Published in Mol Membr Biol on April 13, 2006
Substrate specificity of gamma-secretase and other intramembrane proteases. Cell Mol Life Sci (2008) 2.29
Copper in the brain and Alzheimer's disease. J Biol Inorg Chem (2009) 1.40
Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J Biol Chem (2008) 1.34
Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease. Mol Ther (2009) 1.23
The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway. J Biol Chem (2010) 1.21
Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production. Neurobiol Dis (2007) 1.20
Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes. Int J Alzheimers Dis (2010) 1.17
Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statins. J Cell Mol Med (2007) 1.13
Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships? Biochim Biophys Acta (2010) 1.11
S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. J Biol Chem (2008) 1.09
Lipid raft redox signaling: molecular mechanisms in health and disease. Antioxid Redox Signal (2011) 1.06
Associations between serum cholesterol levels and cerebral amyloidosis. JAMA Neurol (2014) 1.05
Effects of membrane lipids on the activity and processivity of purified γ-secretase. Biochemistry (2012) 1.03
Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease. J Exp Med (2012) 1.02
Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer's disease (AD). Expert Opin Emerg Drugs (2012) 0.97
Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling. Front Physiol (2012) 0.97
Effect of surfaces on amyloid fibril formation. PLoS One (2011) 0.97
CD317/tetherin is an organiser of membrane microdomains. J Cell Sci (2013) 0.94
Cross-talk of membrane lipids and Alzheimer-related proteins. Mol Neurodegener (2013) 0.93
Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease. J Biol Chem (2009) 0.93
Bivalent ligands targeting multiple pathological factors involved in Alzheimer's disease. ACS Med Chem Lett (2012) 0.91
Nogo receptor interacts with brain APP and Abeta to reduce pathologic changes in Alzheimer's transgenic mice. Curr Alzheimer Res (2007) 0.89
Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium. PLoS One (2010) 0.88
Free cholesterol induces higher β-sheet content in Aβ peptide oligomers by aromatic interaction with Phe19. PLoS One (2012) 0.83
Activation of mTOR: a culprit of Alzheimer's disease? Neuropsychiatr Dis Treat (2015) 0.83
Oxidized cholesterol as the driving force behind the development of Alzheimer's disease. Front Aging Neurosci (2015) 0.83
Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease. Mol Med (2008) 0.82
Links between copper and cholesterol in Alzheimer's disease. Front Physiol (2013) 0.81
Influence of hydrophobic mismatch on the catalytic activity of Escherichia coli GlpG rhomboid protease. Protein Sci (2014) 0.80
Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant. Brain Behav (2012) 0.80
Alzheimer's Disease: Mechanism and Approach to Cell Therapy. Int J Mol Sci (2015) 0.79
Distinct subcellular patterns of neprilysin protein and activity in the brains of Alzheimer's disease patients, transgenic mice and cultured human neuronal cells. Am J Transl Res (2013) 0.78
Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer's disease. Bioorg Med Chem (2015) 0.78
Effects of lipid composition and phase on the membrane interaction of the prion peptide 106-126 amide. Biophys J (2009) 0.78
The slowly aggregating salmon Calcitonin: a useful tool for the study of the amyloid oligomers structure and activity. Int J Mol Sci (2011) 0.77
The phenyltetraene lysophospholipid analog PTE-ET-18-OMe as a fluorescent anisotropy probe of liquid ordered membrane domains (lipid rafts) and ceramide-rich membrane domains. Biochim Biophys Acta (2007) 0.77
Phosphatidylinositol-4,5-bisphosphate is enriched in granulovacuolar degeneration bodies and neurofibrillary tangles. Neuropathol Appl Neurobiol (2014) 0.77
The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains. Mol Cell Neurosci (2016) 0.76
Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems. Alzheimers Res Ther (2012) 0.76
Hippocampal lipid differences in Alzheimer's disease: a human brain study using matrix-assisted laser desorption/ionization-imaging mass spectrometry. Brain Behav (2016) 0.75
Relationship between plasma lipids and mild cognitive impairment in the elderly Chinese: a case-control study. Lipids Health Dis (2016) 0.75
Hypercholesterolemia induces short-term spatial memory impairments in mice: up-regulation of acetylcholinesterase activity as an early and causal event? J Neural Transm (Vienna) (2013) 0.75
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
Shedding light on ADAM metalloproteinases. Trends Biochem Sci (2005) 2.41
ADAMs family members as amyloid precursor protein alpha-secretases. J Neurosci Res (2003) 2.29
Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. Proc Natl Acad Sci U S A (2007) 2.05
Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein. Proc Natl Acad Sci U S A (2003) 2.03
Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem J (2004) 1.98
Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). J Biol Chem (2005) 1.73
The prion protein and lipid rafts. Mol Membr Biol (2006) 1.54
The angiotensin-converting enzyme gene family: genomics and pharmacology. Trends Pharmacol Sci (2002) 1.51
Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis. J Cell Sci (2005) 1.38
Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis. Traffic (2010) 1.36
Dual mechanisms for shedding of the cellular prion protein. J Biol Chem (2004) 1.32
Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease? J Neurochem (2011) 1.32
Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases? J Neurochem (2002) 1.30
Amyloid-degrading enzymes as therapeutic targets in Alzheimer's disease. Curr Alzheimer Res (2008) 1.30
Angiotensin-converting enzyme as a GPIase: a critical reevaluation. Nat Med (2005) 1.28
Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease. EMBO Rep (2008) 1.27
Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease. Trends Mol Med (2005) 1.26
Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study. Hypertension (2006) 1.25
The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein. Biochem J (2007) 1.25
Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor. Biochem J (2009) 1.24
The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway. J Biol Chem (2010) 1.21
Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein. J Biol Chem (2009) 1.19
The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein. Eur J Biochem (2004) 1.18
Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes. Int J Alzheimers Dis (2010) 1.17
Reactive oxygen species-mediated beta-cleavage of the prion protein in the cellular response to oxidative stress. J Biol Chem (2005) 1.12
Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells. J Biol Chem (2005) 1.10
Visualization of detergent solubilization of membranes: implications for the isolation of rafts. Biophys J (2007) 1.09
alpha-cleavage of the prion protein occurs in a late compartment of the secretory pathway and is independent of lipid rafts. Mol Cell Neurosci (2008) 1.08
Sodium valproate: an old drug with new roles. Trends Pharmacol Sci (2009) 1.07
The amyloid precursor protein: a biochemical enigma in brain development, function and disease. FEBS Lett (2013) 1.07
Prion protein facilitates uptake of zinc into neuronal cells. Nat Commun (2012) 1.07
Prion protein and Alzheimer disease. Prion (2009) 1.05
The N-terminal region of the prion protein ectodomain contains a lipid raft targeting determinant. J Biol Chem (2003) 1.04
Glypican-1 mediates both prion protein lipid raft association and disease isoform formation. PLoS Pathog (2009) 1.04
Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence. Biochemistry (2003) 1.04
Cell biology, regulation and inhibition of beta-secretase (BACE-1). FEBS J (2009) 1.04
Increased circulating insulin-like growth factor-1 in late-onset Alzheimer's disease. J Alzheimers Dis (2007) 1.04
The prion protein and neuronal zinc homeostasis. Trends Biochem Sci (2003) 1.04
PCSK9: an emerging target for treatment of hypercholesterolemia. Expert Opin Ther Targets (2011) 1.02
Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1. J Biol Chem (2013) 1.01
Effects of hypoxia and oxidative stress on expression of neprilysin in human neuroblastoma cells and rat cortical neurones and astrocytes. Neurochem Res (2007) 1.00
Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein. J Biol Chem (2011) 1.00
A broad-spectrum fluorescence-based peptide library for the rapid identification of protease substrates. Proteomics (2006) 1.00
Endothelial cell confluence regulates Weibel-Palade body formation. Mol Membr Biol (2005) 0.99
Nuclear signalling by membrane protein intracellular domains: the AICD enigma. Cell Signal (2011) 0.98
The kinetics of phase separation in asymmetric membranes. Biophys J (2005) 0.97
Surface coat remodeling during differentiation of Trypanosoma brucei. J Biol Chem (2003) 0.97
Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling. Front Physiol (2012) 0.97
Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system. Biochem Pharmacol (2007) 0.97
The role of lipid rafts in prion protein biology. Front Biosci (Landmark Ed) (2011) 0.96
ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors. Can J Physiol Pharmacol (2002) 0.95
Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cells. Arterioscler Thromb Vasc Biol (2009) 0.95
Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain. FEBS Lett (2007) 0.95
Prion protein is reduced in aging and in sporadic but not in familial Alzheimer's disease. J Alzheimers Dis (2010) 0.94
N-glycans, not the GPI anchor, mediate the apical targeting of a naturally glycosylated, GPI-anchored protein in polarised epithelial cells. J Cell Sci (2004) 0.94
The role of zinc in Alzheimer's disease. Int J Alzheimers Dis (2010) 0.94
Role of lipid rafts in the processing of the pathogenic prion and Alzheimer's amyloid-beta proteins. Semin Cell Dev Biol (2007) 0.93
Effects of periodontopathic bacteria on the expression of endothelin-1 in gingival epithelial cells in adult periodontitis. Clin Sci (Lond) (2002) 0.93
Tethering the N-terminus of the prion protein compromises the cellular response to oxidative stress. J Neurochem (2003) 0.92
Not just angiotensinases: new roles for the angiotensin-converting enzymes. Cell Mol Life Sci (2009) 0.92
The Caenorhabditis elegans orthologue of mammalian puromycin-sensitive aminopeptidase has roles in embryogenesis and reproduction. J Biol Chem (2003) 0.90
Angiotensin-converting enzyme 2: the first decade. Int J Hypertens (2011) 0.90
Effect of hydrophobic mismatch on phase behavior of lipid membranes. Biophys J (2006) 0.90
Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships. BMC Evol Biol (2008) 0.90
A new take on prions: preventing Alzheimer's disease. Trends Biochem Sci (2008) 0.89
ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci (2004) 0.89
Alkaline phosphatase is increased in both brain and plasma in Alzheimer's disease. Neurodegener Dis (2011) 0.89
Differential expression of neutral endopeptidase-24.11 (neprilysin) and endothelin-converting enzyme in human prostate cancer cell lines. Clin Sci (Lond) (2002) 0.88
Plasma angiotensin-converting enzyme in Alzheimer's disease. J Alzheimers Dis (2009) 0.87
Increased expression of endothelin-converting enzyme-1c isoform in response to high glucose levels in endothelial cells. J Vasc Res (2004) 0.87
Secretase-mediated cell surface shedding of the angiotensin-converting enzyme. Protein Pept Lett (2004) 0.87
Neuroconnectivity and valproic acid: the myelin hypothesis. Neurosci Biobehav Rev (2012) 0.87
Emerging and potential therapies for Alzheimer's disease. Expert Opin Ther Targets (2008) 0.87
Effect of hypoxia/ischemia and hypoxic preconditioning/reperfusion on expression of some amyloid-degrading enzymes. Ann N Y Acad Sci (2004) 0.86
Adamalysins in biology and disease. J Pathol (2009) 0.86
Locomotor and geotactic behavior of Drosophila melanogaster over-expressing neprilysin 2. Peptides (2008) 0.86
The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill. J Renin Angiotensin Aldosterone Syst (2008) 0.86
Plasma alkaline phosphatase is elevated in Alzheimer's disease and inversely correlates with cognitive function. Int J Mol Epidemiol Genet (2011) 0.85
Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha. Biochemistry (2002) 0.85
Endothelin system in oral squamous carcinoma cells: specific siRNA targeting of ECE-1 blocks cell proliferation. Int J Cancer (2006) 0.85