Published in Biophys J on March 18, 2005
Phase-field modeling of the dynamics of multicomponent vesicles: Spinodal decomposition, coarsening, budding, and fission. Phys Rev E Stat Nonlin Soft Matter Phys (2009) 1.55
Phase separation in biological membranes: integration of theory and experiment. Annu Rev Biophys (2010) 1.37
Dynamics of multicomponent vesicles in a viscous fluid. J Comput Phys (2010) 1.31
Influence of monolayer-monolayer coupling on the phase behavior of a fluid lipid bilayer. Biophys J (2007) 1.07
Landscape of finite-temperature equilibrium behaviour of curvature-inducing proteins on a bilayer membrane explored using a linearized elastic free energy model. Mol Phys (2008) 0.93
Calculation of free energies in fluid membranes subject to heterogeneous curvature fields. Phys Rev E Stat Nonlin Soft Matter Phys (2009) 0.87
Mesoscale computational studies of membrane bilayer remodeling by curvature-inducing proteins. Phys Rep (2014) 0.83
Equilibrium theory and geometrical constraint equation for two-component lipid bilayer vesicles. J Biol Phys (2008) 0.75
Reversible formation of nanodomains in monolayers of DPPC studied by kinetic modeling. Biophys J (2009) 0.75
Shrinkage dynamics of a vesicle in surfactant solutions. Eur Phys J E Soft Matter (2006) 0.75
Functional rafts in cell membranes. Nature (1997) 38.89
Lipid rafts and signal transduction. Nat Rev Mol Cell Biol (2000) 25.87
Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol (1998) 14.83
Lipid rafts reconstituted in model membranes. Biophys J (2001) 9.19
Lipid domain structure of the plasma membrane revealed by patching of membrane components. J Cell Biol (1998) 8.91
GPI-anchored proteins are organized in submicron domains at the cell surface. Nature (1998) 8.18
Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension. Nature (2003) 7.90
Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells. J Cell Biol (2000) 7.22
Separation of liquid phases in giant vesicles of ternary mixtures of phospholipids and cholesterol. Biophys J (2003) 6.88
A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains. Science (2002) 6.63
Microdomains of GPI-anchored proteins in living cells revealed by crosslinking. Nature (1998) 4.08
Static and dynamic lipid asymmetry in cell membranes. Biochemistry (1991) 3.64
Molecular dynamics and interactions for creation of stimulation-induced stabilized rafts from small unstable steady-state rafts. Traffic (2004) 3.45
Visualizing lipid structure and raft domains in living cells with two-photon microscopy. Proc Natl Acad Sci U S A (2003) 3.17
Role of cholesterol in lipid raft formation: lessons from lipid model systems. Biochim Biophys Acta (2003) 2.67
Rafts: scale-dependent, active lipid organization at the cell surface. Traffic (2004) 2.64
Shrinking patches and slippery rafts: scales of domains in the plasma membrane. Trends Cell Biol (2001) 2.23
Shape transitions and shape stability of giant phospholipid vesicles in pure water induced by area-to-volume changes. Biophys J (1991) 2.21
Large-scale co-aggregation of fluorescent lipid probes with cell surface proteins. J Cell Biol (1994) 2.11
Budding and fission of vesicles. Biophys J (1993) 2.10
Domain-induced budding of vesicles. Phys Rev Lett (1993) 2.06
Transmembrane asymmetry and lateral domains in biological membranes. Traffic (2004) 2.05
Shape transformations of vesicles with intramembrane domains. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics (1996) 1.62
Real-time analysis of the effects of cholesterol on lipid raft behavior using atomic force microscopy. Biophys J (2003) 1.53
Budding dynamics of multicomponent membranes. Phys Rev Lett (2001) 1.35
Dynamics of domain growth in self-assembled fluid vesicles. Phys Rev Lett (2004) 1.29
Sphingomyelin: biophysical aspects. Chem Phys Lipids (1999) 1.08
The effect of shear flow on the Helfrich interaction in lyotropic lamellar systems. Eur Phys J E Soft Matter (2002) 0.93
Internal states of active inclusions and the dynamics of an active membrane. Phys Rev Lett (2004) 0.93
Oxidative damage does not alter membrane phospholipid asymmetry in human erythrocytes. Biochemistry (1997) 0.91
Dynamics of nonequilibrium membrane bud formation. Phys Rev Lett (2004) 0.89
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
Pulling geometry defines the mechanical resistance of a beta-sheet protein. Nat Struct Biol (2003) 3.21
ADAMs family members as amyloid precursor protein alpha-secretases. J Neurosci Res (2003) 2.29
Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. Proc Natl Acad Sci U S A (2007) 2.05
Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein. Proc Natl Acad Sci U S A (2003) 2.03
Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem J (2004) 1.98
Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). J Biol Chem (2005) 1.73
Mechanically unfolding the small, topologically simple protein L. Biophys J (2005) 1.57
The prion protein and lipid rafts. Mol Membr Biol (2006) 1.54
The angiotensin-converting enzyme gene family: genomics and pharmacology. Trends Pharmacol Sci (2002) 1.51
Mechanically unfolding proteins: the effect of unfolding history and the supramolecular scaffold. Protein Sci (2002) 1.39
Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis. J Cell Sci (2005) 1.38
The effect of core destabilization on the mechanical resistance of I27. Biophys J (2002) 1.36
Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis. Traffic (2010) 1.36
Dual mechanisms for shedding of the cellular prion protein. J Biol Chem (2004) 1.32
Angiotensin-converting enzyme as a GPIase: a critical reevaluation. Nat Med (2005) 1.28
The involvement of lipid rafts in Alzheimer's disease. Mol Membr Biol (2006) 1.26
Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease. Trends Mol Med (2005) 1.26
Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study. Hypertension (2006) 1.25
The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein. Biochem J (2007) 1.25
Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor. Biochem J (2009) 1.24
The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway. J Biol Chem (2010) 1.21
Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein. J Biol Chem (2009) 1.19
The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein. Eur J Biochem (2004) 1.18
Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes. Int J Alzheimers Dis (2010) 1.17
Reactive oxygen species-mediated beta-cleavage of the prion protein in the cellular response to oxidative stress. J Biol Chem (2005) 1.12
Mechanical resistance of proteins explained using simple molecular models. Biophys J (2005) 1.10
Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells. J Biol Chem (2005) 1.10
Visualization of detergent solubilization of membranes: implications for the isolation of rafts. Biophys J (2007) 1.09
alpha-cleavage of the prion protein occurs in a late compartment of the secretory pathway and is independent of lipid rafts. Mol Cell Neurosci (2008) 1.08
Prion protein facilitates uptake of zinc into neuronal cells. Nat Commun (2012) 1.07
Prion protein and Alzheimer disease. Prion (2009) 1.05
Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence. Biochemistry (2003) 1.04
Glypican-1 mediates both prion protein lipid raft association and disease isoform formation. PLoS Pathog (2009) 1.04
The N-terminal region of the prion protein ectodomain contains a lipid raft targeting determinant. J Biol Chem (2003) 1.04
Increased circulating insulin-like growth factor-1 in late-onset Alzheimer's disease. J Alzheimers Dis (2007) 1.04
The prion protein and neuronal zinc homeostasis. Trends Biochem Sci (2003) 1.04
PCSK9: an emerging target for treatment of hypercholesterolemia. Expert Opin Ther Targets (2011) 1.02
Mechanical unfolding revisited through a simple but realistic model. J Chem Phys (2006) 1.02
Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1. J Biol Chem (2013) 1.01
A broad-spectrum fluorescence-based peptide library for the rapid identification of protease substrates. Proteomics (2006) 1.00
Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein. J Biol Chem (2011) 1.00
Critical point fluctuations in supported lipid membranes. Faraday Discuss (2013) 0.98
Surface coat remodeling during differentiation of Trypanosoma brucei. J Biol Chem (2003) 0.97
Nanoscale mechanical probing of supported lipid bilayers with atomic force microscopy. Phys Rev E Stat Nonlin Soft Matter Phys (2010) 0.97
Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system. Biochem Pharmacol (2007) 0.97
The role of lipid rafts in prion protein biology. Front Biosci (Landmark Ed) (2011) 0.96
ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors. Can J Physiol Pharmacol (2002) 0.95
Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cells. Arterioscler Thromb Vasc Biol (2009) 0.95
Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain. FEBS Lett (2007) 0.95
Prion protein is reduced in aging and in sporadic but not in familial Alzheimer's disease. J Alzheimers Dis (2010) 0.94
N-glycans, not the GPI anchor, mediate the apical targeting of a naturally glycosylated, GPI-anchored protein in polarised epithelial cells. J Cell Sci (2004) 0.94
The role of zinc in Alzheimer's disease. Int J Alzheimers Dis (2010) 0.94
Role of lipid rafts in the processing of the pathogenic prion and Alzheimer's amyloid-beta proteins. Semin Cell Dev Biol (2007) 0.93
Tethering the N-terminus of the prion protein compromises the cellular response to oxidative stress. J Neurochem (2003) 0.92
The Caenorhabditis elegans orthologue of mammalian puromycin-sensitive aminopeptidase has roles in embryogenesis and reproduction. J Biol Chem (2003) 0.90
Effect of hydrophobic mismatch on phase behavior of lipid membranes. Biophys J (2006) 0.90
Concentrating membrane proteins using asymmetric traps and AC electric fields. J Am Chem Soc (2011) 0.89
Alkaline phosphatase is increased in both brain and plasma in Alzheimer's disease. Neurodegener Dis (2011) 0.89
Simulation studies of stratum corneum lipid mixtures. Biophys J (2009) 0.89
ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci (2004) 0.89
Free energy for protein folding from nonequilibrium simulations using the Jarzynski equality. J Chem Phys (2006) 0.87
Secretase-mediated cell surface shedding of the angiotensin-converting enzyme. Protein Pept Lett (2004) 0.87
Plasma angiotensin-converting enzyme in Alzheimer's disease. J Alzheimers Dis (2009) 0.87
Emerging and potential therapies for Alzheimer's disease. Expert Opin Ther Targets (2008) 0.87
The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill. J Renin Angiotensin Aldosterone Syst (2008) 0.86
Plasma alkaline phosphatase is elevated in Alzheimer's disease and inversely correlates with cognitive function. Int J Mol Epidemiol Genet (2011) 0.85
Manipulation and charge determination of proteins in photopatterned solid supported bilayers. Integr Biol (Camb) (2008) 0.85
Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha. Biochemistry (2002) 0.85
Glycosylation efficiency of Asn-Xaa-Thr sequons is independent of distance from the C-terminus in membrane dipeptidase. Glycobiology (2003) 0.85
Internal protein dynamics shifts the distance to the mechanical transition state. Phys Rev E Stat Nonlin Soft Matter Phys (2006) 0.85
Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE. BMC Genomics (2007) 0.84
Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis. FEBS J (2005) 0.83
Association of a GPI-anchored protein with detergent-resistant membranes facilitates its trafficking through the early secretory pathway. Exp Cell Res (2008) 0.83
Protective effect of prion protein via the N-terminal region in mediating a protective effect on paraquat-induced oxidative injury in neuronal cells. J Neurosci Res (2008) 0.83
Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis. Biochim Biophys Acta (2007) 0.83
BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging. PLoS One (2013) 0.83
Normalized proliferation of normal and psoriatic keratinocytes by suppression of sAPPalpha-release. J Invest Dermatol (2004) 0.83
Prion protein is decreased in Alzheimer's brain and inversely correlates with BACE1 activity, amyloid-β levels and Braak stage. PLoS One (2013) 0.83
Sphingomyelin chain length influences the distribution of GPI-anchored proteins in rafts in supported lipid bilayers. Mol Membr Biol (2007) 0.83
The C-terminal domain, but not the interchain disulphide, is required for the activity and intracellular trafficking of aminopeptidase A. Biochem J (2002) 0.83
Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C(alpha), src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C. Brain Res Mol Brain Res (2002) 0.82
Neuronal zinc regulation and the prion protein. Prion (2013) 0.82
A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema. Hum Mutat (2011) 0.81
Changes of angiotensin-converting enzyme activity in the pancreas of chronic hypoxia and acute pancreatitis. Int J Biochem Cell Biol (2003) 0.81
N-glycans as apical targeting signals in polarized epithelial cells. Biochem Soc Symp (2005) 0.81
Distance of sequons to the C-terminus influences the cellular N-glycosylation of the prion protein. Biochem J (2003) 0.81
Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain. PLoS One (2012) 0.81
The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts. J Cell Sci (2003) 0.81
Coarse-grained simulations of flow-induced nucleation in semicrystalline polymers. Phys Rev Lett (2009) 0.81
Isolation and characterization of glycosylphosphatidylinositol-anchored peptides by hydrophilic interaction chromatography and MALDI tandem mass spectrometry. Anal Chem (2006) 0.80
Regulation of amyloid-β production by the prion protein. Prion (2012) 0.79
Emerging therapeutics for Alzheimer's disease. Expert Rev Neurother (2006) 0.79
Fast cholesterol flip-flop and lack of swelling in skin lipid multilayers. Soft Matter (2014) 0.79
Nitric oxide inhibits the shedding of the glycosylphosphatidylinositol-anchored dipeptidase from porcine renal proximal tubules. Biochem J (2002) 0.78
Contamination of nuclear fractions with plasma membrane lipid rafts. Proteomics (2007) 0.78
Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening. Bioorg Med Chem Lett (2009) 0.78
Lamellar and inverse micellar structures of skin lipids: effect of templating. Phys Rev Lett (2013) 0.78
Influence of boundary conditions and confinement on nonlocal effects in flows of wormlike micellar systems. Phys Rev E Stat Nonlin Soft Matter Phys (2010) 0.78