Published in J Biol Chem on September 24, 2003
Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion. Cancer Res (2008) 1.88
The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts. J Biol Chem (2008) 1.82
The stress of protein misfolding: from single cells to multicellular organisms. Cold Spring Harb Perspect Biol (2011) 1.48
FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells. Mol Cell Biol (2010) 1.36
The middle domain of Hsp90 acts as a discriminator between different types of client proteins. Mol Cell Biol (2006) 1.33
Multiple 40-kDa heat-shock protein chaperones function in Tom70-dependent mitochondrial import. Mol Biol Cell (2007) 1.20
Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation. Biochem J (2005) 1.19
Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination. Biochemistry (2009) 1.01
Role of molecular chaperones and TPR-domain proteins in the cytoplasmic transport of steroid receptors and their passage through the nuclear pore. Nucleus (2011) 0.98
Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome. Proc Natl Acad Sci U S A (2013) 0.94
C331A mutant of neuronal nitric-oxide synthase is labilized for Hsp70/CHIP (C terminus of HSC70-interacting protein)-dependent ubiquitination. J Biol Chem (2010) 0.90
Functions of the Hsp90 chaperone system: lifting client proteins to new heights. Int J Biochem Mol Biol (2013) 0.87
Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness. Sci Rep (2013) 0.87
Differential regulation of the transcriptional activity of the glucocorticoid receptor through site-specific phosphorylation. Biologics (2008) 0.87
Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNA interference-mediated silencing in mammalian cells. Mol Biol Cell (2013) 0.86
NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90. Proc Natl Acad Sci U S A (2010) 0.86
The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability. J Biol Chem (2010) 0.85
The Hsp90 co-chaperone p23 of Toxoplasma gondii: Identification, functional analysis and dynamic interactome determination. Mol Biochem Parasitol (2010) 0.84
Recombinant expression of aryl hydrocarbon receptor for quantitative ligand-binding analysis. Anal Biochem (2008) 0.83
Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins. Proteomics (2014) 0.83
Differences in conformational dynamics within the Hsp90 chaperone family reveal mechanistic insights. Front Mol Biosci (2014) 0.81
Differential modulation of functional dynamics and allosteric interactions in the Hsp90-cochaperone complexes with p23 and Aha1: a computational study. PLoS One (2013) 0.81
Chaperones and the maturation of steroid hormone receptor complexes. Oncotarget (2011) 0.81
A review of the serotonin transporter and prenatal cortisol in the development of autism spectrum disorders. Mol Autism (2013) 0.78
Characterization of orchardgrass p23, a flowering plant Hsp90 cohort protein. Cell Stress Chaperones (2008) 0.78
The Hsp90 Co-chaperones Sti1, Aha1, and P23 Regulate Adaptive Responses to Antifungal Azoles. Front Microbiol (2016) 0.75
Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92
Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature (2011) 9.61
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature (2012) 6.18
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proc Natl Acad Sci U S A (2007) 6.04
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell (2005) 6.00
Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature (2011) 5.35
Conformational biosensors reveal GPCR signalling from endosomes. Nature (2013) 3.29
Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. J Lipid Res (2005) 3.01
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex. Proc Natl Acad Sci U S A (2009) 2.86
Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem (2007) 2.59
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor. Nature (2011) 2.43
Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex. Proc Natl Acad Sci U S A (2011) 2.03
Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer. EMBO J (2009) 1.86
The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts. J Biol Chem (2008) 1.82
Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone. J Biol Chem (2005) 1.81
Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay. Mol Pharmacol (2006) 1.78
A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality. Ann Emerg Med (2008) 1.77
Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Mol Pharmacol (2006) 1.66
Role of molecular chaperones in steroid receptor action. Essays Biochem (2004) 1.64
Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity. Mol Pharmacol (2008) 1.60
Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. J Biol Chem (2009) 1.59
Cocaine esterase: interactions with cocaine and immune responses in mice. J Pharmacol Exp Ther (2006) 1.55
Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage. Exp Biol Med (Maywood) (2010) 1.50
CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins. Hum Mol Genet (2008) 1.43
SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5. Proc Natl Acad Sci U S A (2007) 1.39
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nat Chem Biol (2012) 1.37
N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells. Mol Pharmacol (2007) 1.35
Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation. J Biol Chem (2010) 1.29
Androgen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to expanded glutamine tracts. J Biol Chem (2003) 1.27
Differentially regulated expression of endogenous RGS4 and RGS7. J Biol Chem (2003) 1.25
Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction. Hum Mol Genet (2006) 1.22
Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity. J Med Chem (2015) 1.22
Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus. J Biol Chem (2004) 1.21
Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation. J Biol Chem (2004) 1.20
Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase. J Biol Chem (2004) 1.20
Evidence for glucocorticoid receptor transport on microtubules by dynein. J Biol Chem (2004) 1.20
Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats. J Pharmacol Exp Ther (2009) 1.19
Binding of hsp90-associated immunophilins to cytoplasmic dynein: direct binding and in vivo evidence that the peptidylprolyl isomerase domain is a dynein interaction domain. Biochemistry (2002) 1.18
Nitric oxide-dependent allosteric inhibitory role of a second nucleotide binding site in soluble guanylyl cyclase. J Biol Chem (2005) 1.15
Cigarette smoking and erectile dysfunction: focus on NO bioavailability and ROS generation. J Sex Med (2008) 1.15
A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse. Mol Pharmacol (2010) 1.12
Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues. J Biol Chem (2004) 1.12
Structural analysis of thermostabilizing mutations of cocaine esterase. Protein Eng Des Sel (2010) 1.10
Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases. Annu Rev Pharmacol Toxicol (2014) 1.09
Major SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradations. Pharm Res (2008) 1.09
Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins. Chem Biol Drug Des (2006) 1.08
Prevention and reversal by cocaine esterase of cocaine-induced cardiovascular effects in rats. Drug Alcohol Depend (2009) 1.07
Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats. Neuropsychopharmacology (2011) 1.06
Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation. Brain Res Mol Brain Res (2004) 1.06
Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells. J Biol Chem (2013) 1.05
Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors. Neoplasia (2012) 1.04
Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation. Biochemistry (2005) 1.04
Independent functions of hsp90 in neurotransmitter release and in the continuous synaptic cycling of AMPA receptors. J Neurosci (2004) 1.03
The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase. J Biol Chem (2004) 1.03
Cyclophilin-A is bound through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex. J Biol Chem (2004) 1.02
Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft. J Biol Chem (2003) 1.01
Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination. Biochemistry (2009) 1.01
Ubiquitination and degradation of neuronal nitric-oxide synthase in vitro: dimer stabilization protects the enzyme from proteolysis. Mol Pharmacol (2004) 0.99
Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase. Neuropsychopharmacology (2011) 0.98
Effects of cocaine esterase following its repeated administration with cocaine in mice. Drug Alcohol Depend (2009) 0.97
Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice. J Pharmacol Exp Ther (2009) 0.96
Proteolytic degradation of nitric oxide synthase: effect of inhibitors and role of hsp90-based chaperones. J Pharmacol Exp Ther (2003) 0.96
hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase: geldanamycin-mediated oxidant generation is unrelated to any action of hsp90. J Biol Chem (2002) 0.96
ARF6 activation by Galpha q signaling: Galpha q forms molecular complexes with ARNO and ARF6. Cell Signal (2006) 0.95
Potential role of epigenetic mechanisms in the regulation of drug metabolism and transport. Drug Metab Dispos (2013) 0.92
Allosteric coupling from G protein to the agonist-binding pocket in GPCRs. Nature (2016) 0.92
C331A mutant of neuronal nitric-oxide synthase is labilized for Hsp70/CHIP (C terminus of HSC70-interacting protein)-dependent ubiquitination. J Biol Chem (2010) 0.90
All of the protein interactions that link steroid receptor.hsp90.immunophilin heterocomplexes to cytoplasmic dynein are common to plant and animal cells. Biochemistry (2002) 0.90
Characterization of a plant homolog of hop, a cochaperone of hsp90. Plant Physiol (2003) 0.89
Tetrahydrobiopterin protects against guanabenz-mediated inhibition of neuronal nitric-oxide synthase in vitro and in vivo. Drug Metab Dispos (2006) 0.89
Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time. Mol Pharmacol (2011) 0.89
Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase. Brain Res Mol Brain Res (2005) 0.89
Expression, purification, and assay of cytosolic (catalytic) domains of membrane-bound mammalian adenylyl cyclases. Methods Enzymol (2002) 0.88
PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity. J Control Release (2009) 0.88