Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR.

PubWeight™: 1.45‹?› | Rank: Top 5%

🔗 View Article (PMC 413346)

Published in EMBO J on April 01, 1993

Authors

D Barettino1, T H Bugge, P Bartunek, M D Vivanco Ruiz, V Sonntag-Buck, H Beug, M Zenke, H G Stunnenberg

Author Affiliations

1: EMBL, Gene Expression Programme, Heidelberg, Germany.

Articles citing this

Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. EMBO J (1994) 3.00

Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor. EMBO J (1994) 2.62

The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains. EMBO J (1993) 1.72

Improved method for PCR-mediated site-directed mutagenesis. Nucleic Acids Res (1994) 1.70

OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor. Proc Natl Acad Sci U S A (1995) 1.56

Differential recognition of liganded and unliganded thyroid hormone receptor by retinoid X receptor regulates transcriptional repression. Mol Cell Biol (1997) 1.26

Negative regulation of transcription in eukaryotes. Biochem J (1993) 1.10

Dominant negative retinoid X receptor beta inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells. Mol Cell Biol (1994) 1.09

Identification of a domain required for oncogenic activity and transcriptional suppression by v-erbA and thyroid-hormone receptor alpha. Proc Natl Acad Sci U S A (1993) 1.08

A permissive retinoid X receptor/thyroid hormone receptor heterodimer allows stimulation of prolactin gene transcription by thyroid hormone and 9-cis-retinoic acid. Mol Cell Biol (2004) 1.08

The erbA oncogene represses the actions of both retinoid X and retinoid A receptors but does so by distinct mechanisms. Mol Cell Biol (1993) 1.04

Thyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA. EMBO J (1994) 1.02

Leukemic transformation by the v-ErbA oncoprotein entails constitutive binding to and repression of an erythroid enhancer in vivo. EMBO J (1998) 0.97

Regulation of the mdm2 oncogene by thyroid hormone receptor. Mol Cell Biol (1999) 0.89

Regulation of mucin gene expression in human tracheobronchial epithelial cells by thyroid hormone. Biochem J (2001) 0.89

Thyroid hormone receptor can modulate retinoic acid-mediated axis formation in frog embryogenesis. Mol Cell Biol (1993) 0.85

Vitamin D interferes with transactivation of the growth hormone gene by thyroid hormone and retinoic acid. Mol Cell Biol (1996) 0.84

Myb-Ets fusion oncoprotein inhibits thyroid hormone receptor/c-ErbA and retinoic acid receptor functions: a novel mechanism of action for leukemogenic transformation by E26 avian retrovirus. Mol Cell Biol (1996) 0.84

Chimeric retinoic acid/thyroid hormone receptors implicate RAR-alpha 1 as mediating growth inhibition by retinoic acid. EMBO J (1993) 0.79

Preparation of unoccupied thyroid-hormone receptor. Biochem J (1994) 0.75

Articles cited by this

The c-erb-A gene encodes a thyroid hormone receptor. Nature (1987) 10.53

A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature (1988) 9.07

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell (1991) 8.85

A general method for rapid site-directed mutagenesis using the polymerase chain reaction. Gene (1990) 8.36

A versatile in vivo and in vitro eukaryotic expression vector for protein engineering. Nucleic Acids Res (1988) 7.28

The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature (1987) 7.06

Nuclear receptor that identifies a novel retinoic acid response pathway. Nature (1990) 6.23

RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell (1991) 5.89

Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell (1992) 5.87

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. Nature (1992) 5.76

Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene. Nature (1990) 5.50

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev (1992) 4.69

Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist. Nature (1989) 4.47

Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature (1992) 4.44

The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors. Cell (1991) 4.27

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. Cell (1991) 3.87

A third human retinoic acid receptor, hRAR-gamma. Proc Natl Acad Sci U S A (1989) 3.74

Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature (1989) 3.72

H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes. EMBO J (1992) 3.21

Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene. Proc Natl Acad Sci U S A (1990) 3.17

Transformation of both erythroid and myeloid cells by E26, an avian leukemia virus that contains the myb gene. Cell (1982) 3.09

RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors. EMBO J (1992) 3.03

Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product. Nature (1989) 2.78

Differentially expressed isoforms of the mouse retinoic acid receptor beta generated by usage of two promoters and alternative splicing. EMBO J (1991) 2.68

Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene. Cell (1990) 2.68

Retinoic acid-induced neural differentiation of embryonal carcinoma cells. Mol Cell Biol (1983) 2.45

Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model. Mol Endocrinol (1990) 2.42

Hormone-dependent terminal differentiation in vitro of chicken erythroleukemia cells transformed by ts mutants of avian erythroblastosis virus. Cell (1982) 2.33

v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA. Cell (1990) 2.31

A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma. Nature (1988) 1.96

Contrasting developmental and tissue-specific expression of alpha and beta thyroid hormone receptor genes. EMBO J (1990) 1.79

Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse. Nature (1989) 1.79

High expression of functional adenovirus DNA polymerase and precursor terminal protein using recombinant vaccinia virus. Nucleic Acids Res (1988) 1.77

A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter. EMBO J (1991) 1.74

v-erbA specifically suppresses transcription of the avian erythrocyte anion transporter (band 3) gene. Cell (1988) 1.55

A single point mutation in erbA restores the erythroid transforming potential of a mutant avian erythroblastosis virus (AEV) defective in both erbA and erbB oncogenes. EMBO J (1987) 1.54

Cooperativity in transactivation between retinoic acid receptor and TFIID requires an activity analogous to E1A. Cell (1992) 1.50

A dominant negative mutation of the alpha retinoic acid receptor gene in a retinoic acid-nonresponsive embryonal carcinoma cell. Mol Cell Biol (1990) 1.37

Activation of protein kinase C or cAMP-dependent protein kinase increases phosphorylation of the c-erbA-encoded thyroid hormone receptor and of the v-erbA-encoded protein. EMBO J (1988) 1.37

Cis-acting sequences affecting the length of the poly(A) head of vaccinia virus late transcripts. Nucleic Acids Res (1988) 1.35

Characterization of the hormone-binding domain of the chicken c-erbA/thyroid hormone receptor protein. EMBO J (1988) 1.26

Heterodimerization of thyroid hormone (TH) receptor with H-2RIIBP (RXR beta) enhances DNA binding and TH-dependent transcriptional activation. Proc Natl Acad Sci U S A (1992) 1.24

v-erbA oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action. Cell (1991) 1.11

Modulation of normal erythroid differentiation by the endogenous thyroid hormone and retinoic acid receptors: a possible target for v-erbA oncogene action. Oncogene (1992) 1.11

v-erbA overexpression is required to extinguish c-erbA function in erythroid cell differentiation and regulation of the erbA target gene CAII. Genes Dev (1991) 1.11

EGF-R as a hemopoietic growth factor receptor: the c-erbB product is present in chicken erythrocytic progenitors and controls their self-renewal. Cell (1991) 1.07

Thyroid hormone receptor/and v-erbA. A single amino acid difference in the C-terminal region influences dominant negative activity and receptor dimer formation. J Biol Chem (1991) 1.02

The v-erbA oncogene requires cooperation with tyrosine kinases to arrest erythroid differentiation induced by ligand-activated endogenous c-erbA and retinoic acid receptor. Oncogene (1992) 0.96

Sequence-specific DNA binding by the v-erbA oncogene protein of avian erythroblastosis virus. J Virol (1990) 0.96

Ontogeny of the v-erbA oncoprotein from the thyroid hormone receptor: an alteration in the DNA binding domain plays a role crucial for v-erbA function. J Virol (1991) 0.95

Transcriptional repression of band 3 and CAII in v-erbA transformed erythroblasts accounts for an important part of the leukaemic phenotype. EMBO J (1992) 0.94

The v-erb A oncogene causes repression of erythrocyte-specific genes and an immature, aberrant differentiation phenotype in normal erythroid progenitors. Oncogene (1990) 0.94

The carbonic anhydrase II gene, a gene regulated by thyroid hormone and erythropoietin, is repressed by the v-erbA oncogene in erythrocytic cells. New Biol (1990) 0.90

Articles by these authors

Multiple sequence motifs are involved in SV40 enhancer function. EMBO J (1986) 7.76

The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature (1987) 7.06

Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation. Nature (1979) 5.75

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev (1996) 5.71

Avian leukemia viruses: interaction with their target cells in vivo and in vitro. Biochim Biophys Acta (1978) 5.67

Chicken hematopoietic cells transformed by seven strains of defective avian leukemia viruses display three distinct phenotypes of differentiation. Cell (1979) 5.61

Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes Dev (1990) 5.25

Automated DNA sequencing: ultrasensitive detection of fluorescent bands during electrophoresis. Nucleic Acids Res (1987) 5.14

The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene (2007) 4.90

Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter. Nature (1986) 4.77

Impaired wound healing in mice with a disrupted plasminogen gene. Nat Med (1996) 4.72

TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis. Curr Biol (1998) 4.44

Stimulation of in vitro transcription from the SV40 early promoter by the enhancer involves a specific trans-acting factor. EMBO J (1984) 4.28

Rapid and efficient purification of native histidine-tagged protein expressed by recombinant vaccinia virus. Proc Natl Acad Sci U S A (1991) 3.57

Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion. Cell (1992) 3.37

Biochemical complementation with RNA in the Xenopus oocyte: a small RNA is required for the generation of 3' histone mRNA termini. Cell (1983) 3.36

Discontinuous transcription or RNA processing of vaccinia virus late messengers results in a 5' poly(A) leader. Cell (1987) 3.31

Plasminogen is required for efficient dissemination of B. burgdorferi in ticks and for enhancement of spirochetemia in mice. Cell (1997) 3.25

Cell-type specific protein binding to the enhancer of simian virus 40 in nuclear extracts. Nature (1986) 3.25

Transformation of both erythroid and myeloid cells by E26, an avian leukemia virus that contains the myb gene. Cell (1982) 3.09

Transforming capacities of avian erythroblastosis virus mutants deleted in the erbA or erbB oncogenes. Cell (1983) 3.03

RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors. EMBO J (1992) 3.03

Specific protein binding to the simian virus 40 enhancer in vitro. Mol Cell Biol (1986) 2.82

Epidemiological studies on patients with a persistent vegetative state. J Neurol Neurosurg Psychiatry (1977) 2.81

Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells. Blood (2000) 2.78

Dynamics of antigenic membrane sites relating to cell aggregation in Dictyostelium discoideum. J Cell Biol (1973) 2.73

A central role for P48/45 in malaria parasite male gamete fertility. Cell (2001) 2.73

E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity. J Cell Biol (2001) 2.72

Transferrin-polycation conjugates as carriers for DNA uptake into cells. Proc Natl Acad Sci U S A (1990) 2.64

Erythroblast cell lines transformed by a temperature-sensitive mutant of avian erythroblastosis virus: a model system to study erythroid differentiation in vitro. J Cell Physiol Suppl (1982) 2.63

Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor. EMBO J (1994) 2.62

Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes Dev (2000) 2.62

Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton. J Cell Biol (1999) 2.60

Identification and characterization of the avian erythroblastosis virus erbB gene product as a membrane glycoprotein. Cell (1983) 2.44

Conserved TAAAT motif in vaccinia virus late promoters: overlapping TATA box and site of transcription initiation. EMBO J (1986) 2.41

Hormone-dependent terminal differentiation in vitro of chicken erythroleukemia cells transformed by ts mutants of avian erythroblastosis virus. Cell (1982) 2.33

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. EMBO J (2001) 2.32

v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA. Cell (1990) 2.31

Evidence for the multiple oncogenic potential of cloned leukemia virus: in vitro and in vitro studies with avian erythroblastosis virus. Virology (1976) 2.28

Transformation parameters in chicken fibroblasts transformed by AEV and MC29 avian leukemia viruses. Cell (1978) 2.23

Specific inhibition of cell contact formation in Dictyostelium by univalent antibodies. Exp Cell Res (1970) 2.15

Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle. Nature (1993) 2.15

Derepression of a novel class of vaccinia virus genes upon DNA replication. EMBO J (1988) 2.13

Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity. J Cell Biol (2000) 2.12

Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis. Oncogene (2007) 2.12

DNA-binding activity is associated with purified myb proteins from AMV and E26 viruses and is temperature-sensitive for E26 ts mutants. Cell (1985) 2.11

Translation control: bridging the gap between genomics and proteomics? Trends Biochem Sci (2001) 2.08

Role of the v-erbA and v-erbB oncogenes of avian erythroblastosis virus in erythroid cell transformation. Cell (1983) 2.08

Temperature-sensitive mutant of avian erythroblastosis virus suggests a block of differentiation as mechanism of leukaemogenesis. Nature (1978) 2.06

Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner. Genes Dev (1993) 2.03

An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J Neurosci (1997) 2.03

Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1. EMBO J (2000) 2.00

TFIID is required for in vitro transcription of the human U6 gene by RNA polymerase III. EMBO J (1991) 1.97

The nucleolar transcription factor mUBF is phosphorylated by casein kinase II in the C-terminal hyperacidic tail which is essential for transactivation. EMBO J (1992) 1.94

The glucocorticoid receptor is required for stress erythropoiesis. Genes Dev (1999) 1.92

Vaccinia virus capping enzyme is a transcription initiation factor. EMBO J (1991) 1.87

The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro. Blood (1999) 1.87

Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels. Proc Natl Acad Sci U S A (1990) 1.79

The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions. J Cell Biol (1996) 1.79

Bioassay for components regulating eukaryotic gene expression: a chromosomal factor involved in the generation of histone mRNA 3' termini. Proc Natl Acad Sci U S A (1982) 1.77

Transforming capacities and defectiveness of avian leukemia viruses OK10 and E 26. Virology (1979) 1.74

Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin. J Biol Chem (2001) 1.73

Establishment of normal, terminally differentiating mouse erythroid progenitors: molecular characterization by cDNA arrays. FASEB J (2001) 1.70

Improved method for PCR-mediated site-directed mutagenesis. Nucleic Acids Res (1994) 1.70

Functional overlap between two classes of matrix-degrading proteases in wound healing. EMBO J (1999) 1.69

Fibrin and fibrinolysis in infection and host defense. J Thromb Haemost (2007) 1.66

UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells. EMBO J (1998) 1.65

Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells. Proc Natl Acad Sci U S A (1990) 1.64

Ts mutants of E26 leukemia virus allow transformed myeloblasts, but not erythroblasts or fibroblasts, to differentiate at the nonpermissive temperature. Cell (1984) 1.63

Functional characterization of a natural retinoic acid responsive element. EMBO J (1991) 1.63

Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts. EMBO J (1988) 1.63

A crucial function of PDGF in TGF-beta-mediated cancer progression of hepatocytes. Oncogene (2006) 1.62

Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. Genes Dev (2000) 1.61

Purification and characterization of cMGF, a novel chicken myelomonocytic growth factor. EMBO J (1984) 1.59

Vaccinia virus late transcripts generated in vitro have a poly(A) head. EMBO J (1988) 1.58

Affinity purification of histidine-tagged proteins. Mol Biol Rep (1993) 1.57

Characterization of the hematopoietic target cells of AEV, MC29 and AMV avian leukemia viruses. Exp Cell Res (1981) 1.57

v-erbA cooperates with sarcoma oncogenes in leukemic cell transformation. Cell (1986) 1.56

Isolation of translationally controlled mRNAs by differential screening. FASEB J (2000) 1.56

TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest. Genes Dev (2000) 1.56

Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin. Oncogene (2006) 1.55

Temperature-sensitive changes in the structure of globin chromatin in lines of red cell precursors transformed by ts-AEV. Cell (1982) 1.54

A single point mutation in erbA restores the erythroid transforming potential of a mutant avian erythroblastosis virus (AEV) defective in both erbA and erbB oncogenes. EMBO J (1987) 1.54

A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor). Mol Cell Biol (1993) 1.52

Cooperativity in transactivation between retinoic acid receptor and TFIID requires an activity analogous to E1A. Cell (1992) 1.50

Sequence and transcriptional analysis of the vaccinia virus HindIII I fragment. J Virol (1988) 1.49

PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression. Oncogene (2006) 1.48

Lactational competence and involution of the mouse mammary gland require plasminogen. Development (2000) 1.48

Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development. Oncogene (2006) 1.47

Promoter melting by a stage-specific vaccinia virus transcription factor is independent of the presence of RNA polymerase. Cell (1991) 1.47

The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors. EMBO J (1997) 1.44

Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties. EMBO J (1992) 1.44

Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge. Oncogene (2009) 1.43

Growth and differentiation of human stem cell factor/erythropoietin-dependent erythroid progenitor cells in vitro. Blood (1998) 1.43