Published in EMBO J on December 01, 1991
RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors. EMBO J (1992) 3.03
A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol Cell Biol (1994) 2.85
Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor. EMBO J (1994) 2.62
Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation. Genes Dev (1999) 2.31
Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones. EMBO J (2001) 1.91
The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains. EMBO J (1993) 1.72
Improved method for PCR-mediated site-directed mutagenesis. Nucleic Acids Res (1994) 1.70
Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors. Mol Endocrinol (1997) 1.60
Identification and analysis of all components of a gel retardation assay by combination with immunoblotting. Proc Natl Acad Sci U S A (1993) 1.45
Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping. Mol Cell Biol (1994) 1.40
Regulation of the Oct-4 gene by nuclear receptors. Nucleic Acids Res (1994) 1.32
Nuclear hormone receptors involved in neoplasia: erb A exhibits a novel DNA sequence specificity determined by amino acids outside of the zinc-finger domain. Mol Cell Biol (1993) 1.08
Ligand-dependent occupancy of the retinoic acid receptor beta 2 promoter in vivo. Mol Cell Biol (1994) 1.08
A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors. Proc Natl Acad Sci U S A (2007) 1.07
The erbA oncogene represses the actions of both retinoid X and retinoid A receptors but does so by distinct mechanisms. Mol Cell Biol (1993) 1.04
Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages. Mol Cell Biol (2004) 1.03
Endogenous retinoid X receptors can function as hormone receptors in pituitary cells. Mol Cell Biol (1994) 1.00
DNA recognition by the aberrant retinoic acid receptors implicated in human acute promyelocytic leukemia. Cell Growth Differ (2001) 0.99
RXR-dependent and RXR-independent transactivation by retinoic acid receptors. Nucleic Acids Res (1993) 0.93
A transition in transcriptional activation by the glucocorticoid and retinoic acid receptors at the tumor stage of dermal fibrosarcoma development. EMBO J (1995) 0.92
Targeted disruption of the p160 coactivator interface of androgen receptor (AR) selectively inhibits AR activity in both androgen-dependent and castration-resistant AR-expressing prostate cancer cells. Int J Biochem Cell Biol (2012) 0.89
DNA recognition by thyroid hormone and retinoic acid receptors: 3,4,5 rule modified. Mol Cell Endocrinol (2009) 0.89
Transcriptional regulation by triiodothyronine requires synergistic action of the thyroid receptor with another trans-acting factor. Mol Cell Biol (1992) 0.87
Integration of growth factor, extracellular matrix, and retinoid signals during bronchial epithelial cell differentiation. Mol Cell Biol (1998) 0.85
The promoter context is a decisive factor in establishing selective responsiveness to nuclear class II receptors. EMBO J (1997) 0.84
Transactivation by the thyroid hormone receptor is dependent on the spacer sequence in hormone response elements containing directly repeated half-sites. Nucleic Acids Res (1996) 0.84
The repressor DREAM acts as a transcriptional activator on Vitamin D and retinoic acid response elements. Nucleic Acids Res (2005) 0.83
The p160 coactivator PAS-B motif stabilizes nuclear receptor binding and contributes to isoform-specific regulation by thyroid hormone receptors. J Biol Chem (2009) 0.82
Chimeric retinoic acid/thyroid hormone receptors implicate RAR-alpha 1 as mediating growth inhibition by retinoic acid. EMBO J (1993) 0.79
Signaling through retinoic acid receptors in cardiac development: Doing the right things at the right times. Biochim Biophys Acta (2014) 0.76
Small-molecule hormones: molecular mechanisms of action. Int J Endocrinol (2013) 0.75
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol (1982) 116.75
The steroid and thyroid hormone receptor superfamily. Science (1988) 25.68
Gene regulation by steroid hormones. Cell (1989) 12.96
A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature (1988) 9.07
Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell (1991) 8.85
Identification of a receptor for the morphogen retinoic acid. Nature (1988) 8.32
A versatile in vivo and in vitro eukaryotic expression vector for protein engineering. Nucleic Acids Res (1988) 7.28
Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechniques (1988) 6.83
The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell (1988) 6.59
Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene. Cell (1987) 6.12
Nuclear receptors enhance our understanding of transcription regulation. Trends Genet (1988) 5.95
Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene. Nature (1990) 5.50
Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor. Nature (1987) 5.47
Identification of a second human retinoic acid receptor. Nature (1988) 5.11
Determinants of target gene specificity for steroid/thyroid hormone receptors. Cell (1989) 4.56
The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors. EMBO J (1986) 4.47
The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors. Cell (1991) 4.27
Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site. Cell (1990) 4.13
The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements. Cell (1988) 3.91
A third human retinoic acid receptor, hRAR-gamma. Proc Natl Acad Sci U S A (1989) 3.74
Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature (1989) 3.72
Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation. Cell (1988) 3.46
Retinoic acid and thyroid hormone induce gene expression through a common responsive element. Nature (1988) 3.42
Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor. Cell (1990) 3.37
A new retinoic acid receptor identified from a hepatocellular carcinoma. Nature (1988) 3.33
Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer. Cell (1989) 3.24
Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene. Proc Natl Acad Sci U S A (1990) 3.17
Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element. Nature (1989) 2.82
Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product. Nature (1989) 2.78
Thyroid hormone receptor alpha isoforms generated by alternative splicing differentially activate myosin HC gene transcription. Nature (1988) 2.56
A retinoic acid-responsive element is present in the 5' flanking region of the laminin B1 gene. Proc Natl Acad Sci U S A (1989) 2.32
Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activity. Nature (1989) 2.23
Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha). Mol Cell Biol (1990) 1.96
High expression of functional adenovirus DNA polymerase and precursor terminal protein using recombinant vaccinia virus. Nucleic Acids Res (1988) 1.77
A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter. EMBO J (1991) 1.74
Retinoids and vertebrate limb pattern formation. Trends Genet (1989) 1.73
A retinoic acid response element is part of a pleiotropic domain in the phosphoenolpyruvate carboxykinase gene. Proc Natl Acad Sci U S A (1991) 1.48
A retinoic acid receptor-specific element controls the retinoic acid receptor-beta promoter. Mol Endocrinol (1990) 1.43
Regulation of gene expression by nuclear hormone receptors. Curr Opin Cell Biol (1989) 1.37
Retinoic acid response element in the human alcohol dehydrogenase gene ADH3: implications for regulation of retinoic acid synthesis. Mol Cell Biol (1991) 1.37
Cis-acting sequences affecting the length of the poly(A) head of vaccinia virus late transcripts. Nucleic Acids Res (1988) 1.35
The late retinoic acid induction of laminin B1 gene transcription involves RAR binding to the responsive element. EMBO J (1991) 1.33
Retinoic acid receptor expression vector inhibits differentiation of F9 embryonal carcinoma cells. Genes Dev (1989) 1.22
A major thyroid hormone response element in the third intron of the rat growth hormone gene. EMBO J (1990) 1.22
Dimerization among nuclear hormone receptors. New Biol (1990) 1.17
Retinoic acid induces down-regulation of several growth factors and proto-oncogenes in a human embryonal cancer cell line. Oncogene (1990) 1.12
Functional characterization and receptor binding studies of the malic enzyme thyroid hormone response element. J Biol Chem (1991) 1.05
Retinoic acid, a developmental signalling molecule. Trends Neurosci (1990) 1.05
Impaired wound healing in mice with a disrupted plasminogen gene. Nat Med (1996) 4.72
Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11. Hum Mol Genet (1996) 3.78
Rapid and efficient purification of native histidine-tagged protein expressed by recombinant vaccinia virus. Proc Natl Acad Sci U S A (1991) 3.57
Biochemical complementation with RNA in the Xenopus oocyte: a small RNA is required for the generation of 3' histone mRNA termini. Cell (1983) 3.36
Discontinuous transcription or RNA processing of vaccinia virus late messengers results in a 5' poly(A) leader. Cell (1987) 3.31
Plasminogen is required for efficient dissemination of B. burgdorferi in ticks and for enhancement of spirochetemia in mice. Cell (1997) 3.25
RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors. EMBO J (1992) 3.03
Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells. Blood (2000) 2.78
A central role for P48/45 in malaria parasite male gamete fertility. Cell (2001) 2.73
Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor. EMBO J (1994) 2.62
Conserved TAAAT motif in vaccinia virus late promoters: overlapping TATA box and site of transcription initiation. EMBO J (1986) 2.41
Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle. Nature (1993) 2.15
Derepression of a novel class of vaccinia virus genes upon DNA replication. EMBO J (1988) 2.13
An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J Neurosci (1997) 2.03
TFIID is required for in vitro transcription of the human U6 gene by RNA polymerase III. EMBO J (1991) 1.97
The nucleolar transcription factor mUBF is phosphorylated by casein kinase II in the C-terminal hyperacidic tail which is essential for transactivation. EMBO J (1992) 1.94
Vaccinia virus capping enzyme is a transcription initiation factor. EMBO J (1991) 1.87
Bioassay for components regulating eukaryotic gene expression: a chromosomal factor involved in the generation of histone mRNA 3' termini. Proc Natl Acad Sci U S A (1982) 1.77
Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin. J Biol Chem (2001) 1.73
Improved method for PCR-mediated site-directed mutagenesis. Nucleic Acids Res (1994) 1.70
Functional overlap between two classes of matrix-degrading proteases in wound healing. EMBO J (1999) 1.69
Fibrin and fibrinolysis in infection and host defense. J Thromb Haemost (2007) 1.66
UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells. EMBO J (1998) 1.65
Vaccinia virus late transcripts generated in vitro have a poly(A) head. EMBO J (1988) 1.58
Affinity purification of histidine-tagged proteins. Mol Biol Rep (1993) 1.57
Cooperativity in transactivation between retinoic acid receptor and TFIID requires an activity analogous to E1A. Cell (1992) 1.50
Sequence and transcriptional analysis of the vaccinia virus HindIII I fragment. J Virol (1988) 1.49
Lactational competence and involution of the mouse mammary gland require plasminogen. Development (2000) 1.48
Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development. Oncogene (2006) 1.47
Promoter melting by a stage-specific vaccinia virus transcription factor is independent of the presence of RNA polymerase. Cell (1991) 1.47
Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR. EMBO J (1993) 1.45
Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties. EMBO J (1992) 1.44
Two long homologous retroviral sequence blocks in proximal Yq11 cause AZFa microdeletions as a result of intrachromosomal recombination events. Hum Mol Genet (2000) 1.44
Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver. Proc Natl Acad Sci U S A (1999) 1.38
Cis-acting sequences affecting the length of the poly(A) head of vaccinia virus late transcripts. Nucleic Acids Res (1988) 1.35
Isolation and functional characterization of two distinct sexual-stage-specific promoters of the human malaria parasite Plasmodium falciparum. Mol Cell Biol (1999) 1.34
Prothrombin deficiency results in embryonic and neonatal lethality in mice. Proc Natl Acad Sci U S A (1998) 1.32
Plasminogen activators direct reorganization of the liver lobule after acute injury. Am J Pathol (2001) 1.30
Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin. Proc Natl Acad Sci U S A (1997) 1.26
9-cis retinoic acid signaling: changing partners causes some excitement. Genes Dev (1995) 1.25
Mutational analysis of a vaccinia virus intermediate promoter in vivo and in vitro. J Virol (1990) 1.25
The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis. J Clin Invest (1999) 1.22
BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation. EMBO J (1995) 1.21
The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate. J Cell Biol (2000) 1.21
Ligneous conjunctivitis in plasminogen-deficient mice. Blood (1998) 1.19
Monoclonal antibodies directed against the amino-terminal domain of human TBP cross-react with TBP from other species. Hybridoma (1996) 1.18
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase. Oncogene (2011) 1.18
Residues in the TATA-binding protein required to mediate a transcriptional response to retinoic acid in EC cells. Nature (1993) 1.16
The Mad1-Sin3B interaction involves a novel helical fold. Nat Struct Biol (2000) 1.11
TAC, a TBP-sans-TAFs complex containing the unprocessed TFIIAalphabeta precursor and the TFIIAgamma subunit. Mol Cell (2000) 1.09
Healing of corneal epithelial defects in plasminogen- and fibrinogen-deficient mice. Invest Ophthalmol Vis Sci (1998) 1.06
Retinoid-dependent in vitro transcription mediated by the RXR/RAR heterodimer. Genes Dev (1994) 1.05
Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis. Proc Natl Acad Sci U S A (1997) 1.02
A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad. Hum Mol Genet (1996) 1.00
Leukemic transformation by the v-ErbA oncoprotein entails constitutive binding to and repression of an erythroid enhancer in vivo. EMBO J (1998) 0.97
Rapid screening of the Y chromosome in idiopathic sterile men, diagnostic for deletions in AZF, a genetic Y factor expressed during spermatogenesis. Andrologia (1994) 0.96
Assembly and DNA binding of recombinant Ku (p70/p80) autoantigen defined by a novel monoclonal antibody specific for p70/p80 heterodimers. J Cell Sci (1994) 0.96
Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis. Oncogene (2011) 0.95
Low affinity binding of interleukin-1 beta and intracellular signaling via NF-kappa B identify Fit-1 as a distant member of the interleukin-1 receptor family. J Biol Chem (1995) 0.94
Assembly and expression of a synthetic gene encoding the antigen Pfs48/45 of the human malaria parasite Plasmodium falciparum in yeast. Vaccine (2000) 0.94
Autologous antibody response against the principal neutralizing domain of human immunodeficiency virus type 1 isolated from infected humans. J Virol (1993) 0.92
The azoospermia factor (AZF) of the human Y chromosome in Yq11: function and analysis in spermatogenesis. Reprod Fertil Dev (1995) 0.91
De novo transcriptome characterization and development of genomic tools for Scabiosa columbaria L. using next-generation sequencing techniques. Mol Ecol Resour (2011) 0.91
The glucocorticoid receptor hormone binding domain mediates transcriptional activation in vitro in the absence of ligand. Nucleic Acids Res (1993) 0.90
Plasminogen and wound healing. Nat Med (1996) 0.90
Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice. Biochemistry (2000) 0.89
Genome-wide functions of PML-RARα in acute promyelocytic leukaemia. Br J Cancer (2011) 0.89
Neuronal death and blood-brain barrier breakdown after excitotoxic injury are independent processes. J Neurosci (1999) 0.88
Avian erythroleukemia: a model for corepressor function in cancer. Oncogene (2001) 0.88
RNA polymerase from the fungus, Aspergillus nidulans. Large-scale purification of DNA-dependent RNA polymerase I (or A). Eur J Biochem (1979) 0.88
Human androgen receptor expressed in HeLa cells activates transcription in vitro. Nucleic Acids Res (1994) 0.87
Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient mice. Invest Ophthalmol Vis Sci (2000) 0.87
Thyroid hormone-dependent transcriptional repression of neural cell adhesion molecule during brain maturation. EMBO J (1996) 0.85
Yeast TBP can replace its human homologue in the RNA polymerase I-specific multisubunit factor SL1. J Mol Biol (1994) 0.84
Targeting of frog prodermorphin to the regulated secretory pathway by fusion to proenkephalin. J Cell Biol (1991) 0.84
The promoter context is a decisive factor in establishing selective responsiveness to nuclear class II receptors. EMBO J (1997) 0.84
An alpha-amanitin-resistant DNA-dependent RNA polymerase II from the fungus Aspergillus nidulans. Eur J Biochem (1981) 0.83
Retinoid-dependent transcription: the RAR/RXR-TBP-EIA/EIA-LA connection. Biochem Soc Symp (1996) 0.83
Cloning and expression of a mouse cDNA encoding p59, an immunophilin that associates with the glucocorticoid receptor. Gene (1993) 0.83
Requirement of cofactors for RXR/RAR-mediated transcriptional activation in vitro. Biochim Biophys Acta (1997) 0.83
The long terminal repeat of VL30 retrotransposons contains sequences that determine retinoic acid-induced transcription in cultured keratinocytes. J Biol Chem (1993) 0.82
Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II. Thromb Haemost (2014) 0.81
Plasminogen is a critical determinant of vascular remodeling in mice. Circ Res (2000) 0.81
Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1. J Biomol NMR (2001) 0.81
Retinoid-dependent in vitro transcription. Methods Enzymol (1996) 0.80
Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1). Biochim Biophys Acta (2000) 0.79
Molecular analysis of the genomic structure of the human Y chromosome in the euchromatic part of its long arm (Yq11). Cytogenet Cell Genet (1996) 0.79
Mapping of two new human B-cell epitopes on HIV-1 gp120. AIDS (1992) 0.79
Arylsulfatase D gene in Xp22.3 encodes two protein isoforms. DNA Cell Biol (2000) 0.78
Protoplasts from Aspergillus nidulans. Microbios (1979) 0.78
Retinoic acid posttranscriptionally up-regulates proteolipid protein gene expression in C6 glioma cells. J Biol Chem (1993) 0.77
Depletion in nuclei of proteins associated with hnRNA, as a result of inhibition of RNA synthesis. Exp Cell Res (1978) 0.77
The v-ErbA oncoprotein quenches the activity of an erythroid-specific enhancer. Oncogene (2001) 0.77
Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells. Nucleic Acids Res (2001) 0.76
Mapping of a new immunodominant human linear B-cell epitope on the vpu protein of the human immunodeficiency virus type 1. J Acquir Immune Defic Syndr (1993) 0.75
Conservation of the deleted-in-azoospermia-like-1 (DAZL1) gene structure in old world monkeys points to a homologous function of DAZL1 in this primate class. J Endocrinol Invest (2000) 0.75
Mapping of linear B-cell epitopes on the major core protein p24 of human immunodeficiency virus type 1 (HIV-1). AIDS Res Hum Retroviruses (1992) 0.75