Published in Toxicol Sci on August 06, 2008
Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways. Eukaryot Cell (2009) 1.40
Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. J Biol Chem (2010) 1.12
The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback. PLoS Genet (2009) 1.05
A two-component histidine kinase, MoSLN1, is required for cell wall integrity and pathogenicity of the rice blast fungus, Magnaporthe oryzae. Curr Genet (2010) 1.03
Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast. Mol Genet Genomics (2012) 0.92
Functional conservation of coenzyme Q biosynthetic genes among yeasts, plants, and humans. PLoS One (2014) 0.88
Involvement of a broccoli COQ5 methyltransferase in the production of volatile selenium compounds. Plant Physiol (2009) 0.88
Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe. PLoS One (2011) 0.86
Cadmium-induced proteome remodeling regulated by Spc1/Sty1 and Zip1 in fission yeast. Toxicol Sci (2012) 0.83
Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast. PLoS One (2013) 0.83
A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis. Antimicrob Agents Chemother (2012) 0.82
Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability. PLoS Genet (2014) 0.81
Functional toxicology: tools to advance the future of toxicity testing. Front Genet (2014) 0.80
Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains. G3 (Bethesda) (2014) 0.78
Centaurin-like protein Cnt5 contributes to arsenic and cadmium resistance in fission yeast. FEMS Yeast Res (2008) 0.75
Think outside the box: selenium volatilization altered by a broccoli gene in the ubiquinone biosynthetic pathway. Plant Signal Behav (2010) 0.75
Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast. G3 (Bethesda) (2016) 0.75
Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol (1991) 33.90
GO::TermFinder--open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes. Bioinformatics (2004) 20.23
Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast (1998) 18.47
The genome sequence of Schizosaccharomyces pombe. Nature (2002) 14.26
Heterochromatin revisited. Nat Rev Genet (2007) 8.70
Hazards of heavy metal contamination. Br Med Bull (2003) 7.51
Global transcriptional responses of fission yeast to environmental stress. Mol Biol Cell (2003) 6.04
Isolation of type I and II DNA topoisomerase mutants from fission yeast: single and double mutants show different phenotypes in cell growth and chromatin organization. EMBO J (1984) 5.03
Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast. Nature (1995) 4.17
Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast. Genes Dev (1996) 3.81
Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1. Genes Dev (1998) 3.27
Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe. Mol Cell Biol (1996) 3.18
Isolation of mutants of Schizosaccharomyces pombe unable to synthesize cadystin, small cadmium-binding peptides. Biochem Biophys Res Commun (1988) 3.09
Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology (2003) 2.96
Cadmium is a mutagen that acts by inhibiting mismatch repair. Nat Genet (2003) 2.88
Phytochelatin synthase genes from Arabidopsis and the yeast Schizosaccharomyces pombe. Plant Cell (1999) 2.74
Transport of metal-binding peptides by HMT1, a fission yeast ABC-type vacuolar membrane protein. J Biol Chem (1995) 2.64
Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression. Proc Natl Acad Sci U S A (1997) 2.51
Molecular analysis of kinetochore architecture in fission yeast. EMBO J (2005) 2.29
Sulfur sparing in the yeast proteome in response to sulfur demand. Mol Cell (2002) 2.27
Tolerance to toxic metals by a gene family of phytochelatin synthases from plants and yeast. EMBO J (1999) 2.24
Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review). Biochimie (2006) 2.23
A MAP kinase-dependent actin checkpoint ensures proper spindle orientation in fission yeast. Nature (2001) 2.19
Heavy metal tolerance in the fission yeast requires an ATP-binding cassette-type vacuolar membrane transporter. EMBO J (1992) 2.19
The antioxidant role of coenzyme Q. Mitochondrion (2007) 1.91
Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly. Nat Cell Biol (2001) 1.89
Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway. Mol Biol Cell (2001) 1.80
Spindle-kinetochore attachment requires the combined action of Kin I-like Klp5/6 and Alp14/Dis1-MAPs in fission yeast. EMBO J (2002) 1.70
The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex. Mol Cell Biol (2006) 1.65
Sulfur assimilation and glutathione metabolism under cadmium stress in yeast, protists and plants. FEMS Microbiol Rev (2005) 1.56
Glutathione metabolism. Methods Enzymol (1995) 1.44
Oxidative stress response in yeast: effect of glutathione on adaptation to hydrogen peroxide stress in Saccharomyces cerevisiae. FEBS Lett (1995) 1.43
Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms. Environ Health Perspect (2002) 1.37
Effects of long-term low-dose cadmium exposure on genomic DNA methylation in human embryo lung fibroblast cells. Toxicology (2007) 1.31
Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2. Curr Biol (2000) 1.28
A copper-sensing transcription factor regulates iron uptake genes in Schizosaccharomyces pombe. J Biol Chem (1999) 1.24
Biosynthesis, bioproduction and novel roles of ubiquinone. J Biosci Bioeng (2002) 1.24
High-throughput and sensitive assay to measure yeast cell growth: a bench protocol for testing genotoxic agents. Nat Protoc (2006) 1.24
Dual requirement for the yeast MMS19 gene in DNA repair and RNA polymerase II transcription. Mol Cell Biol (1996) 1.22
Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factors. Mol Cell Biol (2002) 1.21
DNA repair systems as targets of cadmium toxicity. Toxicol Appl Pharmacol (2006) 1.21
A single glutaredoxin or thioredoxin gene is essential for viability in the yeast Saccharomyces cerevisiae. Mol Microbiol (2000) 1.16
Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants. Toxicol Sci (2007) 1.16
Phenotypes of fission yeast defective in ubiquinone production due to disruption of the gene for p-hydroxybenzoate polyprenyl diphosphate transferase. J Bacteriol (2000) 1.11
Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists. Proc Natl Acad Sci U S A (2004) 1.11
Two purine biosynthetic enzymes that are required for cadmium tolerance in Schizosaccharomyces pombe utilize cysteine sulfinate in vitro. Arch Biochem Biophys (1993) 1.10
A fission yeast gene for mitochondrial sulfide oxidation. J Biol Chem (1999) 1.09
SCF(Pof1)-ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast. EMBO J (2005) 1.09
Coenzyme Q10 in cardiovascular disease. Mitochondrion (2007) 1.06
DNA changes in barley (Hordeum vulgare) seedlings induced by cadmium pollution using RAPD analysis. Chemosphere (2005) 1.05
Induction and repair inhibition of oxidative DNA damage by nickel(II) and cadmium(II) in mammalian cells. Carcinogenesis (1997) 1.04
Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe. Eukaryot Cell (2005) 1.04
Cadmium toxicity in animal cells by interference with essential metals. Biochimie (2006) 1.02
Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2-MSH6 complex. Nucleic Acids Res (2005) 1.00
Purine biosynthetic genes are required for cadmium tolerance in Schizosaccharomyces pombe. Mol Cell Biol (1992) 0.99
Interference by toxic metal compounds with isolated zinc finger DNA repair proteins. Toxicol Lett (2000) 0.98
Caulobacter crescentus as a whole-cell uranium biosensor. Appl Environ Microbiol (2007) 0.98
Learning from yeasts: intracellular sensing of stress conditions. Int Microbiol (2003) 0.97
Plant sulfite reductase: molecular structure, catalytic function and interaction with ferredoxin. J Inorg Biochem (2000) 0.97
In vitro cadmium-DNA interactions: cooperativity of cadmium binding and competitive antagonism by calcium, magnesium, and zinc. Toxicol Appl Pharmacol (1984) 0.96
Alterations in cytoskeletal protein sulfhydryls and cellular glutathione in cultured cells exposed to cadmium and nickel ions. Toxicology (1993) 0.93
Yeast genes involved in cadmium tolerance: Identification of DNA replication as a target of cadmium toxicity. DNA Repair (Amst) (2008) 0.93
Pleiotropic phenotypes of fission yeast defective in ubiquinone-10 production. A study from the abc1Sp (coq8Sp) mutant. Biofactors (2003) 0.86
Cellular factors mediate cadmium-dependent actin depolymerization. Toxicol Appl Pharmacol (1996) 0.84
Accumulation of metal-binding peptides in fission yeast requires hmt2+. Mol Microbiol (2001) 0.84
Opposite roles of ERK and p38 mitogen-activated protein kinases in cadmium-induced genotoxicity and mitotic arrest. Chem Res Toxicol (2001) 0.83
Impact assessment of cadmium contamination on rice (Oryza sativa L.) seedlings at molecular and population levels using multiple biomarkers. Chemosphere (2006) 0.83
Molecular cloning and nucleotide sequencing of the gamma-glutamylcysteine synthetase gene of the fission yeast Schizosaccharomyces pombe. J Biochem (1995) 0.79
Role of determinants of cadmium sensitivity in the tolerance of Schizosaccharomyces pombe to cisplatin. Mol Pharmacol (1997) 0.78
Periodic gene expression program of the fission yeast cell cycle. Nat Genet (2004) 5.60
Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol Cell (2007) 5.31
Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases. Cell (2009) 5.05
Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Science (2008) 4.36
Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell (2008) 4.26
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol (2005) 3.25
Elastic modulus determination of normal and glaucomatous human trabecular meshwork. Invest Ophthalmol Vis Sci (2011) 3.19
Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair. Cell (2009) 2.90
Swi1 and Swi3 are components of a replication fork protection complex in fission yeast. Mol Cell Biol (2004) 2.55
Fission yeast Scm3 mediates stable assembly of Cnp1/CENP-A into centromeric chromatin. Mol Cell (2009) 2.49
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. Science (2012) 2.46
The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism. Mol Cell (2003) 2.44
The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1. J Biol Chem (2009) 2.40
S. pombe genome deletion project: an update. Cell Cycle (2010) 2.34
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. Nat Cell Biol (2009) 2.29
Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks. Genes Dev (2006) 2.27
Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA. Cell (2002) 2.23
Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast. Mol Cell Biol (2004) 2.20
Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1. Mol Cell Biol (2003) 2.19
Dual binding of chromomethylase domains to H3K9me2-containing nucleosomes directs DNA methylation in plants. Cell (2012) 2.19
The DNA damage response: sensing and signaling. Curr Opin Cell Biol (2004) 2.13
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Proc Natl Acad Sci U S A (2008) 2.01
A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis. Curr Biol (2010) 1.99
Slx1-Slx4 are subunits of a structure-specific endonuclease that maintains ribosomal DNA in fission yeast. Mol Biol Cell (2003) 1.96
Constraining G1-specific transcription to late G1 phase: the MBF-associated corepressor Nrm1 acts via negative feedback. Mol Cell (2006) 1.92
DNA synthesis and biological security. Nat Biotechnol (2007) 1.91
Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity. Cell (2010) 1.82
Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres. Genetics (2002) 1.78
Fission yeast Mus81.Eme1 Holliday junction resolvase is required for meiotic crossing over but not for gene conversion. Genetics (2003) 1.72
Protection of telomeres by a conserved Stn1-Ten1 complex. Proc Natl Acad Sci U S A (2007) 1.71
Retention but not recruitment of Crb2 at double-strand breaks requires Rad1 and Rad3 complexes. Mol Cell Biol (2003) 1.70
Indentation versus tensile measurements of Young's modulus for soft biological tissues. Tissue Eng Part B Rev (2011) 1.69
Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks. PLoS Genet (2011) 1.66
ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair. Nat Struct Mol Biol (2011) 1.66
Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. Nat Immunol (2005) 1.65
Chemical modification of siRNAs to improve serum stability without loss of efficacy. Biochem Biophys Res Commun (2006) 1.63
Mus81 is essential for sister chromatid recombination at broken replication forks. EMBO J (2008) 1.63
SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV. PLoS Genet (2011) 1.61
Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress. Genes Dev (2005) 1.60
Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast. Cell Cycle (2010) 1.58
Pervasive and cooperative deadenylation of 3'UTRs by embryonic microRNA families. Mol Cell (2010) 1.55
Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes. Immunity (2005) 1.54
Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60. Mol Cell Biol (2003) 1.50
Burkholderia pseudomallei: animal models of infection. Trans R Soc Trop Med Hyg (2008) 1.48
Sws1 is a conserved regulator of homologous recombination in eukaryotic cells. EMBO J (2006) 1.46
The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint. Mol Cell Biol (2003) 1.45
Effect of Lactobacillus gasseri BNR17 on Overweight and Obese Adults: A Randomized, Double-Blind Clinical Trial. Korean J Fam Med (2013) 1.43
Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2. J Biol Chem (2004) 1.41
Characterisation of an acapsular mutant of Burkholderia pseudomallei identified by signature tagged mutagenesis. J Med Microbiol (2002) 1.37
RNA-binding protein Csx1 mediates global control of gene expression in response to oxidative stress. EMBO J (2003) 1.35
Gene and protein expression changes in human trabecular meshwork cells treated with transforming growth factor-beta. Invest Ophthalmol Vis Sci (2004) 1.35
Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy. J Biol Chem (2012) 1.33
A genome-wide resource of cell cycle and cell shape genes of fission yeast. Open Biol (2013) 1.32
Naive recirculating B cells mature simultaneously in the spleen and bone marrow. Blood (2006) 1.31
Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex. J Biol Chem (2005) 1.30
Structure of an atypical orphan response regulator protein supports a new phosphorylation-independent regulatory mechanism. J Biol Chem (2007) 1.30
Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus. J Biochem Mol Biol (2004) 1.28
Mediator coordinates PIC assembly with recruitment of CHD1. Genes Dev (2011) 1.28
gammaH2A binds Brc1 to maintain genome integrity during S-phase. EMBO J (2010) 1.28
The effect of biophysical attributes of the ocular trabecular meshwork associated with glaucoma on the cell response to therapeutic agents. Biomaterials (2011) 1.28
Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair. Philos Trans R Soc Lond B Biol Sci (2011) 1.27
CDK phosphorylation of Drc1 regulates DNA replication in fission yeast. Curr Biol (2002) 1.22
Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance. DNA Repair (Amst) (2009) 1.21
Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast. Mol Cell Biol (2003) 1.20
Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast. Mol Cell Biol (2006) 1.18
RNA interference inhibition of Mus81 reduces mitotic recombination in human cells. Mol Biol Cell (2003) 1.17
Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast. PLoS One (2008) 1.17
Gene expression profiling of TGFbeta2- and/or BMP7-treated trabecular meshwork cells: Identification of Smad7 as a critical inhibitor of TGF-beta2 signaling. Exp Eye Res (2009) 1.14
ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. EMBO J (2014) 1.14
Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast. Mol Cell Biol (2005) 1.13
Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. J Biol Chem (2010) 1.12
Signaling pathways that regulate cell division. Cold Spring Harb Perspect Biol (2012) 1.12
The cell in an era of systems biology. Cell (2011) 1.12
Interactions between Swi1-Swi3, Mrc1 and S phase kinase, Hsk1 may regulate cellular responses to stalled replication forks in fission yeast. Genes Cells (2009) 1.12
Effect of latanoprost on the expression of matrix metalloproteinases and their tissue inhibitors in human trabecular meshwork cells. Invest Ophthalmol Vis Sci (2006) 1.12
Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast. PLoS Genet (2010) 1.11
Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Mol Cell (2011) 1.11