Published in DNA Repair (Amst) on March 23, 2007
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J (2009) 3.89
Novel pro- and anti-recombination activities of the Bloom's syndrome helicase. Genes Dev (2007) 2.82
The histone methyltransferase SET8 is required for S-phase progression. J Cell Biol (2007) 2.74
Factors determining DNA double-strand break repair pathway choice in G2 phase. EMBO J (2011) 2.46
Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis (2008) 2.42
Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase. Mol Cell (2012) 1.91
Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. J Biol Chem (2009) 1.91
DNA repair deficiency and neurological disease. Nat Rev Neurosci (2009) 1.91
ERCC1-XPF endonuclease facilitates DNA double-strand break repair. Mol Cell Biol (2008) 1.88
Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. Mol Cell Biol (2010) 1.73
DNA repair deficiency in neurodegeneration. Prog Neurobiol (2011) 1.55
Single cell trapping and DNA damage analysis using microwell arrays. Proc Natl Acad Sci U S A (2010) 1.53
Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts. J Clin Invest (2011) 1.46
Transcription-associated recombination is dependent on replication in Mammalian cells. Mol Cell Biol (2007) 1.45
Akt: a double-edged sword in cell proliferation and genome stability. J Oncol (2012) 1.44
Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening. ACS Chem Biol (2011) 1.30
The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links. Nucleic Acids Res (2009) 1.30
DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy. Front Oncol (2013) 1.30
DNA strand breaks, neurodegeneration and aging in the brain. Mech Ageing Dev (2008) 1.27
The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants. Mol Cell Biol (2009) 1.26
DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells. Neoplasia (2009) 1.24
Behind the wheel and under the hood: functions of cyclin-dependent kinases in response to DNA damage. DNA Repair (Amst) (2009) 1.23
Understanding the limitations of radiation-induced cell cycle checkpoints. Crit Rev Biochem Mol Biol (2011) 1.22
Roles of the Werner syndrome RecQ helicase in DNA replication. DNA Repair (Amst) (2008) 1.20
RECQ1 possesses DNA branch migration activity. J Biol Chem (2008) 1.19
Receptor signaling as a regulatory mechanism of DNA repair. Radiother Oncol (2009) 1.19
Loss of epigenetic silencing in tumors preferentially affects primate-specific retroelements. Gene (2009) 1.19
Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination. PLoS Genet (2010) 1.16
CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1. Nucleic Acids Res (2010) 1.16
Integrated molecular analysis indicates undetectable change in DNA damage in mice after continuous irradiation at ~ 400-fold natural background radiation. Environ Health Perspect (2012) 1.15
The role of RPA2 phosphorylation in homologous recombination in response to replication arrest. Carcinogenesis (2010) 1.14
Complex DNA repair pathways as possible therapeutic targets to overcome temozolomide resistance in glioblastoma. Front Oncol (2012) 1.14
Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A (2012) 1.13
FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance. Oncogene (2013) 1.11
Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity. Toxicol Appl Pharmacol (2008) 1.11
Quantitative model of R-loop forming structures reveals a novel level of RNA-DNA interactome complexity. Nucleic Acids Res (2011) 1.10
Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination. DNA Repair (Amst) (2012) 1.10
Extreme growth failure is a common presentation of ligase IV deficiency. Hum Mutat (2013) 1.08
Proliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries. PLoS One (2011) 1.07
Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks. Oncotarget (2010) 1.06
A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest. Nucleic Acids Res (2011) 1.06
(212)Pb-radioimmunotherapy induces G(2) cell-cycle arrest and delays DNA damage repair in tumor xenografts in a model for disseminated intraperitoneal disease. Mol Cancer Ther (2012) 1.06
Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising. Front Oncol (2014) 1.06
An arranged marriage for precision medicine: hypoxia and genomic assays in localized prostate cancer radiotherapy. Br J Radiol (2014) 1.04
The role of AKT/mTOR pathway in stress response to UV-irradiation: implication in skin carcinogenesis by regulation of apoptosis, autophagy and senescence. Int J Mol Sci (2013) 1.04
DNA repair and genome maintenance in Bacillus subtilis. Microbiol Mol Biol Rev (2012) 1.03
High-throughput screening platform for engineered nanoparticle-mediated genotoxicity using CometChip technology. ACS Nano (2014) 1.03
DNA damage response. Cold Spring Harb Perspect Biol (2011) 1.03
The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends. Mol Cell Biol (2008) 1.03
An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression. PLoS One (2012) 1.01
DNA damage induced by alkylating agents and repair pathways. J Nucleic Acids (2010) 1.00
Opposing roles for 53BP1 during homologous recombination. Nucleic Acids Res (2013) 0.99
Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition. Semin Cancer Biol (2015) 0.99
Engineering Human Stem Cell Lines with Inducible Gene Knockout using CRISPR/Cas9. Cell Stem Cell (2015) 0.98
Combining PARP-1 inhibition and radiation in Ewing sarcoma results in lethal DNA damage. Mol Cancer Ther (2013) 0.98
Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors. Cell Cycle (2013) 0.97
XRCC1 and base excision repair balance in response to nitric oxide. DNA Repair (Amst) (2011) 0.97
Molecular mechanisms of the whole DNA repair system: a comparison of bacterial and eukaryotic systems. J Nucleic Acids (2010) 0.96
FOXM1: an emerging master regulator of DNA damage response and genotoxic agent resistance. Biochim Biophys Acta (2014) 0.95
Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease. PLoS Genet (2011) 0.95
HOP2-MND1 modulates RAD51 binding to nucleotides and DNA. Nat Commun (2014) 0.95
The ups and downs of DNA repair biomarkers for PARP inhibitor therapies. Am J Cancer Res (2010) 0.95
Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression. Nat Commun (2012) 0.95
Biochemical characterization of bacteriophage T4 Mre11-Rad50 complex. J Biol Chem (2010) 0.95
Essential and distinct roles of the F-box and helicase domains of Fbh1 in DNA damage repair. BMC Mol Biol (2008) 0.94
Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates. Proc Natl Acad Sci U S A (2013) 0.93
Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells. Carcinogenesis (2012) 0.92
Mouse models of DNA double-strand break repair and neurological disease. DNA Repair (Amst) (2008) 0.92
Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks. PLoS One (2013) 0.92
Heavy ions, radioprotectors and genomic instability: implications for human space exploration. Radiat Environ Biophys (2009) 0.91
DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells. Proc Natl Acad Sci U S A (2010) 0.91
Involvement of microRNA-24 and DNA methylation in resistance of nasopharyngeal carcinoma to ionizing radiation. Mol Cancer Ther (2014) 0.90
Analysis of illegitimate genomic integration mediated by zinc-finger nucleases: implications for specificity of targeted gene correction. BMC Mol Biol (2010) 0.89
Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer. Br J Cancer (2016) 0.89
DNA ligase IV as a new molecular target for temozolomide. Biochem Biophys Res Commun (2009) 0.89
The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair. Nucleic Acids Res (2013) 0.89
Topoisomerase II-mediated DNA damage is differently repaired during the cell cycle by non-homologous end joining and homologous recombination. PLoS One (2010) 0.89
Irradiated esophageal cells are protected from radiation-induced recombination by MnSOD gene therapy. Radiat Res (2010) 0.89
Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells. Proc Natl Acad Sci U S A (2015) 0.88
Inflammation-induced cell proliferation potentiates DNA damage-induced mutations in vivo. PLoS Genet (2015) 0.88
DNA damage and repair in endometrial cancer in correlation with the hOGG1 and RAD51 genes polymorphism. Mol Biol Rep (2010) 0.88
Homologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the antileukemia agent CNDAC. Blood (2010) 0.88
Targeting of β1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells. Oncogene (2015) 0.88
High risk of benzo[α]pyrene-induced lung cancer in E160D FEN1 mutant mice. Mutat Res (2011) 0.88
CREB-binding protein regulates Ku70 acetylation in response to ionization radiation in neuroblastoma. Mol Cancer Res (2012) 0.87
Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genet (2013) 0.87
Nuclear dynamics of radiation-induced foci in euchromatin and heterochromatin. Mutat Res (2013) 0.87
Imatinib radiosensitizes bladder cancer by targeting homologous recombination. Cancer Res (2013) 0.86
Targeted DNA methylation by homology-directed repair in mammalian cells. Transcription reshapes methylation on the repaired gene. Nucleic Acids Res (2013) 0.86
An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs. DNA Repair (Amst) (2011) 0.86
Integrated one- and two-photon imaging platform reveals clonal expansion as a major driver of mutation load. Proc Natl Acad Sci U S A (2008) 0.86
Primary immunodeficiency diseases associated with neurologic manifestations. J Clin Immunol (2011) 0.86
Ku regulates signaling to DNA damage response pathways through the Ku70 von Willebrand A domain. Mol Cell Biol (2011) 0.85
ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells. PLoS One (2011) 0.85
GADD45α inhibition of DNMT1 dependent DNA methylation during homology directed DNA repair. Nucleic Acids Res (2011) 0.85
BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle. Nucleic Acids Res (2014) 0.85
Internal priming: an opportunistic pathway for L1 and Alu retrotransposition in hominins. Gene (2009) 0.85
MutS Homologues hMSH4 and hMSH5: Genetic Variations, Functions, and Implications in Human Diseases. Curr Genomics (2013) 0.85
Modeling the biological response of normal human cells, including repair processes, to fractionated carbon beam irradiation. J Radiat Res (2013) 0.85
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. J Cell Biol (2007) 2.92
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc Natl Acad Sci U S A (2006) 2.71
Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells. Eur J Immunol (2002) 2.57
The mechanism of non-homologous end-joining: a synopsis of synapsis. DNA Repair (Amst) (2004) 2.18
Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates. EMBO J (2003) 2.12
MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response. EMBO J (2009) 2.06
Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. J Biol Chem (2003) 1.95
Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature (2002) 1.89
A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining. J Clin Invest (2008) 1.82
Multiple regions-of-interest analysis of setup uncertainties for head-and-neck cancer radiotherapy. Int J Radiat Oncol Biol Phys (2006) 1.75
Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair. Genes Dev (2011) 1.60
A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation. J Clin Invest (2005) 1.59
Single cell trapping and DNA damage analysis using microwell arrays. Proc Natl Acad Sci U S A (2010) 1.53
The role of DNA dependent protein kinase in synapsis of DNA ends. Nucleic Acids Res (2003) 1.51
Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4. Sci Transl Med (2012) 1.42
A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen. Blood (2009) 1.42
Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining. Cancer Res (2006) 1.38
End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4. DNA Repair (Amst) (2004) 1.29
DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP. Nucleic Acids Res (2002) 1.23
Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint in bone marrow. Blood (2002) 1.23
Integrated molecular analysis indicates undetectable change in DNA damage in mice after continuous irradiation at ~ 400-fold natural background radiation. Environ Health Perspect (2012) 1.15
Spontaneous mitotic homologous recombination at an enhanced yellow fluorescent protein (EYFP) cDNA direct repeat in transgenic mice. Proc Natl Acad Sci U S A (2003) 1.12
Three-dimensional tissue cytometer based on high-speed multiphoton microscopy. Cytometry A (2007) 1.11
Defective Artemis nuclease is characterized by coding joints with microhomology in long palindromic-nucleotide stretches. Eur J Immunol (2007) 1.09
Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends. Mol Cell Biol (2005) 1.09
Substituent effects on aryltrifluoroborate solvolysis in water: implications for Suzuki-Miyaura coupling and the design of stable (18)F-labeled aryltrifluoroborates for use in PET imaging. J Org Chem (2008) 1.06
Homologous recombination prevents methylation-induced toxicity in Escherichia coli. Nucleic Acids Res (2006) 1.04
High-throughput screening platform for engineered nanoparticle-mediated genotoxicity using CometChip technology. ACS Nano (2014) 1.03
The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends. Mol Cell Biol (2008) 1.03
Nitric oxide-induced homologous recombination in Escherichia coli is promoted by DNA glycosylases. J Bacteriol (2002) 1.03
MicroRNAs, the DNA damage response and cancer. Mutat Res (2011) 1.03
Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes. DNA Repair (Amst) (2002) 1.02
An XRCC4 splice mutation associated with severe short stature, gonadal failure, and early-onset metabolic syndrome. J Clin Endocrinol Metab (2015) 0.99
Threshold effects of nitric oxide-induced toxicity and cellular responses in wild-type and p53-null human lymphoblastoid cells. Chem Res Toxicol (2006) 0.97
Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors. Cell Cycle (2013) 0.97
Age-dependent accumulation of recombinant cells in the mouse pancreas revealed by in situ fluorescence imaging. Proc Natl Acad Sci U S A (2006) 0.97
XRCC1 and base excision repair balance in response to nitric oxide. DNA Repair (Amst) (2011) 0.97
Open access to research is in the public interest. PLoS Biol (2007) 0.95
Role of Artemis in DSB repair and guarding chromosomal stability following exposure to ionizing radiation at different stages of cell cycle. Mutat Res (2006) 0.95
Major shifts in the spatio-temporal distribution of lung antioxidant enzymes during influenza pneumonia. PLoS One (2012) 0.94
BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1. J Clin Invest (2016) 0.94
MicroRNA responses and stress granule formation modulate the DNA damage response. Cell Cycle (2009) 0.93
Interstrand crosslink-induced homologous recombination carries an increased risk of deletions and insertions. DNA Repair (Amst) (2005) 0.92
DNA-PKcs deficiency in human: long predicted, finally found. Curr Opin Allergy Clin Immunol (2009) 0.91
A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination. J Exp Med (2013) 0.91
New immunoaffinity-LC-MS/MS methodology reveals that Aag null mice are deficient in their ability to clear 1,N6-etheno-deoxyadenosine DNA lesions from lung and liver in vivo. DNA Repair (Amst) (2004) 0.91
Standard fluorescent imaging of live cells is highly genotoxic. Cytometry A (2013) 0.90
In vivo recombination after chronic damage exposure falls to below spontaneous levels in "recombomice". Mol Cancer Res (2004) 0.90
Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines. Funct Integr Genomics (2011) 0.89
In Vivo Gene Expression Dynamics of Tumor-Targeted Bacteria. ACS Synth Biol (2012) 0.89
Multiscale structural analysis of mouse lingual myoarchitecture employing diffusion spectrum magnetic resonance imaging and multiphoton microscopy. J Biomed Opt (2009) 0.87
Delineation of the chemical pathways underlying nitric oxide-induced homologous recombination in mammalian cells. Chem Biol (2005) 0.87
Genotoxicity of 2,6- and 3,5-dimethylaniline in cultured mammalian cells: the role of reactive oxygen species. Toxicol Sci (2012) 0.87
Clinical spectrum of LIG4 deficiency is broadened with severe dysmaturity, primordial dwarfism, and neurological abnormalities. Hum Mutat (2013) 0.87
Quantitative morphometric measurements using site selective image cytometry of intact tissue. J R Soc Interface (2009) 0.86
The DNA damage repair protein Ku70 interacts with FOXO4 to coordinate a conserved cellular stress response. FASEB J (2010) 0.86
Integrated one- and two-photon imaging platform reveals clonal expansion as a major driver of mutation load. Proc Natl Acad Sci U S A (2008) 0.86
Micro-RNAs in regenerating lungs: an integrative systems biology analysis of murine influenza pneumonia. BMC Genomics (2014) 0.85
Applications of fluorescence for detecting rare sequence rearrangements in vivo. Cell Cycle (2006) 0.85
A single acute exposure to a chemotherapeutic agent induces hyper-recombination in distantly descendant cells and in their neighbors. Oncogene (2005) 0.84
p53 null fluorescent yellow direct repeat (FYDR) mice have normal levels of homologous recombination. DNA Repair (Amst) (2011) 0.84
"Recombomice": the past, present, and future of recombination-detection in mice. DNA Repair (Amst) (2004) 0.83
Tissue-specific differences in the accumulation of sequence rearrangements with age. DNA Repair (Amst) (2008) 0.83
Influenza infection induces host DNA damage and dynamic DNA damage responses during tissue regeneration. Cell Mol Life Sci (2015) 0.82
Peptide targeting and imaging of damaged lung tissue in influenza-infected mice. Future Microbiol (2013) 0.80
Development and characterization of a novel variable low dose-rate irradiator for in vivo mouse studies. Health Phys (2010) 0.80
Poromatosis in pregnancy: a case of 8 eruptive poromas in the third trimester. Cutis (2012) 0.80
Investigation of the effects of aging on homologous recombination in long-term bone marrow cultures. In Vivo (2009) 0.80
Cartilage tissue engineering using cryogenic chondrocytes. Arch Otolaryngol Head Neck Surg (2003) 0.79
NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication. DNA Repair (Amst) (2009) 0.78
Spatiotemporal aspects of MicroRNA-mediated gene regulation. Adv Exp Med Biol (2011) 0.77
DNA double strand break repair: zooming in on the focus. Cell Cycle (2009) 0.76
Investigating the efficacy of pamidronate, a chemical inhibitor of farnesyl pyrophosphate synthase, in the inhibition of influenza virus infection in vitro and in vivo. Mol Med Rep (2013) 0.75
Building on the past, shaping the future: the Environmental Mutagenesis and Genomics Society. Environ Mol Mutagen (2013) 0.75
A novel radiosensitive SCID patient with a pronounced G(2)/M sensitivity. DNA Repair (Amst) (2010) 0.75