Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas.

PubWeight™: 1.89‹?› | Rank: Top 3%

🔗 View Article (PMID 1655254)

Published in Cancer Res on October 15, 1991

Authors

Y Murakami1, K Hayashi, S Hirohashi, T Sekiya

Author Affiliations

1: Oncogene Division, National Cancer Center Research Institute, Tokyo, Japan.

Articles citing this

Transcriptional sequencing: A method for DNA sequencing using RNA polymerase. Proc Natl Acad Sci U S A (1998) 3.78

Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis. Genes Cancer (2011) 2.18

Generation and analysis of genetically defined liver carcinomas derived from bipotential liver progenitors. Cold Spring Harb Symp Quant Biol (2005) 2.18

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation. EMBO J (1994) 2.10

New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis. Br J Cancer (1999) 2.05

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc Natl Acad Sci U S A (1993) 1.95

Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation. Am J Pathol (1999) 1.87

Pancreatic adenocarcinomas frequently show p53 gene mutations. Am J Pathol (1993) 1.80

Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1. Proc Natl Acad Sci U S A (1995) 1.41

Relevance of ultraviolet-induced N-ras oncogene point mutations in development of primary human cutaneous melanoma. Am J Pathol (1996) 1.36

Genetic heterogeneity of hepatocellular carcinoma. Proc Natl Acad Sci U S A (1994) 1.28

Neoplasia of the ampulla of Vater. Ki-ras and p53 mutations. Am J Pathol (1993) 1.12

Helicobacter pylori infection generated gastric cancer through p53-Rb tumor-suppressor system mutation and telomerase reactivation. World J Gastroenterol (2003) 1.09

Molecular carcinogenesis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: one step closer to personalized medicine? Cell Biosci (2011) 1.08

Alterations of the p16-pRb pathway and the chromosome locus 9p21-22 in non-small-cell lung carcinomas: relationship with p53 and MDM2 protein expression. Am J Pathol (1998) 1.04

Aflatoxin sufferer and p53 gene mutation in hepatocellular carcinoma. World J Gastroenterol (1998) 1.03

Characterization of six tumor suppressor genes and microsatellite instability in hepatocellular carcinoma in southern African blacks. World J Gastroenterol (1999) 1.01

High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal. Br J Cancer (1993) 0.96

Frequent genomic imbalances suggest commonly altered tumour genes in human hepatocarcinogenesis. Br J Cancer (2001) 0.96

Evidence for the presence of two tumour-suppressor genes for hepatocellular carcinoma on chromosome 13q. Br J Cancer (1995) 0.92

Codon 249 mutations of p53 gene in non-neoplastic liver tissues. World J Gastroenterol (1999) 0.89

Alterations in the tumor suppressor genes p53, RB, p16/MTS1, and p15/MTS2 in human pancreatic cancer and hepatoma cell lines. J Gastroenterol (1997) 0.88

Retinoblastoma gene mutations in primary human bladder cancer. Br J Cancer (1995) 0.87

Molecular cloning of a rat chromosome putative recombinogenic sequence homologous to the hepatitis B virus encapsidation signal. Proc Natl Acad Sci U S A (1996) 0.87

Potential roles of tumor suppressor genes and microsatellite instability in hepatocellular carcinogenesis in southern African blacks. World J Gastroenterol (2000) 0.86

Antioxidant and anticancer activity of Artemisia princeps var. orientalis extract in HepG2 and Hep3B hepatocellular carcinoma cells. Chin J Cancer Res (2013) 0.86

Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone: perspective and prognosis. J Thyroid Res (2011) 0.85

Selective induction of apoptosis in Hep 3B cells by topoisomerase I inhibitors: evidence for a protease-dependent pathway that does not activate cysteine protease P32. J Clin Invest (1996) 0.83

The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations. Cancers (Basel) (2014) 0.82

Identification of drivers from cancer genome diversity in hepatocellular carcinoma. Int J Mol Sci (2014) 0.81

Loss of heterozygosity of the retinoblastoma gene in liver cirrhosis accompanying hepatocellular carcinoma. J Cancer Res Clin Oncol (1997) 0.81

Immunohistochemical analysis of p53, cyclinD1, RB1, c-fos and N-ras gene expression in hepatocellular carcinoma in Iran. World J Gastroenterol (2007) 0.80

The genetics of human cancer: implications for ecotoxicology. Environ Health Perspect (1994) 0.79

Epigenetic activation of E-cadherin is a candidate therapeutic target in human hepatocellular carcinoma. Exp Ther Med (2010) 0.79

Hepatitis C virus core protein modulates pRb2/p130 expression in human hepatocellular carcinoma cell lines through promoter methylation. J Exp Clin Cancer Res (2015) 0.79

Mutation of the endogenous p53 gene in cells transformed by HPV-16 E7 and EJ c-ras confers a growth advantage involving an autocrine mechanism. EMBO J (1994) 0.79

The Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Induces Cell Cycle Arrest and Enhances Cytotoxicity of Cisplatin and Doxorubicin on Human Hepatocellular Carcinoma Cells. Biomed Res Int (2015) 0.78

[Molecular pathogenesis of hepatocellular carcinoma: new therapeutic approaches and predictive pathology]. Pathologe (2007) 0.77

Analysis of integrated ground squirrel hepatitis virus and flanking host DNA in two hepatocellular carcinomas. J Virol (1994) 0.77

p53 expression in hepatocellular carcinoma in a population in Singapore with endemic hepatitis B virus infection. J Clin Pathol (1995) 0.76

Absence of p53 gene expression in selenium molecular prevention of chemically induced hepatocarcinogenesis in rats. Saudi J Gastroenterol (2011) 0.75

"P53 codon 72 single base substitution in viral hepatitis C and hepatocarcinoma incidences". Indian J Clin Biochem (2013) 0.75

Articles by these authors

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics (1989) 19.10

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc Natl Acad Sci U S A (1989) 18.26

Transverse uterine fundal incision for placenta praevia with accreta, involving the entire anterior uterine wall: a case series. BJOG (2013) 7.10

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem (1990) 5.65

Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization. Cell (1992) 5.01

Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial. Lancet (2000) 4.60

Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior. Hum Pathol (1999) 4.48

Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. Cancer Res (1989) 4.34

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc Natl Acad Sci U S A (1995) 4.28

An SV40-immortalized human corneal epithelial cell line and its characterization. Invest Ophthalmol Vis Sci (1995) 4.19

Behçet disease (Behçet syndrome). Semin Arthritis Rheum (1979) 3.88

Small adenocarcinoma of the lung. Histologic characteristics and prognosis. Cancer (1995) 3.83

Detection of ras gene mutations in human lung cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products. Oncogene (1990) 3.65

Cadherin dysfunction in a human cancer cell line: possible involvement of loss of alpha-catenin expression in reduced cell-cell adhesiveness. Cancer Res (1992) 2.89

C-myc transcript is induced in rat liver at a very early stage of regeneration or by cycloheximide treatment. Nature (1984) 2.63

Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion. J Cell Biol (1998) 2.62

A rho-dependent termination site in the gene coding for tyrosine tRNA su3 of Escherichia coli. Nature (1978) 2.58

Expression of E- and P-cadherin in gastric carcinomas. Cancer Res (1991) 2.56

Prevention of cell-to-cell spread of herpes simplex virus by leukocytes. J Exp Med (1973) 2.42

TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Nat Genet (2001) 2.37

Brachial-ankle pulse wave velocity: an index of central arterial stiffness? J Hum Hypertens (2005) 2.36

E-cadherin gene mutations in human gastric carcinoma cell lines. Proc Natl Acad Sci U S A (1994) 2.35

Pioneer factors, genetic competence, and inductive signaling: programming liver and pancreas progenitors from the endoderm. Cold Spring Harb Symp Quant Biol (2008) 2.34

Beta-catenin mutation in carcinoma of the uterine endometrium. Cancer Res (1998) 2.27

ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy. J Clin Oncol (1998) 2.26

Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells. Curr Biol (1999) 2.25

Comparison of direct and indirect solid-phase microradioimmunoassays for the detection of viral antigens and antiviral antibody. Appl Microbiol (1973) 2.23

Growth and spread of hepatocellular carcinoma. A review of 240 consecutive autopsy cases. Cancer (1990) 2.22

Epithelial collagens and glycosaminoglycans in the embryonic cornea. Macromolecular order and morphogenesis in the basement membrane. J Cell Biol (1974) 2.18

A rapid determination of sodium dodecyl sulfate with methylene blue. Anal Biochem (1975) 2.15

Transplantation of human tumors in nude mice. J Natl Cancer Inst (1976) 2.13

Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma. Hum Pathol (1991) 2.10

Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma. Br J Cancer (2007) 2.09

Immunocytochemistry of cell surface heparan sulfate proteoglycan in mouse tissues. A light and electron microscopic study. J Histochem Cytochem (1987) 2.07

Mammalian tRNA genes: nucleotide sequence of rat genes for tRNAAsp, tRNAGly and tRNAGlu. Nucleic Acids Res (1981) 2.06

Nucleotide sequence in the promoter region of the Escherichia coli tyrosine tRNA gene. Proc Natl Acad Sci U S A (1974) 2.01

Scratching behavior induced by pruritogenic but not algesiogenic agents in mice. Eur J Pharmacol (1995) 1.98

Early hepatocellular carcinoma as an entity with a high rate of surgical cure. Hepatology (1998) 1.97

Joining of the c-myc gene and a line 1 family member on chromosome 8 in a human primary giant cell carcinoma of the lung. Cancer Res (1990) 1.97

Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient. Proc Natl Acad Sci U S A (1984) 1.95

Tendon collagen fibrillogenesis: intracellular subassemblies and cell surface changes associated with fibril growth. Dev Biol (1979) 1.95

Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 1. General introduction. J Biol Chem (1976) 1.91

Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 1.90

Alteration of beta-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients. Cancer Res (1996) 1.89

Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis--A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology (2000) 1.87

Lobar atelectasis: diagnostic pitfalls on chest radiography. Br J Radiol (2001) 1.84

Pathologic support for limited hepatectomy in the treatment of liver metastases from colorectal cancer. Ann Surg (1995) 1.81

Pancreatic adenocarcinomas frequently show p53 gene mutations. Am J Pathol (1993) 1.80

Expression of vascular endothelial growth factors A, B, C, and D and their relationships to lymph node status in lung adenocarcinoma. Clin Cancer Res (2000) 1.80

Complications associated with transcatheter arterial embolization for hepatic tumors. Radiographics (1998) 1.79

Rapid micro-radioimmunoassay for the measurement of antiviral antibody. J Immunol (1972) 1.79

Proximal-type epithelioid sarcoma: a clinicopathologic study of 20 cases. Mod Pathol (2001) 1.78

Predictive factors for postoperative recurrence of hepatocellular carcinoma. Gastroenterology (1994) 1.76

Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet (1990) 1.75

[Establishment of a new human endometrial adenocarcinoma cell line, Ishikawa cells, containing estrogen and progesterone receptors]. Nihon Sanka Fujinka Gakkai Zasshi (1985) 1.74

Cadherin intercellular adhesion molecule in hepatocellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma. Cancer Lett (1991) 1.73

Hepatocellular carcinoma: treatment with intraarterial iodized oil with and without chemotherapeutic agents. Radiology (1987) 1.73

Esophageal squamous cell carcinoma: pathology and prognosis. World J Surg (1994) 1.72

Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis. Cancer Res (2000) 1.71

Beta-catenin accumulation and mutation of exon 3 of the beta-catenin gene in hepatocellular carcinoma. Jpn J Cancer Res (1999) 1.71

Large, central acellular zones indicating myoepithelial tumor differentiation in high-grade invasive ductal carcinomas as markers of predisposition to lung and brain metastases. Am J Surg Pathol (2000) 1.69

Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Hepatology (2001) 1.67

Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues. J Cell Biol (1989) 1.66

Theoretical study of the effects of vascular smooth muscle contraction on strain and stress distributions in arteries. Ann Biomed Eng (1999) 1.66

Penetrating atherosclerotic ulcer of the aorta: imaging features and disease concept. Radiographics (2000) 1.64

The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas. Int J Cancer (1997) 1.64

CT diagnosis of catheter-induced septic thrombus of vena cava. J Comput Assist Tomogr (1990) 1.64

E-cadherin gene mutations in signet ring cell carcinoma of the stomach. Jpn J Cancer Res (1996) 1.62

Biomechanical study of full-contact karate contrasted with boxing. J Neurosurg (1986) 1.61

Adult-onset Krabbe disease with homozygous T1853C mutation in the galactocerebrosidase gene. Unusual MRI findings of corticospinal tract demyelination. Neurology (1997) 1.61

Exophytic spread of hepatobiliary disease via perihepatic ligaments: demonstration with CT and US. Radiology (1989) 1.60

8-hydroxydeoxyguanosine levels in DNA of human breast cancer are not significantly different from those of non-cancerous breast tissues by the HPLC-ECD method. Cancer Lett (1995) 1.60

Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung. Cancer Res (1992) 1.60

Pathology of small hepatocellular carcinoma. A proposal for a new gross classification. Cancer (1987) 1.60

Retinal complications during interferon therapy for chronic hepatitis C. Am J Gastroenterol (1996) 1.60

E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro. J Cell Sci (1994) 1.59

F-SSCP: fluorescence-based polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis. PCR Methods Appl (1992) 1.58

Driven by the same Ig enhancer and SV40 T promoter ras induced lung adenomatous tumors, myc induced pre-B cell lymphomas and SV40 large T gene a variety of tumors in transgenic mice. EMBO J (1987) 1.58

Point mutation of the E-cadherin gene in invasive lobular carcinoma of the breast. Jpn J Cancer Res (1994) 1.58

Correlation between long-term survival in breast cancer patients and amplification of two putative oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1. Cancer Res (1989) 1.58

A cloning vehicle suitable for strand separation. Gene (1980) 1.57

Immunologic dynamics in hemophiliac patients infected with hepatitis C virus and human immunodeficiency virus: influence of antiretroviral therapy. Blood (2000) 1.56

Stiffness and elastic behavior of human intracranial and extracranial arteries. J Biomech (1980) 1.56

Targeted therapy of spinal cord glioma with a genetically modified Salmonella typhimurium. Cell Prolif (2009) 1.55

Dedifferentiated liposarcoma of retroperitoneum and mesentery: varied growth patterns and histological grades--a clinicopathologic study of 32 cases. Hum Pathol (2000) 1.55

Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma. Cancer Genet Cytogenet (1997) 1.55

Cerebral hypoperfusion and hypometabolism with altered striatal signal intensity in chorea-acanthocytosis: a combined PET and MRI study. Mov Disord (1998) 1.54

Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia. Leuk Res (1999) 1.54

Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl-2----6 alpha-N-acetylgalactosaminyl (sialosyl-Tn) epitope. Cancer Res (1988) 1.54

Nucleotide sequence of the genes for F0 components of the proton-translocating ATPase from Escherichia coli: prediction of the primary structure of F0 subunits. Biochem Biophys Res Commun (1981) 1.53

Organization of sequences related to U6 RNA in the human genome. Nucleic Acids Res (1981) 1.52

Specific detection of positive and negative stranded hepatitis C viral RNA using chemical RNA modification. Arch Virol (1994) 1.52

Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis. Cancer Genet Cytogenet (1997) 1.52