Published in J Biol Chem on April 25, 2003
Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol (2006) 5.44
A Mitogen-activated protein kinase controls differentiation of bloodstream forms of Trypanosoma brucei. Eukaryot Cell (2006) 1.32
Lipid metabolism in Trypanosoma brucei. Mol Biochem Parasitol (2010) 1.16
Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control. Genome Biol (2011) 1.09
A function for a specific zinc metalloprotease of African trypanosomes. PLoS Pathog (2007) 1.02
Expression of procyclin mRNAs during cyclical transmission of Trypanosoma brucei. PLoS Pathog (2005) 1.02
Role of AP-1 in developmentally regulated lysosomal trafficking in Trypanosoma brucei. Eukaryot Cell (2009) 0.98
Immunobiology of African trypanosomes: need of alternative interventions. J Biomed Biotechnol (2010) 0.94
Major surface protease of trypanosomatids: one size fits all? Infect Immun (2009) 0.94
The glycosylphosphatidylinositol-PLC in Trypanosoma brucei forms a linear array on the exterior of the flagellar membrane before and after activation. PLoS Pathog (2009) 0.89
Acylation in trypanosomatids: an essential process and potential drug target. Trends Parasitol (2014) 0.88
Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence. Mol Microbiol (2007) 0.87
Late endosomal Rab7 regulates lysosomal trafficking of endocytic but not biosynthetic cargo in Trypanosoma brucei. Mol Microbiol (2011) 0.87
Characterization of the late endosomal ESCRT machinery in Trypanosoma brucei. Traffic (2013) 0.86
Cyclical appearance of African trypanosomes in the cerebrospinal fluid: new insights in how trypanosomes enter the CNS. PLoS One (2014) 0.85
Improved prediction of malaria degradomes by supervised learning with SVM and profile kernel. Genetica (2008) 0.85
Proteomics of Trypanosoma evansi infection in rodents. PLoS One (2010) 0.80
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
ADAMs family members as amyloid precursor protein alpha-secretases. J Neurosci Res (2003) 2.29
Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. Proc Natl Acad Sci U S A (2007) 2.05
Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein. Proc Natl Acad Sci U S A (2003) 2.03
Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem J (2004) 1.98
Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). J Biol Chem (2005) 1.73
Developmentally regulated trafficking of the lysosomal membrane protein p67 in Trypanosoma brucei. J Cell Sci (2002) 1.61
The prion protein and lipid rafts. Mol Membr Biol (2006) 1.54
The angiotensin-converting enzyme gene family: genomics and pharmacology. Trends Pharmacol Sci (2002) 1.51
Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis. J Cell Sci (2005) 1.38
Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis. Traffic (2010) 1.36
Dual mechanisms for shedding of the cellular prion protein. J Biol Chem (2004) 1.32
Angiotensin-converting enzyme as a GPIase: a critical reevaluation. Nat Med (2005) 1.28
The involvement of lipid rafts in Alzheimer's disease. Mol Membr Biol (2006) 1.26
Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease. Trends Mol Med (2005) 1.26
Developmentally regulated sphingolipid synthesis in African trypanosomes. Mol Microbiol (2008) 1.26
Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study. Hypertension (2006) 1.25
The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein. Biochem J (2007) 1.25
Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor. Biochem J (2009) 1.24
The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway. J Biol Chem (2010) 1.21
Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein. J Biol Chem (2009) 1.19
The LAMP-like protein p67 plays an essential role in the lysosome of African trypanosomes. Mol Microbiol (2008) 1.19
The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein. Eur J Biochem (2004) 1.18
Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes. Int J Alzheimers Dis (2010) 1.17
Novel membrane-bound eIF2alpha kinase in the flagellar pocket of Trypanosoma brucei. Eukaryot Cell (2007) 1.16
Reactive oxygen species-mediated beta-cleavage of the prion protein in the cellular response to oxidative stress. J Biol Chem (2005) 1.12
De novo sphingolipid synthesis is essential for viability, but not for transport of glycosylphosphatidylinositol-anchored proteins, in African trypanosomes. Eukaryot Cell (2007) 1.10
Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells. J Biol Chem (2005) 1.10
Visualization of detergent solubilization of membranes: implications for the isolation of rafts. Biophys J (2007) 1.09
alpha-cleavage of the prion protein occurs in a late compartment of the secretory pathway and is independent of lipid rafts. Mol Cell Neurosci (2008) 1.08
Prion protein facilitates uptake of zinc into neuronal cells. Nat Commun (2012) 1.07
Expression and function of the Trypanosoma brucei major surface protease (GP63) genes. J Biol Chem (2003) 1.06
Prion protein and Alzheimer disease. Prion (2009) 1.05
The N-terminal region of the prion protein ectodomain contains a lipid raft targeting determinant. J Biol Chem (2003) 1.04
Regulation of surface coat exchange by differentiating African trypanosomes. Mol Biochem Parasitol (2006) 1.04
Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence. Biochemistry (2003) 1.04
Glypican-1 mediates both prion protein lipid raft association and disease isoform formation. PLoS Pathog (2009) 1.04
Increased circulating insulin-like growth factor-1 in late-onset Alzheimer's disease. J Alzheimers Dis (2007) 1.04
The prion protein and neuronal zinc homeostasis. Trends Biochem Sci (2003) 1.04
Streamlined architecture and glycosylphosphatidylinositol-dependent trafficking in the early secretory pathway of African trypanosomes. Mol Biol Cell (2009) 1.03
PCSK9: an emerging target for treatment of hypercholesterolemia. Expert Opin Ther Targets (2011) 1.02
Glycoprotein biosynthesis in a eukaryote lacking the membrane protein Rft1. J Biol Chem (2013) 1.02
Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1. J Biol Chem (2013) 1.01
Glycosylphosphatidylinositol-dependent protein trafficking in bloodstream stage Trypanosoma brucei. Eukaryot Cell (2003) 1.00
Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein. J Biol Chem (2011) 1.00
A broad-spectrum fluorescence-based peptide library for the rapid identification of protease substrates. Proteomics (2006) 1.00
Role of AP-1 in developmentally regulated lysosomal trafficking in Trypanosoma brucei. Eukaryot Cell (2009) 0.98
The kinetics of phase separation in asymmetric membranes. Biophys J (2005) 0.97
Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system. Biochem Pharmacol (2007) 0.97
The role of lipid rafts in prion protein biology. Front Biosci (Landmark Ed) (2011) 0.96
ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors. Can J Physiol Pharmacol (2002) 0.95
Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cells. Arterioscler Thromb Vasc Biol (2009) 0.95
Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain. FEBS Lett (2007) 0.95
N-glycans, not the GPI anchor, mediate the apical targeting of a naturally glycosylated, GPI-anchored protein in polarised epithelial cells. J Cell Sci (2004) 0.94
GPI valence and the fate of secretory membrane proteins in African trypanosomes. J Cell Sci (2005) 0.94
Prion protein is reduced in aging and in sporadic but not in familial Alzheimer's disease. J Alzheimers Dis (2010) 0.94
The role of zinc in Alzheimer's disease. Int J Alzheimers Dis (2010) 0.94
Multiple motifs regulate trafficking of the LAMP-like protein p67 in the ancient eukaryote Trypanosoma brucei. Traffic (2007) 0.93
Role of lipid rafts in the processing of the pathogenic prion and Alzheimer's amyloid-beta proteins. Semin Cell Dev Biol (2007) 0.93
Tethering the N-terminus of the prion protein compromises the cellular response to oxidative stress. J Neurochem (2003) 0.92
The Caenorhabditis elegans orthologue of mammalian puromycin-sensitive aminopeptidase has roles in embryogenesis and reproduction. J Biol Chem (2003) 0.90
A determination of the steady state lysosomal pH of bloodstream stage African trypanosomes. Mol Biochem Parasitol (2008) 0.90
Effect of hydrophobic mismatch on phase behavior of lipid membranes. Biophys J (2006) 0.90
Cell-free synthesis and functional characterization of sphingolipid synthases from parasitic trypanosomatid protozoa. J Biol Chem (2010) 0.90
ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci (2004) 0.89
Alkaline phosphatase is increased in both brain and plasma in Alzheimer's disease. Neurodegener Dis (2011) 0.89
Secretase-mediated cell surface shedding of the angiotensin-converting enzyme. Protein Pept Lett (2004) 0.87
Plasma angiotensin-converting enzyme in Alzheimer's disease. J Alzheimers Dis (2009) 0.87
Late endosomal Rab7 regulates lysosomal trafficking of endocytic but not biosynthetic cargo in Trypanosoma brucei. Mol Microbiol (2011) 0.87
Emerging and potential therapies for Alzheimer's disease. Expert Opin Ther Targets (2008) 0.87
T-cell responses to the trypanosome variant surface glycoprotein are not limited to hypervariable subregions. Infect Immun (2008) 0.86
Intracellular trafficking and glycobiology of TbPDI2, a stage-specific protein disulfide isomerase in Trypanosoma brucei. Eukaryot Cell (2012) 0.86
Characterization of the late endosomal ESCRT machinery in Trypanosoma brucei. Traffic (2013) 0.86
The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill. J Renin Angiotensin Aldosterone Syst (2008) 0.86
Plasma alkaline phosphatase is elevated in Alzheimer's disease and inversely correlates with cognitive function. Int J Mol Epidemiol Genet (2011) 0.85
Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha. Biochemistry (2002) 0.85
Glycosylation efficiency of Asn-Xaa-Thr sequons is independent of distance from the C-terminus in membrane dipeptidase. Glycobiology (2003) 0.85
Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE. BMC Genomics (2007) 0.84
Form and function in the trypanosomal secretory pathway. Curr Opin Microbiol (2012) 0.84
Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis. Biochim Biophys Acta (2007) 0.83
Normalized proliferation of normal and psoriatic keratinocytes by suppression of sAPPalpha-release. J Invest Dermatol (2004) 0.83
BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging. PLoS One (2013) 0.83
Protective effect of prion protein via the N-terminal region in mediating a protective effect on paraquat-induced oxidative injury in neuronal cells. J Neurosci Res (2008) 0.83
Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis. FEBS J (2005) 0.83
Sphingomyelin chain length influences the distribution of GPI-anchored proteins in rafts in supported lipid bilayers. Mol Membr Biol (2007) 0.83
Association of a GPI-anchored protein with detergent-resistant membranes facilitates its trafficking through the early secretory pathway. Exp Cell Res (2008) 0.83
The C-terminal domain, but not the interchain disulphide, is required for the activity and intracellular trafficking of aminopeptidase A. Biochem J (2002) 0.83
Prion protein is decreased in Alzheimer's brain and inversely correlates with BACE1 activity, amyloid-β levels and Braak stage. PLoS One (2013) 0.83
Neuronal zinc regulation and the prion protein. Prion (2013) 0.82
Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C(alpha), src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C. Brain Res Mol Brain Res (2002) 0.82
A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema. Hum Mutat (2011) 0.81
Changes of angiotensin-converting enzyme activity in the pancreas of chronic hypoxia and acute pancreatitis. Int J Biochem Cell Biol (2003) 0.81
The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts. J Cell Sci (2003) 0.81
Distance of sequons to the C-terminus influences the cellular N-glycosylation of the prion protein. Biochem J (2003) 0.81
Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain. PLoS One (2012) 0.81
Sphingolipids in parasitic protozoa. Adv Exp Med Biol (2010) 0.81
N-glycans as apical targeting signals in polarized epithelial cells. Biochem Soc Symp (2005) 0.81
Isolation and characterization of glycosylphosphatidylinositol-anchored peptides by hydrophilic interaction chromatography and MALDI tandem mass spectrometry. Anal Chem (2006) 0.80
Emerging therapeutics for Alzheimer's disease. Expert Rev Neurother (2006) 0.79
Regulation of protein trafficking by glycosylphosphatidylinositol valence in African trypanosomes. J Eukaryot Microbiol (2007) 0.79