Published in Proc Natl Acad Sci U S A on February 08, 2010
ZEB1-responsive genes in non-small cell lung cancer. Cancer Lett (2010) 1.50
Protease-activated receptor 2 signaling in inflammation. Semin Immunopathol (2011) 1.47
Membrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis. Am J Respir Crit Care Med (2016) 1.39
Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. Oncogene (2011) 1.29
The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment. Biochem J (2010) 1.27
Membrane-anchored serine proteases in vertebrate cell and developmental biology. Annu Rev Cell Dev Biol (2011) 1.26
Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation. PLoS Genet (2012) 1.16
Membrane-anchored serine proteases in health and disease. Prog Mol Biol Transl Sci (2011) 1.13
Claudins in intestines: Distribution and functional significance in health and diseases. Tissue Barriers (2013) 1.07
Epithelial cell adhesion molecule (EpCAM) regulates claudin dynamics and tight junctions. J Biol Chem (2013) 1.06
Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway. J Biol Chem (2013) 1.05
The effects of Th17 cytokines on the inflammatory mediator production and barrier function of ARPE-19 cells. PLoS One (2011) 1.03
Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses. J Virol (2012) 1.03
Transport via the transcytotic pathway makes prostasin available as a substrate for matriptase. J Biol Chem (2010) 1.00
The level of claudin-7 is reduced as an early event in colorectal carcinogenesis. BMC Cancer (2011) 0.96
Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis. Oncogene (2011) 0.95
Matriptase protects against experimental colitis and promotes intestinal barrier recovery. Inflamm Bowel Dis (2011) 0.94
Membrane-bound serine protease inhibitor HAI-1 is required for maintenance of intestinal epithelial integrity. Am J Pathol (2011) 0.93
Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice. Part Fibre Toxicol (2011) 0.92
Cleavage of endogenous γENaC and elevated abundance of αENaC are associated with increased Na⁺ transport in response to apical fluid volume expansion in human H441 airway epithelial cells. Pflugers Arch (2011) 0.91
Claudin-14 underlies Ca⁺⁺-sensing receptor-mediated Ca⁺⁺ metabolism via NFAT-microRNA-based mechanisms. J Am Soc Nephrol (2013) 0.90
Intraluminal acid activates esophageal nodose C fibers after mast cell activation. Am J Physiol Gastrointest Liver Physiol (2013) 0.88
Rab25 regulates integrin expression in polarized colonic epithelial cells. Mol Biol Cell (2013) 0.87
Imaging a functional tumorigenic biomarker in the transformed epithelium. Proc Natl Acad Sci U S A (2012) 0.86
The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin. J Biol Chem (2014) 0.86
The Cap1-claudin-4 regulatory pathway is important for renal chloride reabsorption and blood pressure regulation. Proc Natl Acad Sci U S A (2014) 0.85
Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling. Blood (2016) 0.83
Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea. PLoS One (2014) 0.83
TMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisition. Biochem J (2014) 0.81
Generation of mouse small intestinal epithelial cell lines that allow the analysis of specific innate immune functions. PLoS One (2013) 0.80
Changes in the distribution of type II transmembrane serine protease, TMPRSS2 and in paracellular permeability in IPEC-J2 cells exposed to oxidative stress. Inflammation (2015) 0.80
Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden. Oncotarget (2015) 0.79
Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival. PLoS Genet (2014) 0.79
Systems Proteomics View of the Endogenous Human Claudin Protein Family. J Proteome Res (2016) 0.79
Matriptase deletion initiates a Sjögren's syndrome-like disease in mice. PLoS One (2014) 0.78
Inhibition of Matriptase Activity Results in Decreased Intestinal Epithelial Monolayer Integrity In Vitro. PLoS One (2015) 0.78
Detection of active matriptase using a biotinylated chloromethyl ketone peptide. PLoS One (2013) 0.78
Proteinase-activated receptor 2 (PAR2) decreases apoptosis in colonic epithelial cells. J Biol Chem (2014) 0.78
Expression of claudins -2 and -4 and cingulin is coordinated with the start of stratification and differentiation in corneal epithelial cells: retinoic acid reversibly disrupts epithelial barrier. Biol Open (2012) 0.78
SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150. Oncogene (2015) 0.76
Type II transmembrane serine proteases as potential targets for cancer therapy. Biol Chem (2016) 0.76
Viral interactions with the blood-brain barrier: old dog, new tricks. Tissue Barriers (2016) 0.76
Dose-dependent targeted suppression of P-glycoprotein expression and function in Caco-2 cells. Mol Pharm (2013) 0.76
Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis. J Clin Invest (2017) 0.76
Membrane-anchored proteases in endothelial cell biology. Curr Opin Hematol (2016) 0.75
The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss. Sci Rep (2017) 0.75
CANDIDATE GENES FOR LIMITING CHOLESTATIC INTESTINAL INJURY IDENTIFIED BY GENE EXPRESSION PROFILING. Physiol Rep (2013) 0.75
The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction. Am J Physiol Gastrointest Liver Physiol (2016) 0.75
Functional diversity of secreted cestode Kunitz proteins: Inhibition of serine peptidases and blockade of cation channels. PLoS Pathog (2017) 0.75
Coagulation signaling to epithelia. Blood (2016) 0.75
Regulation of intestinal permeability: The role of proteases. World J Gastroenterol (2017) 0.75
Reinforced Epithelial Barrier Integrity via Matriptase Induction with Sphingosine-1-Phosphate Did Not Result in Disturbances in Physiological Redox Status. Oxid Med Cell Longev (2015) 0.75
The role of enterocyte defects in the pathogenesis of congenital diarrheal disorders. Dis Model Mech (2016) 0.75
Proteolytic cleavages in the extracellular domain of receptor tyrosine kinases by membrane-associated serine proteases. Oncotarget (2017) 0.75
Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function. PLoS One (2017) 0.75
Claudins and epithelial paracellular transport. Annu Rev Physiol (2006) 4.79
The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics. Cell Biol Toxicol (2005) 2.79
Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis. Oncogene (2002) 2.74
Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut. Gastroenterology (2001) 2.62
Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes. J Biol Chem (2001) 2.56
Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J Cell Biol (2001) 2.51
Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer. Cancer Metastasis Rev (2003) 2.39
Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions. J Biochem (2003) 2.32
Cytokine regulation of tight junctions. Biochim Biophys Acta (2008) 2.16
Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure. Gastroenterology (2002) 2.02
Study of claudin function by RNA interference. J Biol Chem (2006) 1.78
Characterization of matriptase expression in normal human tissues. J Histochem Cytochem (2003) 1.74
Role of the intestinal barrier in inflammatory bowel disease. World J Gastroenterol (2008) 1.72
Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes. Gastroenterology (1998) 1.69
A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. J Biol Chem (2004) 1.64
Altered permeability in inflammatory bowel disease: pathophysiology and clinical implications. Curr Opin Gastroenterol (2007) 1.59
Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. J Biol Chem (2007) 1.44
Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. J Cell Physiol (2005) 1.36
Ichthyosis, follicular atrophoderma, and hypotrichosis caused by mutations in ST14 is associated with impaired profilaggrin processing. J Invest Dermatol (2008) 1.26
Zymogen activation, inhibition, and ectodomain shedding of matriptase. Front Biosci (2008) 1.24
CVS-3983, a selective matriptase inhibitor, suppresses the growth of androgen independent prostate tumor xenografts. Prostate (2004) 1.18
The E3 ubiquitin ligase LNX1p80 promotes the removal of claudins from tight junctions in MDCK cells. J Cell Sci (2009) 1.17
Matriptase-dependent cell surface proteolysis in epithelial development and pathogenesis. Front Biosci (2007) 1.10
In vitro inhibition of matriptase prevents invasive growth of cell lines of prostate and colon carcinoma. Int J Oncol (2005) 1.06
Claudin-8 expression in renal epithelial cells augments the paracellular barrier by replacing endogenous claudin-2. J Membr Biol (2007) 1.05
Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line. Exp Cell Res (2008) 1.02
Serine proteases decrease intestinal epithelial ion permeability by activation of protein kinase Czeta. Am J Physiol Gastrointest Liver Physiol (2009) 0.89
Protease inhibitors suppress the formation of tight junctions in gastrointestinal cell lines. Exp Cell Res (1992) 0.85
The Oslo definitions for coeliac disease and related terms. Gut (2012) 5.76
Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr (2005) 5.34
Introduction of gluten, HLA status, and the risk of celiac disease in children. N Engl J Med (2014) 4.64
A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. Am J Clin Nutr (2007) 3.91
Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. Immunol Rev (2004) 3.63
Detection of Celiac disease in primary care: a multicenter case-finding study in North America. Am J Gastroenterol (2007) 3.60
Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell (2003) 3.42
Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J Clin Invest (2003) 3.41
Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med (2012) 3.35
Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J Biol Chem (2007) 3.07
Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis. Oncogene (2002) 2.74
Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer. Cancer Metastasis Rev (2003) 2.39
Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives. Diabetes (2006) 2.29
Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves. J Immunol (2003) 2.27
Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Med (2011) 2.19
Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell (2010) 2.19
Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages. Gastroenterology (2008) 2.09
Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1. J Cell Biol (2003) 2.08
Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation. J Biol Chem (2006) 2.07
Proteolytic activation of the 1918 influenza virus hemagglutinin. J Virol (2009) 2.05
Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure. Gastroenterology (2002) 2.02
Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology (2008) 1.98
Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat Clin Pract Gastroenterol Hepatol (2005) 1.96
Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation. Genes Dev (2005) 1.92
Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann Med (2010) 1.91
Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Blood (2010) 1.82
Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scand J Gastroenterol (2006) 1.81
Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int Arch Allergy Immunol (2009) 1.78
Type II transmembrane serine proteases. J Biol Chem (2009) 1.77
Proof of concept of microbiome-metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at-risk infants. PLoS One (2012) 1.74
Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders. Nutrients (2013) 1.74
Characterization of matriptase expression in normal human tissues. J Histochem Cytochem (2003) 1.74
Role for the actomyosin complex in regulated exocytosis revealed by intravital microscopy. Proc Natl Acad Sci U S A (2011) 1.74
The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor. J Biol Chem (2003) 1.71
Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor-induced hepatotoxicity is mediated by Kupffer cells. Mol Cancer Ther (2004) 1.68
Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Natl Acad Sci U S A (2009) 1.67
Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function. J Immunol (2002) 1.66
Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. Proc Natl Acad Sci U S A (2005) 1.65
Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway. Am J Pathol (2009) 1.62
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion. J Cell Biol (2003) 1.60
Mice deficient in complement receptors 1 and 2 lack a tissue injury-inducing subset of the natural antibody repertoire. J Immunol (2002) 1.58
HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease. Am J Physiol Cell Physiol (2005) 1.56
Celiac disease--how to handle a clinical chameleon. N Engl J Med (2003) 1.56
Might gluten traces in wheat substitutes pose a risk in patients with celiac disease? A population-based probabilistic approach to risk estimation. Am J Clin Nutr (2012) 1.56
MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells. J Exp Med (2005) 1.55
Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac disease. J Immunol (2006) 1.51
Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase. J Cell Physiol (2007) 1.51
MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D. J Biol Chem (2007) 1.51
Celiac disease. Curr Opin Gastroenterol (2008) 1.49
Matriptase: potent proteolysis on the cell surface. Mol Med (2006) 1.47
Enteric nematodes induce stereotypic STAT6-dependent alterations in intestinal epithelial cell function. J Immunol (2004) 1.46
Type II transmembrane serine proteases in development and disease. Int J Biochem Cell Biol (2007) 1.45
The acute gastrointestinal subsyndrome of the acute radiation syndrome: a rhesus macaque model. Health Phys (2012) 1.44
Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters. Clin Cancer Res (2002) 1.44
Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent. J Clin Invest (2002) 1.44
Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. J Biol Chem (2007) 1.44
Tight junction modulation and its relationship to drug delivery. Adv Drug Deliv Rev (2006) 1.42
Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy. J Cell Biol (2005) 1.42
A novel biomarker for staging human prostate adenocarcinoma: overexpression of matriptase with concomitant loss of its inhibitor, hepatocyte growth factor activator inhibitor-1. Cancer Epidemiol Biomarkers Prev (2006) 1.41
Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature. J Biol Chem (2007) 1.41
Critical role of IL-25 in nematode infection-induced alterations in intestinal function. J Immunol (2010) 1.40
Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms. Ann N Y Acad Sci (2009) 1.39
Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population. Schizophr Bull (2009) 1.39
Potent antitumor activity of a urokinase-activated engineered anthrax toxin. Proc Natl Acad Sci U S A (2003) 1.38
The prolonged gastrointestinal syndrome in rhesus macaques: the relationship between gastrointestinal, hematopoietic, and delayed multi-organ sequelae following acute, potentially lethal, partial-body irradiation. Health Phys (2012) 1.38
Localized multigene expression patterns support an evolving Th1/Th2-like paradigm in response to infections with Toxoplasma gondii and Ascaris suum. Infect Immun (2005) 1.38
Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity. J Biol Chem (2008) 1.38
Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice. Development (2009) 1.38
The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. J Clin Invest (2010) 1.36
A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancer. Cancer Res (2010) 1.32
Anthrax toxin: structures, functions and tumour targeting. Expert Opin Biol Ther (2003) 1.32
Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis. Am J Pathol (2006) 1.32
Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity. J Biol Chem (2008) 1.31