PubRank

Yue Xiong

Author PubWeight™ 172.37‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell 2011 11.44
2 Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science 2009 10.78
3 Regulation of cellular metabolism by protein lysine acetylation. Science 2010 10.55
4 Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science 2010 6.04
5 Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet 2011 5.62
6 Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Nat Cell Biol 2003 5.18
7 TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol 2008 5.02
8 Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol 2003 4.61
9 BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol 2005 4.53
10 Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell 2011 3.78
11 Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nat Cell Biol 2004 3.72
12 Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol Cell 2006 3.39
13 pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes Dev 2007 3.31
14 TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem 2009 3.20
15 Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases. Cell 2004 3.07
16 NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. Mol Cell 2002 3.03
17 Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol Cell 2011 2.84
18 DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. Genes Dev 2006 2.75
19 Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev 2012 2.70
20 Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc Natl Acad Sci U S A 2005 2.59
21 CRL4s: the CUL4-RING E3 ubiquitin ligases. Trends Biochem Sci 2009 2.59
22 Regulation of intermediary metabolism by protein acetylation. Trends Biochem Sci 2010 2.36
23 The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem 2010 2.27
24 Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep 2011 2.20
25 CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis. Cancer Cell 2009 2.17
26 A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J Biol Chem 2003 2.12
27 An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage. J Biol Chem 2006 1.90
28 Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. Plant Cell 2008 1.77
29 Nutrient sensing, metabolism, and cell growth control. Mol Cell 2013 1.67
30 Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization. Mol Cell 2013 1.65
31 Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues. Oncogene 2005 1.61
32 WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Genes Dev 2008 1.61
33 Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation. Plant Cell 2004 1.60
34 Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis. Mol Cell Biol 2003 1.58
35 Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. Mol Cell Biol 2008 1.36
36 IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives. Clin Cancer Res 2012 1.36
37 DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation. Cancer Res 2009 1.34
38 Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues. Cancer Res 2007 1.32
39 Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins. J Biol Chem 2002 1.29
40 Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell 2013 1.29
41 X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression. Mol Cell 2011 1.29
42 Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes. Plant Cell 2008 1.23
43 Alterations of metabolic genes and metabolites in cancer. Semin Cell Dev Biol 2012 1.18
44 A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression. J Biol Chem 2003 1.18
45 CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells. Immunity 2002 1.18
46 The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. J Biol Chem 2012 1.17
47 Negative regulation of TSC1-TSC2 by mammalian D-type cyclins. Cancer Res 2005 1.16
48 PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ. J Biol Chem 2010 1.15
49 14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin. J Biol Chem 2002 1.14
50 Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. J Biol Chem 2009 1.13
51 Generation of acetyllysine antibodies and affinity enrichment of acetylated peptides. Nat Protoc 2010 1.13
52 p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control. Mol Cell Biol 2006 1.11
53 p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers. Cancer Res 2007 1.10
54 Genetic evidence for functional dependency of p18Ink4c on Cdk4. Mol Cell Biol 2004 1.06
55 Signaling pathways that control cell proliferation. Cold Spring Harb Perspect Biol 2013 1.05
56 p53 binds to and is required for the repression of Arf tumor suppressor by HDAC and polycomb. Cancer Res 2011 1.04
57 Human tumor suppressor ARF impedes S-phase progression independent of p53. Cancer Res 2002 1.03
58 Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1. Cell Metab 2012 1.02
59 Ectromelia virus encodes a novel family of F-box proteins that interact with the SCF complex. J Virol 2008 1.01
60 Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis. Cancer Res 2011 1.00
61 p18Ink4c, but not p27Kip1, collaborates with Men1 to suppress neuroendocrine organ tumors. Mol Cell Biol 2006 0.99
62 NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest 2014 0.97
63 Assays for RING family ubiquitin ligases. Methods Mol Biol 2005 0.96
64 Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail. Mol Cell Biol 2011 0.94
65 Ectromelia virus BTB/kelch proteins, EVM150 and EVM167, interact with cullin-3-based ubiquitin ligases. Virology 2008 0.92
66 Estrogen regulates Hippo signaling via GPER in breast cancer. J Clin Invest 2015 0.91
67 CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth. Proc Natl Acad Sci U S A 2013 0.88
68 R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis. Cancer Cell 2013 0.85
69 VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity. EMBO J 2011 0.84
70 Glyceraldehyde-3-phosphate dehydrogenase is activated by lysine 254 acetylation in response to glucose signal. J Biol Chem 2013 0.84
71 Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage. Biochem J 2012 0.83
72 Recruiting substrates to cullin 4-dependent ubiquitin ligases by DDB1. Cell Cycle 2005 0.83
73 Variants in CUL4B are associated with cerebral malformations. Hum Mutat 2015 0.82
74 The mechanisms of IDH mutations in tumorigenesis. Cell Res 2012 0.82
75 p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Hepatology 2003 0.81
76 Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase. Mol Biol Cell 2010 0.81
77 Targeting protein ubiquitylation: DDB1 takes its RING off. Nat Cell Biol 2009 0.80
78 Twice primed: cyclin E is phosphorylated and isomerized before being ubiquitinated. Mol Cell 2006 0.80
79 Metabolic alteration in tumorigenesis. Sci China Life Sci 2013 0.79
80 Targeted ubiquitylation: the prey becomes predator. Mol Cell 2010 0.78
81 LDH-A acetylation: implication in cancer. Oncotarget 2013 0.78
82 Correction: Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. PLoS Biol 2015 0.77
83 Acetylation control of cancer cell metabolism. Curr Pharm Des 2014 0.77
84 Corrigendum: inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev 2015 0.75
85 Investigation of Protein-Protein Interactions and Conformational Changes in Hedgehog Signaling Pathway by FRET. Methods Mol Biol 2015 0.75
86 Chromatin regulation by CRL4 E3 ubiquitin ligases: CUL4B targets WDR5 ubiquitylation in the nucleus. Cell Cycle 2011 0.75
87 Imaging and detection of morphological changes of single cells before and after secretion using scanning electrochemical microscopy. Analyst 2007 0.75