A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.

PubWeight™: 2.59‹?› | Rank: Top 1%

🔗 View Article (PMID 16571763)

Published in J Neurosci on March 29, 2006

Authors

Zhi-Ye Zhuang1, Yeong-Ray Wen, De-Ren Zhang, Tiziana Borsello, Christophe Bonny, Gary R Strichartz, Isabelle Decosterd, Ru-Rong Ji

Author Affiliations

1: Department of Anesthesiology, Pain Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Articles citing this

(truncated to the top 100)

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. Nat Med (2008) 3.83

MAP kinase and pain. Brain Res Rev (2008) 3.75

p38 MAPK, microglial signaling, and neuropathic pain. Mol Pain (2007) 2.72

JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. J Neurosci (2009) 2.64

Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain. J Neurosci (2007) 2.44

Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. Pharmacol Ther (2010) 2.27

Glia and pain: is chronic pain a gliopathy? Pain (2013) 2.21

Neuron-glia crosstalk gets serious: role in pain hypersensitivity. Curr Opin Anaesthesiol (2008) 1.99

Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase. J Biol Chem (2007) 1.91

Kinase cascades and ligand-directed signaling at the kappa opioid receptor. Psychopharmacology (Berl) (2010) 1.90

Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine. Brain Behav Immun (2006) 1.88

Targeting astrocyte signaling for chronic pain. Neurotherapeutics (2010) 1.88

Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury-induced neuropathic pain in rats. Br J Pharmacol (2009) 1.82

Long-term potentiation in spinal nociceptive pathways as a novel target for pain therapy. Mol Pain (2011) 1.66

Supraspinal glial-neuronal interactions contribute to descending pain facilitation. J Neurosci (2008) 1.61

Emerging roles of resolvins in the resolution of inflammation and pain. Trends Neurosci (2011) 1.60

Emerging targets in neuroinflammation-driven chronic pain. Nat Rev Drug Discov (2014) 1.57

Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats. Exp Neurol (2008) 1.46

Intracellular signaling in primary sensory neurons and persistent pain. Neurochem Res (2008) 1.44

Retracted Comparison of central versus peripheral delivery of pregabalin in neuropathic pain states. Mol Pain (2012) 1.41

Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway. Neuron Glia Biol (2006) 1.41

Glial cells and chronic pain. Neuroscientist (2010) 1.32

Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing. J Exp Med (2007) 1.32

Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. J Formos Med Assoc (2011) 1.24

The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition. Pain (2010) 1.22

Activation of JNK pathway in persistent pain. Neurosci Lett (2008) 1.19

Stress exacerbates neuropathic pain via glucocorticoid and NMDA receptor activation. Brain Behav Immun (2009) 1.18

Chronic-pain-associated astrocytic reaction in the spinal cord dorsal horn of human immunodeficiency virus-infected patients. J Neurosci (2012) 1.15

Crosstalk between spinal astrocytes and neurons in nerve injury-induced neuropathic pain. PLoS One (2009) 1.14

A p38 mitogen-activated protein kinase-dependent mechanism of disinhibition in spinal synaptic transmission induced by tumor necrosis factor-alpha. J Neurosci (2010) 1.10

Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons. Pain (2013) 1.10

Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain. Mol Pain (2010) 1.09

Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1. Glia (2010) 1.09

Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors. Mol Pain (2009) 1.08

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. Brain (2014) 1.08

Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain. J Neuroinflammation (2011) 1.02

Role of spinal cord glia in the central processing of peripheral pain perception. Neurogastroenterol Motil (2010) 1.01

Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia. J Neurochem (2010) 1.00

Matrix metalloprotease regulation of neuropathic pain. Trends Pharmacol Sci (2009) 0.99

Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats. Mol Brain (2012) 0.99

EphrinBs regulate D-serine synthesis and release in astrocytes. J Neurosci (2010) 0.96

Contribution of microglia and astrocytes to the central sensitization, inflammatory and neuropathic pain in the juvenile rat. Mol Pain (2012) 0.96

CXCL12 in astrocytes contributes to bone cancer pain through CXCR4-mediated neuronal sensitization and glial activation in rat spinal cord. J Neuroinflammation (2014) 0.96

TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling. Pain (2014) 0.95

Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model. Exp Neurol (2009) 0.94

The effect of intrathecal administration of glial activation inhibitors on dorsal horn BDNF overexpression and hind paw mechanical allodynia in spinal nerve ligated rats. J Neural Transm (Vienna) (2011) 0.91

Emerging role of astroglia in pain hypersensitivity. Jpn Dent Sci Rev (2010) 0.91

Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9. Mol Pain (2012) 0.91

Peripheral noxious stimulation reduces withdrawal threshold to mechanical stimuli after spinal cord injury: role of tumor necrosis factor alpha and apoptosis. Pain (2014) 0.90

Additive antinociceptive effects of a combination of vitamin C and vitamin E after peripheral nerve injury. PLoS One (2011) 0.90

Pain in experimental autoimmune encephalitis: a comparative study between different mouse models. J Neuroinflammation (2012) 0.89

Neutrophils Infiltrate the Spinal Cord Parenchyma of Rats with Experimental Diabetic Neuropathy. J Diabetes Res (2017) 0.89

Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain. J Neuroinflammation (2012) 0.89

Analgesic effect of acupuncture is mediated via inhibition of JNK activation in astrocytes after spinal cord injury. PLoS One (2013) 0.88

Activation of c-jun N-terminal kinase in spinal cord contributes to breast cancer induced bone pain in rats. Mol Brain (2012) 0.88

NFκB-mediated CXCL1 production in spinal cord astrocytes contributes to the maintenance of bone cancer pain in mice. J Neuroinflammation (2014) 0.87

DNIC-mediated analgesia produced by a supramaximal electrical or a high-dose formalin conditioning stimulus: roles of opioid and alpha2-adrenergic receptors. J Biomed Sci (2010) 0.86

Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase. Mol Pain (2015) 0.86

Curcumin could prevent the development of chronic neuropathic pain in rats with peripheral nerve injury. Curr Ther Res Clin Exp (2013) 0.86

Expression genetics identifies spinal mechanisms supporting formalin late phase behaviors. Mol Pain (2010) 0.86

Analgesic Effect of Electroacupuncture in a Mouse Fibromyalgia Model: Roles of TRPV1, TRPV4, and pERK. PLoS One (2015) 0.86

Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury. Mol Pain (2012) 0.85

SIP30 is regulated by ERK in peripheral nerve injury-induced neuropathic pain. J Biol Chem (2009) 0.85

Spinal astrogliosis in pain models: cause and effects. Cell Mol Neurobiol (2009) 0.85

Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPARγ mechanisms. Pain (2015) 0.85

Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice. Neuroscience (2013) 0.83

JNK is activated but does not mediate hippocampal neuronal apoptosis in experimental neonatal pneumococcal meningitis. Neurobiol Dis (2008) 0.83

Cannabinoid agonists inhibit neuropathic pain induced by brachial plexus avulsion in mice by affecting glial cells and MAP kinases. PLoS One (2011) 0.83

Role of JNK isoforms in the development of neuropathic pain following sciatic nerve transection in the mouse. Mol Pain (2012) 0.83

The impact of JNK inhibitor D-JNKI-1 in a murine model of chronic colitis induced by dextran sulfate sodium. J Inflamm Res (2013) 0.83

Sensitization of P2X3 receptors by cystathionine β-synthetase mediates persistent pain hypersensitivity in a rat model of lumbar disc herniation. Mol Pain (2015) 0.82

Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells. Biochim Biophys Acta (2013) 0.82

Identification of lncRNA expression profile in the spinal cord of mice following spinal nerve ligation-induced neuropathic pain. Mol Pain (2015) 0.82

Combining ketamine with astrocytic inhibitor as a potential analgesic strategy for neuropathic pain ketamine, astrocytic inhibitor and pain. Mol Pain (2010) 0.82

The activation of transient receptor potential vanilloid receptor subtype 1 by capsaicin without extracellular Ca2+ is involved in the mechanism of distinct substance P release in cultured rat dorsal root ganglion neurons. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.82

Painful nerve injury upregulates thrombospondin-4 expression in dorsal root ganglia. J Neurosci Res (2014) 0.82

Spinal glia modulate both adaptive and pathological processes. Brain Behav Immun (2009) 0.82

Delta-opioid receptor analgesia is independent of microglial activation in a rat model of neuropathic pain. PLoS One (2014) 0.81

Extracellular signal-regulated kinase (ERK) activation is required for itch sensation in the spinal cord. Mol Brain (2014) 0.81

Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation. Mol Pain (2012) 0.81

Knockout of the c-Jun N-terminal Kinase 2 aggravates the development of mild chronic dextran sulfate sodium colitis independently of expression of intestinal cytokines TNFα, TGFB1, and IL-6. J Inflamm Res (2013) 0.81

Inhibiting spinal neuron-astrocytic activation correlates with synergistic analgesia of dexmedetomidine and ropivacaine. PLoS One (2014) 0.80

Molecular signaling underlying bulleyaconitine A (BAA)-induced microglial expression of prodynorphin. Sci Rep (2017) 0.80

Role of c-Jun N-terminal kinase (JNK) activation in micturition reflexes in cyclophosphamide (CYP)-induced cystitis in female rats. J Mol Neurosci (2014) 0.80

Development of an intracellularly acting inhibitory peptide selective for PKN. Biochem J (2009) 0.80

Spinal release of tumour necrosis factor activates c-Jun N-terminal kinase and mediates inflammation-induced hypersensitivity. Eur J Pain (2014) 0.80

Activation of different signals identified with glia cells contribute to the progression of hyperalgesia. Cell Mol Neurobiol (2012) 0.79

PD98059 Influences Immune Factors and Enhances Opioid Analgesia in Model of Neuropathy. PLoS One (2015) 0.79

Gp120 in the pathogenesis of human immunodeficiency virus-associated pain. Ann Neurol (2014) 0.79

Contributions of p38 and ERK to the antinociceptive effects of TGF-β1 in chronic constriction injury-induced neuropathic rats. J Headache Pain (2016) 0.79

Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice. Mol Pain (2012) 0.79

Microvesicles shed from microglia activated by the P2X7-p38 pathway are involved in neuropathic pain induced by spinal nerve ligation in rats. Purinergic Signal (2016) 0.78

Glial contributions to visceral pain: implications for disease etiology and the female predominance of persistent pain. Transl Psychiatry (2016) 0.78

Microglia in the spinal cord and neuropathic pain. J Diabetes Investig (2015) 0.77

Involvement of phosphatase and tensin homolog deleted from chromosome 10 in rodent model of neuropathic pain. J Neuroinflammation (2015) 0.77

Intrathecal lamotrigine attenuates mechanical allodynia and suppresses microglial and astrocytic activation in a rat model of spinal nerve ligation. Yonsei Med J (2013) 0.77

Pulsed radiofrequency reduced complete Freund's adjuvant-induced mechanical hyperalgesia via the spinal c-Jun N-terminal kinase pathway. Cell Mol Neurobiol (2013) 0.77

Leukotriene enhances NMDA-induced inward currents in dorsal horn neurons of the rat spinal cord after peripheral nerve injury. Mol Pain (2015) 0.77

Functional Selectivity of Kappa Opioid Receptor Agonists in Peripheral Sensory Neurons. J Pharmacol Exp Ther (2015) 0.77

Inhibition of the spinal astrocytic JNK/MCP-1 pathway activation correlates with the analgesic effects of tanshinone IIA sulfonate in neuropathic pain. J Neuroinflammation (2015) 0.77

Articles by these authors

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Nat Med (2010) 4.23

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. Nat Med (2008) 3.83

MAP kinase and pain. Brain Res Rev (2008) 3.75

Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. J Neurosci (2008) 3.73

p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci (2003) 3.72

ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain (2005) 3.59

A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat Med (2003) 3.45

Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein. Proc Natl Acad Sci U S A (2010) 2.86

JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. J Neurosci (2009) 2.64

VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron (2010) 2.54

Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J Neurosci (2004) 2.41

Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. J Neurosci (2004) 2.33

Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. Pharmacol Ther (2010) 2.27

Nociceptors are interleukin-1beta sensors. J Neurosci (2008) 2.26

Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury. J Neurosci (2005) 2.16

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex. Nat Med (2011) 2.11

Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn. Mol Cell Neurosci (2003) 2.02

Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine. Brain Behav Immun (2006) 1.88

Targeting astrocyte signaling for chronic pain. Neurotherapeutics (2010) 1.88

Toll-like receptor 7 mediates pruritus. Nat Neurosci (2010) 1.86

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. FASEB J (2012) 1.86

Reduction of postincisional allodynia by subcutaneous bupivacaine: findings with a new model in the hairy skin of the rat. Anesthesiology (2005) 1.80

Assessment and analysis of mechanical allodynia-like behavior induced by spared nerve injury (SNI) in the mouse. Pain (2006) 1.79

Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity. J Neurosci (2002) 1.78

A novel tool for the assessment of pain: validation in low back pain. PLoS Med (2009) 1.75

Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. Nat Neurosci (2003) 1.75

DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties. J Neurosci (2004) 1.64

Emerging role of Toll-like receptors in the control of pain and itch. Neurosci Bull (2012) 1.60

The role of sodium channels in chronic inflammatory and neuropathic pain. J Pain (2006) 1.59

Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block. Anesthesiology (2003) 1.59

Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. J Neurosci (2011) 1.58

Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure. Diabetes (2004) 1.55

Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury. Nat Med (2003) 1.54

The effect of high and low frequency electroacupuncture in pain after lower abdominal surgery. Pain (2002) 1.52

Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain. J Neurosci (2006) 1.51

Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia. J Neurosci (2007) 1.50

Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. J Neurosci (2002) 1.47

Hsp27 upregulation and phosphorylation is required for injured sensory and motor neuron survival. Neuron (2002) 1.46

c-Fos and pERK, which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury? Open Pain J (2009) 1.46

Intracellular signaling in primary sensory neurons and persistent pain. Neurochem Res (2008) 1.44

TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. J Clin Invest (2012) 1.44

Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord. Pain (2005) 1.41

Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway. Neuron Glia Biol (2006) 1.41

Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery. Mol Pain (2009) 1.39

Long-term opioid treatment in Behçet's syndrome with intractable abdominal pain--a case report. Acta Anaesthesiol Sin (2002) 1.39

Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch. Anesthesiology (2020) 1.38

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats. Brain (2011) 1.34

Glial cells and chronic pain. Neuroscientist (2010) 1.32

TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2. Pain (2010) 1.31

Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. J Neurosci (2008) 1.30

Do glial cells control pain? Neuron Glia Biol (2007) 1.30

Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons. J Neurosci (2005) 1.29

Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model. Anesthesiology (2007) 1.29

Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. J Neurosci (2011) 1.27

Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. Eur J Neurosci (2004) 1.27

GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap. Eur J Neurosci (2002) 1.25

Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. J Formos Med Assoc (2011) 1.24

Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats. Pain (2003) 1.22

The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition. Pain (2010) 1.22

Activation of JNK pathway in persistent pain. Neurosci Lett (2008) 1.19

An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo. J Biol Chem (2013) 1.18

Microglia and spinal cord synaptic plasticity in persistent pain. Neural Plast (2013) 1.17

D-JNKI1, a cell-penetrating c-Jun-N-terminal kinase inhibitor, protects against cell death in severe cerebral ischemia. Stroke (2004) 1.16

Transcriptional and functional profiles of voltage-gated Na(+) channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain. Mol Cell Neurosci (2007) 1.16

Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals. Mol Pharmacol (2006) 1.15

Blocking c-Jun-N-terminal kinase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicity. Hear Res (2006) 1.14

Antidepressants for the treatment of chronic pain. Drugs (2008) 1.14

Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury. Mol Pain (2009) 1.13

Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity. J Neurosci (2008) 1.13

A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia. J Clin Invest (2013) 1.13

Activation of extracellular signal-regulated kinase in the anterior cingulate cortex contributes to the induction and expression of affective pain. J Neurosci (2009) 1.13

Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion. J Clin Invest (2014) 1.12

The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models. Pain (2002) 1.12

Activation of p38 mitogen-activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia. Anesthesiology (2009) 1.12

Organization of intralaminar and translaminar neuronal connectivity in the superficial spinal dorsal horn. J Neurosci (2009) 1.11

Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases. FASEB J (2008) 1.10

Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons. Pain (2013) 1.10

Distinct ASIC currents are expressed in rat putative nociceptors and are modulated by nerve injury. J Physiol (2006) 1.10

Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. J Neurosci (2005) 1.10

Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1. Glia (2010) 1.09

Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels. J Neurosci (2013) 1.09

Induction of apoptosis in human corneal and HeLa cells by mutated BIGH3. Invest Ophthalmol Vis Sci (2003) 1.08

A peptide inhibitor of c-Jun NH2-terminal kinase reduces myocardial ischemia-reperfusion injury and infarct size in vivo. Am J Physiol Heart Circ Physiol (2006) 1.08

JNK inhibition and inflammation after cerebral ischemia. Brain Behav Immun (2009) 1.08

Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. Glia (2012) 1.08

Dissociative amnesia after general anesthesia--a case report. Acta Anaesthesiol Sin (2002) 1.04

Local injection of a selective endothelin-B receptor agonist inhibits endothelin-1-induced pain-like behavior and excitation of nociceptors in a naloxone-sensitive manner. J Neurosci (2002) 1.03

Induction of CB1 cannabinoid receptor by inflammation in primary afferent neurons facilitates antihyperalgesic effect of peripheral CB1 agonist. Pain (2006) 1.03