Published in J Neurochem on March 29, 2006
Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol (2008) 3.22
Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells. Nat Biotechnol (2012) 2.33
Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol (2008) 1.59
Blood-brain barrier modeling with co-cultured neural progenitor cell-derived astrocytes and neurons. J Neurochem (2011) 1.51
A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources. Sci Rep (2014) 1.38
Differentiating embryonic neural progenitor cells induce blood-brain barrier properties. J Neurochem (2007) 1.29
Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling. Stem Cell Reports (2014) 1.25
A genomic comparison of in vivo and in vitro brain microvascular endothelial cells. J Cereb Blood Flow Metab (2007) 1.02
Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro. PLoS One (2013) 0.98
Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood-brain barrier disruption. J Cell Sci (2011) 0.98
Evidence for differential changes of junctional complex proteins in murine neurocysticercosis dependent upon CNS vasculature. Brain Res (2007) 0.96
Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier. BMC Neurosci (2013) 0.94
A new method for selection of angular aqueous plexus cells from porcine eyes: a model for Schlemm's canal endothelium. Invest Ophthalmol Vis Sci (2010) 0.91
Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nat Commun (2015) 0.91
In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use. J Cereb Blood Flow Metab (2016) 0.90
KLF4 is a key determinant in the development and progression of cerebral cavernous malformations. EMBO Mol Med (2015) 0.89
Novel 3D analysis of Claudin-5 reveals significant endothelial heterogeneity among CNS microvessels. Microvasc Res (2012) 0.88
Modeling the blood-brain barrier using stem cell sources. Fluids Barriers CNS (2013) 0.86
Setting-up an in vitro model of rat blood-brain barrier (BBB): a focus on BBB impermeability and receptor-mediated transport. J Vis Exp (2014) 0.85
Effect of cAMP derivates on assembly and maintenance of tight junctions in human umbilical vein endothelial cells. BMC Cell Biol (2010) 0.84
Rapid endocytosis of interleukin-15 by cerebral endothelia. J Neurochem (2011) 0.83
Optimization of endothelial cell growth in a murine in vitro blood-brain barrier model. Biotechnol J (2011) 0.81
Mouse MCP1 C-terminus inhibits human MCP1-induced chemotaxis and BBB compromise. J Neurochem (2011) 0.80
Glucocorticoids and endothelial cell barrier function. Cell Tissue Res (2013) 0.78
P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy. Cell Res (2015) 0.78
CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events. PLoS One (2014) 0.78
An Isogenic Blood-Brain Barrier Model Comprising Brain Endothelial Cells, Astrocytes and Neurons Derived from Human Induced Pluripotent Stem Cells. J Neurochem (2016) 0.78
Identifying blood-brain-barrier selective single-chain antibody fragments. Biotechnol J (2014) 0.77
A Triple Culture Model of the Blood-Brain Barrier Using Porcine Brain Endothelial cells, Astrocytes and Pericytes. PLoS One (2015) 0.77
Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown. Stroke (2016) 0.77
Interplay between VEGF and Nrf2 regulates angiogenesis due to intracranial venous hypertension. Sci Rep (2016) 0.75
Nitric oxide from brain microvascular endothelial cells may initiate the compensatory response to mild hypoxia of astrocytes in a hypoxia-inducible factor-1α dependent manner. Am J Transl Res (2016) 0.75
P-glycoprotein mediated efflux limits the transport of the novel anti-Parkinson's disease candidate drug FLZ across the physiological and PD pathological in vitro BBB models. PLoS One (2014) 0.75
Accelerated differentiation of human induced pluripotent stem cells to blood-brain barrier endothelial cells. Fluids Barriers CNS (2017) 0.75
Asn-Gly-Arg-modified polydopamine-coated nanoparticles for dual-targeting therapy of brain glioma in rats. Oncotarget (2016) 0.75
Corticosterone primes the neuroinflammatory response to Gulf War Illness-relevant organophosphates independently of acetylcholinesterase inhibition. J Neurochem (2017) 0.75
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science (2011) 3.52
Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells. Nat Biotechnol (2012) 2.33
Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each other. Biochemistry (2005) 1.81
Macrophages and neurodegeneration. Brain Res Brain Res Rev (2005) 1.64
Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling. FASEB J (2007) 1.63
Blood-brain barrier transport of therapeutics via receptor-mediation. Pharm Res (2007) 1.54
Blood-brain barrier modeling with co-cultured neural progenitor cell-derived astrocytes and neurons. J Neurochem (2011) 1.51
Radical changes in multiple sclerosis pathogenesis. Biochim Biophys Acta (2010) 1.40
Pluriformity of inflammation in multiple sclerosis shown by ultra-small iron oxide particle enhancement. Brain (2008) 1.38
A decade of yeast surface display technology: where are we now? Comb Chem High Throughput Screen (2008) 1.37
Diapedesis of monocytes is associated with MMP-mediated occludin disappearance in brain endothelial cells. FASEB J (2006) 1.34
Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration? Mitochondrion (2010) 1.34
Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis. J Exp Med (2004) 1.34
The blood-brain barrier and its role in immune privilege in the central nervous system. J Neuropathol Exp Neurol (2003) 1.32
Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity. J Immunol (2006) 1.30
Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy. Antioxid Redox Signal (2011) 1.29
Differentiating embryonic neural progenitor cells induce blood-brain barrier properties. J Neurochem (2007) 1.29
Comparison of SPIO and USPIO for in vitro labeling of human monocytes: MR detection and cell function. Radiology (2007) 1.28
A beta-lactam antibiotic dampens excitotoxic inflammatory CNS damage in a mouse model of multiple sclerosis. PLoS One (2008) 1.24
Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes. Acta Neuropathol (2012) 1.22
Interferon-beta prevents cytokine-induced neutrophil infiltration and attenuates blood-brain barrier disruption. J Cereb Blood Flow Metab (2003) 1.21
The blood-brain barrier in cortical multiple sclerosis lesions. J Neuropathol Exp Neurol (2007) 1.20
Retinoic acid induces blood-brain barrier development. J Neurosci (2013) 1.17
RhoA activation promotes transendothelial migration of monocytes via ROCK. J Leukoc Biol (2003) 1.16
Intracerebral dendritic cells critically modulate encephalitogenic versus regulatory immune responses in the CNS. J Neurosci (2009) 1.16
Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation. Epilepsia (2012) 1.15
Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis. Neurobiol Dis (2005) 1.14
Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions. J Neuroimmunol (2003) 1.14
Mining a yeast library for brain endothelial cell-binding antibodies. Nat Methods (2007) 1.13
Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation. J Neuroinflammation (2012) 1.09
Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis. Ann Neurol (2009) 1.08
Comparative whole-grain intake of British adults in 1986-7 and 2000-1. Br J Nutr (2007) 1.07
MRI of monocyte infiltration in an animal model of neuroinflammation using SPIO-labeled monocytes or free USPIO. J Cereb Blood Flow Metab (2007) 1.07
Ultrasound and microbubble-induced intra- and intercellular bioeffects in primary endothelial cells. Ultrasound Med Biol (2009) 1.07
The use of scFv-displaying yeast in mammalian cell surface selections. J Immunol Methods (2005) 1.07
MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis. J Neurosci (2013) 1.07
Development of GFP-based biosensors possessing the binding properties of antibodies. Proc Natl Acad Sci U S A (2009) 1.06
SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function. Am J Physiol Heart Circ Physiol (2007) 1.05
Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathology. Brain Res Rev (2007) 1.04
Basement membrane proteins in multiple sclerosis-associated inflammatory cuffs: potential role in influx and transport of leukocytes. J Neuropathol Exp Neurol (2005) 1.03
αB-crystallin: a novel regulator of breast cancer metastasis to the brain. Clin Cancer Res (2013) 1.02
Extensive extracellular matrix depositions in active multiple sclerosis lesions. Neurobiol Dis (2006) 1.02
A genomic comparison of in vivo and in vitro brain microvascular endothelial cells. J Cereb Blood Flow Metab (2007) 1.02
Production of soluble and active transferrin receptor-targeting single-chain antibody using Saccharomyces cerevisiae. Pharm Res (2006) 1.01
A novel high-throughput screen reveals yeast genes that increase secretion of heterologous proteins. Appl Environ Microbiol (2006) 1.00
Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions. Free Radic Biol Med (2010) 1.00
Functions of lipid raft membrane microdomains at the blood-brain barrier. J Mol Med (Berl) (2009) 0.99
Secretion and surface display of green fluorescent protein using the yeast Saccharomyces cerevisiae. Biotechnol Prog (2005) 0.99
Soluble helminth products suppress clinical signs in murine experimental autoimmune encephalomyelitis and differentially modulate human dendritic cell activation. Mol Immunol (2012) 0.98
Macrophages migrate in an activation-dependent manner to chemokines involved in neuroinflammation. J Neuroinflammation (2014) 0.97
Blood-brain barrier genomics and proteomics: elucidating phenotype, identifying disease targets and enabling brain drug delivery. Drug Discov Today (2006) 0.97
Leukemia inhibitory factor modulates production of inflammatory mediators and myelin phagocytosis by macrophages. J Neuroimmunol (2008) 0.97
Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastoma. FASEB J (2012) 0.95
Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier. J Immunol (2008) 0.95
Tumor infiltrating macrophages reduce development of peritoneal colorectal carcinoma metastases. Cancer Lett (2008) 0.95
Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex. Acta Neuropathol (2012) 0.95
Flavonoids inhibit myelin phagocytosis by macrophages; a structure-activity relationship study. Biochem Pharmacol (2003) 0.93
Regulatory T cells exhibit enhanced migratory characteristics, a feature impaired in patients with multiple sclerosis. Eur J Immunol (2010) 0.92
Antioxidative defense mechanisms controlled by Nrf2: state-of-the-art and clinical perspectives in neurodegenerative diseases. Arch Toxicol (2014) 0.92
A yeast display immunoprecipitation method for efficient isolation and characterization of antigens. J Immunol Methods (2008) 0.92
The extracellular matrix in multiple sclerosis pathology. J Neurochem (2007) 0.91
Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier. J Neuroinflammation (2012) 0.91
Pericyte-endothelial cell interaction increases MMP-9 secretion at the blood-brain barrier in vitro. Brain Res (2007) 0.90
T lymphocytes impair P-glycoprotein function during neuroinflammation. J Autoimmun (2009) 0.90
NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesions. Free Radic Biol Med (2006) 0.90
P-glycoprotein acts as an immunomodulator during neuroinflammation. PLoS One (2009) 0.90
Murine in vitro model of the blood-brain barrier for evaluating drug transport. Eur J Pharm Sci (2010) 0.90
Surgery-induced reactive oxygen species enhance colon carcinoma cell binding by disrupting the liver endothelial cell lining. Gut (2011) 0.90
Brain endothelial barrier passage by monocytes is controlled by the endothelin system. J Neurochem (2011) 0.89
Dynamics and fate of USPIO in the central nervous system in experimental autoimmune encephalomyelitis. NMR Biomed (2010) 0.89
Characteristics of dyshoric capillary cerebral amyloid angiopathy. J Neuropathol Exp Neurol (2010) 0.89
The NR1 subunit of NMDA receptor regulates monocyte transmigration through the brain endothelial cell barrier. J Neurochem (2010) 0.88
Neuroinflammation and blood-brain barrier changes in capillary amyloid angiopathy. Neurodegener Dis (2012) 0.87
Concise review: tissue-specific microvascular endothelial cells derived from human pluripotent stem cells. Stem Cells (2014) 0.87
Identification and expression profiling of blood-brain barrier membrane proteins. J Neurochem (2009) 0.87
Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation. J Control Release (2012) 0.87
T cell suppression by naturally occurring HLA-G-expressing regulatory CD4+ T cells is IL-10-dependent and reversible. J Leukoc Biol (2009) 0.87
Protective effects of peroxiredoxin-1 at the injured blood-brain barrier. Free Radic Biol Med (2008) 0.87
A yeast platform for the production of single-chain antibody-green fluorescent protein fusions. Appl Environ Microbiol (2006) 0.86
Modeling the blood-brain barrier using stem cell sources. Fluids Barriers CNS (2013) 0.86
Targeting receptor-mediated transport for delivery of biologics across the blood-brain barrier. Annu Rev Pharmacol Toxicol (2014) 0.85
Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions. Glia (2014) 0.85
Astrocyte-derived retinoic acid: a novel regulator of blood-brain barrier function in multiple sclerosis. Acta Neuropathol (2014) 0.85
MRI of ICAM-1 upregulation after stroke: the importance of choosing the appropriate target-specific particulate contrast agent. Mol Imaging Biol (2013) 0.85
Dietary intake of plant sterols stably increases plant sterol levels in the murine brain. J Lipid Res (2012) 0.84
Antibody library screens using detergent-solubilized mammalian cell lysates as antigen sources. Protein Eng Des Sel (2010) 0.84
Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions. Free Radic Biol Med (2010) 0.84
Cells and cell lysates: a direct approach for engineering antibodies against membrane proteins using yeast surface display. Methods (2012) 0.84
Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders. Free Radic Biol Med (2012) 0.83
Magnetic resonance imaging of monocytes labeled with ultrasmall superparamagnetic particles of iron oxide using magnetoelectroporation in an animal model of multiple sclerosis. Mol Imaging (2010) 0.83
Antibody affinity maturation using yeast display with detergent-solubilized membrane proteins as antigen sources. Protein Eng Des Sel (2012) 0.82
Influence of hydrocortisone on the mechanical properties of the cerebral endothelium in vitro. Biophys J (2005) 0.82
Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis. Acta Neuropathol Commun (2014) 0.82
Neuronal and axonal loss in normal-appearing gray matter and subpial lesions in multiple sclerosis. J Neuropathol Exp Neurol (2015) 0.82
What are the barriers which discourage 15-16 year-old girls from participating in team sports and how can we overcome them? Biomed Res Int (2013) 0.81
Increasing yeast secretion of heterologous proteins by regulating expression rates and post-secretory loss. Biotechnol Bioeng (2008) 0.81
Confirmation among college women: the eating disorders not otherwise specified diagnostic profile. J Am Coll Health (2008) 0.81