Published in Cell Signal on March 14, 2006
ADP-ribosylation factor 1 controls the activation of the phosphatidylinositol 3-kinase pathway to regulate epidermal growth factor-dependent growth and migration of breast cancer cells. J Biol Chem (2008) 1.27
ARAP1 regulates endocytosis of EGFR. Traffic (2008) 1.10
The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling. Genes Dev (2010) 1.05
ARF6-dependent regulation of P2Y receptor traffic and function in human platelets. PLoS One (2012) 0.92
Prolonged G(q) activity triggers fly rhodopsin endocytosis and degradation, and reduces photoreceptor sensitivity. EMBO J (2007) 0.85
ADP-ribosylation factor 6 expression and activation are reduced in myometrium in complicated pregnancies. PLoS One (2012) 0.83
Rab family proteins regulate the endosomal trafficking and function of RGS4. J Biol Chem (2013) 0.82
The adaptor proteins p66Shc and Grb2 regulate the activation of the GTPases ARF1 and ARF6 in invasive breast cancer cells. J Biol Chem (2014) 0.82
Mutation of a TADR protein leads to rhodopsin and Gq-dependent retinal degeneration in Drosophila. J Neurosci (2008) 0.79
The small GTPase ADP-Ribosylation Factor 1 mediates the sensitivity of triple negative breast cancer cells to EGFR tyrosine kinase inhibitors. Cancer Biol Ther (2015) 0.79
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Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ. BMC Cancer (2015) 0.75
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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature (2012) 6.18
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proc Natl Acad Sci U S A (2007) 6.04
Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature (2011) 5.35
Conformational biosensors reveal GPCR signalling from endosomes. Nature (2013) 3.29
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex. Proc Natl Acad Sci U S A (2009) 2.86
Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem (2007) 2.59
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor. Nature (2011) 2.43
Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex. Proc Natl Acad Sci U S A (2011) 2.03
Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer. EMBO J (2009) 1.86
Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay. Mol Pharmacol (2006) 1.78
A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality. Ann Emerg Med (2008) 1.77
The relationship between cerebral oxygen saturation changes and postoperative cognitive dysfunction in elderly patients after coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth (2010) 1.67
Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans. Semin Immunol (2012) 1.66
Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Mol Pharmacol (2006) 1.66
Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity. Mol Pharmacol (2008) 1.60
Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50). J Biol Chem (2003) 1.60
Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. J Biol Chem (2009) 1.59
The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors. Cell Signal (2004) 1.56
Cocaine esterase: interactions with cocaine and immune responses in mice. J Pharmacol Exp Ther (2006) 1.55
Comparison of health-related quality-of-life outcomes of men and women after coronary artery bypass surgery through 1 year: findings from the POST CABG Biobehavioral Study. Am Heart J (2003) 1.53
G protein-coupled receptors stimulation and the control of cell migration. Cell Signal (2009) 1.46
Signal transduction and functional changes in neutrophils with aging. Aging Cell (2004) 1.41
SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5. Proc Natl Acad Sci U S A (2007) 1.39
N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells. Mol Pharmacol (2007) 1.35
Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression. Nucleic Acids Res (2008) 1.34
Chemical and functional analysis of hydroxyurea oral solutions. J Pediatr Hematol Oncol (2004) 1.30
Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways. Mol Pharmacol (2009) 1.30
ADP-ribosylation factor 1 controls the activation of the phosphatidylinositol 3-kinase pathway to regulate epidermal growth factor-dependent growth and migration of breast cancer cells. J Biol Chem (2008) 1.27
Differentially regulated expression of endogenous RGS4 and RGS7. J Biol Chem (2003) 1.25
Endogenous ARF6 interacts with Rac1 upon angiotensin II stimulation to regulate membrane ruffling and cell migration. Mol Biol Cell (2006) 1.20
Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats. J Pharmacol Exp Ther (2009) 1.19
The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex. J Biol Chem (2003) 1.18
G protein-coupled receptor endocytosis in ADP-ribosylation factor 6-depleted cells. J Biol Chem (2004) 1.17
Sex differences in the prevalence of psychiatric disorders and psychological distress in patients with COPD. Chest (2007) 1.16
Nitric oxide-dependent allosteric inhibitory role of a second nucleotide binding site in soluble guanylyl cyclase. J Biol Chem (2005) 1.15
Unraveling G protein-coupled receptor endocytosis pathways using real-time monitoring of agonist-promoted interaction between beta-arrestins and AP-2. J Biol Chem (2007) 1.15
Rab11 regulates the recycling of the beta2-adrenergic receptor through a direct interaction. Biochem J (2009) 1.15
A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse. Mol Pharmacol (2010) 1.12
Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues. J Biol Chem (2004) 1.12
Age-associated alterations in the recruitment of signal-transduction proteins to lipid rafts in human T lymphocytes. J Leukoc Biol (2003) 1.10
Thymic stromal lymphopoietin and thymic stromal lymphopoietin-conditioned dendritic cells induce regulatory T-cell differentiation and protection of NOD mice against diabetes. Diabetes (2008) 1.10
Structural analysis of thermostabilizing mutations of cocaine esterase. Protein Eng Des Sel (2010) 1.10
Benefits of physical exercise training on cognition and quality of life in frail older adults. J Gerontol B Psychol Sci Soc Sci (2012) 1.08
Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins. Chem Biol Drug Des (2006) 1.08
Differential β-arrestin-dependent conformational signaling and cellular responses revealed by angiotensin analogs. Sci Signal (2012) 1.07
Trafficking, ubiquitination, and down-regulation of the human platelet-activating factor receptor. J Biol Chem (2003) 1.07
Differential role of lipid rafts in the functions of CD4+ and CD8+ human T lymphocytes with aging. Cell Signal (2005) 1.07
Prevention and reversal by cocaine esterase of cocaine-induced cardiovascular effects in rats. Drug Alcohol Depend (2009) 1.07
Death receptors, Fas and TRAIL receptors, are involved in human osteoclast apoptosis. Biochem Biophys Res Commun (2005) 1.06
The intracellular trafficking of the G protein-coupled receptor TPbeta depends on a direct interaction with Rab11. J Biol Chem (2005) 1.06
Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats. Neuropsychopharmacology (2011) 1.06
Ageing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing - a biochemical paradigm for the ageing immune system. Arthritis Res Ther (2003) 1.05
Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells. J Biol Chem (2013) 1.05
Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation. Biochemistry (2005) 1.04
Portrait of rural emergency departments in Quebec and utilisation of the Quebec Emergency Department Management Guide: a study protocol. BMJ Open (2013) 1.03
Modulation of human lymphocyte proliferative response with aging. Exp Gerontol (2002) 1.02
Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2. Biochemistry (2002) 1.01
Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50). J Biol Chem (2002) 0.98
Peroxiredoxin-4 interacts with and regulates the thromboxane A(2) receptor. FEBS Lett (2007) 0.98
Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase. Neuropsychopharmacology (2011) 0.98
Quality of work life, burnout, and stress in emergency department physicians: a qualitative review. Eur J Emerg Med (2015) 0.97
Effects of cocaine esterase following its repeated administration with cocaine in mice. Drug Alcohol Depend (2009) 0.97
Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice. J Pharmacol Exp Ther (2009) 0.96
Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity. Proc Natl Acad Sci U S A (2011) 0.96
Production of prostaglandin D(2) by human osteoblasts and modulation of osteoprotegerin, RANKL, and cellular migration by DP and CRTH2 receptors. J Bone Miner Res (2004) 0.96
The multiple dimensions of frailty: physical capacity, cognition, and quality of life. Int Psychogeriatr (2012) 0.96
Residues 293 and 294 are ligand contact points of the human angiotensin type 1 receptor. Biochemistry (2002) 0.95
Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. Mol Endocrinol (2013) 0.94
The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging. Immun Ageing (2005) 0.94
Galphaq-coupled receptor internalization specifically induced by Galphaq signaling. Regulation by EBP50. J Biol Chem (2003) 0.94
Role of the Rab11-associated intracellular pool of receptors formed by constitutive endocytosis of the beta isoform of the thromboxane A2 receptor (TP beta). Biochemistry (2004) 0.94
GM-CSF activates the Jak/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals. Biogerontology (2006) 0.93
Effects of methyl-beta-cyclodextrin on T lymphocytes lipid rafts with aging. Exp Gerontol (2004) 0.93
Role of extracellular cysteine residues in dimerization/oligomerization of the human prostacyclin receptor. Eur J Pharmacol (2004) 0.93
Sex differences in chest pain and prediction of exercise-induced ischemia. Can J Cardiol (2003) 0.93
RACK1 regulates the cell surface expression of the G protein-coupled receptor for thromboxane A(2). Traffic (2007) 0.93
Allosteric coupling from G protein to the agonist-binding pocket in GPCRs. Nature (2016) 0.92
ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin. Cell Signal (2007) 0.91
G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis. Mol Immunol (2012) 0.91
Oligomerization of the alpha and beta isoforms of the thromboxane A2 receptor: relevance to receptor signaling and endocytosis. Cell Signal (2005) 0.91
A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway. J Biol Chem (2010) 0.91
Chronic obstructive pulmonary disease patients with psychiatric disorders are at greater risk of exacerbations. Psychosom Med (2009) 0.90
Distinct motifs of neuropeptide Y receptors differentially regulate trafficking and desensitization. Traffic (2007) 0.90
G-protein signaling modulator-3 regulates heterotrimeric G-protein dynamics through dual association with Gβ and Gαi protein subunits. J Biol Chem (2011) 0.89
Nm23-H2 interacts with a G protein-coupled receptor to regulate its endocytosis through an Rac1-dependent mechanism. J Biol Chem (2004) 0.89