Clonal diversity in tumor progression.

DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer. Nat Commun (2016) 0.93

Biomolecular self-defense and futility of high-specificity therapeutic targeting. Gene Regul Syst Bio (2011) 0.81

Stochastic epigenetic outliers can define field defects in cancer. BMC Bioinformatics (2016) 0.76

Diversity of Gene Expression in Hepatocellular Carcinoma Cells. Genomics Proteomics Bioinformatics (2016) 0.75

Genetic clonal diversity predicts progression to esophageal adenocarcinoma. Nat Genet (2006) 6.71

Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science (2012) 4.92

Low-level microsatellite instability in most colorectal carcinomas. Cancer Res (2002) 2.87

Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers. Proc Natl Acad Sci U S A (2009) 1.98

Methylation reveals a niche: stem cell succession in human colon crypts. Oncogene (2002) 1.88

Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors. Cancer Res (2004) 1.82

In vitro mutation artifacts after formalin fixation and error prone translesion synthesis during PCR. BMC Clin Pathol (2004) 1.71

Pretumor progression: clonal evolution of human stem cell populations. Am J Pathol (2004) 1.57

The fuzzy math of solid tumor stem cells: a perspective. Cancer Res (2007) 1.56

Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. Cancer Res (2006) 1.52

Enhanced stem cell survival in familial adenomatous polyposis. Am J Pathol (2004) 1.51

The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair (Amst) (2002) 1.41

The stem cell population of the human colon crypt: analysis via methylation patterns. PLoS Comput Biol (2007) 1.38

Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization. Cancer Res (2012) 1.28

Counting human somatic cell replications: methylation mirrors endometrial stem cell divisions. Proc Natl Acad Sci U S A (2005) 1.24

Inferring relative numbers of human leucocyte genome replications. Br J Haematol (2008) 1.22

Unregulated smooth-muscle myosin in human intestinal neoplasia. Proc Natl Acad Sci U S A (2008) 1.20

DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair. Mol Cell Biol (2002) 1.18

A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates. BMC Cancer (2010) 1.16

Many colorectal cancers are "flat" clonal expansions. Cell Cycle (2009) 1.10

Age-related human small intestine methylation: evidence for stem cell niches. BMC Med (2005) 1.06

Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging. BMC Med Genet (2007) 1.04

IL-12 facilitates both the recovery of endogenous hematopoiesis and the engraftment of stem cells after ionizing radiation. Exp Hematol (2007) 1.04

Tractable Cre-lox system for stochastic alteration of genes in mice. Nat Methods (2008) 1.03

The role of theorem proving in systems biology. J Theor Biol (2011) 1.00

High DNA methylation pattern intratumoral diversity implies weak selection in many human colorectal cancers. PLoS One (2011) 0.98

Tracing ancestry with methylation patterns: most crypts appear distantly related in normal adult human colon. BMC Gastroenterol (2004) 0.98

Colorectal pretumor progression before and after loss of DNA mismatch repair. Am J Pathol (2004) 0.97

Modeling DNA methylation in a population of cancer cells. Stat Appl Genet Mol Biol (2008) 0.92

Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res (2009) 0.92

Hormone therapy, DNA methylation and colon cancer. Carcinogenesis (2010) 0.91

PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper. Am J Pathol (2002) 0.90

Heterogeneity and randomness of DNA methylation patterns in human embryonic stem cells. DNA Cell Biol (2012) 0.90

Human hair genealogies and stem cell latency. BMC Biol (2006) 0.89

Diet, cancer and aging in DNA mismatch repair deficient mice. Carcinogenesis (2002) 0.89

Using DNA methylation patterns to infer tumor ancestry. PLoS One (2010) 0.89

Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention. Carcinogenesis (2013) 0.89

Older individuals appear to acquire mitotically older colorectal cancers. J Pathol (2009) 0.88

Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice. J Transl Med (2008) 0.86

The gene expression profiles of induced pluripotent stem cells from individuals with childhood cerebral adrenoleukodystrophy are consistent with proposed mechanisms of pathogenesis. Stem Cell Res Ther (2012) 0.85

Is there any genetic instability in human cancer? DNA Repair (Amst) (2010) 0.83

Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations. J Cell Biochem (2010) 0.83

Numbers of mutations to different types of colorectal cancer. BMC Cancer (2005) 0.81

Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice. Carcinogenesis (2011) 0.80

Diethylstilbestrol effects and lymphomagenesis in Mlh1-deficient mice. Int J Cancer (2005) 0.80

Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors. PLoS One (2011) 0.80

Stability of colon stem cell methylation after neo-adjuvant therapy in a patient with attenuated familial adenomatous polyposis. BMC Gastroenterol (2005) 0.77

Direct measurements of human colon crypt stem cell niche genetic fidelity: the role of chance in non-darwinian mutation selection. Front Oncol (2013) 0.76

Mistakes make history: visualizing intestinal tectonics. Gastroenterology (2008) 0.75

Diffuse large B-cell lymphoma of germinal center and nongerminal center phenotypes presenting concurrently at the same anatomic site: intratumoral heterogeneity or composite lymphoma? Appl Immunohistochem Mol Morphol (2015) 0.75