Published in Mol Cell Biol on May 01, 2002
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet (2012) 2.94
Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation. Nucleic Acids Res (2007) 2.69
DNA methyltransferases: a novel target for prevention and therapy. Front Oncol (2014) 1.62
The relationship between hypomethylation and CpG island methylation in colorectal neoplasia. Am J Pathol (2003) 1.60
Effects of arsenic exposure on DNA methylation and epigenetic gene regulation. Epigenomics (2010) 1.56
Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline. Hum Mol Genet (2008) 1.28
Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia. J Clin Invest (2013) 1.19
Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells. Nucleic Acids Res (2004) 1.17
Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer. Ann Oncol (2008) 1.12
Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells. DNA Repair (Amst) (2009) 1.08
Aberrant DNA methylation in malignant melanoma. Melanoma Res (2010) 1.04
Current concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia. Front Oncol (2014) 0.97
Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma. Cancer Res (2012) 0.97
DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development. Epigenetics (2008) 0.92
Epigenetic mechanisms and genome stability. Clin Epigenetics (2011) 0.89
Insights into the role of DNA methylation in disease through the use of mouse models. Dis Model Mech (2010) 0.89
Opposing roles of Dnmt1 in early- and late-stage murine prostate cancer. Mol Cell Biol (2010) 0.87
Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet. PLoS One (2012) 0.83
Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice. Carcinogenesis (2011) 0.80
Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model. Urology (2013) 0.78
Overexpression of Ribosomal RNA in the Development of Human Cervical Cancer Is Associated with rDNA Promoter Hypomethylation. PLoS One (2016) 0.75
DNA Methylation, Nuclear Organization, and Cancer. Front Genet (2017) 0.75
Embryonic stem cells lacking the epigenetic regulator Cfp1 are hypersensitive to DNA-damaging agents and exhibit decreased Ape1/Ref-1 protein expression and endonuclease activity. DNA Repair (Amst) (2009) 0.75
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell (1992) 27.80
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell (1999) 25.75
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature (1998) 18.36
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet (1998) 13.27
CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A (1999) 13.02
Cancer epigenetics comes of age. Nat Genet (1999) 12.63
Simplified mammalian DNA isolation procedure. Nucleic Acids Res (1991) 12.56
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature (1993) 10.95
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66
MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res (2000) 9.30
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development (1996) 7.98
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet (1998) 7.52
Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Nat Genet (1998) 7.49
Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell (1991) 7.16
A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell (1992) 7.11
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat Genet (2001) 6.92
DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet (2000) 6.57
MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell (1997) 6.45
Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature (1999) 6.42
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nat Genet (1996) 6.06
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat Genet (2000) 5.72
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell (1995) 5.54
Methyl-directed repair of DNA base-pair mismatches in vitro. Proc Natl Acad Sci U S A (1983) 5.34
DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet (2000) 5.29
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet (2000) 5.09
Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. Science (1997) 5.05
The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res (1999) 4.74
DNA methylation in health and disease. Nat Rev Genet (2000) 4.58
Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis. Cell (1996) 4.47
Suppression of intestinal neoplasia by DNA hypomethylation. Cell (1995) 4.16
A modified and improved method for bisulphite based cytosine methylation analysis. Nucleic Acids Res (1996) 4.16
The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. Proc Natl Acad Sci U S A (1999) 4.13
Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc Natl Acad Sci U S A (1998) 3.90
Hypomethylation of DNA from benign and malignant human colon neoplasms. Science (1985) 3.72
Epigenetic patterns in the progression of esophageal adenocarcinoma. Cancer Res (2001) 3.70
CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. Cancer Res (1999) 3.66
DNA hypomethylation leads to elevated mutation rates. Nature (1998) 3.60
The puzzle of PCNA's many partners. Bioessays (2000) 3.54
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell (1995) 3.34
Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors. Cell (1989) 3.31
Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes. Genes Dev (1996) 3.29
PCNA binding through a conserved motif. Bioessays (1998) 3.23
Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res (1988) 3.22
Meiotic pachytene arrest in MLH1-deficient mice. Cell (1996) 3.18
DNA methylation and chromatin modification. Curr Opin Genet Dev (1999) 3.14
Association between CpG island methylation and microsatellite instability in colorectal cancer. Cancer Res (1997) 3.09
Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene. Cell (2001) 3.05
DNA methylation and genetic instability in colorectal cancer cells. Proc Natl Acad Sci U S A (1997) 3.03
Conversion of the lac repressor into an allosterically regulated transcriptional activator for mammalian cells. Mol Cell Biol (1990) 3.00
Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability. Nat Med (1998) 2.91
Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma. Cancer Res (2000) 2.73
Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Nat Genet (1999) 2.62
MSH2 deficient mice are viable and susceptible to lymphoid tumours. Nat Genet (1995) 2.49
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell (1997) 2.46
Cell lineage-specific undermethylation of mouse repetitive DNA. Nature (1984) 2.43
Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer. Proc Natl Acad Sci U S A (2000) 2.38
Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat Genet (1998) 2.32
One role for DNA methylation in vertebrate cells is strand discrimination in mismatch repair. Proc Natl Acad Sci U S A (1985) 2.19
DNA loop repair by human cell extracts. Science (1994) 2.19
High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer. Proc Natl Acad Sci U S A (1991) 2.07
MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1. Proc Natl Acad Sci U S A (1999) 1.99
Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis. Genes Dev (1999) 1.95
Increased cytosine DNA-methyltransferase activity during colon cancer progression. J Natl Cancer Inst (1993) 1.94
Developmental differences in methylation of human Alu repeats. Mol Cell Biol (1993) 1.79
Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells. Nucleic Acids Res (2000) 1.73
DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture. J Biol Chem (1986) 1.72
Identification of critical CpG sites for repression of L1 transcription by DNA methylation. Gene (1997) 1.71
Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase. Proc Natl Acad Sci U S A (1997) 1.70
Proposed roles for DNA methylation in Alu transcriptional repression and mutational inactivation. Nucleic Acids Res (1993) 1.66
Control of V(D)J recombinational accessibility of the D beta 1 gene segment at the TCR beta locus by a germline promoter. Immunity (1999) 1.57
Rotavirus open cores catalyze 5'-capping and methylation of exogenous RNA: evidence that VP3 is a methyltransferase. Virology (1999) 1.51
Promoter-region hypermethylation and gene silencing in human cancer. Curr Top Microbiol Immunol (2000) 1.38
Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice. Cancer Res (1999) 1.34
Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis. J Biol Chem (1995) 1.28
Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide. Proc Natl Acad Sci U S A (1997) 1.19
Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells. Mol Cell Biol (2001) 1.17
Inhibition of DNA methyltransferase inhibits DNA replication. J Biol Chem (2000) 1.06
Mouse model systems to study multistep tumorigenesis. Cold Spring Harb Symp Quant Biol (1994) 1.06
Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation. Proc Natl Acad Sci U S A (1996) 1.05
Mismatch repair deficiency and CpG island hypermethylation in sporadic colon adenocarcinomas. Cancer Epidemiol Biomarkers Prev (2001) 0.92
Inversions produced during V(D)J rearrangement at IgH, the immunoglobulin heavy-chain locus. Mol Cell Biol (1995) 0.89
DNA methylator and mismatch repair phenotypes are not mutually exclusive in colorectal cancer cell lines. Oncogene (2000) 0.86
Transcriptional silencing of human Alu sequences and inhibition of protein binding in the box B regulatory elements by 5'-CG-3' methylation. FEBS Lett (1995) 0.81
Dynamic interrelationships between DNA replication, methylation, and repair. Am J Hum Genet (1997) 0.81
Use of lac activator proteins for regulated expression of oncogenes. Methods Enzymol (1995) 0.76
Mouse models in DNA-methylation research. Curr Top Microbiol Immunol (2000) 0.76
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med (2013) 19.87
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell (2010) 16.12
Integrated genomic characterization of endometrial carcinoma. Nature (2013) 14.29
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet (2006) 13.63
The somatic genomic landscape of glioblastoma. Cell (2013) 11.73
Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol (2012) 10.87
Epigenetic stem cell signature in cancer. Nat Genet (2006) 9.62
Pan-cancer patterns of somatic copy number alteration. Nat Genet (2013) 7.73
Analysis of repetitive element DNA methylation by MethyLight. Nucleic Acids Res (2005) 6.49
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res (2010) 6.03
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains. Nat Genet (2011) 5.70
Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science (2012) 4.92
Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Res (2011) 4.84
Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis. J Mol Diagn (2006) 4.68
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97
Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium. J Mol Cell Cardiol (2002) 3.79
Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol (2002) 3.61
DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One (2007) 3.30
Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen. Cancer Res (2004) 3.23
Interplay between the cancer genome and epigenome. Cell (2013) 3.05
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med (2015) 3.00
Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun (2013) 2.94
Low-level microsatellite instability in most colorectal carcinomas. Cancer Res (2002) 2.87
Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns. Hum Mol Genet (2009) 2.85
Cigarette smoking and colorectal cancer risk by molecularly defined subtypes. J Natl Cancer Inst (2010) 2.38
Low-level processing of Illumina Infinium DNA Methylation BeadArrays. Nucleic Acids Res (2013) 2.19
Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening. Cancer Epidemiol Biomarkers Prev (2008) 2.12
Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice. Cancer Prev Res (Phila) (2008) 2.04
DNA methylation as a biomarker for cardiovascular disease risk. PLoS One (2010) 2.04
Bis-SNP: combined DNA methylation and SNP calling for Bisulfite-seq data. Genome Biol (2012) 2.02
Breast cancer DNA methylation profiles in cancer cells and tumor stroma: association with HER-2/neu status in primary breast cancer. Cancer Res (2006) 1.99
Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers. Proc Natl Acad Sci U S A (2009) 1.98
Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog (2010) 1.94
A comparison of cluster analysis methods using DNA methylation data. Bioinformatics (2004) 1.94
Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling. PLoS One (2009) 1.90
Methylation reveals a niche: stem cell succession in human colon crypts. Oncogene (2002) 1.88
Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors. Cancer Res (2004) 1.82
DNA hypomethylation and ovarian cancer biology. Cancer Res (2004) 1.75
Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice. Cancer Res (2002) 1.73
Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun (2013) 1.73
In vitro mutation artifacts after formalin fixation and error prone translesion synthesis during PCR. BMC Clin Pathol (2004) 1.71
The landscape of microsatellite instability in colorectal and endometrial cancer genomes. Cell (2013) 1.68
DNA methylation profiles of ovarian epithelial carcinoma tumors and cell lines. PLoS One (2010) 1.65
Sensitive detection of DNA methylation. Ann N Y Acad Sci (2003) 1.65
Hypomethylation and hypermethylation of DNA in Wilms tumors. Oncogene (2002) 1.59
Pretumor progression: clonal evolution of human stem cell populations. Am J Pathol (2004) 1.57
Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology (2007) 1.56
The fuzzy math of solid tumor stem cells: a perspective. Cancer Res (2007) 1.56
Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm. PLoS One (2007) 1.55
Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. Cancer Res (2006) 1.52
Enhanced stem cell survival in familial adenomatous polyposis. Am J Pathol (2004) 1.51
Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells. Stem Cells (2010) 1.50
Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue. Cancer Res (2010) 1.47
Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet (2012) 1.47
Discovery of multi-dimensional modules by integrative analysis of cancer genomic data. Nucleic Acids Res (2012) 1.46
MethyLight. Methods Mol Biol (2009) 1.45
Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine. Oncotarget (2013) 1.44
DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight. Nucleic Acids Res (2008) 1.42
An epidemiologic and genomic investigation into the obesity paradox in renal cell carcinoma. J Natl Cancer Inst (2013) 1.42
The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair (Amst) (2002) 1.41
The stem cell population of the human colon crypt: analysis via methylation patterns. PLoS Comput Biol (2007) 1.38
Distinct methylation profiles of glioma subtypes. Int J Cancer (2003) 1.38
Hierarchical clustering of lung cancer cell lines using DNA methylation markers. Cancer Epidemiol Biomarkers Prev (2002) 1.38
Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines. Cancer Res (2008) 1.36
Sex differential in methylation patterns of selected genes in Singapore Chinese. Hum Genet (2005) 1.35
DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis. Lab Invest (2007) 1.34
Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function. Circulation (2002) 1.32
Correlation of pathologic features with CpG island methylator phenotype (CIMP) by quantitative DNA methylation analysis in colorectal carcinoma. Am J Surg Pathol (2006) 1.29
Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization. Cancer Res (2012) 1.28
Counting human somatic cell replications: methylation mirrors endometrial stem cell divisions. Proc Natl Acad Sci U S A (2005) 1.24
Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer. Mol Cancer (2008) 1.24
Inferring relative numbers of human leucocyte genome replications. Br J Haematol (2008) 1.22
Combined bisulfite restriction analysis (COBRA). Methods Mol Biol (2002) 1.20
Unregulated smooth-muscle myosin in human intestinal neoplasia. Proc Natl Acad Sci U S A (2008) 1.20
Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels. Hum Genet (2002) 1.19
Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells. Nucleic Acids Res (2004) 1.17
A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates. BMC Cancer (2010) 1.16
Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer. PLoS One (2012) 1.14
The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification. Int J Cancer (2009) 1.14
Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma. Mol Cancer (2007) 1.14
DNA methylation profile of 28 potential marker loci in malignant mesothelioma. Lung Cancer (2007) 1.11
Many colorectal cancers are "flat" clonal expansions. Cell Cycle (2009) 1.10
Ovarian cancer early detection claims are biased. Clin Cancer Res (2008) 1.10