Published in Biochem Biophys Res Commun on April 14, 2006
Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene. Cell Host Microbe (2009) 1.90
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity. Nucleic Acids Res (2009) 1.84
Biological barriers to therapy with antisense and siRNA oligonucleotides. Mol Pharm (2009) 1.65
Progress toward in vivo use of siRNAs-II. Mol Ther (2011) 1.60
Oligonucleotide therapeutic approaches for Huntington disease. J Clin Invest (2011) 1.54
Self-assembling RNA nanorings based on RNAI/II inverse kissing complexes. Nano Lett (2011) 1.49
Therapeutic siRNA: principles, challenges, and strategies. Yale J Biol Med (2012) 1.35
Engineering RNA for targeted siRNA delivery and medical application. Adv Drug Deliv Rev (2010) 1.32
Asymmetric shorter-duplex siRNA structures trigger efficient gene silencing with reduced nonspecific effects. Mol Ther (2009) 1.19
Chemical modification patterns compatible with high potency dicer-substrate small interfering RNAs. Oligonucleotides (2008) 1.17
Research progress on siRNA delivery with nonviral carriers. Int J Nanomedicine (2011) 1.13
siRNA Versus miRNA as Therapeutics for Gene Silencing. Mol Ther Nucleic Acids (2015) 1.12
Fabrication of pRNA nanoparticles to deliver therapeutic RNAs and bioactive compounds into tumor cells. Nat Protoc (2013) 1.11
Sequence-non-specific effects of RNA interference triggers and microRNA regulators. Nucleic Acids Res (2009) 1.11
MALDI-TOF mass spectral analysis of siRNA degradation in serum confirms an RNAse A-like activity. Mol Biosyst (2006) 1.10
MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression. Pharmaceuticals (Basel) (2013) 1.04
Light-activated RNA interference using double-stranded siRNA precursors modified using a remarkable regiospecificity of diazo-based photolabile groups. Nucleic Acids Res (2009) 1.04
Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing. Nucleic Acids Res (2010) 1.03
2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity. Nat Commun (2014) 1.03
Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs. RNA (2009) 1.02
Tuning response curves for synthetic biology. ACS Synth Biol (2013) 1.01
Preclinical and clinical development of siRNA-based therapeutics. Adv Drug Deliv Rev (2015) 1.01
Chemical modification resolves the asymmetry of siRNA strand degradation in human blood serum. RNA (2007) 0.97
Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1. Nucleic Acids Res (2009) 0.97
The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing. Nucleic Acids Res (2010) 0.96
Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering. Front Genet (2012) 0.95
Antiviral RNAi: translating science towards therapeutic success. Pharm Res (2011) 0.94
Minor-groove-modulating adenosine replacements control protein binding and RNAi activity in siRNAs. ACS Chem Biol (2010) 0.94
Duplex end breathing determines serum stability and intracellular potency of siRNA-Au NPs. Mol Pharm (2011) 0.93
CD40 gene silencing reduces the progression of experimental lupus nephritis modulating local milieu and systemic mechanisms. PLoS One (2013) 0.93
Degradation of nuclease-stabilized RNA oligonucleotides in Mycoplasma-contaminated cell culture media. Nucleic Acid Ther (2012) 0.92
Modified dsRNAs that are not processed by Dicer maintain potency and are incorporated into the RISC. Nucleic Acids Res (2010) 0.91
Selective local delivery of RANK siRNA to bone phagocytes using bone augmentation biomaterials. Biomaterials (2012) 0.85
Delivery of therapeutic RNAi by nanovehicles. Chembiochem (2009) 0.85
RNA as a stable polymer to build controllable and defined nanostructures for material and biomedical applications. Nano Today (2015) 0.84
RNA interference for improving the outcome of islet transplantation. Adv Drug Deliv Rev (2010) 0.84
Functionally enhanced siRNA targeting TNFα attenuates DSS-induced colitis and TLR-mediated immunostimulation in mice. Mol Ther (2011) 0.83
Wound healing improvement with PHD-2 silenced fibroblasts in diabetic mice. PLoS One (2013) 0.83
Human Papillomavirus E6/E7-Specific siRNA Potentiates the Effect of Radiotherapy for Cervical Cancer in Vitro and in Vivo. Int J Mol Sci (2015) 0.82
Inhibition of cell proliferation and migration by miR-509-3p that targets CDK2, Rac1, and PIK3C2A. Mol Cells (2014) 0.82
Protection and Systemic Translocation of siRNA Following Oral Administration of Chitosan/siRNA Nanoparticles. Mol Ther Nucleic Acids (2013) 0.82
Probing the inherent stability of siRNA immobilized on nanoparticle constructs. Proc Natl Acad Sci U S A (2014) 0.81
RNA therapeutics targeting osteoclast-mediated excessive bone resorption. Adv Drug Deliv Rev (2011) 0.80
Not so pseudo anymore: pseudogenes as therapeutic targets. Pharmacogenomics (2013) 0.80
siRNA-based topical microbicides targeting sexually transmitted infections. Curr Opin Mol Ther (2010) 0.79
Targeted delivery of chemically modified anti-miR-221 to hepatocellular carcinoma with negatively charged liposomes. Int J Nanomedicine (2015) 0.79
Strategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers. J Biol Eng (2012) 0.78
The chemical evolution of oligonucleotide therapies of clinical utility. Nat Biotechnol (2017) 0.77
Tuning RNA Interference by Enhancing siRNA/PAZ Recognition. ACS Med Chem Lett (2012) 0.77
Possibilities for RNA interference in developing hepatitis C virus therapeutics. Viruses (2010) 0.77
Site-specific RNase A activity was dramatically reduced in serum from multiple types of cancer patients. PLoS One (2014) 0.77
Disease-causing allele-specific silencing by RNA interference. Pharmaceuticals (Basel) (2013) 0.76
Conformational Dynamics of Ago-Mediated Silencing Processes. Int J Mol Sci (2015) 0.76
Rational design of novel N-alkyl-N capped biostable RNA nanostructures for efficient long-term inhibition of gene expression. Nucleic Acids Res (2016) 0.75
RNAi Therapeutics in Autoimmune Disease. Pharmaceuticals (Basel) (2013) 0.75
Achieving HIV-1 Control through RNA-Directed Gene Regulation. Genes (Basel) (2016) 0.75
Delivery systems for in vivo use of nucleic Acid drugs. Drug Target Insights (2007) 0.75
Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development. Mol Pain (2016) 0.75
Gene and virotherapy for hematological malignancies. Int J Hematol (2016) 0.75
Lipid Nanovectors to Deliver RNA Oligonucleotides in Cancer. Nanomaterials (Basel) (2016) 0.75
Photocrosslinkable, biodegradable hydrogels with controlled cell adhesivity for prolonged siRNA delivery to hMSCs to enhance their osteogenic differentiation. J Mater Chem B Mater Biol Med (2016) 0.75
Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Science (2008) 4.36
S. pombe genome deletion project: an update. Cell Cycle (2010) 2.34
MicroRNA miR-199a* regulates the MET proto-oncogene and the downstream extracellular signal-regulated kinase 2 (ERK2). J Biol Chem (2008) 2.28
Treatment effects of ultrasound-guided capsular distension with hyaluronic acid in adhesive capsulitis of the shoulder. Arch Phys Med Rehabil (2012) 2.17
Comparative study of the linkage disequilibrium of an ENCODE region, chromosome 7p15, in Korean, Japanese, and Han Chinese samples. Genomics (2006) 2.15
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Proc Natl Acad Sci U S A (2008) 2.01
DNA synthesis and biological security. Nat Biotechnol (2007) 1.91
Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity. Cell (2010) 1.82
Evaluation of plasma leptin levels & BMI as predictor of postpartum weight retention. Indian J Med Res (2008) 1.47
The 3rd DBCLS BioHackathon: improving life science data integration with Semantic Web technologies. J Biomed Semantics (2013) 1.44
Effect of Lactobacillus gasseri BNR17 on Overweight and Obese Adults: A Randomized, Double-Blind Clinical Trial. Korean J Fam Med (2013) 1.43
Association between Cerebral Performance Category, Modified Rankin Scale, and discharge disposition after cardiac arrest. Resuscitation (2011) 1.40
A genome-wide resource of cell cycle and cell shape genes of fission yeast. Open Biol (2013) 1.32
Preparation of a promising angiogenesis PET imaging agent: 68Ga-labeled c(RGDyK)-isothiocyanatobenzyl-1,4,7-triazacyclononane-1,4,7-triacetic acid and feasibility studies in mice. J Nucl Med (2008) 1.32
MR imaging of orbital inflammatory pseudotumors with extraorbital extension. Korean J Radiol (2005) 1.32
Sporadic ALS has compartment-specific aberrant exon splicing and altered cell-matrix adhesion biology. Hum Mol Genet (2009) 1.27
H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells. J Biol Chem (2005) 1.21
Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance. DNA Repair (Amst) (2009) 1.21
Acute bilateral basal ganglia lesions in diabetic uraemia: diffusion-weighted MRI. Neuroradiology (2007) 1.20
Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast. PLoS One (2008) 1.17
FESD: a Functional Element SNPs Database in human. Nucleic Acids Res (2005) 1.16
Human Noxin is an anti-apoptotic protein in response to DNA damage of A549 non-small cell lung carcinoma. Int J Cancer (2013) 1.15
A protein interaction network associated with asthma. J Theor Biol (2008) 1.14
Clinical Diversity of SCN4A-Mutation-Associated Skeletal Muscle Sodium Channelopathy. J Clin Neurol (2009) 1.13
Central obesity as a risk factor for prostatic hyperplasia. Obesity (Silver Spring) (2006) 1.12
Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Mol Cell (2011) 1.11
A genome-wide scan for the Sasang constitution in a Korean family suggests significant linkage at chromosomes 8q11.22-23 and 11q22.1-3. J Altern Complement Med (2009) 1.08
Break-induced ATR and Ddb1-Cul4(Cdt)² ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast. Genes Dev (2010) 1.08
Mutation analysis of the GNE gene in Korean patients with distal myopathy with rimmed vacuoles. J Hum Genet (2005) 1.06
Association of tumor necrosis factor polymorphisms with asthma and serum total IgE. Hum Mol Genet (2003) 1.05
Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary fibrosis. J Biol Chem (2012) 1.04
CT evaluation of vocal cord paralysis due to thoracic diseases: a 10-year retrospective study. Yonsei Med J (2011) 1.04
A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe. Toxicol Sci (2008) 1.04
Effects of Lactobacillus gasseri BNR17 on body weight and adipose tissue mass in diet-induced overweight rats. J Microbiol (2010) 1.03
Induction of growth arrest by miR-542-3p that targets survivin. FEBS Lett (2010) 1.02
Differences between the measured and calculated free serum phenytoin concentrations in epileptic patients. Yonsei Med J (2009) 1.02
Bioinformatics in the post-genome era. J Biochem Mol Biol (2004) 1.01
Regulation of Polo-like kinase 1 by DNA damage in mitosis. Inhibition of mitotic PLK-1 by protein phosphatase 2A. J Biol Chem (2006) 0.99
Repression of phospho-JNK and infarct volume in ischemic brain of JIP1-deficient mice. J Neurosci Res (2003) 0.97
Prognosis of ocular myasthenia in Korea: a retrospective multicenter analysis of 202 patients. J Neurol Sci (2008) 0.95
SNP@Domain: a web resource of single nucleotide polymorphisms (SNPs) within protein domain structures and sequences. Nucleic Acids Res (2006) 0.94
Immune activation by siRNA/liposome complexes in mice is sequence- independent: lack of a role for Toll-like receptor 3 signaling. Mol Cells (2007) 0.93
Novel CLCN1 mutations and clinical features of Korean patients with myotonia congenita. J Korean Med Sci (2009) 0.93
Phenotypic variability in Kennedy's disease: implication of the early diagnostic features. Acta Neurol Scand (2005) 0.92
Multiple biomarkers and their relative contributions to identifying metabolic syndrome. Clin Chim Acta (2009) 0.92
Anti-obesity effect of Lactobacillus gasseri BNR17 in high-sucrose diet-induced obese mice. PLoS One (2013) 0.92
The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human breast cancer cells by inhibiting a PI-5 kinase for ROS generation. PLoS One (2012) 0.92
Serum BAFF expression in patients with myasthenia gravis. J Neuroimmunol (2008) 0.90
Therapeutic horseback riding outcomes of parent-identified goals for children with autism spectrum disorder: an ABA' multiple case design examining dosing and generalization to the home and community. J Autism Dev Disord (2014) 0.90
Insulin resistance is independently associated with peripheral and autonomic neuropathy in Korean type 2 diabetic patients. Acta Diabetol (2010) 0.90
Heterogeneous characteristics of Korean patients with dysferlinopathy. J Korean Med Sci (2012) 0.89
Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells. Oncol Rep (2012) 0.88
Dual knockdown of p65 and p50 subunits of NF-kappaB by siRNA inhibits the induction of inflammatory cytokines and significantly enhance apoptosis in human primary synoviocytes treated with tumor necrosis factor-alpha. Mol Biol Rep (2007) 0.87
Anti-nuclear antibody reactivity in lupus may be partly hard-wired into the primary B-cell repertoire. Mol Immunol (2009) 0.87
Hypermethylation of the Ras association domain family 1A (RASSF1A) gene in gallbladder cancer. Mol Cells (2007) 0.87
Prediction of early clinical severity and extent of neuronal damage in anterior-circulation infarction using the initial serum neuron-specific enolase level. Arch Neurol (2003) 0.87
Elevated serum level of interleukin-32α in the patients with myasthenia gravis. J Neurol (2011) 0.87
Three cases of manifesting female carriers in patients with Duchenne muscular dystrophy. Yonsei Med J (2011) 0.86
Comparison between clinical disabilities and electrophysiological values in Charcot-Marie-Tooth 1A patients with PMP22 duplication. J Clin Neurol (2012) 0.86
Treatment of spontaneous cervical spinal subdural hematoma with methylprednisolone pulse therapy. Yonsei Med J (2011) 0.86
Expression of matrix metalloproteinase-2 and -9 and tissue inhibitor of metalloproteinase-1 and -2 in intraductal and nonintraductal growth type of cholangiocarcinoma. Am J Gastroenterol (2004) 0.85
A complex phenotype of peripheral neuropathy, myopathy, hoarseness, and hearing loss is linked to an autosomal dominant mutation in MYH14. Hum Mutat (2011) 0.84
Association between survivor motor neuron 2 (SMN2) gene homozygous deletion and sporadic lower motor neuron disease in a Korean population. Ann Clin Lab Sci (2010) 0.84
Two common mutations (p.Gln832X and c.663+1G>C) account for about a third of the DYSF mutations in Korean patients with dysferlinopathy. Neuromuscul Disord (2012) 0.84
Clinical and pathological characteristics of four Korean patients with limb-girdle muscular dystrophy type 2B. J Korean Med Sci (2004) 0.84
A novel real-time PCR assay for the detection of Plasmodium falciparum and Plasmodium vivax malaria in low parasitized individuals. Acta Trop (2011) 0.84
Clinical characteristics and outcomes of juvenile and adult dermatomyositis. J Korean Med Sci (2009) 0.84
Comparisons of the various partial-thickness rotator cuff tears on MR arthrography and arthroscopic correlation. Korean J Radiol (2010) 0.84
AsiDesigner: exon-based siRNA design server considering alternative splicing. Nucleic Acids Res (2008) 0.83
Retinal proteome analysis in a mouse model of oxygen-induced retinopathy. J Proteome Res (2012) 0.83
Functional genomics of adhesion, invasion, and mycelial formation in Schizosaccharomyces pombe. Eukaryot Cell (2009) 0.83
The prevalence of thyrotoxicosis-related seizures. Thyroid (2010) 0.83
Quantitative positron emission tomography imaging of angiogenesis in rats with forelimb ischemia using (68)Ga-NOTA-c(RGDyK). Angiogenesis (2013) 0.82
The finding of new genetic polymorphism of UCP-1 A-1766G and its effects on body fat accumulation. Biochim Biophys Acta (2004) 0.82
Inhibition of cell proliferation and migration by miR-509-3p that targets CDK2, Rac1, and PIK3C2A. Mol Cells (2014) 0.82
Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B. Mol Biol Cell (2011) 0.82
Occurrence of norovirus infections in asymptomatic food handlers in South Korea. J Clin Microbiol (2012) 0.82
Preferences for the "screen and treat" strategy of Helicobacter pylori to prevent gastric cancer in healthy Korean populations. Helicobacter (2013) 0.82
The expression of BAFF in the muscles of patients with dermatomyositis. J Neuroimmunol (2012) 0.81
A case of adult-onset centronuclear myopathy. Yonsei Med J (2004) 0.81
Association of the adiponectin gene variations with risk of ischemic stroke in a Korean population. Yonsei Med J (2011) 0.81
Pneumomediastinum due to intractable hiccup as the presenting symptom of multiple sclerosis. Yonsei Med J (2005) 0.81
Formulation of 68Ga BAPEN kit for myocardial positron emission tomography imaging and biodistribution study. Nucl Med Biol (2009) 0.81
Serum and cerebrospinal fluid neuron-specific enolase for diagnosis of tuberculous meningitis. Yonsei Med J (2012) 0.81
Polarization-independent dual-band perfect absorber utilizing multiple magnetic resonances. Opt Express (2013) 0.80
Radioiodine gene therapy of hepatocellular carcinoma targeted human alpha fetoprotein. Cancer Biother Radiopharm (2008) 0.80
Comparison of clinical characteristics between congenital fiber type disproportion myopathy and congenital myopathy with type 1 fiber predominance. Yonsei Med J (2006) 0.80
Preparation of (188) Re-labeled paper for treating skin cancer. Appl Radiat Isot (2003) 0.80
SigCS base: an integrated genetic information resource for human cerebral stroke. BMC Syst Biol (2011) 0.79
Construction of the first compendium of chemical-genetic profiles in the fission yeast Schizosaccharomyces pombe and comparative compendium approach. Biochem Biophys Res Commun (2013) 0.79
Serum cystatin C is related to pulse wave velocity even in subjects with normal serum creatinine. Hypertens Res (2008) 0.79
Effect of enzyme replacement therapy in late onset Pompe disease: open pilot study of 48 weeks follow-up. Neurol Sci (2014) 0.79
Development of a ¹⁷⁷Lu-labeled RGD derivative for targeting angiogenesis. Cancer Biother Radiopharm (2010) 0.79
Contribution of specific foods to fat, fatty acids, and cholesterol in the development of a food frequency questionnaire in Koreans. Asia Pac J Clin Nutr (2004) 0.79
An improved method of 18F peptide labeling: hydrazone formation with HYNIC-conjugated c(RGDyK). Nucl Med Biol (2006) 0.78
The tumor suppressor homolog in fission yeast, myh1(+), displays a strong interaction with the checkpoint gene rad1(+). Mutat Res (2008) 0.78