Published in Infect Immun on May 01, 2004
The Legionella pneumophila replication vacuole: making a cosy niche inside host cells. Nat Rev Microbiol (2008) 4.09
Autophagy is an immediate macrophage response to Legionella pneumophila. Cell Microbiol (2005) 2.68
RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics. PLoS Pathog (2006) 2.44
A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death. Proc Natl Acad Sci U S A (2006) 2.21
Molecular pathogenesis of infections caused by Legionella pneumophila. Clin Microbiol Rev (2010) 2.04
De-AMPylation of the small GTPase Rab1 by the pathogen Legionella pneumophila. Science (2011) 1.98
Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole. PLoS Pathog (2006) 1.94
Manipulation of rab GTPase function by intracellular bacterial pathogens. Microbiol Mol Biol Rev (2007) 1.82
IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole. Infect Immun (2004) 1.76
A Dot/Icm-translocated ankyrin protein of Legionella pneumophila is required for intracellular proliferation within human macrophages and protozoa. Mol Microbiol (2008) 1.61
The Legionella pneumophila effector SidJ is required for efficient recruitment of endoplasmic reticulum proteins to the bacterial phagosome. Infect Immun (2006) 1.54
The E Block motif is associated with Legionella pneumophila translocated substrates. Cell Microbiol (2010) 1.51
LidA, a translocated substrate of the Legionella pneumophila type IV secretion system, interferes with the early secretory pathway. Infect Immun (2005) 1.49
The protein SdhA maintains the integrity of the Legionella-containing vacuole. Proc Natl Acad Sci U S A (2012) 1.47
Macrophages from mice with the restrictive Lgn1 allele exhibit multifactorial resistance to Legionella pneumophila. Infect Immun (2004) 1.45
Incomplete activation of macrophage apoptosis during intracellular replication of Legionella pneumophila. Infect Immun (2005) 1.44
Legionella pneumophila regulates the small GTPase Rab1 activity by reversible phosphorylcholination. Proc Natl Acad Sci U S A (2011) 1.42
MTOR-Driven Metabolic Reprogramming Regulates Legionella pneumophila Intracellular Niche Homeostasis. PLoS Pathog (2016) 1.39
Chlamydia pneumoniae inclusion membrane protein Cpn0585 interacts with multiple Rab GTPases. Infect Immun (2007) 1.37
Members of a Legionella pneumophila family of proteins with ExoU (phospholipase A) active sites are translocated to target cells. Infect Immun (2006) 1.36
Autophagy and inflammatory cell death, partners of innate immunity. Autophagy (2005) 1.30
Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA. EMBO J (2009) 1.26
LnaB: a Legionella pneumophila activator of NF-kappaB. Cell Microbiol (2010) 1.23
Membrane vesicles shed by Legionella pneumophila inhibit fusion of phagosomes with lysosomes. Infect Immun (2006) 1.20
Bacterial Type IV secretion systems: versatile virulence machines. Future Microbiol (2012) 1.19
Subversion of membrane transport pathways by vacuolar pathogens. J Cell Biol (2011) 1.16
The glyceraldehyde-3-phosphate dehydrogenase and the small GTPase Rab 2 are crucial for Brucella replication. PLoS Pathog (2009) 1.16
High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA. EMBO Rep (2010) 1.14
Endocytic Rab proteins are required for hepatitis C virus replication complex formation. Virology (2009) 1.14
Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila. Infect Immun (2010) 1.13
Cell biology of infection by Legionella pneumophila. Microbes Infect (2012) 1.10
The early secretory pathway contributes to the growth of the Coxiella-replicative niche. Infect Immun (2010) 1.09
Legionella pneumophila promotes functional interactions between plasma membrane syntaxins and Sec22b. Traffic (2010) 1.08
The Anaplasma phagocytophilum-occupied vacuole selectively recruits Rab-GTPases that are predominantly associated with recycling endosomes. Cell Microbiol (2010) 1.07
The purified and recombinant Legionella pneumophila chaperonin alters mitochondrial trafficking and microfilament organization. Infect Immun (2009) 1.07
Master manipulators: an update on Legionella pneumophila Icm/Dot translocated substrates and their host targets. Future Microbiol (2014) 1.06
Exploitation of host cell biology and evasion of immunity by francisella tularensis. Front Microbiol (2011) 1.05
A Rab-centric perspective of bacterial pathogen-occupied vacuoles. Cell Host Microbe (2013) 1.05
The Legionella pneumophila effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion. Cell Host Microbe (2012) 1.03
Multiple MyD88-dependent responses contribute to pulmonary clearance of Legionella pneumophila. Cell Microbiol (2008) 1.02
The professional phagocyte Dictyostelium discoideum as a model host for bacterial pathogens. Curr Drug Targets (2011) 1.02
Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A. Oncotarget (2015) 1.02
Anchors for effectors: subversion of phosphoinositide lipids by legionella. Front Microbiol (2011) 1.00
Phosphatidylcholine synthesis is required for optimal function of Legionella pneumophila virulence determinants. Cell Microbiol (2007) 1.00
Actin dynamics and Rho GTPases regulate the size and formation of parasitophorous vacuoles containing Coxiella burnetii. Infect Immun (2009) 0.99
Functional symmetry of endomembranes. Mol Biol Cell (2007) 0.99
Immunology taught by bacteria. J Clin Immunol (2010) 0.98
Secrets of a successful pathogen: legionella resistance to progression along the autophagic pathway. Front Microbiol (2011) 0.98
The PmrA/PmrB two-component system of Legionella pneumophila is a global regulator required for intracellular replication within macrophages and protozoa. Infect Immun (2008) 0.97
Rapid escape of the dot/icm mutants of Legionella pneumophila into the cytosol of mammalian and protozoan cells. Infect Immun (2007) 0.97
Legionella pneumophila LidA affects nucleotide binding and activity of the host GTPase Rab1. J Bacteriol (2012) 0.95
Mouse infection by Legionella, a model to analyze autophagy. Autophagy (2006) 0.95
Functional role(s) of phagosomal Rab GTPases. Small GTPases (2013) 0.94
Structural insights into a unique Legionella pneumophila effector LidA recognizing both GDP and GTP bound Rab1 in their active state. PLoS Pathog (2012) 0.92
Reconceptualizing the chlamydial inclusion as a pathogen-specified parasitic organelle: an expanded role for Inc proteins. Front Cell Infect Microbiol (2014) 0.92
Molecular characterization of the Dot/Icm-translocated AnkH and AnkJ eukaryotic-like effectors of Legionella pneumophila. Infect Immun (2009) 0.91
Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection. PLoS Pathog (2013) 0.91
The taming of a Rab GTPase by Legionella pneumophila. Small GTPases (2012) 0.88
Maintenance of vacuole integrity by bacterial pathogens. Curr Opin Microbiol (2013) 0.87
Autophagic clearance of bacterial pathogens: molecular recognition of intracellular microorganisms. Front Cell Infect Microbiol (2013) 0.87
AMPylation is critical for Rab1 localization to vacuoles containing Legionella pneumophila. MBio (2014) 0.87
MavN is a Legionella pneumophila vacuole-associated protein required for efficient iron acquisition during intracellular growth. Proc Natl Acad Sci U S A (2015) 0.86
The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism. J Biol Chem (2013) 0.86
The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins. PLoS Pathog (2014) 0.86
Endosomal and secretory markers of the Legionella-containing vacuole. Commun Integr Biol (2009) 0.85
Characterization of enzymes from Legionella pneumophila involved in reversible adenylylation of Rab1 protein. J Biol Chem (2012) 0.83
Targeting of the small GTPase Rab6A' by the Legionella pneumophila effector LidA. Infect Immun (2013) 0.82
Structural basis for Rab1 de-AMPylation by the Legionella pneumophila effector SidD. PLoS Pathog (2013) 0.81
Complete and ubiquitinated proteome of the Legionella-containing vacuole within human macrophages. J Proteome Res (2014) 0.81
Characterization of Legionella pneumophila pmiA, a gene essential for infectivity of protozoa and macrophages. Infect Immun (2005) 0.81
Processing and major histocompatibility complex class II presentation of Legionella pneumophila antigens by infected macrophages. Infect Immun (2005) 0.80
Catch and release: Rab1 exploitation by Legionella pneumophila. Cell Logist (2011) 0.79
Take it and release it: The use of the Rab1 small GTPase at a bacterium's will. Cell Logist (2011) 0.79
LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1. Infect Immun (2013) 0.78
Endoplasmic Reticulum Tubule Protein Reticulon 4 Associates with the Legionella pneumophila Vacuole and with Translocated Substrate Ceg9. Infect Immun (2015) 0.77
Type II Secretion Is Necessary for Optimal Association of the Legionella-Containing Vacuole with Macrophage Rab1B but Enhances Intracellular Replication Mainly by Rab1B-Independent Mechanisms. Infect Immun (2016) 0.76
Beyond Rab GTPases Legionella activates the small GTPase Ran to promote microtubule polymerization, pathogen vacuole motility, and infection. Small GTPases (2014) 0.76
Host Cell-catalyzed S-Palmitoylation Mediates Golgi Targeting of the Legionella Ubiquitin Ligase GobX. J Biol Chem (2015) 0.76
Bacterial subversion of the host secretory pathway. Proc Natl Acad Sci U S A (2005) 0.76
Purification and proteomics of pathogen-modified vacuoles and membranes. Front Cell Infect Microbiol (2015) 0.76
Poison domains block transit of translocated substrates via the Legionella pneumophila Icm/Dot system. Infect Immun (2013) 0.76
Yersinia pestis Requires Host Rab1b for Survival in Macrophages. PLoS Pathog (2015) 0.76
Caspase Exploitation by Legionella pneumophila. Front Microbiol (2016) 0.75
Legionella pneumophila Type IV Effectors YlfA and YlfB Are SNARE-Like Proteins that Form Homo- and Heteromeric Complexes and Enhance the Efficiency of Vacuole Remodeling. PLoS One (2016) 0.75
Strategies Used by Bacteria to Grow in Macrophages. Microbiol Spectr (2016) 0.75
Comparative Proteomics of Purified Pathogen Vacuoles Correlates Intracellular Replication of Legionella pneumophila with the Small GTPase Ras-related protein 1 (Rap1). Mol Cell Proteomics (2017) 0.75
ER remodeling by the large GTPase atlastin promotes vacuolar growth of Legionella pneumophila. EMBO Rep (2017) 0.75
Legionnaires' disease: description of an epidemic of pneumonia. N Engl J Med (1977) 24.44
Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. J Histochem Cytochem (1974) 20.88
The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes. J Exp Med (1983) 8.82
Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes. J Exp Med (1983) 7.65
Conjugative transfer by the virulence system of Legionella pneumophila. Science (1998) 7.29
Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila. Mol Microbiol (1993) 5.99
Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome. Proc Natl Acad Sci U S A (1998) 5.65
Association of Legionella pneumophila with the macrophage endoplasmic reticulum. Infect Immun (1995) 5.35
Legionella pneumophila inhibits acidification of its phagosome in human monocytes. J Cell Biol (1984) 4.88
Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages. Cell (2002) 4.52
A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes. Science (2002) 4.49
Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites. Nat Cell Biol (2002) 3.98
Phagosomes are competent organelles for antigen cross-presentation. Nature (2003) 3.97
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells. Trends Microbiol (2000) 3.93
Interaction between the legionnaires' disease bacterium (Legionella pneumophila) and human alveolar macrophages. Influence of antibody, lymphokines, and hydrocortisone. J Clin Invest (1984) 3.59
The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity. Mol Microbiol (2003) 3.20
How the parasitic bacterium Legionella pneumophila modifies its phagosome and transforms it into rough ER: implications for conversion of plasma membrane to the ER membrane. J Cell Sci (2001) 2.83
Rab GTPases, intracellular traffic and disease. Trends Mol Med (2002) 2.72
Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering. Traffic (2001) 2.53
Intracellular growth of Legionella pneumophila in Dictyostelium discoideum, a system for genetic analysis of host-pathogen interactions. Infect Immun (2000) 2.46
Legionella pneumophila replication vacuoles mature into acidic, endocytic organelles. J Exp Med (2000) 2.40
Growth-supporting activity for Legionella pneumophila in tap water cultures and implication of hartmannellid amoebae as growth factors. Appl Environ Microbiol (1988) 2.32
Subunit structure of a mammalian ER/Golgi SNARE complex. J Biol Chem (2000) 1.39
A Rab2 mutant with impaired GTPase activity stimulates vesicle formation from pre-Golgi intermediates. Mol Biol Cell (1999) 1.21
SNARE complex structure and function. Exp Cell Res (2001) 1.20
Expression of wild-type and mutant green fluorescent protein-Rab1 for fluorescence microscopy analysis. Methods Enzymol (2001) 0.88
Multiple substrates of the Legionella pneumophila Dot/Icm system identified by interbacterial protein transfer. Proc Natl Acad Sci U S A (2004) 4.27
Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host Microbe (2009) 3.86
The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity. Mol Microbiol (2003) 3.20
Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila. Dev Cell (2006) 3.06
A bifunctional bacterial protein links GDI displacement to Rab1 activation. Science (2007) 2.60
RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics. PLoS Pathog (2006) 2.44
A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death. Proc Natl Acad Sci U S A (2006) 2.21
An open letter to Elias Zerhouni. Science (2005) 2.19
Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine. J Exp Med (2006) 2.11
NF-kappaB translocation prevents host cell death after low-dose challenge by Legionella pneumophila. J Exp Med (2006) 2.06
Legionella pneumophila Dot/Icm translocated substrates: a sum of parts. Curr Opin Microbiol (2009) 2.01
Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogen. Science (2012) 1.87
The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science (2012) 1.82
IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole. Infect Immun (2004) 1.76
The E Block motif is associated with Legionella pneumophila translocated substrates. Cell Microbiol (2010) 1.51
Minimization of the Legionella pneumophila genome reveals chromosomal regions involved in host range expansion. Proc Natl Acad Sci U S A (2011) 1.50
LidA, a translocated substrate of the Legionella pneumophila type IV secretion system, interferes with the early secretory pathway. Infect Immun (2005) 1.49
Large-scale identification of Legionella pneumophila Dot/Icm substrates that modulate host cell vesicle trafficking pathways. Cell Microbiol (2008) 1.47
The protein SdhA maintains the integrity of the Legionella-containing vacuole. Proc Natl Acad Sci U S A (2012) 1.47
Macrophages from mice with the restrictive Lgn1 allele exhibit multifactorial resistance to Legionella pneumophila. Infect Immun (2004) 1.45
Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction. Infect Immun (2008) 1.40
Innate immune recognition of Yersinia pseudotuberculosis type III secretion. PLoS Pathog (2009) 1.38
Members of a Legionella pneumophila family of proteins with ExoU (phospholipase A) active sites are translocated to target cells. Infect Immun (2006) 1.36
E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates. Infect Immun (2010) 1.34
CD8(+) T cells restrict Yersinia pseudotuberculosis infection: bypass of anti-phagocytosis by targeting antigen-presenting cells. PLoS Pathog (2009) 1.24
LnaB: a Legionella pneumophila activator of NF-kappaB. Cell Microbiol (2010) 1.23
Towards a molecular understanding of human diseases using Dictyostelium discoideum. Trends Mol Med (2006) 1.22
Yersinia pseudotuberculosis spatially controls activation and misregulation of host cell Rac1. PLoS Pathog (2005) 1.20
Macrophage-induced genes of Legionella pneumophila: protection from reactive intermediates and solute imbalance during intracellular growth. Infect Immun (2002) 1.19
Dictyostelium discoideum strains lacking the RtoA protein are defective for maturation of the Legionella pneumophila replication vacuole. Cell Microbiol (2005) 1.15
The DotL protein, a member of the TraG-coupling protein family, is essential for Viability of Legionella pneumophila strain Lp02. J Bacteriol (2005) 1.11
Experimental evolution of Legionella pneumophila in mouse macrophages leads to strains with altered determinants of environmental survival. PLoS Pathog (2012) 1.10
Growth of Yersinia pseudotuberculosis in mice occurs independently of Toll-like receptor 2 expression and induction of interleukin-10. Infect Immun (2007) 1.10
Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake. J Exp Med (2003) 1.08
IcmR-regulated membrane insertion and efflux by the Legionella pneumophila IcmQ protein. J Biol Chem (2003) 1.05
Intracellular replication of Mycobacterium marinum within Dictyostelium discoideum: efficient replication in the absence of host coronin. Infect Immun (2003) 1.05
Identification of MrtAB, an ABC transporter specifically required for Yersinia pseudotuberculosis to colonize the mesenteric lymph nodes. PLoS Pathog (2012) 1.02
Legionella pneumophila EnhC is required for efficient replication in tumour necrosis factor alpha-stimulated macrophages. Cell Microbiol (2008) 1.01
Phosphatidylcholine synthesis is required for optimal function of Legionella pneumophila virulence determinants. Cell Microbiol (2007) 1.00
The polybasic region of Rac1 modulates bacterial uptake independently of self-association and membrane targeting. J Biol Chem (2008) 0.97
Bacterial pathogen manipulation of host membrane trafficking. Annu Rev Cell Dev Biol (2014) 0.97
Yersinia entry into host cells requires Rab5-dependent dephosphorylation of PI(4,5)P₂ and membrane scission. Cell Host Microbe (2012) 0.95
Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1). J Biol Chem (2010) 0.92
Disruption of RhoGDI and RhoA regulation by a Rac1 specificity switch mutant. J Biol Chem (2006) 0.91
The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA. Cell Host Microbe (2009) 0.89
Non-vertebrate hosts in the analysis of host-pathogen interactions. Microbes Infect (2006) 0.88
Yersinia pseudotuberculosis virulence determinants invasin, YopE, and YopT modulate RhoG activity and localization. Infect Immun (2009) 0.87
Cdc42 interacts with the exocyst complex to promote phagocytosis. J Cell Biol (2013) 0.87
Control of host cell phosphorylation by legionella pneumophila. Front Microbiol (2011) 0.87
A hemidominant Naip5 allele in mouse strain MOLF/Ei-derived macrophages restricts Legionella pneumophila intracellular growth. Infect Immun (2008) 0.85
Emerging views on integrin signaling via Rac1 during invasin-promoted bacterial uptake. Curr Opin Microbiol (2005) 0.85
Analyzing microbial disease at high resolution: following the fate of the bacterium during infection. Curr Opin Microbiol (2011) 0.84
The Legionella pneumophila EnhC protein interferes with immunostimulatory muramyl peptide production to evade innate immunity. Cell Host Microbe (2012) 0.83
Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophila. Structure (2009) 0.81
IcmQ in the Type 4b secretion system contains an NAD+ binding domain. Structure (2013) 0.77
Host signal transduction and protein kinases implicated in Legionella infection. Curr Top Microbiol Immunol (2013) 0.77
Analysis of Legionella infection using RNAi in Drosophila cells. Methods Mol Biol (2013) 0.77
Poison domains block transit of translocated substrates via the Legionella pneumophila Icm/Dot system. Infect Immun (2013) 0.76
QnAs with Ralph R. Isberg. Proc Natl Acad Sci U S A (2013) 0.75