Non-vertebrate hosts in the analysis of host-pathogen interactions.

PubWeight™: 0.88‹?›

🔗 View Article (PMID 16697687)

Published in Microbes Infect on January 27, 2006

Authors

Marion S Dorer1, Ralph R Isberg

Author Affiliations

1: Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA.

Articles by these authors

Multiple substrates of the Legionella pneumophila Dot/Icm system identified by interbacterial protein transfer. Proc Natl Acad Sci U S A (2004) 4.27

Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host Microbe (2009) 3.86

The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity. Mol Microbiol (2003) 3.20

Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila. Dev Cell (2006) 3.06

A bifunctional bacterial protein links GDI displacement to Rab1 activation. Science (2007) 2.60

RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics. PLoS Pathog (2006) 2.44

Legionella pneumophila replication vacuole formation involves rapid recruitment of proteins of the early secretory system. Infect Immun (2004) 2.25

A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death. Proc Natl Acad Sci U S A (2006) 2.21

An open letter to Elias Zerhouni. Science (2005) 2.19

Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine. J Exp Med (2006) 2.11

NF-kappaB translocation prevents host cell death after low-dose challenge by Legionella pneumophila. J Exp Med (2006) 2.06

Legionella pneumophila Dot/Icm translocated substrates: a sum of parts. Curr Opin Microbiol (2009) 2.01

Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogen. Science (2012) 1.87

The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science (2012) 1.82

IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole. Infect Immun (2004) 1.76

The E Block motif is associated with Legionella pneumophila translocated substrates. Cell Microbiol (2010) 1.51

Minimization of the Legionella pneumophila genome reveals chromosomal regions involved in host range expansion. Proc Natl Acad Sci U S A (2011) 1.50

LidA, a translocated substrate of the Legionella pneumophila type IV secretion system, interferes with the early secretory pathway. Infect Immun (2005) 1.49

Large-scale identification of Legionella pneumophila Dot/Icm substrates that modulate host cell vesicle trafficking pathways. Cell Microbiol (2008) 1.47

The protein SdhA maintains the integrity of the Legionella-containing vacuole. Proc Natl Acad Sci U S A (2012) 1.47

Macrophages from mice with the restrictive Lgn1 allele exhibit multifactorial resistance to Legionella pneumophila. Infect Immun (2004) 1.45

Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction. Infect Immun (2008) 1.40

Innate immune recognition of Yersinia pseudotuberculosis type III secretion. PLoS Pathog (2009) 1.38

Members of a Legionella pneumophila family of proteins with ExoU (phospholipase A) active sites are translocated to target cells. Infect Immun (2006) 1.36

E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates. Infect Immun (2010) 1.34

CD8(+) T cells restrict Yersinia pseudotuberculosis infection: bypass of anti-phagocytosis by targeting antigen-presenting cells. PLoS Pathog (2009) 1.24

LnaB: a Legionella pneumophila activator of NF-kappaB. Cell Microbiol (2010) 1.23

Towards a molecular understanding of human diseases using Dictyostelium discoideum. Trends Mol Med (2006) 1.22

Yersinia pseudotuberculosis spatially controls activation and misregulation of host cell Rac1. PLoS Pathog (2005) 1.20

Macrophage-induced genes of Legionella pneumophila: protection from reactive intermediates and solute imbalance during intracellular growth. Infect Immun (2002) 1.19

Dictyostelium discoideum strains lacking the RtoA protein are defective for maturation of the Legionella pneumophila replication vacuole. Cell Microbiol (2005) 1.15

The DotL protein, a member of the TraG-coupling protein family, is essential for Viability of Legionella pneumophila strain Lp02. J Bacteriol (2005) 1.11

Experimental evolution of Legionella pneumophila in mouse macrophages leads to strains with altered determinants of environmental survival. PLoS Pathog (2012) 1.10

Growth of Yersinia pseudotuberculosis in mice occurs independently of Toll-like receptor 2 expression and induction of interleukin-10. Infect Immun (2007) 1.10

Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake. J Exp Med (2003) 1.08

IcmR-regulated membrane insertion and efflux by the Legionella pneumophila IcmQ protein. J Biol Chem (2003) 1.05

Intracellular replication of Mycobacterium marinum within Dictyostelium discoideum: efficient replication in the absence of host coronin. Infect Immun (2003) 1.05

Identification of MrtAB, an ABC transporter specifically required for Yersinia pseudotuberculosis to colonize the mesenteric lymph nodes. PLoS Pathog (2012) 1.02

Legionella pneumophila EnhC is required for efficient replication in tumour necrosis factor alpha-stimulated macrophages. Cell Microbiol (2008) 1.01

Phosphatidylcholine synthesis is required for optimal function of Legionella pneumophila virulence determinants. Cell Microbiol (2007) 1.00

The polybasic region of Rac1 modulates bacterial uptake independently of self-association and membrane targeting. J Biol Chem (2008) 0.97

Bacterial pathogen manipulation of host membrane trafficking. Annu Rev Cell Dev Biol (2014) 0.97

Yersinia entry into host cells requires Rab5-dependent dephosphorylation of PI(4,5)P₂ and membrane scission. Cell Host Microbe (2012) 0.95

Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1). J Biol Chem (2010) 0.92

Disruption of RhoGDI and RhoA regulation by a Rac1 specificity switch mutant. J Biol Chem (2006) 0.91

The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA. Cell Host Microbe (2009) 0.89

Yersinia pseudotuberculosis virulence determinants invasin, YopE, and YopT modulate RhoG activity and localization. Infect Immun (2009) 0.87

Cdc42 interacts with the exocyst complex to promote phagocytosis. J Cell Biol (2013) 0.87

Control of host cell phosphorylation by legionella pneumophila. Front Microbiol (2011) 0.87

Emerging views on integrin signaling via Rac1 during invasin-promoted bacterial uptake. Curr Opin Microbiol (2005) 0.85

A hemidominant Naip5 allele in mouse strain MOLF/Ei-derived macrophages restricts Legionella pneumophila intracellular growth. Infect Immun (2008) 0.85

Analyzing microbial disease at high resolution: following the fate of the bacterium during infection. Curr Opin Microbiol (2011) 0.84

The Legionella pneumophila EnhC protein interferes with immunostimulatory muramyl peptide production to evade innate immunity. Cell Host Microbe (2012) 0.83

Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophila. Structure (2009) 0.81

Analysis of Legionella infection using RNAi in Drosophila cells. Methods Mol Biol (2013) 0.77

Host signal transduction and protein kinases implicated in Legionella infection. Curr Top Microbiol Immunol (2013) 0.77

IcmQ in the Type 4b secretion system contains an NAD+ binding domain. Structure (2013) 0.77

Poison domains block transit of translocated substrates via the Legionella pneumophila Icm/Dot system. Infect Immun (2013) 0.76

QnAs with Ralph R. Isberg. Proc Natl Acad Sci U S A (2013) 0.75