Published in Proc Natl Acad Sci U S A on May 01, 1952
Direct conversion of fibroblasts to functional neurons by defined factors. Nature (2010) 18.76
Clonal growth in vitro of human cells with fibroblastic morphology; comparison of growth and genetic characteristics of single epithelioid and fibroblast-like cells from a variety of human organs. J Exp Med (1957) 6.35
Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature (2010) 6.20
Nuclear reprogramming to a pluripotent state by three approaches. Nature (2010) 5.26
Epigenetic reprogramming and induced pluripotency. Development (2009) 4.90
Induced pluripotency: history, mechanisms, and applications. Genes Dev (2010) 4.89
Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature (2013) 2.85
Direct lineage conversions: unnatural but useful? Nat Biotechnol (2011) 2.69
Measurement of single-cell dynamics. Nature (2010) 2.55
Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell (2012) 2.15
Characterization of somatic cell nuclear reprogramming by oocytes in which a linker histone is required for pluripotency gene reactivation. Proc Natl Acad Sci U S A (2010) 2.01
Pluripotency and nuclear reprogramming. Philos Trans R Soc Lond B Biol Sci (2008) 1.82
Molecular roadblocks for cellular reprogramming. Mol Cell (2012) 1.74
Upping the ante: recent advances in direct reprogramming. Mol Ther (2009) 1.73
From teratocarcinomas to embryonic stem cells. Philos Trans R Soc Lond B Biol Sci (2002) 1.56
Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies. Nat Rev Mol Cell Biol (2013) 1.52
Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer. Proc Natl Acad Sci U S A (2005) 1.50
Deficient induction response in a Xenopus nucleocytoplasmic hybrid. PLoS Biol (2011) 1.50
A blueprint for engineering cell fate: current technologies to reprogram cell identity. Cell Res (2013) 1.50
Rethinking differentiation: stem cells, regeneration, and plasticity. Cell (2014) 1.41
The first half-century of nuclear transplantation. Proc Natl Acad Sci U S A (2003) 1.37
Neoplasms, differentiations and mutations. Am J Pathol (1974) 1.30
Stable haploid cultured cell lines from frog embryos. Proc Natl Acad Sci U S A (1970) 1.28
Development-inspired reprogramming of the mammalian central nervous system. Science (2014) 1.21
From intestine to muscle: nuclear reprogramming through defective cloned embryos. Proc Natl Acad Sci U S A (2002) 1.11
From stealing fire to cellular reprogramming: a scientific history leading to the 2012 Nobel Prize. Stem Cell Reports (2013) 1.10
Autologous blood cell therapies from pluripotent stem cells. Blood Rev (2009) 1.09
The demoiselle of X-inactivation: 50 years old and as trendy and mesmerising as ever. PLoS Genet (2011) 1.08
Tissue engineering, stem cells, cloning, and parthenogenesis: new paradigms for therapy. J Exp Clin Assist Reprod (2004) 1.08
Puromycin resistance in haploid and heteroploid frog cells: gene or membrane determined? J Cell Biol (1971) 1.08
Boveri's long experiment: sea urchin merogones and the establishment of the role of nuclear chromosomes in development. Dev Biol (2007) 1.05
The cell cycle and pluripotency. Biochem J (2013) 1.03
ES, iPS, MSC, and AFS cells. Stem cells exploitation for Pediatric Surgery: current research and perspective. Pediatr Surg Int (2009) 1.02
Extranuclear histone in the amphibian oocyte. Proc Natl Acad Sci U S A (1962) 1.00
The area code hypothesis revisited: olfactory receptors and other related transmembrane receptors may function as the last digits in a cell surface code for assembling embryos. Proc Natl Acad Sci U S A (1998) 0.98
Xenopus tropicalis as a model organism for genetics and genomics: past, present, and future. Methods Mol Biol (2012) 0.98
The genus Xenopus as a multispecies model for evolutionary and comparative immunobiology of the 21st century. Dev Comp Immunol (2011) 0.96
A brief history of epigenetics. Cold Spring Harb Perspect Biol (2014) 0.96
Histone variant H3.3 is an essential maternal factor for oocyte reprogramming. Proc Natl Acad Sci U S A (2014) 0.94
Large animal induced pluripotent stem cells as pre-clinical models for studying human disease. J Cell Mol Med (2012) 0.93
Nuclear reprogramming in mammalian somatic cell nuclear cloning. Cytogenet Genome Res (2004) 0.92
Efficiencies and mechanisms of nuclear reprogramming. Cold Spring Harb Symp Quant Biol (2010) 0.92
Maternal investment influences expression of resource polymorphism in amphibians: implications for the evolution of novel resource-use phenotypes. PLoS One (2010) 0.90
Feeding tadpoles cloned from Rana erythrocyte nuclei. Proc Natl Acad Sci U S A (1986) 0.89
Scientific and clinical opportunities for modeling blood disorders with embryonic stem cells. Blood (2005) 0.88
Fertile and diploid nuclear transplants derived from embryonic cells of a small laboratory fish, medaka (Oryzias latipes). Proc Natl Acad Sci U S A (2001) 0.88
The mysteries of induced pluripotency: where will they lead? Nat Methods (2010) 0.87
Directed Fusion of Mesenchymal Stem Cells with Cardiomyocytes via VSV-G Facilitates Stem Cell Programming. Stem Cells Int (2012) 0.87
Stem cell therapy: an exercise in patience and prudence. Philos Trans R Soc Lond B Biol Sci (2013) 0.86
Influence of spermine and reduced temperature on the ability of transplanted nuclei to promote normal development in eggs of Rana pipiens. Proc Natl Acad Sci U S A (1970) 0.86
Nuclear reprogramming in eggs. Nat Med (2009) 0.86
Induced pluripotent stem cells: emerging techniques for nuclear reprogramming. Antioxid Redox Signal (2011) 0.85
Patient-specific pluripotent stem cells: promises and challenges. Nat Rev Endocrinol (2009) 0.85
Evolutionary perspectives on clonal reproduction in vertebrate animals. Proc Natl Acad Sci U S A (2015) 0.85
Understanding the roadmaps to induced pluripotency. Cell Death Dis (2014) 0.85
Cycling through developmental decisions: how cell cycle dynamics control pluripotency, differentiation and reprogramming. Development (2016) 0.84
Mouse cloning and somatic cell reprogramming using electrofused blastomeres. Cell Res (2010) 0.84
Artificial cloning of domestic animals. Proc Natl Acad Sci U S A (2015) 0.84
Programming and reprogramming neuronal subtypes in the central nervous system. Dev Neurobiol (2012) 0.83
Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells. Int J Dev Biol (2010) 0.83
Modelling human disease with pluripotent stem cells. Curr Gene Ther (2013) 0.83
Drug discovery models and toxicity testing using embryonic and induced pluripotent stem-cell-derived cardiac and neuronal cells. Stem Cells Int (2012) 0.82
Dysregulation of genome-wide gene expression and DNA methylation in abnormal cloned piglets. BMC Genomics (2014) 0.82
Epigenetic rejuvenation. Genes Cells (2012) 0.82
Transplantation of nucle in Drosophila melanogaster. Proc Natl Acad Sci U S A (1971) 0.82
Transcription factor-mediated epigenetic reprogramming. J Biol Chem (2012) 0.81
Nonviral methods for inducing pluripotency to cells. Biomed Res Int (2013) 0.81
Transcription factor-mediated reprogramming toward hematopoietic stem cells. EMBO J (2015) 0.81
MiRiad Roles for MicroRNAs in Cardiac Development and Regeneration. Cells (2014) 0.80
A poor imitation of a natural process: a call to reconsider the iPSC engineering technique. Cell Cycle (2012) 0.80
An unknown piece of early work of nuclear reprogramming in fish eggs. Int J Biol Sci (2010) 0.80
Progress and obstacles towards generating hematopoietic stem cells from pluripotent stem cells. Curr Opin Hematol (2015) 0.80
Unexplored potentials of epigenetic mechanisms of plants and animals-theoretical considerations. Genet Epigenet (2013) 0.79
Molecular mechanisms of pluripotency and reprogramming. Stem Cell Res Ther (2010) 0.79
A highly efficient method for generation of therapeutic quality human pluripotent stem cells by using naive induced pluripotent stem cells nucleus for nuclear transfer. SAGE Open Med (2014) 0.78
Induced pluripotency for translational research. Genomics Proteomics Bioinformatics (2013) 0.78
Cellular reprogramming for understanding and treating human disease. Front Cell Dev Biol (2014) 0.78
Your brain under the microscope: the promise of stem cells. Cerebrum (2014) 0.78
Transdetermination: a new trend in cellular reprogramming. Mol Ther (2009) 0.78
In vitro fertilization and artificial activation of eggs of the direct-developing anuran Eleutherodactylus coqui. Reprod Biol Endocrinol (2004) 0.78
Somatic Cell Reprogramming into Cardiovascular Lineages. J Cardiovasc Pharmacol Ther (2014) 0.77
Cellular plasticity: 1712 to the present day. Curr Opin Cell Biol (2016) 0.77
A background to nuclear transfer and its applications in agriculture and human therapeutic medicine. J Anat (2002) 0.77
Induced pluripotent stem cells in dermatology: potentials, advances, and limitations. Cold Spring Harb Perspect Med (2014) 0.77
Tinkering with transcription factors uncovers plasticity of somatic cells. Genes Cancer (2010) 0.77
Sheep: the first large animal model in nuclear transfer research. Cell Reprogram (2013) 0.77
The Egg and the Nucleus: A Battle for Supremacy. Rambam Maimonides Med J (2015) 0.77
Cell fusion and plasticity. Cytotechnology (2003) 0.76
Profile of John Gurdon and Shinya Yamanaka, 2012 Nobel laureates in medicine or physiology. Proc Natl Acad Sci U S A (2013) 0.76
The decay of stem cell nourishment at the niche. Rejuvenation Res (2013) 0.76
Five classic articles in somatic cell reprogramming. Yale J Biol Med (2010) 0.76
Induced pluripotent stem cell technology and stem cell therapy for diabetes. Exp Ther Med (2010) 0.76
Reprogramming cells for brain repair. Brain Sci (2013) 0.76
Amphibian interorder nuclear transfer embryos reveal conserved embryonic gene transcription, but deficient DNA replication or chromosome segregation. Int J Dev Biol (2012) 0.76
Pluripotency and its layers of complexity. Cell Regen (Lond) (2012) 0.76
Sir John Gurdon: father of nuclear reprogramming. Differentiation (2014) 0.75
Maternal Messages to Live by: A personal historical perspective. Genesis (2017) 0.75
An uphill battle toward pluripotency. Nat Genet (2009) 0.75
Network analysis of transcription factors for nuclear reprogramming into induced pluripotent stem cell using bioinformatics. Cell J (2013) 0.75
p53 switches off pluripotency on differentiation. Stem Cell Res Ther (2017) 0.75
A study of the metabolism of amphibian neural crest cells during their migration and pigmentation in vitro. J Exp Zool (1949) 4.74
An investigation of the capacity for cleavage and differentiation in Rana pipiens eggs lacking "functional" chromosomes. J Exp Zool (1951) 2.29
Transplantation of nuclei from cell to cell. Nature (1950) 2.19
Somatic cell nuclear transfer. Nature (2002) 2.64
Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactum. J Chem Soc Perkin 1 (1976) 1.79
The conservation of dinucleotide microsatellites among mammalian genomes allows the use of heterologous PCR primer pairs in closely related species. Genomics (1991) 1.76
Clinicopathological investigation of primary, uncomplicated maedi-visna virus infection. Vet Rec (1992) 1.59
Primary closure of fasciotomy incisions with a skin-stretching device in patients with burn and trauma. J Burn Care Rehabil (1997) 0.95
The structure and absolute stereochemistry of zincophorin (antibiotic M144255): a monobasic carboxylic acid ionophore having a remarkable specificity for divalent cations. J Antibiot (Tokyo) (1984) 0.95
Studies in mycological chemistry. XXX and last. Isolation and structure of purpuride, a metabolite of Penicillium purpurogenum Stoll. J Chem Soc Perkin 1 (1973) 0.95
Antibiotic suseptibility of bacteria isolated from oral infections. J Oral Surg (1978) 0.94
The action of natural and synthetic isomers of quisqualic acid at a well-defined glutamatergic synapse. Brain Res (1986) 0.92
Systemic mycosis due to Aspergillus deflectus in a dog. Aust Vet J (2000) 0.89
Metabolites from the sponge Pachymatisma johnstoni; L-6-bromo-hypaphorine, a new amino-acid (and its crystal structure). J Chem Soc Perkin 1 (1977) 0.89
Mechanical property evaluation of pressable restorative ceramics. Dent Mater (2000) 0.88
Development and cellular differentiation of neural nuclear-transplants of known karyotype. Dev Biol (1967) 0.88
Transplantation of nuclei from the frog renal adenocarcinoma. I. Development of tumor nuclear-transplant embryos. Ann N Y Acad Sci (1965) 0.88
Retroviral arthritis: phenotypic analysis of cells in the synovial fluid of sheep with inflammatory synovitis associated with visna virus infection. Clin Immunol Immunopathol (1991) 0.87
Thermal and cyclic loading of endodontic posts. Eur J Oral Sci (1999) 0.80
A case of visna in the United Kingdom. Vet Rec (1990) 0.76
Acute pancreatitis associated with celecoxib. Ann Intern Med (2000) 0.76
Successful fostering of orphan lambs by non-pregnant ewes induced to lactate using exogenous hormone treatment. N Z Vet J (1993) 0.75
The Cancer Centers Program. J Natl Cancer Inst (1977) 0.75
Hormonal induction of lactation in non-pregnant ewes. N Z Vet J (1993) 0.75
CMV enhancer-promoter is preferentially active in exocrine cells in vivo. Transgenic Res (2008) 0.75
Further observations on resorption in guinea pigs following injections of trypan blue. Anat Rec (1967) 0.75
Biochemical and haematological evidence of endotoxic shock in gnotobiotic lambs with watery mouth disease. Res Vet Sci (1989) 0.75
Beverages : Report of the Committee. Am J Public Health Nations Health (1929) 0.75
Radiation oncology and the National Cancer Program. Int J Radiat Oncol Biol Phys (1977) 0.75
Reaction of ethyl diazoacetate with cobalt porphyrins. Part 3. structure and reactions of the 2:1 adducts. J Chem Soc Perkin 1 (1977) 0.75
Crystallographic studies and semi-empirical MNDO calculations on quisqualic acid and its analogues: systems containing unusual pyramidal heterocyclic ring nitrogens. J Comput Aided Mol Des (1989) 0.75
Renal adenocarcinomas promoted by crowded conditions in laboratory frogs. Cancer Res (1965) 0.75
Prologue: nuclear transplantation in amphibia. Int Rev Cytol Suppl (1979) 0.75
Laparoscopic intracorporeal harvest of jejunal tissue for autologous transplantation. Surg Laparosc Endosc (1994) 0.75
Revised constitution, absolute configuration, and conformation of griseoviridin, a modified cyclic peptide antibiotic. J Chem Soc Perkin 1 (1976) 0.75
Anthelmintic resistance. Vet Rec (1991) 0.75
Serum protein concentrations in clinical cases of ovine paratuberculosis (Johne's disease). Vet Rec (1995) 0.75
The Organ Site Programs and the National Cancer Program. Cancer Res (1977) 0.75