Published in Am J Pathol on May 01, 2006
Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway. Am J Pathol (2009) 1.62
Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase. Am J Hum Genet (2007) 1.56
Matriptase: potent proteolysis on the cell surface. Mol Med (2006) 1.47
Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice. Development (2009) 1.38
Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity. J Biol Chem (2008) 1.31
The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment. Biochem J (2010) 1.27
Membrane-anchored serine proteases in vertebrate cell and developmental biology. Annu Rev Cell Dev Biol (2011) 1.26
Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality. Am J Pathol (2009) 1.20
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase. Oncogene (2011) 1.18
Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation. PLoS Genet (2012) 1.16
Membrane-anchored serine proteases in health and disease. Prog Mol Biol Transl Sci (2011) 1.13
Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/Spint1) leads to ichthyosis-like condition and abnormal hair development in mice. Am J Pathol (2008) 1.11
Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome. Nat Genet (2010) 1.09
Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway. J Biol Chem (2013) 1.05
Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itinerary. Biochem J (2008) 1.02
Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota. J Invest Dermatol (2009) 1.01
The level of claudin-7 is reduced as an early event in colorectal carcinogenesis. BMC Cancer (2011) 0.96
Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis. Oncogene (2014) 0.95
Mechanisms of hepatocyte growth factor activation in cancer tissues. Cancers (Basel) (2014) 0.94
Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice. Dev Biol (2008) 0.92
Platelet-derived growth factor-C (PDGF-C) activation by serine proteases: implications for breast cancer progression. Biochem J (2012) 0.92
Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase. Exp Cell Res (2013) 0.91
Endogenous expression of matriptase in neural progenitor cells promotes cell migration and neuron differentiation. J Biol Chem (2010) 0.88
The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin. J Biol Chem (2014) 0.86
HATL5: a cell surface serine protease differentially expressed in epithelial cancers. PLoS One (2014) 0.82
Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling. Nat Commun (2015) 0.82
Androgen receptor non-nuclear regulation of prostate cancer cell invasion mediated by Src and matriptase. Oncotarget (2015) 0.81
TMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisition. Biochem J (2014) 0.81
Detection of active matriptase using a biotinylated chloromethyl ketone peptide. PLoS One (2013) 0.78
Human DESC1 serine protease confers tumorigenic properties to MDCK cells and it is upregulated in tumours of different origin. Br J Cancer (2007) 0.78
Matriptase deletion initiates a Sjögren's syndrome-like disease in mice. PLoS One (2014) 0.78
Matriptase expression and zymogen activation in human pilosebaceous unit. J Histochem Cytochem (2013) 0.77
Roles of CUB and LDL receptor class A domain repeats of a transmembrane serine protease matriptase in its zymogen activation. J Biochem (2012) 0.77
Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity. PLoS One (2017) 0.75
The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol (2005) 6.27
A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol (2001) 6.12
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Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis. Oncogene (2002) 2.74
Contribution of stem cells and differentiated cells to epidermal tumours. Nat Rev Cancer (2003) 2.69
Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease. J Biol Chem (2000) 2.47
The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope. J Biol Chem (1995) 2.39
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Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1. J Cell Biol (2003) 2.08
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Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity. Nat Genet (2004) 1.99
Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation. Genes Dev (2005) 1.92
Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins. J Cell Biol (1986) 1.91
Gene expression profiling identifies matriptase overexpression in malignant mesothelioma. Chest (2004) 1.89
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Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity. J Biol Chem (1999) 1.62
Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo. Am J Pathol (2001) 1.57
Promiscuous gene expression and central T-cell tolerance: more than meets the eye. Trends Immunol (2002) 1.46
Complex redundancy to build a simple epidermal permeability barrier. Curr Opin Cell Biol (2003) 1.46
Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues. Br J Cancer (2005) 1.45
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The novel serine protease tumor-associated differentially expressed gene-15 (matriptase/MT-SP1) is highly overexpressed in cervical carcinoma. Cancer (2003) 1.18
CVS-3983, a selective matriptase inhibitor, suppresses the growth of androgen independent prostate tumor xenografts. Prostate (2004) 1.18
Ovarian tumor cells express a transmembrane serine protease: a potential candidate for early diagnosis and therapeutic intervention. Tumour Biol (2001) 1.16
Deregulated activation of matriptase in breast cancer cells. Clin Exp Metastasis (2002) 1.12
Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase. J Biol Chem (2004) 1.10
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Corticosteroids regulate epithelial cell differentiation and Hassall body formation in the human thymus. J Immunol (2004) 1.01
Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells. Biol Chem (2003) 0.98
Cloning and expression of novel mosaic serine proteases with and without a transmembrane domain from human lung. Biochim Biophys Acta (2001) 0.97
Evidence that filaggrin is a component of cornified cell envelopes in human plantar epidermis. Biochem J (1996) 0.97
Increased expression of matriptase is associated with histopathologic grades of cervical neoplasia. Hum Pathol (2005) 0.95
The effect of hepatocyte growth factor/scatter factor on human hair follicle growth. J Dermatol Sci (1995) 0.85
Functional analysis of keratin components in the mouse hair follicle inner root sheath. Br J Dermatol (2004) 0.83
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Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell (2003) 3.42
Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J Clin Invest (2003) 3.41
Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis. Oncogene (2002) 2.74
Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma. Nat Genet (2011) 2.60
Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer. Cancer Metastasis Rev (2003) 2.39
Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1. J Cell Biol (2003) 2.08
Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation. J Biol Chem (2006) 2.07
Proteolytic activation of the 1918 influenza virus hemagglutinin. J Virol (2009) 2.05
Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation. Genes Dev (2005) 1.92
Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Blood (2010) 1.82
Robust one-day in situ hybridization protocol for detection of microRNAs in paraffin samples using LNA probes. Methods (2010) 1.78
Role for the actomyosin complex in regulated exocytosis revealed by intravital microscopy. Proc Natl Acad Sci U S A (2011) 1.74
Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor-induced hepatotoxicity is mediated by Kupffer cells. Mol Cancer Ther (2004) 1.68
Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases. Int J Cancer (2009) 1.66
The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Cancer Cell (2006) 1.63
Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway. Am J Pathol (2009) 1.62
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion. J Cell Biol (2003) 1.60
MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells. J Exp Med (2005) 1.55
Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine. Proc Natl Acad Sci U S A (2010) 1.52
Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase. J Cell Physiol (2007) 1.51
MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D. J Biol Chem (2007) 1.51
Matriptase: potent proteolysis on the cell surface. Mol Med (2006) 1.47
Type II transmembrane serine proteases in development and disease. Int J Biochem Cell Biol (2007) 1.45
Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent. J Clin Invest (2002) 1.44
Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. J Biol Chem (2007) 1.44
Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy. J Cell Biol (2005) 1.42
Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature. J Biol Chem (2007) 1.41
Potent antitumor activity of a urokinase-activated engineered anthrax toxin. Proc Natl Acad Sci U S A (2003) 1.38
Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma. Proc Natl Acad Sci U S A (2010) 1.38
Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice. Development (2009) 1.38
Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. Cancer Res (2009) 1.37
Anthrax toxin: structures, functions and tumour targeting. Expert Opin Biol Ther (2003) 1.32
Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity. J Biol Chem (2008) 1.31
Membrane-anchored serine proteases in vertebrate cell and developmental biology. Annu Rev Cell Dev Biol (2011) 1.26
Inhibition of Mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions. Clin Cancer Res (2008) 1.26
Accelerated wound healing by mTOR activation in genetically defined mouse models. PLoS One (2010) 1.25
Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation. J Biol Chem (2007) 1.25
Type II transmembrane serine proteases. Thromb Haemost (2003) 1.25
Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. Cancer Res (2009) 1.24
uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV. Exp Cell Res (2004) 1.23
Complementary roles of intracellular and pericellular collagen degradation pathways in vivo. Mol Cell Biol (2007) 1.22
Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity. J Biol Chem (2002) 1.21
Imaging specific cell-surface proteolytic activity in single living cells. Nat Methods (2006) 1.20
Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality. Am J Pathol (2009) 1.20
Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma. Mol Cancer Res (2010) 1.19
M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. J Cell Biol (2013) 1.19
Mechanism of FGF23 processing in fibrous dysplasia. J Bone Miner Res (2012) 1.17
Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin. Nat Biotechnol (2005) 1.17
Expression of plasmid DNA in the salivary gland epithelium: novel approaches to study dynamic cellular processes in live animals. Am J Physiol Cell Physiol (2009) 1.16
Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation. PLoS Genet (2012) 1.16
The urokinase receptor as a potential target in cancer therapy. Curr Pharm Des (2004) 1.16
Expression of plasminogen activator inhibitor-1, urokinase receptor and laminin gamma-2 chain is an early coordinated event in incipient oral squamous cell carcinoma. Int J Cancer (2006) 1.16
Design, synthesis, and characterization of urokinase plasminogen-activator-sensitive near-infrared reporter. Chem Biol (2004) 1.15
Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity. Biochem J (2005) 1.13
Membrane-anchored serine proteases in health and disease. Prog Mol Biol Transl Sci (2011) 1.13
The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer. Breast Cancer Res Treat (2012) 1.13
Expression of urokinase plasminogen activator, its receptor and type-1 inhibitor in malignant and benign prostate tissue. Int J Cancer (2005) 1.12
MiR-21 expression in the tumor cell compartment holds unfavorable prognostic value in gliomas. J Neurooncol (2012) 1.11
Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis. Int J Cancer (2008) 1.10
Matriptase-dependent cell surface proteolysis in epithelial development and pathogenesis. Front Biosci (2007) 1.10
A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation. J Biol Chem (2013) 1.09
The non-phagocytic route of collagen uptake: a distinct degradation pathway. J Biol Chem (2011) 1.09
Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome. Nat Genet (2010) 1.09
MMP-9 is differentially expressed in primary human colorectal adenocarcinomas and their metastases. Mol Cancer Res (2006) 1.08
Lung metastasis fails in MMTV-PyMT oncomice lacking S100A4 due to a T-cell deficiency in primary tumors. Cancer Res (2010) 1.07
Extracellular protease mRNAs are predominantly expressed in the stromal areas of microdissected mouse breast carcinomas. Carcinogenesis (2005) 1.06
The myofibroblast is the predominant plasminogen activator inhibitor-1-expressing cell type in human breast carcinomas. Am J Pathol (2003) 1.05
High expression of miR-21 in tumor stroma correlates with increased cancer cell proliferation in human breast cancer. APMIS (2011) 1.04
Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter. Am J Pathol (2006) 1.04
Mannose receptor 2 attenuates renal fibrosis. J Am Soc Nephrol (2011) 1.04
PTEN deficiency contributes to the development and progression of head and neck cancer. Neoplasia (2013) 1.03
Rab25 regulates invasion and metastasis in head and neck cancer. Clin Cancer Res (2013) 1.02
Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itinerary. Biochem J (2008) 1.02
Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota. J Invest Dermatol (2009) 1.01
Transport via the transcytotic pathway makes prostasin available as a substrate for matriptase. J Biol Chem (2010) 1.00
The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer. Endocr Relat Cancer (2009) 0.99