Published in Stem Cells on April 20, 2006
EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology (2008) 5.53
Human hepatic stem cells from fetal and postnatal donors. J Exp Med (2007) 4.15
Nuclear signalling by tumour-associated antigen EpCAM. Nat Cell Biol (2009) 4.05
Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology (2009) 3.92
Acute liver failure: Summary of a workshop. Hepatology (2008) 3.49
Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Genes Dev (2011) 2.53
A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease. Gastroenterology (2011) 2.06
Human hepatic stem cell and maturational liver lineage biology. Hepatology (2011) 1.99
Self-renewing endodermal progenitor lines generated from human pluripotent stem cells. Cell Stem Cell (2012) 1.94
Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages. PLoS Pathog (2014) 1.88
Hedgehog signaling in the liver. J Hepatol (2010) 1.80
Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med (2011) 1.74
New concepts in liver regeneration. J Gastroenterol Hepatol (2011) 1.55
Human hepatocyte transplantation: current experience and future challenges. Nat Rev Gastroenterol Hepatol (2010) 1.52
Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. J Biol Chem (2010) 1.52
Biliary tree stem/progenitor cells in glands of extrahepatic and intraheptic bile ducts: an anatomical in situ study yielding evidence of maturational lineages. J Anat (2011) 1.51
The biliary tree--a reservoir of multipotent stem cells. Nat Rev Gastroenterol Hepatol (2012) 1.50
Stem cells, cell transplantation and liver repopulation. Biochim Biophys Acta (2007) 1.37
Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells? Cancer Res (2011) 1.33
Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. Gastroenterology (2010) 1.25
Cell therapies for liver diseases. Liver Transpl (2012) 1.24
Paracrine signals from mesenchymal cell populations govern the expansion and differentiation of human hepatic stem cells to adult liver fates. Hepatology (2010) 1.22
The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets. EMBO Mol Med (2012) 1.15
Phenotype reversion in fetal human liver epithelial cells identifies the role of an intermediate meso-endodermal stage before hepatic maturation. J Cell Sci (2008) 1.12
The critical role of CD133(+)CD44(+/high) tumor cells in hematogenous metastasis of liver cancers. Cell Res (2011) 1.10
Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells. Hepatology (2014) 1.09
KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development. Cell Stem Cell (2013) 1.06
Concise review: clinical programs of stem cell therapies for liver and pancreas. Stem Cells (2013) 1.03
Regulation of hepatic stem/progenitor phenotype by microenvironment stiffness in hydrogel models of the human liver stem cell niche. Biomaterials (2011) 1.01
EpCAM and the biology of hepatic stem/progenitor cells. Am J Physiol Gastrointest Liver Physiol (2014) 0.99
Expression of hepatocyte epidermal growth factor receptor, FAS and glypican 3 in EpCAM-positive regenerative clusters of hepatocytes, cholangiocytes, and progenitor cells in human liver failure. Hum Pathol (2012) 0.96
Proteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replication. Hepatology (2011) 0.96
Liver bioengineering: current status and future perspectives. World J Gastroenterol (2012) 0.95
Fetal liver cell transplantation as a potential alternative to whole liver transplantation? J Gastroenterol (2011) 0.95
Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals. Stem Cells Dev (2013) 0.95
Model systems and experimental conditions that lead to effective repopulation of the liver by transplanted cells. Int J Biochem Cell Biol (2010) 0.94
Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration. Hepatology (2012) 0.94
The origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells. Curr Top Dev Biol (2014) 0.93
High expression of cancer stem cell markers in cholangiolocellular carcinoma. Surg Today (2012) 0.93
Gene signatures in hepatocellular carcinoma (HCC). Semin Cancer Biol (2010) 0.93
Possibility of undifferentiated human thigh adipose stem cells differentiating into functional hepatocytes. Arch Plast Surg (2012) 0.90
Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle. Am J Pathol (2014) 0.89
Ex vivo conditions for self-replication of human hepatic stem cells. Tissue Eng Part C Methods (2008) 0.89
Stem cell-based therapies for liver diseases: state of the art and new perspectives. Stem Cells Int (2010) 0.88
Thinking outside the liver: induced pluripotent stem cells for hepatic applications. World J Gastroenterol (2013) 0.88
Successful transplantation of human hepatic stem cells with restricted localization to liver using hyaluronan grafts. Hepatology (2013) 0.86
Enrichment of a bipotent hepatic progenitor cell from naïve adult liver tissue. Biochem Biophys Res Commun (2007) 0.86
Human telomerase activity, telomerase and telomeric template expression in hepatic stem cells and in livers from fetal and postnatal donors. Eur J Gastroenterol Hepatol (2009) 0.85
Human hepatic progenitor cells express hematopoietic cell markers CD45 and CD109. Int J Med Sci (2013) 0.84
CK19 and Glypican 3 Expression Profiling in the Prognostic Indication for Patients with HCC after Surgical Resection. PLoS One (2016) 0.84
Label-free quantitative proteomics of CD133-positive liver cancer stem cells. Proteome Sci (2012) 0.84
Activin A, p15INK4b signaling, and cell competition promote stem/progenitor cell repopulation of livers in aging rats. Gastroenterology (2010) 0.83
Orchestration of hepatocellular carcinoma development by diverse liver cancer stem cells. J Gastroenterol (2014) 0.83
Cell therapy for the diseased liver: from stem cell biology to novel models for hepatotropic human pathogens. Dis Model Mech (2008) 0.83
Three-dimensional reconstructions of intrahepatic bile duct tubulogenesis in human liver. BMC Dev Biol (2011) 0.82
Role of stem cells in repair of liver injury: experimental and clinical benefit of transferred stem cells on liver failure. World J Gastroenterol (2013) 0.82
Characterization of hepatic progenitors from human fetal liver during second trimester. World J Gastroenterol (2008) 0.81
Human liver cells expressing albumin and mesenchymal characteristics give rise to insulin-producing cells. J Transplant (2011) 0.80
Human adipose-derived mesenchymal stem cells are resistant to HBV infection during differentiation into hepatocytes in vitro. Int J Mol Sci (2014) 0.80
Isolation of human fetal liver progenitors and their enhanced proliferation by three-dimensional coculture with endothelial cells. Tissue Eng Part A (2008) 0.80
In situ labeling and magnetic resonance imaging of transplanted human hepatic stem cells. Mol Imaging Biol (2011) 0.79
Stem/Progenitor Cell Niches Involved in Hepatic and Biliary Regeneration. Stem Cells Int (2016) 0.79
Different cytokeratin and neuronal cell adhesion molecule staining patterns in focal nodular hyperplasia and hepatic adenoma and their significance. Hum Pathol (2008) 0.79
In vitro quantitative and relative gene expression analysis of pancreatic transcription factors Pdx-1, Ngn-3, Isl-1, Pax-4, Pax-6 and Nkx-6.1 in trans-differentiated human hepatic progenitors. J Diabetes Investig (2014) 0.78
Simple Risk Score for Prediction of Early Recurrence of Hepatocellular Carcinoma within the Milan Criteria after Orthotopic Liver Transplantation. Sci Rep (2017) 0.77
Hepatic stem cells: A viable approach for the treatment of liver cirrhosis. World J Stem Cells (2015) 0.77
Enhanced hepatogenic transdifferentiation of human adipose tissue mesenchymal stem cells by gene engineering with Oct4 and Sox2. PLoS One (2015) 0.77
Promoter-defined isolation and identification of hepatic progenitor cells from the human fetal liver. Histochem Cell Biol (2008) 0.77
Epithelial cell adhesion molecule in human hepatocellular carcinoma cell lines: a target of chemoresistence. BMC Cancer (2016) 0.77
Cell therapeutic options in liver diseases: cell types, medical devices and regulatory issues. J Mater Sci Mater Med (2011) 0.76
Induction of Hepatic and Endothelial Differentiation by Perfusion in a Three-Dimensional Cell Culture Model of Human Fetal Liver. Tissue Eng Part C Methods (2015) 0.76
The fetal liver as cell source for the regenerative medicine of liver and pancreas. Ann Transl Med (2013) 0.76
Endodermal stem cell populations derived from pluripotent stem cells. Curr Opin Cell Biol (2013) 0.76
Isolation of Hepatic Progenitor Cells From Human Liver With Cirrhosis Secondary to Biliary Atresia Using EpCAM or Thy-1 Markers. Cell Med (2012) 0.75
Cell sources for in vitro human liver cell culture models. Exp Biol Med (Maywood) (2016) 0.75
Management of Liver Failure: From Transplantation to Cell-Based Therapy. Cell Med (2011) 0.75
An efficient protocol for deriving liver stem cells from neonatal mice: validating its differentiation potential. Anal Cell Pathol (Amst) (2015) 0.75
H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro. Stem Cell Reports (2016) 0.75
A Convenient and Efficient Method to Enrich and Maintain Highly Proliferative Human Fetal Liver Stem Cells. Rejuvenation Res (2015) 0.75
Bioenergetic Changes during Differentiation of Human Embryonic Stem Cells along the Hepatic Lineage. Oxid Med Cell Longev (2017) 0.75
Expression kinetics of hepatic progenitor markers in cellular models of human liver development recapitulating hepatocyte and biliary cell fate commitment. Exp Biol Med (Maywood) (2016) 0.75
The Progress and Prospects of Putative Biomarkers for Liver Cancer Stem Cells in Hepatocellular Carcinoma. Stem Cells Int (2016) 0.75
Side Population Cells From an Immortalized Human Liver Epithelial Cell Line Exhibit Hepatic Stem-Like Cell Properties. Cell Med (2012) 0.75
Human Liver Progenitor Cells for Liver Repair. Cell Med (2013) 0.75
Inhibition of wnt/β-catenin Signaling in Hepatocellular Carcinoma by an Antipsychotic Drug Pimozide. Int J Biol Sci (2016) 0.75
Implication of the Hedgehog pathway in hepatocellular carcinoma. World J Gastroenterol (2017) 0.75
The diversity and plasticity of adult hepatic progenitor cells and their niche. Liver Int (2017) 0.75
EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology (2008) 5.53
Human hepatic stem cells from fetal and postnatal donors. J Exp Med (2007) 4.15
Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology (2009) 3.92
Hedgehog signaling maintains resident hepatic progenitors throughout life. Am J Physiol Gastrointest Liver Physiol (2005) 2.02
Human hepatic stem cell and maturational liver lineage biology. Hepatology (2011) 1.99
Multipotent stem/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets. Hepatology (2011) 1.94
The stem cell niche of human livers: symmetry between development and regeneration. Hepatology (2008) 1.94
Sal-like protein 4 (SALL4), a stem cell biomarker in liver cancers. Hepatology (2013) 1.63
Biliary tree stem/progenitor cells in glands of extrahepatic and intraheptic bile ducts: an anatomical in situ study yielding evidence of maturational lineages. J Anat (2011) 1.51
The biliary tree--a reservoir of multipotent stem cells. Nat Rev Gastroenterol Hepatol (2012) 1.50
Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds. Hepatology (2010) 1.48
Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London. Cell Transplant (2012) 1.31
Identification and characterization of vitamin A-storing cells in fetal liver: implications for functional importance of hepatic stellate cells in liver development and hematopoiesis. Stem Cells (2007) 1.28
Paracrine signals from mesenchymal cell populations govern the expansion and differentiation of human hepatic stem cells to adult liver fates. Hepatology (2010) 1.22
EpCAM expression in normal, non-pathological tissues. Front Biosci (2008) 1.16
Nuclear magnetic resonance metabolomic footprinting of human hepatic stem cells and hepatoblasts cultured in hyaluronan-matrix hydrogels. Stem Cells (2008) 1.12
Human hepatoblast phenotype maintained by hyaluronan hydrogels. J Biomed Mater Res B Appl Biomater (2007) 1.05
Concise review: clinical programs of stem cell therapies for liver and pancreas. Stem Cells (2013) 1.03
Biliary tree stem cells, precursors to pancreatic committed progenitors: evidence for possible life-long pancreatic organogenesis. Stem Cells (2013) 1.02
Regulation of hepatic stem/progenitor phenotype by microenvironment stiffness in hydrogel models of the human liver stem cell niche. Biomaterials (2011) 1.01
Three-dimensional perfusion bioreactor culture supports differentiation of human fetal liver cells. Tissue Eng Part A (2010) 1.00
Citron kinase is a cell cycle-dependent, nuclear protein required for G2/M transition of hepatocytes. J Biol Chem (2002) 0.96
Variant forms of alpha-fetoprotein transcripts expressed in human hematopoietic progenitors. Implications for their developmental potential towards endoderm. J Biol Chem (2002) 0.96
Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration. Hepatology (2012) 0.94
Gradients in the liver's extracellular matrix chemistry from periportal to pericentral zones: influence on human hepatic progenitors. Tissue Eng Part A (2008) 0.91
Ex vivo conditions for self-replication of human hepatic stem cells. Tissue Eng Part C Methods (2008) 0.89
Proliferation and hepatic differentiation of adult-derived progenitor cells. Cells Tissues Organs (2003) 0.87
Successful transplantation of human hepatic stem cells with restricted localization to liver using hyaluronan grafts. Hepatology (2013) 0.86
Mature human hepatocytes from ex vivo differentiation of alginate-encapsulated hepatoblasts. Tissue Eng Part A (2008) 0.86
Mucin-producing cholangiocarcinoma might derive from biliary tree stem/progenitor cells located in peribiliary glands. Hepatology (2012) 0.86
Human telomerase activity, telomerase and telomeric template expression in hepatic stem cells and in livers from fetal and postnatal donors. Eur J Gastroenterol Hepatol (2009) 0.85
Hyaluronan-supplemented buffers preserve adhesion mechanisms facilitating cryopreservation of human hepatic stem/progenitor cells. Cell Transplant (2012) 0.83
Lineage-dependent effects of aryl hydrocarbon receptor agonists contribute to liver tumorigenesis. Hepatology (2015) 0.83
A novel multi-coaxial hollow fiber bioreactor for adherent cell types. Part 1: hydrodynamic studies. Biotechnol Bioeng (2002) 0.82
In situ labeling and magnetic resonance imaging of transplanted human hepatic stem cells. Mol Imaging Biol (2011) 0.79
Functional ultrasound imaging for assessment of extracellular matrix scaffolds used for liver organoid formation. Biomaterials (2013) 0.79
Notch2 signaling and undifferentiated liver cancers: evidence of hepatic stem/progenitor cell origin. Hepatology (2013) 0.77
Cholangiocarcinoma: a cancer in search of the right classification. Hepatology (2012) 0.75
Metabolic oxidation controls the hepatic stem cells (HpSCs) fate and the hepatic lineage organization in physiologic and pathologic conditions. Hepatology (2012) 0.75