Published in BMC Bioinformatics on April 27, 2006
Cubic exact solutions for the estimation of pairwise haplotype frequencies: implications for linkage disequilibrium analyses and a web tool 'CubeX'. BMC Bioinformatics (2007) 2.15
Adaptive introgression across species boundaries in Heliconius butterflies. PLoS Genet (2012) 1.49
Genetic evidence for hybrid trait speciation in heliconius butterflies. PLoS Genet (2010) 1.31
Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome. PLoS One (2012) 1.21
Molecular and population analysis of natural selection on the human haptoglobin duplication. Ann Hum Genet (2012) 0.98
Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity. PLoS One (2013) 0.96
SNP HiTLink: a high-throughput linkage analysis system employing dense SNP data. BMC Bioinformatics (2009) 0.94
Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study. Arthritis Res Ther (2009) 0.90
Heritable variation of ERBB2 and breast cancer risk. Cancer Epidemiol Biomarkers Prev (2009) 0.89
Haplotype analysis of CYP11A1 identifies promoter variants associated with breast cancer risk. Cancer Res (2007) 0.89
Emerging paradigms in genomics-based crop improvement. ScientificWorldJournal (2013) 0.86
Analytical methods for immunogenetic population data. Methods Mol Biol (2012) 0.84
A microsatellite-based analysis for the detection of selection on BTA1 and BTA20 in northern Eurasian cattle (Bos taurus) populations. Genet Sel Evol (2010) 0.84
Interferon lambda polymorphisms associate with body iron indices and hepatic expression of interferon-responsive long non-coding RNA in chronic hepatitis C. Clin Exp Med (2016) 0.83
The genetic content of chromosomal inversions across a wide latitudinal gradient. PLoS One (2012) 0.82
Species discrimination, population structure and linkage disequilibrium in Eucalyptus camaldulensis and Eucalyptus tereticornis using SSR markers. PLoS One (2011) 0.81
Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality. Infect Immun (2011) 0.80
Sex-specific population structure, natural selection, and linkage disequilibrium in a wild bird population as revealed by genome-wide microsatellite analyses. BMC Evol Biol (2010) 0.78
The Relation between eNOS -786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, -384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease. Dis Markers (2015) 0.78
ABCB1 genotype and CSF beta-amyloid in Alzheimer disease. J Geriatr Psychiatry Neurol (2011) 0.78
Reduced interferon (IFN)-α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality. Hum Genet (2012) 0.78
Polymorphic SVA retrotransposons at four loci and their association with classical HLA class I alleles in Japanese, Caucasians and African Americans. Immunogenetics (2010) 0.77
A linkage disequilibrium perspective on the genetic mosaic of speciation in two hybridizing Mediterranean white oaks. Heredity (Edinb) (2014) 0.77
Patterns of cyto-nuclear linkage disequilibrium in Silene latifolia: genomic heterogeneity and temporal stability. Heredity (Edinb) (2013) 0.77
Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival. Medicine (Baltimore) (2014) 0.76
Microsatellite polymorphism and its association with body weight and selected morphometrics of farm red fox (Vulpes vulpes L.). J Appl Genet (2014) 0.75
Single Marker and Haplotype-Based Association Analysis of Semolina and Pasta Colour in Elite Durum Wheat Breeding Lines Using a High-Density Consensus Map. PLoS One (2017) 0.75
Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (2004) 125.23
A haplotype map of the human genome. Nature (2005) 105.70
The International HapMap Project. Nature (2003) 73.65
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Patterns of linkage disequilibrium in the human genome. Nat Rev Genet (2002) 7.09
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Linkage disequilibrium and the search for complex disease genes. Genome Res (2000) 3.57
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GOLDsurfer: three dimensional display of linkage disequilibrium. Bioinformatics (2004) 2.61
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Linkage disequilibrium for different scales and applications. Brief Bioinform (2004) 1.70
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Genetically indistinguishable SNPs and their influence on inferring the location of disease-associated variants. Genome Res (2005) 1.25
Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males. Hum Mol Genet (2001) 1.23
Sampling variance and distribution of the D' measure of overall gametic disequilibrium between multiallelic loci. Ann Hum Genet (2001) 1.14
Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits. Hum Mol Genet (2004) 1.00
Evidence of multiple causal sites affecting weight in the IGF2-INS-TH region of human chromosome 11. Hum Genet (2002) 0.99
Distribution of nonrandom associations between pairs of protein loci along the third chromosome of Drosophila melanogaster. Genetics (2002) 0.96
Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males. Int J Obes Relat Metab Disord (1997) 0.95
Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster. J Clin Endocrinol Metab (2004) 0.95
Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes. Eur J Hum Genet (2006) 0.94
Associations of IGF2 ApaI RFLP and INS VNTR class I allele size with obesity. Eur J Hum Genet (2000) 0.92
Spectrum of nonrandom associations between microsatellite loci on human chromosome 11p15. Genetics (2001) 0.90
Human genome-wide screen of haplotype-like blocks of reduced diversity. Gene (2005) 0.84
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
C-reactive protein and its role in metabolic syndrome: mendelian randomisation study. Lancet (2005) 5.51
Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am J Epidemiol (2009) 4.70
Predicting the functional, molecular, and phenotypic consequences of amino acid substitutions using hidden Markov models. Hum Mutat (2012) 3.60
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Association of C-reactive protein with blood pressure and hypertension: life course confounding and mendelian randomization tests of causality. Arterioscler Thromb Vasc Biol (2005) 2.42
Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study. J Am Coll Cardiol (2013) 2.18
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15
Predicting the functional consequences of cancer-associated amino acid substitutions. Bioinformatics (2013) 2.12
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet (2009) 2.04
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet (2012) 1.96
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. Am J Clin Nutr (2010) 1.61
IQ, educational attainment, memory and plasma lipids: associations with apolipoprotein E genotype in 5995 children. Biol Psychiatry (2011) 1.59
The association of oestrogen receptor alpha-haplotypes with cardiovascular risk factors in the British Women's Heart and Health Study. Eur Heart J (2006) 1.57
Dependence of deodorant usage on ABCC11 genotype: scope for personalized genetics in personal hygiene. J Invest Dermatol (2013) 1.51
Use of genotype frequencies in medicated groups to investigate prescribing practice: APOE and statins as a proof of principle. Clin Chem (2011) 1.49
Blood pressure loci identified with a gene-centric array. Am J Hum Genet (2011) 1.44
Clinically relevant differences in the model for end-stage liver disease and model for end-stage liver disease-sodium scores determined at three university-based laboratories of the same area. Liver Transpl (2009) 1.43
Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies. Eur Heart J (2012) 1.30
The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants. PLoS One (2008) 1.28
Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis. Am J Med Genet B Neuropsychiatr Genet (2008) 1.24
Influences of matrix metalloproteinase-3 gene variation on extent of coronary atherosclerosis and risk of myocardial infarction. J Am Coll Cardiol (2003) 1.24
Lactase persistence-related genetic variant: population substructure and health outcomes. Eur J Hum Genet (2008) 1.13
The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis. BMC Genet (2004) 1.12
Fetal alcohol exposure and IQ at age 8: evidence from a population-based birth-cohort study. PLoS One (2012) 1.11
ACTN3 genotype, athletic status, and life course physical capability: meta-analysis of the published literature and findings from nine studies. Hum Mutat (2011) 1.10
Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease. Hum Genet (2007) 1.06
Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI. Eur J Hum Genet (2009) 1.02
Exonization of AluYa5 in the human ACE gene requires mutations in both 3' and 5' splice sites and is facilitated by a conserved splicing enhancer. Nucleic Acids Res (2005) 1.02
Genetic variants in the vitamin d receptor are associated with advanced prostate cancer at diagnosis: findings from the prostate testing for cancer and treatment study and a systematic review. Cancer Epidemiol Biomarkers Prev (2009) 1.02
Prevalence and functionality of paucimorphic and private MC4R mutations in a large, unselected European British population, scanned by meltMADGE. Hum Mutat (2007) 1.02
Variants in the human insulin gene that affect pre-mRNA splicing: is -23HphI a functional single nucleotide polymorphism at IDDM2? Diabetes (2006) 1.01
Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits. Hum Mol Genet (2004) 1.00
Independent effects of the -219 G>T and epsilon 2/ epsilon 3/ epsilon 4 polymorphisms in the apolipoprotein E gene on coronary artery disease: the Southampton Atherosclerosis Study. Eur J Hum Genet (2003) 1.00
Evidence of multiple causal sites affecting weight in the IGF2-INS-TH region of human chromosome 11. Hum Genet (2002) 0.99
Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy. Circ Cardiovasc Genet (2011) 0.99
Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children. BMC Genet (2007) 0.99
A novel medium throughput quantitative competitive PCR technology to simultaneously measure mRNA levels from multiple genes. Nucleic Acids Res (2002) 0.98
CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents. Pharmacogenet Genomics (2005) 0.98
Ranking non-synonymous single nucleotide polymorphisms based on disease concepts. Hum Genomics (2014) 0.98
Molecular and population analysis of natural selection on the human haptoglobin duplication. Ann Hum Genet (2012) 0.98
Genetic variants associated with Von Willebrand factor levels in healthy men and women identified using the HumanCVD BeadChip. Ann Hum Genet (2011) 0.96
Association between interleukin 1-beta promoter (-511) polymorphism and depressive symptoms in Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet (2004) 0.95
A pathway-based data integration framework for prediction of disease progression. Bioinformatics (2013) 0.95
Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster. J Clin Endocrinol Metab (2004) 0.95
The association of the PON1 Q192R polymorphism with complications and outcomes of pregnancy: findings from the British Women's Heart and Health cohort study. Paediatr Perinat Epidemiol (2006) 0.94
From a single whole exome read to notions of clinical screening: primary ciliary dyskinesia and RSPH9 p.Lys268del in the Arabian Peninsula. Ann Hum Genet (2012) 0.94
Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes. Eur J Hum Genet (2006) 0.94
Manual 768 or 384 well microplate gel 'dry' electrophoresis for PCR checking and SNP genotyping. Nucleic Acids Res (2003) 0.92
Integrated single-label liquid-phase assay of APOE codons 112 and 158 and a lipoprotein study in British women. Clin Chem (2006) 0.90
Polymorphism of the IGF2 gene, birth weight and grip strength in adult men. Age Ageing (2002) 0.89
Evidence of admixture from haplotyping in an epidemiological study of UK Caucasian males: implications for association analyses. Hum Hered (2004) 0.89
Molecular pathogenesis of subarachnoid haemorrhage. Int J Biochem Cell Biol (2003) 0.88
Mutation scanning by meltMADGE: validations using BRCA1 and LDLR, and demonstration of the potential to identify severe, moderate, silent, rare, and paucimorphic mutations in the general population. Genome Res (2005) 0.87
Inflammation and not cardiovascular risk factors is associated with short leukocyte telomere length in 13- to 16-year-old adolescents. Arterioscler Thromb Vasc Biol (2012) 0.86
Proposed association between the COL1A1 and COL1A2 genes and otosclerosis is not supported by a case-control study in Spain. Am J Med Genet A (2004) 0.86
Amplification ratio control system for copy number variation genotyping. Nucleic Acids Res (2011) 0.85
Evidence for phosphorylation of the major seed storage protein of the common bean and its phosphorylation-dependent degradation during germination. Plant Mol Biol (2013) 0.83
Microplate array diagonal gel electrophoresis for cohort studies of microsatellite loci. Biotechniques (2002) 0.82
The association of the paraoxonase (PON1) Q192R polymorphism with depression in older women: findings from the British Women's Heart and Health Study. J Epidemiol Community Health (2007) 0.82
Complexity of a complex trait locus: HP, HPR, haemoglobin and cholesterol. Gene (2012) 0.82
An expectation-maximization program for determining allelic spectrum from CNV data (CoNVEM): insights into population allelic architecture and its mutational history. Hum Mutat (2010) 0.82
Very low PSA concentrations and deletions of the KLK3 gene. Clin Chem (2012) 0.82
Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits. Hum Mutat (2007) 0.82
A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys. Pharmacogenet Genomics (2006) 0.82
A gene-centric analysis of activated partial thromboplastin time and activated protein C resistance using the HumanCVD focused genotyping array. Eur J Hum Genet (2012) 0.82
CARD15 mutations in patients with Crohn's disease in a homogeneous Spanish population. Am J Gastroenterol (2004) 0.82
Absence of association of a single-nucleotide polymorphism in the TERT-CLPTM1L locus with age-related phenotypes in a large multicohort study: the HALCyon programme. Aging Cell (2011) 0.82
Homogeneous assay of rs4343, an ACE I/D proxy, and an analysis in the British Women's Heart and Health Study (BWHHS). Dis Markers (2008) 0.81
Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients. Hum Mol Genet (2007) 0.81
Non-replication of an association of Apolipoprotein E2 with sinistrality. Laterality (2012) 0.80
A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme. PLoS One (2012) 0.80
Non-recombining chromosome Y haplogroups and centromeric HindIII RFLP in relation to blood pressure in 2,743 middle-aged Caucasian men from the UK. Hum Genet (2005) 0.79
Integration of genetics into a systems model of electrocardiographic traits using HumanCVD BeadChip. Circ Cardiovasc Genet (2012) 0.79
Nonsense mutation in coiled-coil domain containing 151 gene (CCDC151) causes primary ciliary dyskinesia. Hum Mutat (2014) 0.79
Interaction between birthweight and polymorphism in the calcium-sensing receptor gene in determination of adult bone mass: the Hertfordshire cohort study. J Rheumatol (2007) 0.79
Insulin-like growth factor-I genotype and birthweight. Lancet (2002) 0.79
Structural and population-based evaluations of TBC1D1 p.Arg125Trp. PLoS One (2013) 0.79
Associations between a polymorphism in the pleiotropic GCKR and Age-related phenotypes: the HALCyon programme. PLoS One (2013) 0.79
Null mutation in human ciliary neurotrophic factor gene confers higher body mass index in males. Eur J Hum Genet (2002) 0.79
Haplotype of growth hormone and angiotensin I-converting enzyme genes, serum angiotensin I-converting enzyme and ventricular growth: pathway inference in pharmacogenetics. Pharmacogenet Genomics (2007) 0.78
A study of relationships between single nucleotide polymorphisms from the growth hormone-insulin-like growth factor axis and bone mass: the Hertfordshire cohort study. J Rheumatol (2009) 0.78
Questioning INS VNTR role in obesity and diabetes: subclasses tag IGF2-INS-TH haplotypes; and -23HphI as a STEP (splicing and translational efficiency polymorphism). Physiol Genomics (2006) 0.78
Typing dinucleotide repeats under nondenaturing conditions with single-base resolution and high sizing precision. Mol Biotechnol (2002) 0.78
Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme. Age (Dordr) (2014) 0.78