A gene-centric analysis of activated partial thromboplastin time and activated protein C resistance using the HumanCVD focused genotyping array.

PubWeight™: 0.82‹?›

🔗 View Article (PMC 3682876)

Published in Eur J Hum Genet on November 28, 2012

Authors

Tom R Gaunt1, Gordon D O Lowe, Debbie A Lawlor, Juan-Pablo Casas, Ian N M Day

Author Affiliations

1: MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield Grove, Bristol, UK. tom.gaunt@bristol.ac.uk

Articles cited by this

PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92

A haplotype map of the human genome. Nature (2005) 105.70

A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res (1988) 77.80

Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature (1994) 9.06

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet (2011) 5.26

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A (1993) 4.57

The effect of ABO blood group on the diagnosis of von Willebrand disease. Blood (1987) 2.84

Enhanced blood coagulation and fibrinolysis in mice lacking histidine-rich glycoprotein (HRG). J Thromb Haemost (2005) 1.72

Inherited resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a property of factor V. Proc Natl Acad Sci U S A (1994) 1.51

Functional effects of the ABO locus polymorphism on plasma levels of von Willebrand factor, factor VIII, and activated partial thromboplastin time. Arterioscler Thromb Vasc Biol (2000) 1.27

Genetic regulation of serum phytosterol levels and risk of coronary artery disease. Circ Cardiovasc Genet (2010) 1.23

Prediction of deep vein thrombosis after elective hip replacement surgery by preoperative clinical and haemostatic variables: the ECAT DVT Study. European Concerted Action on Thrombosis. Thromb Haemost (1999) 1.17

Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time. Am J Hum Genet (2010) 1.15

The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis. BMC Genet (2004) 1.12

Can haematological tests predict cardiovascular risk? The 2005 Kettle Lecture. Br J Haematol (2006) 1.12

A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism. Blood (2004) 1.04

Short activated partial thromboplastin times are related to increased thrombin generation and an increased risk for thromboembolism. Am J Clin Pathol (2000) 1.02

Histidine-rich glycoprotein: the Swiss Army knife of mammalian plasma. Blood (2010) 0.99

KNG1 Ile581Thr and susceptibility to venous thrombosis. Blood (2011) 0.98

Heritability of hemostasis phenotypes and their correlation with type 2 diabetes status in Mexican Americans. Hum Biol (2005) 0.97

The dilute phospholipid APTT: a sensitive assay for verification of lupus anticoagulants. Thromb Haemost (1985) 0.93

Shortened activated partial thromboplastin time, a hemostatic marker for hypercoagulable state during acute coronary event. Transl Res (2010) 0.90

Resistance to activated protein C due to mutated factor V as a novel cause of inherited thrombophilia. Haematologica (1995) 0.87

Association of ABO(H) and I blood group system development with von Willebrand factor and Factor VIII plasma levels in children and adolescents. Transfusion (2010) 0.85

Activated protein C resistance and the FV:R506Q mutation in a random population sample--associations with cardiovascular risk factors and coagulation variables. Thromb Haemost (1999) 0.85

Articles by these authors

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88

Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med (2004) 15.30

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Cohort Profile: the 'children of the 90s'--the index offspring of the Avon Longitudinal Study of Parents and Children. Int J Epidemiol (2012) 11.79

Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet (2009) 9.90

Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet (2011) 9.07

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94

Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31

Indicators of socioeconomic position (part 1). J Epidemiol Community Health (2006) 7.09

Cohort Profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort. Int J Epidemiol (2012) 6.91

Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ (2007) 6.73

Birth weight and risk of type 2 diabetes: a systematic review. JAMA (2008) 6.73

C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81

Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA (2005) 5.60

C-reactive protein and its role in metabolic syndrome: mendelian randomisation study. Lancet (2005) 5.51

Childhood obesity. Lancet (2010) 5.47

Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev (2011) 5.30

Aspirin for prevention of cardiovascular events in a general population screened for a low ankle brachial index: a randomized controlled trial. JAMA (2010) 5.10

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71

Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am J Epidemiol (2009) 4.70

Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review. PLoS Med (2008) 4.34

Exercise for depression. Cochrane Database Syst Rev (2013) 4.30

Association of maternal weight gain in pregnancy with offspring obesity and metabolic and vascular traits in childhood. Circulation (2010) 4.12

Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94

Measuring socio-economic position for epidemiological studies in low- and middle-income countries: a methods of measurement in epidemiology paper. Int J Epidemiol (2012) 3.93

Indicators of socioeconomic position (part 2). J Epidemiol Community Health (2006) 3.87

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76

Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75

Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. PLoS Med (2007) 3.71

Predicting the functional, molecular, and phenotypic consequences of amino acid substitutions using hidden Markov models. Hum Mutat (2012) 3.60

C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes (2002) 3.59

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest (2008) 3.51

Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet (2010) 3.34

Exercise for depression. Cochrane Database Syst Rev (2009) 3.23

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03

Quality in epidemiological research: should we be submitting papers before we have the results and submitting more hypothesis-generating research? Int J Epidemiol (2007) 3.03

Using multiple genetic variants as instrumental variables for modifiable risk factors. Stat Methods Med Res (2011) 2.83

Association of body mass index with suicide mortality: a prospective cohort study of more than one million men. Am J Epidemiol (2005) 2.82

Comparison of the associations of body mass index and measures of central adiposity and fat mass with coronary heart disease, diabetes, and all-cause mortality: a study using data from 4 UK cohorts. Am J Clin Nutr (2010) 2.82

Treatment and prevention of obesity--are there critical periods for intervention? Int J Epidemiol (2006) 2.81

Objective measures of physical capability and subsequent health: a systematic review. Age Ageing (2010) 2.78

Physical activity and hemostatic and inflammatory variables in elderly men. Circulation (2002) 2.75

Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls. Lancet (2006) 2.72

Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis. Cancer Causes Control (2008) 2.68

Associations of gestational weight gain with maternal body mass index, waist circumference, and blood pressure measured 16 y after pregnancy: the Avon Longitudinal Study of Parents and Children (ALSPAC). Am J Clin Nutr (2011) 2.67

Associations of gestational weight gain with offspring body mass index and blood pressure at 21 years of age: evidence from a birth cohort study. Circulation (2009) 2.56

What are the causal effects of breastfeeding on IQ, obesity and blood pressure? Evidence from comparing high-income with middle-income cohorts. Int J Epidemiol (2011) 2.54

Associations of pregnancy complications with calculated cardiovascular disease risk and cardiovascular risk factors in middle age: the Avon Longitudinal Study of Parents and Children. Circulation (2012) 2.54

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53

C-reactive protein, interleukin-6, and soluble adhesion molecules as predictors of progressive peripheral atherosclerosis in the general population: Edinburgh Artery Study. Circulation (2005) 2.53

A systematic review of the association between circulating concentrations of C reactive protein and cancer. J Epidemiol Community Health (2007) 2.50

Loss to follow-up in cohort studies: bias in estimates of socioeconomic inequalities. Epidemiology (2013) 2.46

A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet (2006) 2.44

Missed appointments in primary care: questionnaire and focus group study of health professionals. Br J Gen Pract (2004) 2.43

Association of C-reactive protein with blood pressure and hypertension: life course confounding and mendelian randomization tests of causality. Arterioscler Thromb Vasc Biol (2005) 2.42

Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts. BMJ (2013) 2.41

Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. Lancet (2011) 2.35

Substantial intergenerational increases in body mass index are not explained by the fetal overnutrition hypothesis: the Cardiovascular Risk in Young Finns Study. Am J Clin Nutr (2007) 2.28

Socioeconomic position, co-occurrence of behavior-related risk factors, and coronary heart disease: the Finnish Public Sector study. Am J Public Health (2007) 2.28

Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis. Am J Clin Nutr (2006) 2.24

Alanine aminotransferase, gamma-glutamyltransferase, and incident diabetes: the British Women's Heart and Health Study and meta-analysis. Diabetes Care (2009) 2.23

Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999-2004. Gastroenterology (2007) 2.22

Associations between cigarette smoking, pipe/cigar smoking, and smoking cessation, and haemostatic and inflammatory markers for cardiovascular disease. Eur Heart J (2005) 2.21

Common mental disorder and obesity: insight from four repeat measures over 19 years: prospective Whitehall II cohort study. BMJ (2009) 2.19

Reasons for and consequences of missed appointments in general practice in the UK: questionnaire survey and prospective review of medical records. BMC Fam Pract (2005) 2.18

Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study. J Am Coll Cardiol (2013) 2.18

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15

Gestational-age-specific reference ranges for blood pressure in pregnancy: findings from a prospective cohort. J Hypertens (2015) 2.14

Predicting the functional consequences of cancer-associated amino acid substitutions. Bioinformatics (2013) 2.12

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet (2012) 2.12

Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Am J Respir Crit Care Med (2011) 2.07

Sedentary time in relation to cardio-metabolic risk factors: differential associations for self-report vs accelerometry in working age adults. Int J Epidemiol (2012) 2.04

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet (2009) 2.04

Lipoprotein(a) levels and risk of future coronary heart disease: large-scale prospective data. Arch Intern Med (2008) 2.01

Cohort Profile: the Born in Bradford multi-ethnic family cohort study. Int J Epidemiol (2012) 1.99

Does maternal smoking during pregnancy have a direct effect on future offspring obesity? Evidence from a prospective birth cohort study. Am J Epidemiol (2006) 1.98

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet (2012) 1.96

Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream. PLoS Med (2008) 1.95

Fasting blood glucose and the risk of stroke and myocardial infarction. Circulation (2009) 1.92