Published in Bioinformatics on February 01, 2000
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet (2004) 14.76
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet (2006) 9.56
Linkage disequilibrium--understanding the evolutionary past and mapping the medical future. Nat Rev Genet (2008) 7.08
Handling marker-marker linkage disequilibrium: pedigree analysis with clustered markers. Am J Hum Genet (2005) 6.12
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A (2008) 5.27
Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet (2004) 5.02
CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. Nat Genet (2006) 4.51
Linkage disequilibrium and persistence of phase in Holstein-Friesian, Jersey and Angus cattle. Genetics (2008) 4.20
PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis. Am J Hum Genet (2005) 3.95
Extent and distribution of linkage disequilibrium in three genomic regions. Am J Hum Genet (2000) 3.68
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24. Nat Genet (2009) 3.58
A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci U S A (2007) 3.50
Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet (2009) 3.38
Whole genome linkage disequilibrium maps in cattle. BMC Genet (2007) 3.28
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. Am J Hum Genet (2008) 3.27
The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet (2007) 3.21
Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am J Med Genet B Neuropsychiatr Genet (2009) 2.86
A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms. Am J Hum Genet (2005) 2.85
Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. PLoS Genet (2006) 2.80
Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate. J Med Genet (2003) 2.72
Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease. Proc Natl Acad Sci U S A (2006) 2.71
Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc Natl Acad Sci U S A (2005) 2.68
Caution on pedigree haplotype inference with software that assumes linkage equilibrium. Am J Hum Genet (2002) 2.51
Contrasting linkage-disequilibrium patterns between cases and controls as a novel association-mapping method. Am J Hum Genet (2006) 2.47
Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proc Natl Acad Sci U S A (2004) 2.36
DCDC2 is associated with reading disability and modulates neuronal development in the brain. Proc Natl Acad Sci U S A (2005) 2.35
Linkage disequilibrium in domestic sheep. Genetics (2002) 2.29
The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. Am J Hum Genet (2004) 2.21
Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence. Am J Hum Genet (2005) 2.18
Extent of genome-wide linkage disequilibrium in Australian Holstein-Friesian cattle based on a high-density SNP panel. BMC Genomics (2008) 2.16
Cubic exact solutions for the estimation of pairwise haplotype frequencies: implications for linkage disequilibrium analyses and a web tool 'CubeX'. BMC Bioinformatics (2007) 2.15
Differential contributions of rare and common, coding and noncoding Ret mutations to multifactorial Hirschsprung disease liability. Am J Hum Genet (2010) 2.12
Linkage disequilibrium and association of MAPT H1 in Parkinson disease. Am J Hum Genet (2004) 2.10
A linkage map of the Atlantic salmon (Salmo salar) based on EST-derived SNP markers. BMC Genomics (2008) 2.07
Strong evidence of linkage disequilibrium between polymorphisms at the IRF6 locus and nonsyndromic cleft lip with or without cleft palate, in an Italian population. Am J Hum Genet (2004) 2.06
Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. Am J Hum Genet (2005) 2.06
The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3. Am J Hum Genet (2004) 1.91
Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. Am J Hum Genet (2006) 1.82
Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis. PLoS Genet (2009) 1.80
Confirmation and fine-mapping of a major QTL for resistance to infectious pancreatic necrosis in Atlantic salmon (Salmo salar): population-level associations between markers and trait. BMC Genomics (2009) 1.77
Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function. Am J Hum Genet (2008) 1.77
A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States. Am J Hum Genet (2004) 1.76
Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition. J Clin Invest (2007) 1.74
Haplotype block partitioning and tag SNP selection using genotype data and their applications to association studies. Genome Res (2004) 1.74
Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease. Am J Hum Genet (2004) 1.70
Chromogranin A polymorphisms are associated with hypertensive renal disease. J Am Soc Nephrol (2008) 1.68
Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection. Am J Hum Genet (2004) 1.61
Genomic hotspots for adaptation: the population genetics of Müllerian mimicry in Heliconius erato. PLoS Genet (2010) 1.61
Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus. Am J Hum Genet (2005) 1.59
Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology. Am J Hum Genet (2004) 1.58
CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis. Am J Hum Genet (2007) 1.56
Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT. Am J Hum Genet (2005) 1.56
Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease. Am J Hum Genet (2007) 1.55
Linkage disequilibrium mapping of schizophrenia susceptibility to the CAPON region of chromosome 1q22. Am J Hum Genet (2004) 1.55
A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2. PLoS Genet (2008) 1.53
Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions. Am J Med Genet B Neuropsychiatr Genet (2006) 1.51
JLIN: a java based linkage disequilibrium plotter. BMC Bioinformatics (2006) 1.51
Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: linkage and association analyses. Hum Genet (2004) 1.51
The Impact of Genetic Relationship and Linkage Disequilibrium on Genomic Selection. PLoS One (2015) 1.48
Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia. Proc Natl Acad Sci U S A (2007) 1.46
Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. Hum Genet (2009) 1.45
Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans. J Clin Invest (2008) 1.43
Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. Proc Natl Acad Sci U S A (2006) 1.41
Application of association mapping to understanding the genetic diversity of plant germplasm resources. Int J Plant Genomics (2008) 1.40
Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. Hum Mol Genet (2008) 1.39
Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR. Hum Genet (2005) 1.37
Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia. Am J Hum Genet (2005) 1.35
Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. Environ Health Perspect (2006) 1.33
A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q. BMC Genet (2006) 1.33
Investigation of autism and GABA receptor subunit genes in multiple ethnic groups. Neurogenetics (2006) 1.33
CRISPLD2: a novel NSCLP candidate gene. Hum Mol Genet (2007) 1.32
Genomic selection for fruit quality traits in apple (Malus×domestica Borkh.). PLoS One (2012) 1.32
Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Hum Mol Genet (2003) 1.32
GATA2 is associated with familial early-onset coronary artery disease. PLoS Genet (2006) 1.32
Evidence for linkage and association with reading disability on 6p21.3-22. Am J Hum Genet (2002) 1.31
Analysis of the IBD5 locus and potential gene-gene interactions in Crohn's disease. Gut (2003) 1.31
Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease. Am J Hum Genet (2005) 1.31
The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region. Am J Hum Genet (2005) 1.28
Association of specific language impairment (SLI) to the region of 7q31. Am J Hum Genet (2003) 1.26
Haplotype and linkage disequilibrium architecture for human cancer-associated genes. Genome Res (2002) 1.26
Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk. J Clin Invest (2007) 1.25
In search of causal variants: refining disease association signals using cross-population contrasts. BMC Genet (2008) 1.24
MIDAS: software for analysis and visualisation of interallelic disequilibrium between multiallelic markers. BMC Bioinformatics (2006) 1.24
The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis. Am J Hum Genet (2004) 1.24
Enamel formation genes influence enamel microhardness before and after cariogenic challenge. PLoS One (2012) 1.24
Mutation history of the roma/gypsies. Am J Hum Genet (2004) 1.24
SNPAnalyzer: a web-based integrated workbench for single-nucleotide polymorphism analysis. Nucleic Acids Res (2005) 1.23
Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets. Hum Mol Genet (2008) 1.21
Genetic dissection of the human leukocyte antigen region by use of haplotypes of Tasmanians with multiple sclerosis. Am J Hum Genet (2002) 1.21
CD36 polymorphism is associated with protection from cerebral malaria. Am J Hum Genet (2002) 1.21
Family-based association analysis implicates IL-4 in susceptibility to Kawasaki disease. Genes Immun (2005) 1.21
Haplotype information and linkage disequilibrium mapping for single nucleotide polymorphisms. Genome Res (2003) 1.21
Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis. PLoS Genet (2009) 1.20
Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated with CTLA4 and TGFbeta gene variants. BMC Immunol (2009) 1.20
KIR haplotype content at the allele level in 77 Northern Irish families. Immunogenetics (2007) 1.19
Novel genomic approaches unravel genetic architecture of complex traits in apple. BMC Genomics (2013) 1.18
Identifying nineteenth century genealogical links from genotypes. Hum Genet (2005) 1.17
Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa. Proc Natl Acad Sci U S A (2006) 1.16
COL4A1 is associated with arterial stiffness by genome-wide association scan. Circ Cardiovasc Genet (2009) 1.16
A general test of association for quantitative traits in nuclear families. Am J Hum Genet (2000) 22.45
GRR: graphical representation of relationship errors. Bioinformatics (2001) 6.09
Pedigree tests of transmission disequilibrium. Eur J Hum Genet (2000) 5.93
Extent and distribution of linkage disequilibrium in three genomic regions. Am J Hum Genet (2000) 3.68
A genome-wide search for quantitative trait loci underlying asthma. Nature (1996) 3.58
Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor. Nat Genet (1994) 2.91
Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. Lancet (1993) 2.88
Single nucleotide polymorphism and linkage disequilibrium within the TCR alpha/delta locus. Hum Mol Genet (2000) 2.51
Association analysis in a variance components framework. Genet Epidemiol (2001) 2.38
Adult familial cryptogenic fibrosing alveolitis in the United Kingdom. Thorax (2000) 2.16
Independent inheritance of serum immunoglobulin E concentrations and airway responsiveness. Am J Respir Crit Care Med (2000) 1.80
Genetic variance components analysis for binary phenotypes using generalized linear mixed models (GLMMs) and Gibbs sampling. Genet Epidemiol (1999) 1.77
Association of atopic dermatitis to the beta subunit of the high affinity immunoglobulin E receptor. Br J Dermatol (1998) 1.69
Gene polymorphism in Netherton and common atopic disease. Nat Genet (2001) 1.66
The power to detect linkage disequilibrium with quantitative traits in selected samples. Am J Hum Genet (2001) 1.64
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HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens. Clin Exp Allergy (1994) 1.56
Tumour necrosis factor haplotypes and asthma. Hum Mol Genet (1997) 1.48
Fc epsilon RI-beta polymorphism and risk of atopy in a general population sample. BMJ (1995) 1.40
Confirmation of genetic linkage between atopic IgE responses and chromosome 11q13. J Med Genet (1992) 1.32
Compensation, radiographic changes, and survival in applicants for asbestosis compensation. Br J Ind Med (1985) 1.31
Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy. J Med Genet (1996) 1.28
A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness. Hum Mol Genet (1996) 1.27
Symptoms and longitudinal changes in lung function in young seasonal grain handlers. Br J Ind Med (1986) 1.15
Delta 32 deletion of CCR5 gene and association with asthma or atopy. Lancet (2000) 1.12
Prevalence of radiographic asbestosis in crocidolite miners and millers at Wittenoom, Western Australia. Br J Ind Med (1986) 1.11
The effect of genotype and pedigree error on linkage analysis: analysis of three asthma genome scans. Genet Epidemiol (2001) 1.08
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Increases in airway responsiveness to histamine precede allergen-induced late asthmatic responses. J Allergy Clin Immunol (1988) 1.06
Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample. Eur J Hum Genet (2001) 1.04
Linkage of chromosome 5q and 11q gene markers to asthma-associated quantitative traits in Australian children. Am J Respir Crit Care Med (1998) 1.01
Aspirin-induced asthma and HLA-DRB1 and HLA-DPB1 genotypes. Clin Exp Allergy (1997) 1.00
Dysgerminoma, gonadoblastoma, and testicular germ cell neoplasia in phenotypically female and male siblings with 46 XY genotype. Cancer (1987) 0.99
Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families. Eur J Hum Genet (2000) 0.98
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A genome-wide screen for asthma-associated quantitative trait loci in a mouse model of allergic asthma. Hum Mol Genet (1999) 0.93
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A high-density genetic map of the chromosome 13q14 atopy locus. Genomics (2000) 0.82
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