IL-12p70 and IL-18 gene-modified dendritic cells loaded with tumor antigen-derived peptides or recombinant protein effectively stimulate specific Type-1 CD4+ T-cell responses from normal donors and melanoma patients in vitro.

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Published in Cancer Gene Ther on April 28, 2006

Authors

L Vujanovic1, E Ranieri, A Gambotto, W C Olson, J M Kirkwood, W J Storkus

Author Affiliations

1: Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

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