Induced pluripotency for translational research.

Systematic optimization of human pluripotent stem cells media using Design of Experiments. Sci Rep (2015) 0.82

Survival and migration of pre-induced adult human peripheral blood mononuclear cells in retinal degeneration slow (rds) mice three months after subretinal transplantation. Curr Stem Cell Res Ther (2014) 0.79

Translational Prospects and Challenges in Human Induced Pluripotent Stem Cell Research in Drug Discovery. Cells (2016) 0.76

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51

Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42

Embryonic stem cell lines derived from human blastocysts. Science (1998) 65.53

Generation of germline-competent induced pluripotent stem cells. Nature (2007) 32.77

Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84

Establishment in culture of pluripotential cells from mouse embryos. Nature (1981) 30.49

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24

Viable offspring derived from fetal and adult mammalian cells. Nature (1997) 22.46

Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell (1987) 22.17

Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A (1981) 18.96

Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc Natl Acad Sci U S A (2008) 13.09

Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41

A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell (2010) 7.94

Stepwise reprogramming of B cells into macrophages. Cell (2004) 7.68

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature (1988) 7.61

A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell (2010) 7.51

Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell (2010) 7.51

Modelling schizophrenia using human induced pluripotent stem cells. Nature (2011) 7.41

iPS cells produce viable mice through tetraploid complementation. Nature (2009) 6.51

Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell (2009) 5.49

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature (2012) 5.47

Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science (2013) 4.94

The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. J Embryol Exp Morphol (1962) 4.37

Transplantation of Living Nuclei From Blastula Cells into Enucleated Frogs' Eggs. Proc Natl Acad Sci U S A (1952) 4.32

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus. Nat Commun (2011) 3.23

Redesigning the body plan of Drosophila by ectopic expression of the homoeotic gene Antennapedia. Nature (1987) 2.81

Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell (2013) 2.69

Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors. Immunity (2006) 2.58

Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination. Cell Stem Cell (2013) 2.51

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. Cell Stem Cell (2013) 2.32

Modeling familial Alzheimer's disease with induced pluripotent stem cells. Hum Mol Genet (2011) 2.26

A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell (2013) 2.14

Differentiation of spinal motor neurons from pluripotent human stem cells. Nat Protoc (2009) 2.11

CHANGES IN THE NUCLEI OF DIFFERENTIATING GASTRULA CELLS, AS DEMONSTRATED BY NUCLEAR TRANSPLANTATION. Proc Natl Acad Sci U S A (1955) 1.90

Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions. Stem Cells (2010) 1.74

Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression. Nat Biotechnol (2012) 1.74

The developmental capacity of nuclei transplanted from keratinized skin cells of adult frogs. J Embryol Exp Morphol (1975) 1.64

Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies. Nat Rev Mol Cell Biol (2013) 1.52

Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells. PLoS One (2010) 1.48

Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nat Cell Biol (2013) 1.47

Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease. PLoS One (2011) 1.23

An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression. Cell Rep (2013) 1.21

Using human pluripotent stem cell-derived dopaminergic neurons to evaluate candidate Parkinson's disease therapeutic agents in MPP+ and rotenone models. J Biomol Screen (2013) 0.93

Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient. Biochem J (2012) 0.93

Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice. Cell Stem Cell (2012) 2.62

Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation. Ann Neurol (2011) 1.67

Human-derived neural progenitors functionally replace astrocytes in adult mice. J Clin Invest (2015) 0.86