007) 3.69
The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair. Mol Cell (2004) 3.44
BRCA2 germline mutations in familial pancreatic carcinoma. J Natl Cancer Inst (2003) 3.37
Recombinational DNA repair and human disease. Mutat Res (2002) 2.70
Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation. Nucleic Acids Res (1996) 2.65
p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. EMBO J (1996) 2.25
Homologous recombination resolution defect in werner syndrome. Mol Cell Biol (2002) 2.21
Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. J Biol Chem (2003) 1.95
Targeted inactivation of p53 in human cells does not result in aneuploidy. Cancer Res (2002) 1.86
BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination. EMBO J (2003) 1.71
p53 modulation of the DNA damage response. J Cell Biochem (2007) 1.61
Loss of Werner syndrome protein function promotes aberrant mitotic recombination. Genes Dev (2001) 1.61
High-frequency genetic reversion mediated by a DNA duplication: the mouse pink-eyed unstable mutation. Proc Natl Acad Sci U S A (1993) 1.61
Reversal of p53 epigenetic silencing in multiple myeloma permits apoptosis by a p53 activator. Cancer Biol Ther (2006) 1.53
Inactivation of p53 results in high rates of homologous recombination. Oncogene (1997) 1.51
Direct molecular identification of the mouse pink-eyed unstable mutation by genome scanning. Science (1991) 1.49
Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice. Cancer Res (1995) 1.42
Functional interaction of p53 and BLM DNA helicase in apoptosis. J Biol Chem (2001) 1.37
DNA substrate dependence of p53-mediated regulation of double-strand break repair. Mol Cell Biol (2002) 1.32
Germ line Fanconi anemia complementation group C mutations and pancreatic cancer. Cancer Res (2005) 1.25
Human p53 binds Holliday junctions strongly and facilitates their cleavage. J Biol Chem (1997) 1.25
Chromosome instability contributes to loss of heterozygosity in mice lacking p53. Proc Natl Acad Sci U S A (2000) 1.23
Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation. Cancer Res (2002) 1.22
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem (2002) 1.22
Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein. Oncogene (1997) 1.19
RecQ family helicases: roles as tumor suppressor proteins. Oncogene (2002) 1.18
Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control. Oncogene (2000) 1.18
Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development. Cancer Res (2003) 1.17
Extensive chromosomal instability in Rad51d-deficient mouse cells. Cancer Res (2005) 1.16
The interaction of p53 with replication protein A mediates suppression of homologous recombination. Oncogene (2004) 1.16
Spontaneous mitotic homologous recombination at an enhanced yellow fluorescent protein (EYFP) cDNA direct repeat in transgenic mice. Proc Natl Acad Sci U S A (2003) 1.12
p53 Modulates the exonuclease activity of Werner syndrome protein. J Biol Chem (2001) 1.07
A novel host cell reactivation assay to assess homologous recombination capacity in human cancer cell lines. Biochem Biophys Res Commun (2001) 1.05
p53 protects from replication-associated DNA double-strand breaks in mammalian cells. Oncogene (2004) 1.04
Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination. Mol Cell Biol (1998) 1.04
p53 prevents the accumulation of double-strand DNA breaks at stalled-replication forks induced by UV in human cells. Cell Cycle (2004) 1.00
Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation. Mol Cell Biol (1994) 0.99
In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes. J Virol (1996) 0.98
Threshold effects of nitric oxide-induced toxicity and cellular responses in wild-type and p53-null human lymphoblastoid cells. Chem Res Toxicol (2006) 0.97
Age-dependent accumulation of recombinant cells in the mouse pancreas revealed by in situ fluorescence imaging. Proc Natl Acad Sci U S A (2006) 0.97
Increased UV-induced SCEs but normal repair of DNA damage in p53-deficient mouse cells. Int J Cancer (1994) 0.95
The p53/Mdm2/p14ARF cell cycle control pathway genes may be inactivated by genetic and epigenetic mechanisms in gliomas. Cancer Genet Cytogenet (2006) 0.93
TP53 is frequently altered by methylation, mutation, and/or deletion in acute lymphoblastic leukaemia. Mol Carcinog (2003) 0.90
Homologous recombination in extrachromosomal plasmid substrates is not suppressed by p53. Carcinogenesis (2001) 0.90
Illegitimate recombination leading to allelic loss and unbalanced translocation in p53-mutated human lymphoblastoid cells. Mol Cell Biol (1997) 0.90
Discriminatory suppression of homologous recombination by p53. Nucleic Acids Res (2004) 0.89
Loss of wild-type p53 function is responsible for upregulated homologous recombination in immortal rodent fibroblasts. Int J Radiat Biol (2000) 0.88
Cytotoxic and mutagenic responses to X-rays and chemical mutagens in normal and p53-mutated human lymphoblastoid cells. Mutat Res (1997) 0.87
Integrated one- and two-photon imaging platform reveals clonal expansion as a major driver of mutation load. Proc Natl Acad Sci U S A (2008) 0.86
Wild-type p53 inhibits replication-associated homologous recombination. Oncogene (2002) 0.86
Applications of fluorescence for detecting rare sequence rearrangements in vivo. Cell Cycle (2006) 0.85
Radiation-induced genetic instability in vivo depends on p53 status. Mutat Res (2002) 0.85
Cell-cycle distribution of pancreatic cells from rats with acute pancreatitis induced by bile-pancreatic obstruction. Cell Tissue Res (2000) 0.82
p53 blocks RuvAB promoted branch migration and modulates resolution of Holliday junctions by RuvC. J Mol Biol (2002) 0.80
Involvement of p53 in X-ray induced intrachromosomal recombination in mice. Carcinogenesis (1999) 0.80
p53 is involved in clearance of ionizing radiation-induced RAD51 foci in a human colon cancer cell line. Biochem Biophys Res Commun (2006) 0.79
Absence of p53 enhances growth defects and etoposide sensitivity of human cells lacking the Bloom syndrome helicase BLM. DNA Cell Biol (2007) 0.79
The effect of functional inactivation of TP53 by HPV-E6 transformation on the induction of chromosome aberrations by gamma rays in human tumor cells. Radiat Res (1999) 0.76
DNA double-strand break repair: from mechanistic understanding to cancer treatment. DNA Repair (Amst) (2007) 3.69
Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. J Biol Chem (2003) 1.95
Single cell trapping and DNA damage analysis using microwell arrays. Proc Natl Acad Sci U S A (2010) 1.53
Integrated molecular analysis indicates undetectable change in DNA damage in mice after continuous irradiation at ~ 400-fold natural background radiation. Environ Health Perspect (2012) 1.15
Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts. J Biol Chem (2012) 1.14
Spontaneous mitotic homologous recombination at an enhanced yellow fluorescent protein (EYFP) cDNA direct repeat in transgenic mice. Proc Natl Acad Sci U S A (2003) 1.12
Three-dimensional tissue cytometer based on high-speed multiphoton microscopy. Cytometry A (2007) 1.11
Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling. Cold Spring Harb Perspect Biol (2012) 1.05
Homologous recombination prevents methylation-induced toxicity in Escherichia coli. Nucleic Acids Res (2006) 1.04
High-throughput screening platform for engineered nanoparticle-mediated genotoxicity using CometChip technology. ACS Nano (2014) 1.03
Nitric oxide-induced homologous recombination in Escherichia coli is promoted by DNA glycosylases. J Bacteriol (2002) 1.03
Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes. DNA Repair (Amst) (2002) 1.02
Threshold effects of nitric oxide-induced toxicity and cellular responses in wild-type and p53-null human lymphoblastoid cells. Chem Res Toxicol (2006) 0.97
XRCC1 and base excision repair balance in response to nitric oxide. DNA Repair (Amst) (2011) 0.97
Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors. Cell Cycle (2013) 0.97
Age-dependent accumulation of recombinant cells in the mouse pancreas revealed by in situ fluorescence imaging. Proc Natl Acad Sci U S A (2006) 0.97
Open access to research is in the public interest. PLoS Biol (2007) 0.95
Major shifts in the spatio-temporal distribution of lung antioxidant enzymes during influenza pneumonia. PLoS One (2012) 0.94
Interstrand crosslink-induced homologous recombination carries an increased risk of deletions and insertions. DNA Repair (Amst) (2005) 0.92
New immunoaffinity-LC-MS/MS methodology reveals that Aag null mice are deficient in their ability to clear 1,N6-etheno-deoxyadenosine DNA lesions from lung and liver in vivo. DNA Repair (Amst) (2004) 0.91
Standard fluorescent imaging of live cells is highly genotoxic. Cytometry A (2013) 0.90
In vivo recombination after chronic damage exposure falls to below spontaneous levels in "recombomice". Mol Cancer Res (2004) 0.90
Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines. Funct Integr Genomics (2011) 0.89
Multiscale structural analysis of mouse lingual myoarchitecture employing diffusion spectrum magnetic resonance imaging and multiphoton microscopy. J Biomed Opt (2009) 0.87
Genotoxicity of 2,6- and 3,5-dimethylaniline in cultured mammalian cells: the role of reactive oxygen species. Toxicol Sci (2012) 0.87
Delineation of the chemical pathways underlying nitric oxide-induced homologous recombination in mammalian cells. Chem Biol (2005) 0.87
Quantitative morphometric measurements using site selective image cytometry of intact tissue. J R Soc Interface (2009) 0.86
Integrated one- and two-photon imaging platform reveals clonal expansion as a major driver of mutation load. Proc Natl Acad Sci U S A (2008) 0.86
Micro-RNAs in regenerating lungs: an integrative systems biology analysis of murine influenza pneumonia. BMC Genomics (2014) 0.85
Applications of fluorescence for detecting rare sequence rearrangements in vivo. Cell Cycle (2006) 0.85
A single acute exposure to a chemotherapeutic agent induces hyper-recombination in distantly descendant cells and in their neighbors. Oncogene (2005) 0.84
Tissue-specific differences in the accumulation of sequence rearrangements with age. DNA Repair (Amst) (2008) 0.83
"Recombomice": the past, present, and future of recombination-detection in mice. DNA Repair (Amst) (2004) 0.83
Influenza infection induces host DNA damage and dynamic DNA damage responses during tissue regeneration. Cell Mol Life Sci (2015) 0.82
Development and characterization of a novel variable low dose-rate irradiator for in vivo mouse studies. Health Phys (2010) 0.80
Peptide targeting and imaging of damaged lung tissue in influenza-infected mice. Future Microbiol (2013) 0.80
Investigation of the effects of aging on homologous recombination in long-term bone marrow cultures. In Vivo (2009) 0.80
Building on the past, shaping the future: the Environmental Mutagenesis and Genomics Society. Environ Mol Mutagen (2013) 0.75
Investigating the efficacy of pamidronate, a chemical inhibitor of farnesyl pyrophosphate synthase, in the inhibition of influenza virus infection in vitro and in vivo. Mol Med Rep (2013) 0.75