Published in J Biol Chem on May 11, 2006
ENaC at the cutting edge: regulation of epithelial sodium channels by proteases. J Biol Chem (2009) 2.57
Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella. J Cell Biol (2007) 1.94
Plasmin activates epithelial Na+ channels by cleaving the gamma subunit. J Biol Chem (2008) 1.86
Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation. J Biol Chem (2008) 1.79
A segment of gamma ENaC mediates elastase activation of Na+ transport. J Gen Physiol (2007) 1.57
Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the γ-subunit by a second protease. Am J Physiol Renal Physiol (2014) 1.52
ENaC structure and function in the wake of a resolved structure of a family member. Am J Physiol Renal Physiol (2011) 1.44
Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC). Pflugers Arch (2009) 1.44
Cleavage in the {gamma}-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels. J Physiol (2008) 1.38
Constraint-based, homology model of the extracellular domain of the epithelial Na+ channel α subunit reveals a mechanism of channel activation by proteases. J Biol Chem (2010) 1.23
Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 1.21
Novel determinants of epithelial sodium channel gating within extracellular thumb domains. J Biol Chem (2009) 1.20
Role of epithelial sodium channels and their regulators in hypertension. J Biol Chem (2010) 1.20
Acute regulation of the epithelial sodium channel in airway epithelia by proteases and trafficking. Am J Respir Cell Mol Biol (2010) 1.18
Regulation of the epithelial Na+ channel by peptidases. Curr Top Dev Biol (2007) 1.17
Regulation of transport in the connecting tubule and cortical collecting duct. Compr Physiol (2012) 1.16
Epithelial Na(+) channel regulation by cytoplasmic and extracellular factors. Exp Cell Res (2012) 1.08
Allosteric inhibition of the epithelial Na+ channel through peptide binding at peripheral finger and thumb domains. J Biol Chem (2010) 1.08
Defining an inhibitory domain in the gamma subunit of the epithelial sodium channel. Am J Physiol Renal Physiol (2010) 1.06
Deubiquitylation regulates activation and proteolytic cleavage of ENaC. J Am Soc Nephrol (2008) 1.03
Cys palmitoylation of the beta subunit modulates gating of the epithelial sodium channel. J Biol Chem (2010) 1.02
The epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes. J Cell Sci (2013) 1.01
TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site. Am J Physiol Renal Physiol (2011) 1.00
Regulation of sodium transport by ENaC in the kidney. Curr Opin Nephrol Hypertens (2010) 1.00
Interleukin-6 stimulates epithelial sodium channels in mouse cortical collecting duct cells. Am J Physiol Regul Integr Comp Physiol (2010) 1.00
New role for plasmin in sodium homeostasis. Curr Opin Nephrol Hypertens (2010) 0.99
Regulation and dysregulation of epithelial Na+ channels. Clin Exp Nephrol (2011) 0.98
Blood pressure and amiloride-sensitive sodium channels in vascular and renal cells. Nat Rev Nephrol (2014) 0.94
Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures. Am J Physiol Lung Cell Mol Physiol (2013) 0.93
The delta-subunit of the epithelial sodium channel (ENaC) enhances channel activity and alters proteolytic ENaC activation. J Biol Chem (2009) 0.92
Alternative mechanism of activation of the epithelial na+ channel by cleavage. J Biol Chem (2009) 0.92
AICAR activates AMPK and alters PIP2 association with the epithelial sodium channel ENaC to inhibit Na+ transport in H441 lung epithelial cells. J Physiol (2008) 0.91
ENaCs and ASICs as therapeutic targets. Am J Physiol Cell Physiol (2012) 0.91
ENaC regulation by proteases and shear stress. Curr Mol Pharmacol (2013) 0.91
Second transmembrane domain modulates epithelial sodium channel gating in response to shear stress. Am J Physiol Renal Physiol (2011) 0.90
Feedback inhibition of ENaC during acute sodium loading in vivo. Am J Physiol Renal Physiol (2012) 0.89
Single-channel analysis of functional epithelial sodium channel (ENaC) stability at the apical membrane of A6 distal kidney cells. Am J Physiol Renal Physiol (2008) 0.89
Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases. Gene (2016) 0.89
Extracellular finger domain modulates the response of the epithelial sodium channel to shear stress. J Biol Chem (2012) 0.88
External Cu2+ inhibits human epithelial Na+ channels by binding at a subunit interface of extracellular domains. J Biol Chem (2011) 0.88
Urinary prostasin: a possible biomarker for renal pressure natriuresis in black adolescents. Pediatr Res (2009) 0.88
Inhibitory tract traps the epithelial Na+ channel in a low activity conformation. J Biol Chem (2012) 0.86
Retracted Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways. FASEB J (2012) 0.85
Na+ inhibits the epithelial Na+ channel by binding to a site in an extracellular acidic cleft. J Biol Chem (2014) 0.83
A long isoform of the epithelial sodium channel alpha subunit forms a highly active channel. Channels (Austin) (2015) 0.83
Regulation of renal sodium handling through the interaction between serine proteases and serine protease inhibitors. Clin Exp Nephrol (2010) 0.82
Interacting domains in the epithelial sodium channel that mediate proteolytic activation. Channels (Austin) (2015) 0.82
Sodium retention and volume expansion in nephrotic syndrome: implications for hypertension. Adv Chronic Kidney Dis (2015) 0.80
Cysteine palmitoylation of the γ subunit has a dominant role in modulating activity of the epithelial sodium channel. J Biol Chem (2014) 0.79
Structural mechanisms underlying the function of epithelial sodium channel/acid-sensing ion channel. Curr Opin Nephrol Hypertens (2011) 0.78
The role of pendrin in blood pressure regulation. Am J Physiol Renal Physiol (2015) 0.78
Gamma subunit second transmembrane domain contributes to epithelial sodium channel gating and amiloride block. Am J Physiol Renal Physiol (2013) 0.78
Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension. Clin Exp Nephrol (2011) 0.77
Functional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na+ Channel Knuckle Domain. J Biol Chem (2015) 0.77
Pendrin gene ablation alters ENaC subcellular distribution and open probability. Am J Physiol Renal Physiol (2015) 0.76
Pseudohypoaldosteronism type 1 and Liddle's syndrome mutations that affect the single-channel properties of the epithelial Na+ channel. Physiol Rep (2015) 0.75
Expression and purification of the alpha subunit of the epithelial sodium channel, ENaC. Protein Expr Purif (2015) 0.75
Clues to renal sodium retention. Am J Physiol Renal Physiol (2011) 0.75
Role of Epithelium Sodium Channel in Bone Formation. Chin Med J (Engl) (2016) 0.75
Regulation of the Epithelial Na(+) Channel by Paraoxonase-2. J Biol Chem (2017) 0.75
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med (2008) 9.05
Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation. N Engl J Med (2010) 6.23
Epithelial sodium channels are activated by furin-dependent proteolysis. J Biol Chem (2004) 3.36
Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit. J Biol Chem (2007) 3.09
Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation. Thorax (2011) 2.84
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol (2009) 2.70
Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PLoS One (2008) 2.67
ENaC at the cutting edge: regulation of epithelial sodium channels by proteases. J Biol Chem (2009) 2.57
Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A (2004) 2.42
Maturation of the epithelial Na+ channel involves proteolytic processing of the alpha- and gamma-subunits. J Biol Chem (2003) 2.37
Autoantibodies in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2007) 1.94
Distinct pools of epithelial sodium channels are expressed at the plasma membrane. J Biol Chem (2004) 1.87
Plasmin activates epithelial Na+ channels by cleaving the gamma subunit. J Biol Chem (2008) 1.86
Palliative care and location of death in decedents with idiopathic pulmonary fibrosis. Chest (2015) 1.85
Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition. Am J Physiol Renal Physiol (2006) 1.82
Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation. J Biol Chem (2008) 1.79
Airway surface liquid volume regulates ENaC by altering the serine protease-protease inhibitor balance: a mechanism for sodium hyperabsorption in cystic fibrosis. J Biol Chem (2006) 1.77
Patients with idiopathic pulmonary fibrosis with antibodies to heat shock protein 70 have poor prognoses. Am J Respir Crit Care Med (2013) 1.77
Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells. J Biol Chem (2005) 1.70
Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1. Cardiovasc Res (2012) 1.69
ENaC structure and function in the wake of a resolved structure of a family member. Am J Physiol Renal Physiol (2011) 1.44
SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia. J Gen Physiol (2009) 1.44
Cellular and humoral autoreactivity in idiopathic pulmonary fibrosis. J Immunol (2007) 1.39
Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels. Proc Natl Acad Sci U S A (2006) 1.39
High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen. Diagn Microbiol Infect Dis (2011) 1.38
Regulation of cation transport in the distal nephron by mechanical forces. Am J Physiol Renal Physiol (2006) 1.37
Role of proteolysis in the activation of epithelial sodium channels. Curr Opin Nephrol Hypertens (2007) 1.36
Epithelial Na+ channels are activated by laminar shear stress. J Biol Chem (2003) 1.34
Ca2+ dependence of flow-stimulated K secretion in the mammalian cortical collecting duct. Am J Physiol Renal Physiol (2007) 1.34
Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension. Arthritis Rheum (2011) 1.33
Extracellular histidine residues crucial for Na+ self-inhibition of epithelial Na+ channels. J Biol Chem (2003) 1.33
Dietary K+ regulates apical membrane expression of maxi-K channels in rabbit cortical collecting duct. Am J Physiol Renal Physiol (2005) 1.29
Secreted and transmembrane mucins inhibit gene transfer with AAV4 more efficiently than AAV5. J Biol Chem (2002) 1.27
AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells. Am J Respir Cell Mol Biol (2009) 1.27
Clathrin-mediated endocytosis of the epithelial sodium channel. Role of epsin. J Biol Chem (2006) 1.27
Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis. J Clin Invest (2010) 1.27
Role of N- and O-glycans in polarized biosynthetic sorting. Am J Physiol Cell Physiol (2006) 1.26
Constraint-based, homology model of the extracellular domain of the epithelial Na+ channel α subunit reveals a mechanism of channel activation by proteases. J Biol Chem (2010) 1.23
Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 1.21
Role of epithelial sodium channels and their regulators in hypertension. J Biol Chem (2010) 1.20
Novel determinants of epithelial sodium channel gating within extracellular thumb domains. J Biol Chem (2009) 1.20
Mechanism underlying flow stimulation of sodium absorption in the mammalian collecting duct. Am J Physiol Renal Physiol (2006) 1.20
Ontogeny of flow-stimulated potassium secretion in rabbit cortical collecting duct: functional and molecular aspects. Am J Physiol Renal Physiol (2003) 1.18
Acute regulation of the epithelial sodium channel in airway epithelia by proteases and trafficking. Am J Respir Cell Mol Biol (2010) 1.18
Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia. FASEB J (2008) 1.17
The endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones. Mol Biol Cell (2010) 1.17
Insulin-like growth factor-binding protein-5 induces pulmonary fibrosis and triggers mononuclear cellular infiltration. Am J Pathol (2006) 1.17
Arachidonic acid regulates surface expression of epithelial sodium channels. J Biol Chem (2003) 1.15
Effect of aldosterone on BK channel expression in mammalian cortical collecting duct. Am J Physiol Renal Physiol (2008) 1.15
Defining an inhibitory domain in the alpha-subunit of the epithelial sodium channel. Am J Physiol Renal Physiol (2007) 1.15
c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cells. J Biol Chem (2010) 1.15
Posaconazole serum concentrations among cardiothoracic transplant recipients: factors impacting trough levels and correlation with clinical response to therapy. Antimicrob Agents Chemother (2010) 1.15
External nickel inhibits epithelial sodium channel by binding to histidine residues within the extracellular domains of alpha and gamma subunits and reducing channel open probability. J Biol Chem (2002) 1.13
Molecular and functional properties of lung SP cells. Am J Physiol Lung Cell Mol Physiol (2006) 1.12
Recycling of MUC1 is dependent on its palmitoylation. J Biol Chem (2006) 1.12
Prospective, observational study of voriconazole therapeutic drug monitoring among lung transplant recipients receiving prophylaxis: factors impacting levels of and associations between serum troughs, efficacy, and toxicity. Antimicrob Agents Chemother (2012) 1.11
Extracellular Zn2+ activates epithelial Na+ channels by eliminating Na+ self-inhibition. J Biol Chem (2004) 1.10
Functional role of extracellular loop cysteine residues of the epithelial Na+ channel in Na+ self-inhibition. J Biol Chem (2007) 1.10
Mutations in the pore region modify epithelial sodium channel gating by shear stress. J Biol Chem (2004) 1.09
Epithelial Na(+) channel regulation by cytoplasmic and extracellular factors. Exp Cell Res (2012) 1.08
Allosteric inhibition of the epithelial Na+ channel through peptide binding at peripheral finger and thumb domains. J Biol Chem (2010) 1.08
Base of the thumb domain modulates epithelial sodium channel gating. J Biol Chem (2011) 1.07
Defining an inhibitory domain in the gamma subunit of the epithelial sodium channel. Am J Physiol Renal Physiol (2010) 1.06
Lung lining fluid glutathione attenuates IL-13-induced asthma. Am J Respir Cell Mol Biol (2007) 1.06
MUC1 membrane trafficking is modulated by multiple interactions. J Biol Chem (2004) 1.06
CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema. Am J Pathol (2008) 1.06
Role of NKCC in BK channel-mediated net K⁺ secretion in the CCD. Am J Physiol Renal Physiol (2011) 1.05
Plasma B lymphocyte stimulator and B cell differentiation in idiopathic pulmonary fibrosis patients. J Immunol (2013) 1.05
Extracellular allosteric regulatory subdomain within the gamma subunit of the epithelial Na+ channel. J Biol Chem (2010) 1.04