PubRank

John D Wade

Author PubWeight™ 105.71‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity. J Neurosci 2008 1.86
2 INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. J Biol Chem 2002 1.71
3 Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family. J Biol Chem 2001 1.57
4 Paracrine regulation of mammalian oocyte maturation and male germ cell survival. Proc Natl Acad Sci U S A 2004 1.55
5 Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer. Eur J Cancer 2011 1.22
6 Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation. J Biol Chem 2003 1.14
7 Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity. J Biol Chem 2005 1.14
8 Designer antibacterial peptides kill fluoroquinolone-resistant clinical isolates. J Med Chem 2005 1.13
9 Chromatin remodeling and modification during HIV-1 Tat-activated transcription. Curr HIV Res 2003 1.12
10 Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge. J Biol Chem 2006 1.10
11 The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors. J Biol Chem 2008 1.06
12 Alternative stabilities of a proline-rich antibacterial peptide in vitro and in vivo. Protein Sci 2008 1.05
13 Alzheimer disease beta-amyloid activity mimics cholesterol oxidase. J Clin Invest 2005 1.04
14 R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization. J Biol Chem 2007 1.03
15 Relaxin-3: improved synthesis strategy and demonstration of its high-affinity interaction with the relaxin receptor LGR7 both in vitro and in vivo. Biochemistry 2006 1.03
16 The human insulin superfamily of polypeptide hormones. Vitam Horm 2009 1.02
17 Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria. Amino Acids 2014 1.01
18 Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3. J Biol Chem 2005 0.99
19 Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production. Proc Natl Acad Sci U S A 2013 0.98
20 Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus. Learn Mem 2009 0.98
21 Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling. J Biol Chem 2005 0.94
22 Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3. J Biol Chem 2006 0.94
23 The designer proline-rich antibacterial peptide A3-APO is effective against systemic Escherichia coli infections in different mouse models. Int J Antimicrob Agents 2009 0.93
24 Site-specific conjugation of a lanthanide chelator and its effects on the chemical synthesis and receptor binding affinity of human relaxin-2 hormone. Biochem Biophys Res Commun 2012 0.93
25 Defining the LGR8 residues involved in binding insulin-like peptide 3. Mol Endocrinol 2007 0.92
26 INSL3/RXFP2 signaling in testicular descent. Ann N Y Acad Sci 2009 0.92
27 Dimeric structures of alpha-synuclein bind preferentially to lipid membranes. Biochim Biophys Acta 2008 0.92
28 Inhibition of HIV-1 virus replication using small soluble Tat peptides. Virology 2005 0.92
29 Amphipathic alpha-helical peptide, HP (2-20), and its analogues derived from Helicobacter pylori: pore formation mechanism in various lipid compositions. Biochim Biophys Acta 2007 0.92
30 Scope and limitations of the designer proline-rich antibacterial peptide dimer, A3-APO, alone or in synergy with conventional antibiotics. Peptides 2008 0.91
31 A structural core within apolipoprotein C-II amyloid fibrils identified using hydrogen exchange and proteolysis. J Mol Biol 2006 0.91
32 Solid-phase synthesis of europium-labeled human INSL3 as a novel probe for the study of ligand-receptor interactions. Bioconjug Chem 2008 0.91
33 Amyloid-beta as a "difficult sequence" in solid phase peptide synthesis. Protein Pept Lett 2004 0.91
34 Use of a temporary "solubilizing" peptide tag for the Fmoc solid-phase synthesis of human insulin glargine via use of regioselective disulfide bond formation. Bioconjug Chem 2009 0.91
35 Peptide-based leptin receptor antagonists for cancer treatment and appetite regulation. Biopolymers 2011 0.90
36 Metal effects on the membrane interactions of amyloid-beta peptides. Eur Biophys J 2008 0.90
37 Analogs of insulin-like peptide 3 (INSL3) B-chain are LGR8 antagonists in vitro and in vivo. J Biol Chem 2006 0.90
38 Design, synthesis, and characterization of a single-chain peptide antagonist for the relaxin-3 receptor RXFP3. J Am Chem Soc 2011 0.90
39 Negative cooperativity in H2 relaxin binding to a dimeric relaxin family peptide receptor 1. Mol Cell Endocrinol 2008 0.89
40 Spatial proximity between a photolabile residue in position 19 of salmon calcitonin and the amino terminus of the human calcitonin receptor. J Biol Chem 2003 0.89
41 Development of a pharmacologically improved peptide agonist of the leptin receptor. Biochim Biophys Acta 2008 0.89
42 Synthesis, conformation, and activity of human insulin-like peptide 5 (INSL5). Chembiochem 2008 0.89
43 Improved chemical synthesis and demonstration of the relaxin receptor binding affinity and biological activity of mouse relaxin. Biochemistry 2007 0.89
44 Preclinical advantages of intramuscularly administered peptide A3-APO over existing therapies in Acinetobacter baumannii wound infections. J Antimicrob Chemother 2010 0.88
45 INSL3 as a biomarker of Leydig cell functionality. Biol Reprod 2013 0.88
46 Structure of the R3/I5 chimeric relaxin peptide, a selective GPCR135 and GPCR142 agonist. J Biol Chem 2008 0.88
47 Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis. Peptides 2011 0.88
48 Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity. Neurobiol Aging 2009 0.87
49 Designer peptide antagonist of the leptin receptor with peripheral antineoplastic activity. Peptides 2013 0.87
50 Relaxin-3/RXFP3 system regulates alcohol-seeking. Proc Natl Acad Sci U S A 2013 0.87
51 Prior antibacterial peptide-mediated inhibition of protein folding in bacteria mutes resistance enzymes. Antimicrob Agents Chemother 2006 0.86
52 Broad-spectrum antimicrobial efficacy of peptide A3-APO in mouse models of multidrug-resistant wound and lung infections cannot be explained by in vitro activity against the pathogens involved. Int J Antimicrob Agents 2011 0.86
53 Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework. Biochem J 2009 0.85
54 The relaxin peptide family--structure, function and clinical applications. Protein Pept Lett 2011 0.85
55 Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1. J Med Chem 2012 0.85
56 Design, synthesis and pharmacological evaluation of cyclic mimetics of the insulin-like peptide 3 (INSL3) B-chain. J Pept Sci 2007 0.85
57 The minimal active structure of human relaxin-2. J Biol Chem 2011 0.85
58 Imaging the action of antimicrobial peptides on living bacterial cells. Sci Rep 2013 0.84
59 Relaxin family peptide receptor (RXFP1) coupling to G(alpha)i3 involves the C-terminal Arg752 and localization within membrane Raft Microdomains. Mol Pharmacol 2008 0.84
60 H2 relaxin is a biased ligand relative to H3 relaxin at the relaxin family peptide receptor 3 (RXFP3). Mol Pharmacol 2010 0.84
61 Cooperative binding of insulin-like Peptide 3 to a dimeric relaxin family peptide receptor 2. Endocrinology 2007 0.84
62 The chemically synthesized human relaxin-2 analog, B-R13/17K H2, is an RXFP1 antagonist. Amino Acids 2009 0.83
63 The designer leptin antagonist peptide Allo-aca compensates for short serum half-life with very tight binding to the receptor. Amino Acids 2013 0.83
64 Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity. Org Biomol Chem 2009 0.83
65 H3 relaxin demonstrates antifibrotic properties via the RXFP1 receptor. Biochemistry 2011 0.83
66 The role of Abeta peptides in Alzheimer's disease. Protein Pept Lett 2005 0.83
67 Chimeric RXFP1 and RXFP2 Receptors Highlight the Similar Mechanism of Activation Utilizing Their N-Terminal Low-Density Lipoprotein Class A Modules. Front Endocrinol (Lausanne) 2013 0.83
68 Structure and function relationship of murine insulin-like peptide 5 (INSL5): free C-terminus is essential for RXFP4 receptor binding and activation. Biochemistry 2011 0.83
69 Synthetic human insulin 4 does not activate the G-protein-coupled receptors LGR7 or LGR8. J Pept Sci 2004 0.82
70 Central relaxin-3 receptor (RXFP3) activation decreases anxiety- and depressive-like behaviours in the rat. Behav Brain Res 2013 0.82
71 Slow insertion kinetics during interaction of a model antimicrobial peptide with unilamellar phospholipid vesicles. Langmuir 2011 0.82
72 Amyloid Beta (Aβ) Peptide and Factors that Play Important Roles in Alzheimer's Disease. Curr Med Chem 2016 0.82
73 Relaxin family peptides and receptors in mammalian brain. Ann N Y Acad Sci 2009 0.81
74 Killer bee molecules: antimicrobial peptides as effector molecules to target sporogonic stages of Plasmodium. PLoS Pathog 2013 0.81
75 Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin. J Biol Chem 2012 0.81
76 Cholesterol and Clioquinol modulation of A beta(1-42) interaction with phospholipid bilayers and metals. Biochim Biophys Acta 2007 0.81
77 Melittin peptides exhibit different activity on different cells and model membranes. Amino Acids 2014 0.81
78 Synthesis, conformational analysis and biological properties of a dicarba derivative of the antimicrobial peptide, brevinin-1BYa. Eur Biophys J 2011 0.80
79 The structural determinants of insulin-like Peptide 3 activity. Front Endocrinol (Lausanne) 2012 0.80
80 Membrane interactions and the effect of metal ions of the amyloidogenic fragment Abeta(25-35) in comparison to Abeta(1-42). Biochim Biophys Acta 2007 0.80
81 High density lipoproteins bind Abeta and apolipoprotein C-II amyloid fibrils. J Lipid Res 2006 0.80
82 Design and development of analogues of dimers of insulin-like peptide 3 B-chain as high-affinity antagonists of the RXFP2 receptor. Biopolymers 2011 0.80
83 Structural insights into the function of relaxins. Ann N Y Acad Sci 2009 0.80
84 Overview of solid phase synthesis of "difficult peptide" sequences. Curr Protoc Protein Sci 2007 0.80
85 Dimerization and negative cooperativity in the relaxin family peptide receptors. Ann N Y Acad Sci 2009 0.80
86 Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist. J Med Chem 2016 0.79
87 Mapping key regions of the RXFP2 low-density lipoprotein class-A module that are involved in signal activation. Biochemistry 2014 0.79
88 Human relaxin-2: historical perspectives and role in cancer biology. Amino Acids 2012 0.79
89 Studies on soluble ectodomain proteins of relaxin (LGR7) and insulin 3 (LGR8) receptors. Ann N Y Acad Sci 2005 0.79
90 The roles of the A- and B-chains of human relaxin-2 and -3 on their biological activity. Curr Protein Pept Sci 2010 0.79
91 A simple approach for the preparation of mature human relaxin-3. Peptides 2010 0.79
92 Minimum active structure of insulin-like peptide 5. J Med Chem 2013 0.79
93 Design and recombinant expression of insulin-like peptide 5 precursors and the preparation of mature human INSL5. Amino Acids 2010 0.78
94 Role of the intra-A-chain disulfide bond of insulin-like peptide 3 in binding and activation of its receptor, RXFP2. Peptides 2010 0.78
95 Chimeric relaxin peptides highlight the role of the A-chain in the function of H2 relaxin. Peptides 2012 0.78
96 Intramuscularly administered peptide A3-APO is effective against carbapenem-resistant Acinetobacter baumannii in mouse models of systemic infections. Biopolymers 2011 0.78
97 Aberrant protein expression in plasma and kidney tissue during experimental obstructive nephropathy. Proteomics Clin Appl 2009 0.78
98 Structural dynamics of a lytic peptide interacting with a supported lipid bilayer. Biophys J 2011 0.78
99 Structure and activity in the relaxin family of peptides. Ann N Y Acad Sci 2009 0.78
100 Agonists and partial antagonists acting on the leptin--leptin receptor interface. Adv Exp Med Biol 2009 0.77
101 Conformationally constrained single-chain peptide mimics of relaxin B-chain secondary structure. J Pept Sci 2005 0.77
102 Human gene 2 relaxin chain combination and folding. Biochemistry 2003 0.77
103 Relaxin-3 innervation of the intergeniculate leaflet of the rat thalamus - neuronal tract-tracing and in vitro electrophysiological studies. Eur J Neurosci 2013 0.77
104 Effect of helix-promoting strategies on the biological activity of novel analogues of the B-chain of INSL3. Amino Acids 2008 0.77
105 Roles of the receptor, the ligand, and the cell in the signal transduction pathways utilized by the relaxin family peptide receptors 1-3. Ann N Y Acad Sci 2009 0.77
106 Solution structure, aggregation behavior, and flexibility of human relaxin-2. ACS Chem Biol 2015 0.77
107 RXFP1 couples to the Galpha-Gbetagamma-PI3K-PKCzeta pathway via the final 10 amino acids of the receptor C-terminal tail. Ann N Y Acad Sci 2009 0.77
108 Insulin-relaxin family peptide signaling and receptors in mouse brain membranes and neuronal cells. Ann N Y Acad Sci 2005 0.77
109 Long-time-scale interaction dynamics between a model antimicrobial peptide and giant unilamellar vesicles. Langmuir 2013 0.77
110 General method for selective labelling of double-chain cysteine-rich peptides with a lanthanide chelate via solid-phase synthesis. J Pept Sci 2011 0.77
111 Rapid systemic and local treatments with the antibacterial peptide dimer A3-APO and its monomeric metabolite eliminate bacteria and reduce inflammation in intradermal lesions infected with Propionibacterium acnes and meticillin-resistant Staphylococcus aureus. Int J Antimicrob Agents 2013 0.77
112 The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BDelta23-27)R/I5. Chem Biol Drug Des 2009 0.76
113 Probing the functional domains of relaxin-3 and the creation of a selective antagonist for RXFP3/GPCR135 over relaxin receptor RXFP1/LGR7. Ann N Y Acad Sci 2009 0.76
114 Structural properties of relaxin chimeras. Ann N Y Acad Sci 2009 0.76
115 Chemical synthesis and orexigenic activity of rat/mouse relaxin-3. Amino Acids 2013 0.76
116 Pharmacological activation of RXFP3 is not orexigenic in C57BL/6J mice. Ital J Anat Embryol 2013 0.76
117 2-nitroveratryl as a photocleavable thiol-protecting group for directed disulfide bond formation in the chemical synthesis of insulin. Chemistry 2014 0.76
118 Total chemical synthesis of a heterodimeric interchain bis-lactam-linked Peptide: application to an analogue of human insulin-like Peptide 3. Int J Pept 2013 0.75
119 Structural requirements for the interaction of sheep insulin-like factor 3 with relaxin receptors in rat atria. Eur J Pharmacol 2002 0.75
120 Recombinant expression of an insulin-like peptide 3 (INSL3) precursor and its enzymatic conversion to mature human INSL3. FEBS J 2009 0.75
121 Susceptibility of intracellular Coxiella burnetii to antimicrobial peptides in mouse fibroblast cells. Protein Pept Lett 2014 0.75
122 Synergy between a lead proline-rich antibacterial peptide derivative and small molecule antibiotics. Adv Exp Med Biol 2009 0.75
123 Sequential formation of regioselective disulfide bonds in synthetic peptides with multiple disulfide bonds. Methods Mol Biol 2013 0.75
124 Relaxin-like bioactivity of ovine Insulin 3 (INSL3) analogues. Eur J Biochem 2002 0.75
125 Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability. Org Biomol Chem 2015 0.75
126 SELDI-TOF mass spectrometry-based protein profiling of kidney tissue. Methods Mol Biol 2009 0.75
127 Analysis of Abeta interactions using ProteinChip technology. Methods Mol Biol 2008 0.75
128 Evaluation of relaxin's antifibrotic action by SELDI-TOF mass spectrometry-based profiling of relaxin knockout mice, a model of progressive fibrosis. Ann N Y Acad Sci 2009 0.75
129 De novo design and synthesis of cyclic and linear peptides to mimic the binding cassette of human relaxin. Ann N Y Acad Sci 2009 0.75
130 Correction to "Atomic Force Microscopy Reveals the Mechanobiology of Lytic Peptide Action on Bacteria". Langmuir 2016 0.75
131 Site-specific DOTA/europium-labeling of recombinant human relaxin-3 for receptor-ligand interaction studies. Amino Acids 2011 0.75
132 Aqueous microwave-assisted solid-phase peptide synthesis using Fmoc strategy. III: racemization studies and water-based synthesis of histidine-containing peptides. Amino Acids 2014 0.75
133 Development of lanthanide-labeled human INSL3 as an alternative probe to radioactively labeled INSL3 for use in bioassays. Ann N Y Acad Sci 2009 0.75
134 The chemistry and biology of human relaxin-3. Ann N Y Acad Sci 2005 0.75
135 Intramolecular acyl transfer in peptide and protein ligation and synthesis. J Pept Sci 2015 0.75
136 Addition of a carboxy-terminal green fluorescent protein does not alter the binding and signaling properties of relaxin family Peptide receptor 3. Ann N Y Acad Sci 2009 0.75
137 Direct Measurement of Pore Dynamics and Leakage Induced by a Model Antimicrobial Peptide in Single Vesicles and Cells. Langmuir 2016 0.75
138 Detection, localization, and action of the INSL3 receptor, LGR8, in rat kidney. Ann N Y Acad Sci 2005 0.75